lymphoid leukemia |
Disease ID | 831 |
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Disease | lymphoid leukemia |
Manually Symptom | (Waiting for update.) |
Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:4) C1841971 | glucocorticoid resistance | 2 C0442874 | neuropathy | 2 C0034150 | purpura | 2 C0008049 | varicella | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
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(Waiting for update.) |
All Snps(Total Genotypes:17) | |||||||||||||
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snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
rs10821936 | 19684603 | 84159 | ARID5B | umls:C0023448 | GAD | [germline variants affect susceptibility to, and characteristics of, specific ALL subtypes.] | 0.004734064 | 2009 | ARID5B | 10 | 61963818 | C | T |
rs10849033 | 19684603 | 894 | CCND2 | umls:C0023448 | GAD | [germline variants affect susceptibility to, and characteristics of, specific ALL subtypes.] | 0.002367032 | 2009 | NA | 12 | 4315956 | G | A |
rs12621643 | 19684603 | 23704 | KCNE4 | umls:C0023448 | GAD | [germline variants affect susceptibility to, and characteristics of, specific ALL subtypes.] | 0.002367032 | 2009 | KCNE4 | 2 | 223053265 | T | G |
rs1879352 | 19684603 | 56651 | LINC00470 | umls:C0023448 | GAD | [germline variants affect susceptibility to, and characteristics of, specific ALL subtypes.] | 0.002367032 | 2009 | NA | 18 | 2498055 | T | C |
rs1881797 | 19684603 | 441932 | OR2W5 | umls:C0023448 | GAD | [germline variants affect susceptibility to, and characteristics of, specific ALL subtypes.] | 0.002367032 | 2009 | GCSAML;GCSAML-AS1 | 1 | 247526230 | C | T |
rs2032582 | 24142546 | 5243 | ABCB1 | umls:C0023448 | BeFree | In the subgroup analysis, according to the type of leukemia, significant association was found between MDR1 G2677T polymorphism and myeloid leukemia but not lymphoblastic leukemia (TT vs. GG: OR = 0.66, 95% CI = 0.46-0.95, P = 0.026; TT vs. | 0.006634157 | 2013 | ABCB1 | 7 | 87531302 | A | T,C |
rs2089222 | 19684603 | 643246 | MAP1LC3B2 | umls:C0023448 | GAD | [germline variants affect susceptibility to, and characteristics of, specific ALL subtypes.] | 0.002367032 | 2009 | MAP1LC3B2 | 12 | 116564853 | G | A |
rs2191566 | 19684603 | 7773 | ZNF230 | umls:C0023448 | GAD | [germline variants affect susceptibility to, and characteristics of, specific ALL subtypes.] | 0.002367032 | 2009 | ZNF230 | 19 | 44007237 | G | T |
rs2239633 | 19684604 | 1053 | CEBPE | umls:C0023448 | GAD | [Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.] | 0.002367032 | 2009 | CEBPE | 14 | 23119848 | G | A |
rs267607131 | 10077164 | 7150 | TOP1 | umls:C0023448 | BeFree | In previous studies, we isolated a mutant DNA topoisomerase I cDNA from a camptothecin (CPT)-resistant human T-lymphoblastic leukemia cell line, CPT-K5, and demonstrated that an amino acid change from Asp to Gly at residue 533 is responsible for the CPT resistance of the enzyme. | 0.000271442 | 1999 | TOP1;PLCG1-AS1 | 20 | 41114115 | A | G |
rs391525 | 21131588 | 3394 | IRF8 | umls:C0023448 | GAD | [Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL.] | 0.002367032 | 2011 | IRF8 | 16 | 85910833 | A | G |
rs563507 | 19684603 | 56288 | PARD3 | umls:C0023448 | GAD | [germline variants affect susceptibility to, and characteristics of, specific ALL subtypes.] | 0.002367032 | 2009 | PARD3 | 10 | 34529060 | G | A |
rs6428370 | 19684603 | 3078 | CFHR1 | umls:C0023448 | GAD | [germline variants affect susceptibility to, and characteristics of, specific ALL subtypes.] | 0.002367032 | 2009 | NA | 1 | 196875463 | A | G |
rs7089424 | 19684604 | 84159 | ARID5B | umls:C0023448 | GAD | [Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.] | 0.004734064 | 2009 | ARID5B | 10 | 61992400 | T | G |
rs7554607 | 19684603 | 6262 | RYR2 | umls:C0023448 | GAD | [germline variants affect susceptibility to, and characteristics of, specific ALL subtypes.] | 0.002367032 | 2009 | RYR2 | 1 | 237103303 | A | G |
rs9290663 | 19684603 | 10242 | KCNMB2 | umls:C0023448 | GAD | [germline variants affect susceptibility to, and characteristics of, specific ALL subtypes.] | 0.002367032 | 2009 | KCNMB2;KCNMB2-AS1 | 3 | 178712151 | A | T |
rs9378805 | 21131588 | 3662 | IRF4 | umls:C0023448 | GAD | [Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL.] | 0.002367032 | 2011 | NA | 6 | 417727 | A | C |
GWASdb Annotation(Total Genotypes:0) | |
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(Waiting for update.) |
GWASdb Snp Trait(Total Genotypes:0) | |
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(Waiting for update.) |
Mapped by lexical matching(Total Items:0) |
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(Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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(Waiting for update.) |
Chemical(Total Drugs:17) | |||||||||
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CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
C0023448 | allopurinol | D000493 | 315-30-0 | leukemia, lymphoid | MESH:D007945 | therapeutic | 12708945 | ||
C0023448 | arsenic trioxide | C006632 | 1327-53-3 | leukemia, lymphoid | MESH:D007945 | therapeutic | 20039766 | ||
C0023448 | bendamustine hydrochloride | D000069461 | - | leukemia, lymphoid | MESH:D007945 | therapeutic | 23353698 | ||
C0023448 | chlorambucil | D002699 | 305-03-3 | leukemia, lymphoid | MESH:D007945 | therapeutic | 23353698 | ||
C0023448 | cladribine | D017338 | 4291-63-8 | leukemia, lymphoid | MESH:D007945 | therapeutic | 23353698 | ||
C0023448 | cyclophosphamide | D003520 | 50-18-0 | leukemia, lymphoid | MESH:D007945 | therapeutic | 23353698 | ||
C0023448 | pentostatin | D015649 | 53910-25-1 | leukemia, lymphoid | MESH:D007945 | therapeutic | 23353698 | ||
C0023448 | cisplatin | D002945 | 15663-27-1 | leukemia, lymphoid | MESH:D007945 | therapeutic | 9921918 | ||
C0023448 | calcitriol | D002117 | 32222-06-3 | leukemia, lymphoid | MESH:D007945 | therapeutic | 20039766 | ||
C0023448 | hydroxyurea | D006918 | 127-07-1 | leukemia, lymphoid | MESH:D007945 | therapeutic | 12708945 | ||
C0023448 | idelalisib | C552946 | - | leukemia, lymphoid | MESH:D007945 | therapeutic | 23676220 | ||
C0023448 | methotrexate | D008727 | 1959/5/2 | leukemia, lymphoid | MESH:D007945 | therapeutic | 288556 | ||
C0023448 | mitoxantrone | D008942 | 65271-80-9 | leukemia, lymphoid | MESH:D007945 | therapeutic | 21239698 | ||
C0023448 | paclitaxel | D017239 | - | leukemia, lymphoid | MESH:D007945 | therapeutic | 17059768 | ||
C0023448 | theophylline | D013806 | 58-55-9 | leukemia, lymphoid | MESH:D007945 | therapeutic | 11128117 | ||
C0023448 | thiotepa | D013852 | 52-24-4 | leukemia, lymphoid | MESH:D007945 | marker/mechanism | 10069464 | ||
C0023448 | vincristine | D014750 | - | leukemia, lymphoid | MESH:D007945 | therapeutic | 4348690 |
FDA approved drug and dosage information(Total Drugs:0) | |
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(Waiting for update.) |
FDA labeling changes(Total Drugs:0) | |
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(Waiting for update.) |