PedAM
Pediatric Disease Annotations & Medicines
| lymphedema | ||||
| Disease ID | 265 |
|---|---|
| Disease | lymphedema |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:17) C2598155 | pain C2073625 | pleural effusion C2025995 | cellulitis C1963138 | hypertension C1768507 | yellow nails C0348754 | hepatotoxicity C0302314 | xanthomas C0302314 | xanthoma C0151448 | rotator cuff tendonitis C0078981 | arachnoid cysts C0042345 | varicose veins C0042345 | varices C0040053 | thrombosis C0039520 | tenosynovitis C0024225 | lymphangitis C0024224 | lymphangiosarcoma C0018923 | angiosarcoma |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:6) C0030193 | pain | 8 C0018923 | angiosarcoma | 7 C0024224 | lymphangiosarcoma | 5 C0007642 | cellulitis | 4 C0042345 | varicose veins | 1 C0032227 | pleural effusion | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:2) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0024236 | melphalan | D008558 | 148-82-3 | lymphedema | MESH:D008209 | marker/mechanism | 7802575 | ||
| C0024236 | sirolimus | D020123 | 53123-88-9 | lymphedema | MESH:D008209 | marker/mechanism | 18339149 | ||
FDA approved drug and dosage information(Total Drugs:2) | ||||||||
|---|---|---|---|---|---|---|---|---|
| DiseaseID | Drug_name | active_ingredients | strength | Dosage Form/Route | Marketing Status | TE code | RLD | RS |
| MESH:D008209 | rapamune | sirolimus | 1MG/ML | SOLUTION;ORAL | Prescription | None | Yes | Yes |
| MESH:D008209 | rapamune | sirolimus | 1MG | TABLET;ORAL | Prescription | AB | Yes | No |
FDA labeling changes(Total Drugs:2) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DiseaseID | Pediatric_Labeling_Date | Trade_Name | Generic_Name_or_Proper_Name | Indications Studied | Label Changes Summary | Product Labeling | BPCA(B) | PREA(P) | BPCA(B) and PREA(P) | Pediatric Rule (R) | Sponsor | Pediatric Exclusivity Granted Date | NNPS |
| MESH:D008209 | 11/3/2005 | rapamune | sirolimus | Prophylaxis of organ rejection in patients undergoing renal transplants | Safety and efficacy established in children 13 years or older judged to be at low to moderate immunologic risk Safety was assessed in a controlled clinical trial in pediatric ( | Labeling | B | - | - | - | Wyeth | 11/17/2004 | FALSE' |
| MESH:D008209 | 11/3/2005 | rapamune | sirolimus | Prophylaxis of organ rejection in patients undergoing renal transplants | Safety and efficacy established in children 13 years or older judged to be at low to moderate immunologic risk Safety was assessed in a controlled clinical trial in pediatric ( | Labeling | B | - | - | - | Wyeth | 11/17/2004 | FALSE' |