PedAM

Pediatric Disease Annotations & Medicines


	liver disease

Disease ID	675
Disease	liver disease
Definition	Pathological processes of the LIVER.
Synonym	[x]diseases of the liver [x]diseases of the liver (disorder) disease hepatocellular disease of liver disease of liver (disorder) disease of liver [ambiguous] disease of liver, nos disease, liver diseases of liver diseases of the liver diseases, liver disorder hepatic disorder liver disorder of liver disorder of liver (disorder) fector hepaticus hepatic disease hepatic disease (nos) hepatic diseases hepatic disorder hepatic disorder (nos) hepatic disorders hepatic: hepatocellular hepatocellular disease hepatopathy ld - liver disease liver and intrahepatic bile duct disorder liver dis liver disease, nos liver diseases liver diseases [disease/finding] liver diseases of liver disorder liver disorder nos liver disorder nos (disorder) liver disorders liver--diseases unspecified disorder of liver
DOID	DOID:409
UMLS	C0023895
MeSH	D008107
SNOMED-CT	SNOMEDCT_US_2016_09_01:235856003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:319) C0023890 \| cirrhosis \| 175 C0019158 \| hepatitis \| 144 C0028754 \| obesity \| 83 C0019204 \| hepatocellular carcinoma \| 82 C0011847 \| diabetes \| 70 C0019196 \| hepatitis c \| 69 C0020538 \| hypertension \| 63 C0020541 \| portal hypertension \| 56 C0948265 \| metabolic syndrome \| 52 C0019163 \| hepatitis b \| 50 C0011860 \| type 2 diabetes \| 45 C0011849 \| diabetes mellitus \| 25 C0023890 \| liver cirrhosis \| 25 C0040034 \| thrombocytopenia \| 22 C0011860 \| type 2 diabetes mellitus \| 21 C0019151 \| hepatic encephalopathy \| 19 C0042721 \| viral hepatitis \| 19 C0042373 \| vascular disease \| 17 C0010674 \| cystic fibrosis \| 16 C0042769 \| virus infection \| 15 C0007222 \| cardiovascular disease \| 15 C0010068 \| coronary artery disease \| 14 C0282193 \| iron overload \| 13 C0042870 \| vitamin d defic \| 12 C0042345 \| varices \| 12 C0042870 \| vitamin d deficiency \| 12 C0022658 \| kidney disease \| 12 C0004153 \| atherosclerosis \| 11 C0162429 \| malnutrition \| 11 C0035078 \| renal failure \| 10 C0029456 \| osteoporosis \| 10 C0040053 \| thrombosis \| 10 C0014867 \| esophageal varices \| 9 C0023903 \| liver cancer \| 9 C0022658 \| renal disease \| 9 C0008370 \| cholestasis \| 8 C0011570 \| depression \| 8 C0020542 \| pulmonary hypertension \| 8 C0007113 \| rectal cancer \| 7 C0021390 \| inflammatory bowel disease \| 7 C0002871 \| anemia \| 7 C0032460 \| polycystic ovary syndrome \| 7 C0032460 \| polycystic ovary \| 7 C0022661 \| chronic kidney disease \| 6 C0008313 \| sclerosing cholangitis \| 6 C0018799 \| heart disease \| 6 C0007570 \| celiac disease \| 6 C0019187 \| alcoholic hepatitis \| 6 C0021831 \| bowel disease \| 6 C0019196 \| hepatitis c infection \| 6 C0241910 \| autoimmune hepatitis \| 6 C0020676 \| hypothyroidism \| 5 C0008311 \| cholangitis \| 5 C0019202 \| wilson's disease \| 5 C0020456 \| hyperglycemia \| 5 C0020532 \| hypersplenism \| 5 C0019202 \| wilson disease \| 5 C0005940 \| bone disease \| 5 C0009402 \| colorectal cancer \| 5 C0024141 \| systemic lupus erythematosus \| 5 C0005411 \| biliary atresia \| 5 C0037061 \| siderosis \| 4 C0008312 \| primary biliary cirrhosis \| 4 C0010068 \| coronary heart disease \| 4 C0600452 \| hepatopulmonary syndrome \| 4 C1565489 \| renal insufficiency \| 4 C0001973 \| alcoholism \| 4 C0014867 \| oesophageal varices \| 4 C0566602 \| primary sclerosing cholangitis \| 4 C0018801 \| heart failure \| 4 C0032285 \| pneumonia \| 4 C0022679 \| cystic kidney \| 4 C0019212 \| hepatorenal syndrome \| 3 C0003467 \| anxiety \| 3 C0042373 \| vascular disorder \| 3 C0162429 \| malnourished \| 3 C0041296 \| tuberculosis \| 3 C0028756 \| morbid obesity \| 3 C0004623 \| bacterial infection \| 3 C0019163 \| hepatitis b infection \| 3 C0022661 \| chronic renal failure \| 3 C0409974 \| lupus erythematosus \| 3 C0008312 \| biliary cirrhosis \| 3 C0206698 \| cholangiocarcinoma \| 3 C0019322 \| umbilical hernia \| 3 C0520679 \| obstructive sleep apnea \| 3 C0159069 \| impaired glucose tolerance \| 3 C0155773 \| portal vein thrombosis \| 3 C0001623 \| adrenal insufficiency \| 3 C0037315 \| sleep apnea \| 3 C0085413 \| autosomal dominant polycystic kidney \| 3 C0023891 \| alcoholic cirrhosis \| 3 C0042373 \| vascular diseases \| 3 C0009319 \| colitis \| 3 C0007222 \| cardiovascular diseases \| 3 C0022661 \| chronic renal disease \| 2 C0033860 \| psoriasis \| 2 C0022661 \| end stage renal disease \| 2 C0442874 \| neuropathy \| 2 C0019204 \| hepatocellular carcinomas \| 2 C0011854 \| type 1 diabetes \| 2 C0007570 \| coeliac disease \| 2 C0042373 \| vascular disorders \| 2 C0023895 \| liver diseases \| 2 C0027765 \| neurological disorder \| 2 C0011226 \| hepatitis d \| 2 C0024523 \| malabsorption \| 2 C0028756 \| severe obesity \| 2 C0004623 \| bacterial infections \| 2 C0017178 \| gastrointestinal disorders \| 2 C0036992 \| short bowel syndrome \| 2 C1561644 \| chronic kidney disease (ckd) \| 2 C0345905 \| intrahepatic cholangiocarcinoma \| 2 C0009324 \| ulcerative colitis \| 2 C0017168 \| esophageal reflux \| 2 C0028754 \| adiposity \| 2 C0018991 \| hemiplegia \| 2 C0007222 \| cardiovascular disorders \| 2 C0035579 \| hypovitaminosis d \| 2 C0039446 \| telangiectasias \| 2 C0034150 \| purpura \| 2 C0032285 \| pneumoniae \| 2 C0017168 \| oesophageal reflux \| 2 C0036323 \| schistosomiasis \| 2 C0016977 \| gallbladder disease \| 2 C1510471 \| hypovitaminosis \| 2 C0856761 \| budd-chiari syndrome \| 2 C0271650 \| prediabetes \| 2 C0011644 \| scleroderma \| 2 C0022661 \| end-stage renal disease \| 2 C0017168 \| gastroesophageal reflux \| 2 C0085413 \| autosomal dominant polycystic kidney disease \| 2 C0005940 \| bone diseases \| 2 C0031154 \| peritonitis \| 2 C0042769 \| viral infection \| 2 C0006142 \| breast cancer \| 2 C0085293 \| hepatitis e \| 2 C0022658 \| nephropathy \| 2 C0017178 \| gastrointestinal disorder \| 2 C0019045 \| hemoglobinopathies \| 2 C0042075 \| urologic disease \| 2 C0020459 \| hyperinsulinemia \| 2 C0851578 \| sleep disorders \| 2 C0002766 \| analgesia \| 2 C0036341 \| schizophrenia \| 2 C0010068 \| coronary disease \| 2 C0004096 \| asthma \| 1 C0020455 \| hypergammaglobulinemia \| 1 C0039730 \| thalassaemia \| 1 C0003873 \| rheumatoid arthritis \| 1 C0398623 \| hypercoagulable state \| 1 C0005586 \| bipolar disorder \| 1 C0206754 \| neuroendocrine tumour \| 1 C0850572 \| colonic adenoma \| 1 C0008370 \| bile stasis \| 1 C0013338 \| growth hormone deficiency \| 1 C0003873 \| rheumatoid disease \| 1 C0162429 \| undernutrition \| 1 C0011226 \| delta infection \| 1 C0022661 \| end stage renal disease (esrd) \| 1 C0155765 \| microangiopathy \| 1 C0017205 \| gaucher disease \| 1 C0042384 \| vasculitis \| 1 C0019045 \| haemoglobinopathies \| 1 C1384514 \| primary aldosteronism \| 1 C0004134 \| ataxia \| 1 C0238198 \| gastrointestinal stromal tumors \| 1 C0021053 \| immune disease \| 1 C0041408 \| turner's syndrome \| 1 C0008049 \| chickenpox \| 1 C0024623 \| gastric cancer \| 1 C0011226 \| hepatitis delta \| 1 C0030312 \| pancytopenia \| 1 C0023903 \| hepatic cancer \| 1 C0008372 \| intrahepatic cholestasis \| 1 C0026718 \| mucormycosis \| 1 C0085253 \| adult onset still's disease \| 1 C0021670 \| insulinoma \| 1 C0014118 \| endocarditis \| 1 C0032914 \| preeclampsia \| 1 C0011860 \| niddm \| 1 C0015930 \| fetal distress \| 1 C0002878 \| haemolytic anaemia \| 1 C0004030 \| aspergillosis \| 1 C0349604 \| intracranial meningioma \| 1 C0018099 \| gout \| 1 C0006309 \| brucellosis \| 1 C0020474 \| familial combined hyperlipidemia \| 1 C0028709 \| nutrition disorders \| 1 C0085762 \| ethanol abuse \| 1 C0023895 \| liver disorders \| 1 C0015645 \| fasciitis \| 1 C0009492 \| compartment syndrome \| 1 C0023903 \| hepatic tumor \| 1 C0221757 \| alpha-1-antitrypsin def \| 1 C0011860 \| type ii diabetes \| 1 C0021053 \| immune disorders \| 1 C0206754 \| neuroendocrine tumors \| 1 C0162429 \| nutritional deficiencies \| 1 C0494165 \| liver metastasis \| 1 C0021843 \| bowel obstruction \| 1 C0024314 \| lymphoproliferative disorder \| 1 C0033677 \| protein-energy malnutrition \| 1 C0014735 \| erysipelothrix \| 1 C0008350 \| cholelithiasis \| 1 C0206754 \| neuroendocrine tumor \| 1 C0036319 \| schistosoma mansoni \| 1 C0149521 \| chronic pancreatitis \| 1 C0002878 \| hemolytic anemia \| 1 C0029442 \| osteomalacia \| 1 C0022661 \| end-stage renal failure \| 1 C0015230 \| rash \| 1 C0027765 \| neurologic disorder \| 1 C0162429 \| nutritional deficiency \| 1 C0031090 \| periodontal disease \| 1 C1619734 \| pulmonary arterial hypertension \| 1 C0011633 \| dermatomyositis \| 1 C0023895 \| liver disorder \| 1 C0023241 \| legionella pneumonia \| 1 C0021390 \| inflammatory bowel diseases \| 1 C0268483 \| tyrosinemia \| 1 C0349604 \| intracranial meningiomas \| 1 C1145670 \| respiratory failure \| 1 C0010631 \| cystadenocarcinoma \| 1 C0019621 \| langerhans cell histiocytosis \| 1 C0018920 \| cavernoma \| 1 C0021053 \| immune disorder \| 1 C0398623 \| hypercoagulability \| 1 C0037317 \| sleep disturbance \| 1 C0017665 \| membranous nephropathy \| 1 C0259749 \| autonomic neuropathy \| 1 C0085681 \| hyperphosphatemia \| 1 C0751711 \| anterior ischemic optic neuropathy \| 1 C0036337 \| schizoaffective disorder \| 1 C0010403 \| cryoglobulinemia \| 1 C0238124 \| necrotizing fasciitis \| 1 C0162429 \| poor nutrition \| 1 C0035309 \| retinopathy \| 1 C0085253 \| adult-onset still's disease \| 1 C0221757 \| alpha-1 antitrypsin deficiency \| 1 C0039128 \| syphilis \| 1 C0021141 \| syndrome of inappropriate antidiuretic hormone secretion \| 1 C0553662 \| juvenile idiopathic arthritis \| 1 C0014761 \| hemolytic disease of the newborn \| 1 C0022660 \| acute renal failure \| 1 C0020538 \| high blood pressure \| 1 C0002895 \| sickle cell disease \| 1 C0042769 \| viral infections \| 1 C0029089 \| ophthalmoplegia \| 1 C0002871 \| anaemia \| 1 C0027765 \| neurologic disorders \| 1 C0014544 \| epilepsy \| 1 C0026846 \| muscle wasting \| 1 C0019163 \| viral hepatitis b \| 1 C0026764 \| myeloma \| 1 C0030305 \| pancreatitis \| 1 C0025286 \| meningiomas \| 1 C0023530 \| leukopenia \| 1 C0221757 \| alpha 1 antitrypsin deficiency \| 1 C0027765 \| neurological disorders \| 1 C0010054 \| coronary atherosclerosis \| 1 C0745140 \| hyperthyroid \| 1 C0003864 \| arthritis \| 1 C0343386 \| clostridium difficile infection \| 1 C0206698 \| cholangiocellular carcinoma \| 1 C0036202 \| sarcoidosis \| 1 C0008533 \| hemophilia b \| 1 C0008049 \| varicella \| 1 C0242350 \| erectile dysfunction \| 1 C0162568 \| protoporphyria \| 1 C0035435 \| rheumatic diseases \| 1 C0011991 \| diarrhea \| 1 C0008354 \| vibrio cholerae \| 1 C0267211 \| gastric antral vascular ectasia \| 1 C0242379 \| lung cancer \| 1 C0035435 \| rheumatic disease \| 1 C0221757 \| alpha-1-antitrypsin deficiency \| 1 C0679466 \| cognitive deficits \| 1 C0029132 \| optic neuropathy \| 1 C0024115 \| lung disease \| 1 C0023787 \| lipodystrophy \| 1 C0017168 \| esophageal reflux disease \| 1 C0019618 \| histiocytosis \| 1 C0272286 \| immune thrombocytopenia \| 1 C0027947 \| neutropenia \| 1 C0879615 \| stromal tumor \| 1 C0006666 \| calciphylaxis \| 1 C0022104 \| irritable bowel syndrome \| 1 C0030293 \| pancreatic insufficiency \| 1 C0030326 \| panniculitis \| 1 C0021400 \| influenza \| 1 C0022104 \| irritable bowel \| 1 C0017675 \| glossitis \| 1 C0041696 \| major depressive disorder \| 1 C0019196 \| viral hepatitis c \| 1 C0016977 \| gallbladder diseases \| 1 C0026946 \| fungal infection \| 1 C0028326 \| noonan syndrome \| 1 C0271650 \| glucose intolerance \| 1 C0376545 \| hematologic malignancies \| 1 C0020428 \| hyperaldosteronism \| 1 C0043541 \| zygomycosis \| 1 C0031069 \| familial mediterranean fever \| 1 C0019069 \| hemophilia \| 1 C0520459 \| necrotizing enterocolitis \| 1 C1257763 \| overnutrition \| 1 C0027121 \| myositis \| 1 C0017168 \| gastroesophageal reflux disease \| 1 C0042075 \| urological disorders \| 1 C0003507 \| aortic stenosis \| 1 C0034734 \| raynaud's disease \| 1 C0041696 \| major depression \| 1 C0149985 \| secondary syphilis \| 1 C0272170 \| shwachman-diamond syndrome \| 1 C0018916 \| haemangioma \| 1 C1527311 \| brain edema \| 1 C0008350 \| gallstones \| 1 C0085548 \| autosomal recessive polycystic kidney disease \| 1 C0238198 \| gastrointestinal stromal tumor \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:77) TNF \| 7124 \| CTD_human NQO1 \| 1728 \| CTD_human ATP8B1 \| 5205 \| UniProtKB-KW SOD1 \| 6647 \| CTD_human CD79B \| 974 \| CTD_human ABCB11 \| 8647 \| UniProtKB-KW;GHR AMACR \| 23600 \| CTD_human;UniProtKB-KW NRP1 \| 8829 \| CTD_human TIMP3 \| 7078 \| CTD_human NOTCH2 \| 4853 \| GHR HMOX1 \| 3162 \| CTD_human PRNP \| 5621 \| GHR CCL2 \| 6347 \| CTD_human MMP9 \| 4318 \| CTD_human BCL2L1 \| 598 \| CTD_human NOS2 \| 4843 \| CTD_human SOCS1 \| 8651 \| CTD_human TJP2 \| 9414 \| UniProtKB-KW COL3A1 \| 1281 \| CTD_human SLC25A13 \| 10165 \| UniProtKB-KW TGM1 \| 7051 \| CTD_human NPC1 \| 4864 \| CTD_human NR1H4 \| 9971 \| CTD_human;UniProtKB-KW CYP7B1 \| 9420 \| CTD_human;UniProtKB-KW ACTA2 \| 59 \| CTD_human JUP \| 3728 \| CTD_human ATP7B \| 540 \| CTD_human;GHR MTHFR \| 4524 \| CTD_human CSF3 \| 1440 \| CTD_human ABCB4 \| 5244 \| UniProtKB-KW;GHR SERPINA1 \| 5265 \| CTD_human HSD3B7 \| 80270 \| UniProtKB-KW CCR2 \| 729230 \| CTD_human CCR1 \| 1230 \| CTD_human CD86 \| 942 \| CTD_human HSPA1A \| 3303 \| CTD_human JAG1 \| 182 \| GHR GGT1 \| 2678 \| CTD_human TXN \| 7295 \| CTD_human IL1R2 \| 7850 \| CTD_human CD3D \| 915 \| CTD_human CCK \| 885 \| CTD_human SULT1E1 \| 6783 \| CTD_human SC5D \| 6309 \| CTD_human ITGB6 \| 3694 \| CTD_human ALPL \| 249 \| CTD_human AHR \| 196 \| CTD_human ENO3 \| 2027 \| CTD_human RAC1 \| 5879 \| CTD_human DDAH1 \| 23576 \| CTD_human LAT \| 27040 \| CTD_human HK3 \| 3101 \| CTD_human TYROBP \| 7305 \| CTD_human IL11 \| 3589 \| CTD_human AKR1D1 \| 6718 \| UniProtKB-KW SCO1 \| 6341 \| CTD_human NFKB1 \| 4790 \| CTD_human ALAD \| 210 \| CTD_human CRISPLD2 \| 83716 \| CTD_human IL1RAP \| 3556 \| CTD_human IL9R \| 3581 \| CTD_human GRK5 \| 2869 \| CTD_human AFP \| 174 \| CTD_human TREM1 \| 54210 \| CTD_human ASAH2 \| 56624 \| CTD_human RNASE6 \| 6039 \| CTD_human ST8SIA1 \| 6489 \| CTD_human CYP1A2 \| 1544 \| CTD_human ALOX5AP \| 241 \| CTD_human SRSF5 \| 6430 \| CTD_human SOCS3 \| 9021 \| CTD_human GPT \| 2875 \| CTD_human GABRR2 \| 2570 \| CTD_human HPGDS \| 27306 \| CTD_human TM4SF4 \| 7104 \| CTD_human GNG8 \| 94235 \| CTD_human LTB4R \| 1241 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:31) 155 \| ADRB3 \| infer 217 \| ALDH2 \| infer 1586 \| CYP17A1 \| infer 1557 \| CYP2C19 \| infer 1565 \| CYP2D6 \| infer 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer 3586 \| IL10 \| infer 4353 \| MPO \| infer 5696 \| PSMB8 \| infer 5265 \| SERPINA1 \| infer 6891 \| TAP2 \| infer 126 \| ADH1C \| infer 929 \| CD14 \| infer 1075 \| CTSC \| infer 22943 \| DKK1 \| infer 1807 \| DPYS \| infer 2952 \| GSTT1 \| infer 9953 \| HS3ST3B1 \| infer 11253 \| MAN1B1 \| infer 4153 \| MBL2 \| infer 4524 \| MTHFR \| infer 92345 \| NAF1 \| infer 4886 \| NPY1R \| infer 4889 \| NPY5R \| infer 5444 \| PON1 \| infer 5445 \| PON2 \| infer 5446 \| PON3 \| infer 9317 \| PTER \| infer 6317 \| SERPINB3 \| infer 8403 \| SOX14 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:1342) 100505854 \| APTR \| DISEASES 282706 \| DAOA-AS1 \| DISEASES 1080 \| CFTR \| DISEASES 6376 \| CX3CL1 \| DISEASES 920 \| CD4 \| DISEASES 6344 \| SCTR \| DISEASES 1634 \| DCN \| DISEASES 10911 \| UTS2 \| DISEASES 84957 \| RELT \| DISEASES 84699 \| CREB3L3 \| DISEASES 3385 \| ICAM3 \| DISEASES 23152 \| CIC \| DISEASES 634 \| CEACAM1 \| DISEASES 7132 \| TNFRSF1A \| DISEASES 2249 \| FGF4 \| DISEASES 6480 \| ST6GAL1 \| DISEASES 3566 \| IL4R \| DISEASES 9817 \| KEAP1 \| DISEASES 6343 \| SCT \| DISEASES 30009 \| TBX21 \| DISEASES 1361 \| CPB2 \| DISEASES 2191 \| FAP \| DISEASES 359 \| AQP2 \| DISEASES 7066 \| THPO \| DISEASES 350 \| APOH \| DISEASES 2099 \| ESR1 \| DISEASES 124 \| ADH1A \| DISEASES 25984 \| KRT23 \| DISEASES 23411 \| SIRT1 \| DISEASES 266 \| AMELY \| DISEASES 8174 \| MADCAM1 \| DISEASES 3053 \| SERPIND1 \| DISEASES 4282 \| MIF \| DISEASES 5008 \| OSM \| DISEASES 11274 \| USP18 \| DISEASES 5594 \| MAPK1 \| DISEASES 6576 \| SLC25A1 \| DISEASES 7494 \| XBP1 \| DISEASES 140564 \| APOBEC3D \| DISEASES 3162 \| HMOX1 \| DISEASES 80339 \| PNPLA3 \| DISEASES 11035 \| RIPK3 \| DISEASES 1511 \| CTSG \| DISEASES 3002 \| GZMB \| DISEASES 1113 \| CHGA \| DISEASES 6554 \| SLC10A1 \| DISEASES 5106 \| PCK2 \| DISEASES 4792 \| NFKBIA \| DISEASES 2937 \| GSS \| DISEASES 5834 \| PYGB \| DISEASES 28231 \| SLCO4A1 \| DISEASES 128866 \| CHMP4B \| DISEASES 3929 \| LBP \| DISEASES 191 \| AHCY \| DISEASES 5716 \| PSMD10 \| DISEASES 51311 \| TLR8 \| DISEASES 2158 \| F9 \| DISEASES 27344 \| PCSK1N \| DISEASES 7076 \| TIMP1 \| DISEASES 479 \| ATP12A \| DISEASES 4313 \| MMP2 \| DISEASES 6367 \| CCL22 \| DISEASES 4210 \| MEFV \| DISEASES 3163 \| HMOX2 \| DISEASES 10423 \| CDIPT \| DISEASES 51285 \| RASL12 \| DISEASES 2137 \| EXTL3 \| DISEASES 7038 \| TG \| DISEASES 1666 \| DECR1 \| DISEASES 5327 \| PLAT \| DISEASES 83988 \| NCALD \| DISEASES 2936 \| GSR \| DISEASES 8797 \| TNFRSF10A \| DISEASES 54793 \| KCTD9 \| DISEASES 56729 \| RETN \| DISEASES 2091 \| FBL \| DISEASES 7040 \| TGFB1 \| DISEASES 10226 \| PLIN3 \| DISEASES 973 \| CD79A \| DISEASES 1048 \| CEACAM5 \| DISEASES 6822 \| SULT2A1 \| DISEASES 9545 \| RAB3D \| DISEASES 26291 \| FGF21 \| DISEASES 57817 \| HAMP \| DISEASES 5444 \| PON1 \| DISEASES 3082 \| HGF \| DISEASES 10135 \| NAMPT \| DISEASES 4967 \| OGDH \| DISEASES 1577 \| CYP3A5 \| DISEASES 7036 \| TFR2 \| DISEASES 5054 \| SERPINE1 \| DISEASES 5919 \| RARRES2 \| DISEASES 727 \| C5 \| DISEASES 7431 \| VIM \| DISEASES 10105 \| PPIF \| DISEASES 6348 \| CCL3 \| DISEASES 4353 \| MPO \| DISEASES 1440 \| CSF3 \| DISEASES 1362 \| CPD \| DISEASES 1655 \| DDX5 \| DISEASES 6347 \| CCL2 \| DISEASES 6346 \| CCL1 \| DISEASES 6928 \| HNF1B \| DISEASES 1277 \| COL1A1 \| DISEASES 7448 \| VTN \| DISEASES 230 \| ALDOC \| DISEASES 952 \| CD38 \| DISEASES 6783 \| SULT1E1 \| DISEASES 4790 \| NFKB1 \| DISEASES 3558 \| IL2 \| DISEASES 3732 \| CD82 \| DISEASES 3312 \| HSPA8 \| DISEASES 595 \| CCND1 \| DISEASES 345 \| APOC3 \| DISEASES 3587 \| IL10RA \| DISEASES 8050 \| PDHX \| DISEASES 84649 \| DGAT2 \| DISEASES 4254 \| KITLG \| DISEASES 969 \| CD69 \| DISEASES 9761 \| MLEC \| DISEASES 51561 \| IL23A \| DISEASES 4055 \| LTBR \| DISEASES 3458 \| IFNG \| DISEASES 2597 \| GAPDH \| DISEASES 7167 \| TPI1 \| DISEASES 55907 \| CMAS \| DISEASES 57379 \| AICDA \| DISEASES 3820 \| KLRB1 \| DISEASES 2729 \| GCLC \| DISEASES 1432 \| MAPK14 \| DISEASES 55856 \| ACOT13 \| DISEASES 135152 \| B3GAT2 \| DISEASES 9841 \| ZBTB24 \| DISEASES 9896 \| FIG4 \| DISEASES 6908 \| TBP \| DISEASES 55754 \| TMEM30A \| DISEASES 2690 \| GHR \| DISEASES 4015 \| LOX \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 2908 \| NR3C1 \| DISEASES 3273 \| HRG \| DISEASES 5947 \| RBP1 \| DISEASES 7035 \| TFPI \| DISEASES 338 \| APOB \| DISEASES 4358 \| MPV17 \| DISEASES 10297 \| APC2 \| DISEASES 374291 \| NDUFS7 \| DISEASES 3485 \| IGFBP2 \| DISEASES 3554 \| IL1R1 \| DISEASES 5624 \| PROC \| DISEASES 5657 \| PRTN3 \| DISEASES 2023 \| ENO1 \| DISEASES 6402 \| SELL \| DISEASES 1509 \| CTSD \| DISEASES 4317 \| MMP8 \| DISEASES 335 \| APOA1 \| DISEASES 7276 \| TTR \| DISEASES 9429 \| ABCG2 \| DISEASES 9615 \| GDA \| DISEASES 7043 \| TGFB3 \| DISEASES 4360 \| MRC1 \| DISEASES 8600 \| TNFSF11 \| DISEASES 1958 \| EGR1 \| DISEASES 847 \| CAT \| DISEASES 10804 \| GJB6 \| DISEASES 8743 \| TNFSF10 \| DISEASES 4852 \| NPY \| DISEASES 6718 \| AKR1D1 \| DISEASES 28981 \| IFT81 \| DISEASES 540 \| ATP7B \| DISEASES 6626 \| SNRPA \| DISEASES 6615 \| SNAI1 \| DISEASES 5184 \| PEPD \| DISEASES 1026 \| CDKN1A \| DISEASES 2806 \| GOT2 \| DISEASES 6555 \| SLC10A2 \| DISEASES 3659 \| IRF1 \| DISEASES 6662 \| SOX9 \| DISEASES 30833 \| NT5C \| DISEASES 79143 \| MBOAT7 \| DISEASES 57187 \| THOC2 \| DISEASES 718 \| C3 \| DISEASES 10045 \| SH2D3A \| DISEASES 7389 \| UROD \| DISEASES 1236 \| CCR7 \| DISEASES 51119 \| SBDS \| DISEASES 6945 \| MLX \| DISEASES 7355 \| SLC35A2 \| DISEASES 5199 \| CFP \| DISEASES 821 \| CANX \| DISEASES 10365 \| KLF2 \| DISEASES 2671 \| GFER \| DISEASES 3315 \| HSPB1 \| DISEASES 10875 \| FGL2 \| DISEASES 2678 \| GGT1 \| DISEASES 2952 \| GSTT1 \| DISEASES 22933 \| SIRT2 \| DISEASES 8930 \| MBD4 \| DISEASES 1315 \| COPB1 \| DISEASES 968 \| CD68 \| DISEASES 6351 \| CCL4 \| DISEASES 1215 \| CMA1 \| DISEASES 3630 \| INS \| DISEASES 64151 \| NCAPG \| DISEASES 5894 \| RAF1 \| DISEASES 2006 \| ELN \| DISEASES 5589 \| PRKCSH \| DISEASES 348 \| APOE \| DISEASES 55821 \| ALLC \| DISEASES 59272 \| ACE2 \| DISEASES 1463 \| NCAN \| DISEASES 684 \| BST2 \| DISEASES 2056 \| EPO \| DISEASES 9518 \| GDF15 \| DISEASES 3727 \| JUND \| DISEASES 1571 \| CYP2E1 \| DISEASES 445 \| ASS1 \| DISEASES 25926 \| NOL11 \| DISEASES 10343 \| PKDREJ \| DISEASES 9104 \| RGN \| DISEASES 2161 \| F12 \| DISEASES 9945 \| GFPT2 \| DISEASES 2538 \| G6PC \| DISEASES 50617 \| ATP6V0A4 \| DISEASES 8431 \| NR0B2 \| DISEASES 3958 \| LGALS3 \| DISEASES 3337 \| DNAJB1 \| DISEASES 6382 \| SDC1 \| DISEASES 6737 \| TRIM21 \| DISEASES 23225 \| NUP210 \| DISEASES 5791 \| PTPRE \| DISEASES 182 \| JAG1 \| DISEASES 1401 \| CRP \| DISEASES 325 \| APCS \| DISEASES 6341 \| SCO1 \| DISEASES 1116 \| CHI3L1 \| DISEASES 3845 \| KRAS \| DISEASES 759 \| CA1 \| DISEASES 10894 \| LYVE1 \| DISEASES 1965 \| EIF2S1 \| DISEASES 9695 \| EDEM1 \| DISEASES 10752 \| CHL1 \| DISEASES 4853 \| NOTCH2 \| DISEASES 23175 \| LPIN1 \| DISEASES 10468 \| FST \| DISEASES 10599 \| SLCO1B1 \| DISEASES 2694 \| GIF \| DISEASES 187 \| APLNR \| DISEASES 6947 \| TCN1 \| DISEASES 6927 \| HNF1A \| DISEASES 8638 \| OASL \| DISEASES 29969 \| MDFIC \| DISEASES 4907 \| NT5E \| DISEASES 1019 \| CDK4 \| DISEASES 10024 \| TROAP \| DISEASES 1593 \| CYP27A1 \| DISEASES 3569 \| IL6 \| DISEASES 10241 \| CALCOCO2 \| DISEASES 3557 \| IL1RN \| DISEASES 26525 \| IL36RN \| DISEASES 84317 \| CCDC115 \| DISEASES 9394 \| HS6ST1 \| DISEASES 570 \| BAAT \| DISEASES 5168 \| ENPP2 \| DISEASES 3442 \| IFNA5 \| DISEASES 8737 \| RIPK1 \| DISEASES 7097 \| TLR2 \| DISEASES 7274 \| TTPA \| DISEASES 4316 \| MMP7 \| DISEASES 4322 \| MMP13 \| DISEASES 7057 \| THBS1 \| DISEASES 3795 \| KHK \| DISEASES 64240 \| ABCG5 \| DISEASES 1559 \| CYP2C9 \| DISEASES 2660 \| MSTN \| DISEASES 6741 \| SSB \| DISEASES 9360 \| PPIG \| DISEASES 30061 \| SLC40A1 \| DISEASES 10063 \| COX17 \| DISEASES 28234 \| SLCO1B3 \| DISEASES 4659 \| PPP1R12A \| DISEASES 4069 \| LYZ \| DISEASES 7450 \| VWF \| DISEASES 10162 \| LPCAT3 \| DISEASES 949 \| SCARB1 \| DISEASES 6532 \| SLC6A4 \| DISEASES 217 \| ALDH2 \| DISEASES 2184 \| FAH \| DISEASES 999 \| CDH1 \| DISEASES 5159 \| PDGFRB \| DISEASES 58517 \| RBM25 \| DISEASES 23531 \| MMD \| DISEASES 4481 \| MSR1 \| DISEASES 9172 \| MYOM2 \| DISEASES 54947 \| LPCAT2 \| DISEASES 4092 \| SMAD7 \| DISEASES 4087 \| SMAD2 \| DISEASES 4591 \| TRIM37 \| DISEASES 3595 \| IL12RB2 \| DISEASES 3674 \| ITGA2B \| DISEASES 6521 \| SLC4A1 \| DISEASES 6558 \| SLC12A2 \| DISEASES 79792 \| GSDMD \| DISEASES 495 \| ATP4A \| DISEASES 3249 \| HPN \| DISEASES 5465 \| PPARA \| DISEASES 7077 \| TIMP2 \| DISEASES 3959 \| LGALS3BP \| DISEASES 671 \| BPI \| DISEASES 25939 \| SAMHD1 \| DISEASES 91039 \| DPP9 \| DISEASES 5595 \| MAPK3 \| DISEASES 10133 \| OPTN \| DISEASES 22858 \| ICK \| DISEASES 10998 \| SLC27A5 \| DISEASES 23523 \| CABIN1 \| DISEASES 2033 \| EP300 \| DISEASES 4924 \| NUCB1 \| DISEASES 50507 \| NOX4 \| DISEASES 7299 \| TYR \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 645 \| BLVRB \| DISEASES 23476 \| BRD4 \| DISEASES 55717 \| WDR11 \| DISEASES 1991 \| ELANE \| DISEASES 64135 \| IFIH1 \| DISEASES 975 \| CD81 \| DISEASES 6403 \| SELP \| DISEASES 9410 \| SNRNP40 \| DISEASES 4072 \| EPCAM \| DISEASES 8647 \| ABCB11 \| DISEASES 10578 \| GNLY \| DISEASES 3791 \| KDR \| DISEASES 943 \| TNFRSF8 \| DISEASES 3931 \| LCAT \| DISEASES 3299 \| HSF4 \| DISEASES 1716 \| DGUOK \| DISEASES 4811 \| NID1 \| DISEASES 941 \| CD80 \| DISEASES 590 \| BCHE \| DISEASES 374 \| AREG \| DISEASES 59067 \| IL21 \| DISEASES 2247 \| FGF2 \| DISEASES 3589 \| IL11 \| DISEASES 1356 \| CP \| DISEASES 6774 \| STAT3 \| DISEASES 80725 \| SRCIN1 \| DISEASES 3818 \| KLKB1 \| DISEASES 5443 \| POMC \| DISEASES 8626 \| TP63 \| DISEASES 7297 \| TYK2 \| DISEASES 3383 \| ICAM1 \| DISEASES 10891 \| PPARGC1A \| DISEASES 54464 \| XRN1 \| DISEASES 3827 \| KNG1 \| DISEASES 64083 \| GOLPH3 \| DISEASES 1950 \| EGF \| DISEASES 10058 \| ABCB6 \| DISEASES 1390 \| CREM \| DISEASES 23534 \| TNPO3 \| DISEASES 127 \| ADH4 \| DISEASES 4547 \| MTTP \| DISEASES 644 \| BLVRA \| DISEASES 5446 \| PON3 \| DISEASES 1374 \| CPT1A \| DISEASES 51083 \| GAL \| DISEASES 5244 \| ABCB4 \| DISEASES 5243 \| ABCB1 \| DISEASES 63898 \| SH2D4A \| DISEASES 51608 \| GET4 \| DISEASES 5286 \| PIK3C2A \| DISEASES 3263 \| HPX \| DISEASES 3700 \| ITIH4 \| DISEASES 6425 \| SFRP5 \| DISEASES 56938 \| ARNTL2 \| DISEASES 4704 \| NDUFA9 \| DISEASES 939 \| CD27 \| DISEASES 4060 \| LUM \| DISEASES 7112 \| TMPO \| DISEASES 1017 \| CDK2 \| DISEASES 51411 \| BIN2 \| DISEASES 6751 \| SSTR1 \| DISEASES 6652 \| SORD \| DISEASES 3480 \| IGF1R \| DISEASES 5371 \| PML \| DISEASES 5428 \| POLG \| DISEASES 5045 \| FURIN \| DISEASES 3687 \| ITGAX \| DISEASES 54957 \| TXNL4B \| DISEASES 1000 \| CDH2 \| DISEASES 4864 \| NPC1 \| DISEASES 409 \| ARRB2 \| DISEASES 432 \| ASGR1 \| DISEASES 7157 \| TP53 \| DISEASES 2064 \| ERBB2 \| DISEASES 5409 \| PNMT \| DISEASES 54858 \| PGPEP1 \| DISEASES 3454 \| IFNAR1 \| DISEASES 150094 \| SIK1 \| DISEASES 207 \| AKT1 \| DISEASES 126147 \| NTN5 \| DISEASES 6531 \| SLC6A3 \| DISEASES 58985 \| IL22RA1 \| DISEASES 3756 \| KCNH1 \| DISEASES 3930 \| LBR \| DISEASES 2052 \| EPHX1 \| DISEASES 5972 \| REN \| DISEASES 64241 \| ABCG8 \| DISEASES 805 \| CALM2 \| DISEASES 27233 \| SULT1C4 \| DISEASES 185 \| AGTR1 \| DISEASES 2495 \| FTH1 \| DISEASES 9515 \| STXBP5L \| DISEASES 2169 \| FABP2 \| DISEASES 3001 \| GZMA \| DISEASES 635 \| BHMT \| DISEASES 167410 \| LIX1 \| DISEASES 3950 \| LECT2 \| DISEASES 3578 \| IL9 \| DISEASES 51302 \| CYP39A1 \| DISEASES 134864 \| TAAR1 \| DISEASES 1956 \| EGFR \| DISEASES 3484 \| IGFBP1 \| DISEASES 6872 \| TAF1 \| DISEASES 92129 \| RIPPLY1 \| DISEASES 55909 \| BIN3 \| DISEASES 8795 \| TNFRSF10B \| DISEASES 123 \| PLIN2 \| DISEASES 3439 \| IFNA1 \| DISEASES 3934 \| LCN2 \| DISEASES 4851 \| NOTCH1 \| DISEASES 133 \| ADM \| DISEASES 3145 \| HMBS \| DISEASES 9415 \| FADS2 \| DISEASES 149986 \| LSM14B \| DISEASES 1489 \| CTF1 \| DISEASES 1737 \| DLAT \| DISEASES 3606 \| IL18 \| DISEASES 5805 \| PTS \| DISEASES 7082 \| TJP1 \| DISEASES 5741 \| PTH \| DISEASES 3087 \| HHEX \| DISEASES 1360 \| CPB1 \| DISEASES 3694 \| ITGB6 \| DISEASES 23250 \| ATP11A \| DISEASES 925 \| CD8A \| DISEASES 5205 \| ATP8B1 \| DISEASES 6317 \| SERPINB3 \| DISEASES 7070 \| THY1 \| DISEASES 7345 \| UCHL1 \| DISEASES 89780 \| WNT3A \| DISEASES 136991 \| ASZ1 \| DISEASES 118611 \| C10orf90 \| DISEASES 4645 \| MYO5B \| DISEASES 8714 \| ABCC3 \| DISEASES 760 \| CA2 \| DISEASES 761 \| CA3 \| DISEASES 231 \| AKR1B1 \| DISEASES 9601 \| PDIA4 \| DISEASES 1436 \| CSF1R \| DISEASES 10 \| NAT2 \| DISEASES 27163 \| NAAA \| DISEASES 10563 \| CXCL13 \| DISEASES 7547 \| ZIC3 \| DISEASES 6750 \| SST \| DISEASES 5468 \| PPARG \| DISEASES 3156 \| HMGCR \| DISEASES 3815 \| KIT \| DISEASES 6296 \| ACSM3 \| DISEASES 909 \| CD1A \| DISEASES 653361 \| NCF1 \| DISEASES 29881 \| NPC1L1 \| DISEASES 11309 \| SLCO2B1 \| DISEASES 23516 \| SLC39A14 \| DISEASES 3588 \| IL10RB \| DISEASES 539 \| ATP5O \| DISEASES 55687 \| TRMU \| DISEASES 1636 \| ACE \| DISEASES 808 \| CALM3 \| DISEASES 326 \| AIRE \| DISEASES 10841 \| FTCD \| DISEASES 6285 \| S100B \| DISEASES 2220 \| FCN2 \| DISEASES 9437 \| NCR1 \| DISEASES 643 \| CXCR5 \| DISEASES 729230 \| CCR2 \| DISEASES 1234 \| CCR5 \| DISEASES 2264 \| FGFR4 \| DISEASES 3046 \| HBE1 \| DISEASES 114757 \| CYGB \| DISEASES 6352 \| CCL5 \| DISEASES 6359 \| CCL15 \| DISEASES 3856 \| KRT8 \| DISEASES 6777 \| STAT5B \| DISEASES 10197 \| PSME3 \| DISEASES 1990 \| CELA1 \| DISEASES 58191 \| CXCL16 \| DISEASES 9965 \| FGF19 \| DISEASES 178 \| AGL \| DISEASES 7412 \| VCAM1 \| DISEASES 2215 \| FCGR3B \| DISEASES 5966 \| REL \| DISEASES 27306 \| HPGDS \| DISEASES 10461 \| MERTK \| DISEASES 4880 \| NPPC \| DISEASES 248 \| ALPI \| DISEASES 9076 \| CLDN1 \| DISEASES 3577 \| CXCR1 \| DISEASES 5798 \| PTPRN \| DISEASES 3549 \| IHH \| DISEASES 5274 \| SERPINI1 \| DISEASES 2168 \| FABP1 \| DISEASES 213 \| ALB \| DISEASES 285368 \| PRRT3 \| DISEASES 6374 \| CXCL5 \| DISEASES 5473 \| PPBP \| DISEASES 5196 \| PF4 \| DISEASES 7047 \| TGM4 \| DISEASES 1230 \| CCR1 \| DISEASES 5648 \| MASP1 \| DISEASES 128 \| ADH5 \| DISEASES 327 \| APEH \| DISEASES 84315 \| MON1A \| DISEASES 308 \| ANXA5 \| DISEASES 3600 \| IL15 \| DISEASES 3673 \| ITGA2 \| DISEASES 51151 \| SLC45A2 \| DISEASES 4724 \| NDUFS4 \| DISEASES 6690 \| SPINK1 \| DISEASES 9607 \| CARTPT \| DISEASES 7098 \| TLR3 \| DISEASES 27242 \| TNFRSF21 \| DISEASES 3562 \| IL3 \| DISEASES 1437 \| CSF2 \| DISEASES 168667 \| BMPER \| DISEASES 6469 \| SHH \| DISEASES 1278 \| COL1A2 \| DISEASES 4982 \| TNFRSF11B \| DISEASES 4846 \| NOS3 \| DISEASES 80270 \| HSD3B7 \| DISEASES 7373 \| COL14A1 \| DISEASES 139324 \| HDX \| DISEASES 360 \| AQP3 \| DISEASES 10935 \| PRDX3 \| DISEASES 5267 \| SERPINA4 \| DISEASES 3429 \| IFI27 \| DISEASES 3990 \| LIPC \| DISEASES 3611 \| ILK \| DISEASES 5896 \| RAG1 \| DISEASES 5055 \| SERPINB2 \| DISEASES 79053 \| ALG8 \| DISEASES 7184 \| HSP90B1 \| DISEASES 4314 \| MMP3 \| DISEASES 5479 \| PPIB \| DISEASES 5346 \| PLIN1 \| DISEASES 6778 \| STAT6 \| DISEASES 26585 \| GREM1 \| DISEASES 5245 \| PHB \| DISEASES 90678 \| LRSAM1 \| DISEASES 64127 \| NOD2 \| DISEASES 10308 \| ZNF267 \| DISEASES 1548 \| CYP2A6 \| DISEASES 1549 \| CYP2A7 \| DISEASES 124935 \| SLC43A2 \| DISEASES 1581 \| CYP7A1 \| DISEASES 8772 \| FADD \| DISEASES 116071 \| BATF2 \| DISEASES 3960 \| LGALS4 \| DISEASES 53354 \| PANK1 \| DISEASES 5617 \| PRL \| DISEASES 6356 \| CCL11 \| DISEASES 51523 \| CXXC5 \| DISEASES 598 \| BCL2L1 \| DISEASES 64581 \| CLEC7A \| DISEASES 189 \| AGXT \| DISEASES 3175 \| ONECUT1 \| DISEASES 3479 \| IGF1 \| DISEASES 2990 \| GUSB \| DISEASES 3308 \| HSPA4 \| DISEASES 10972 \| TMED10 \| DISEASES 4144 \| MAT2A \| DISEASES 54578 \| UGT1A6 \| DISEASES 255738 \| PCSK9 \| DISEASES 59350 \| RXFP1 \| DISEASES 3688 \| ITGB1 \| DISEASES 8988 \| HSPB3 \| DISEASES 7200 \| TRH \| DISEASES 29 \| ABR \| DISEASES 1493 \| CTLA4 \| DISEASES 3171 \| FOXA3 \| DISEASES 3094 \| HINT1 \| DISEASES 5068 \| REG3A \| DISEASES 10663 \| CXCR6 \| DISEASES 171558 \| PTCRA \| DISEASES 7064 \| THOP1 \| DISEASES 2194 \| FASN \| DISEASES 79071 \| ELOVL6 \| DISEASES 375611 \| SLC26A5 \| DISEASES 54658 \| UGT1A1 \| DISEASES 3667 \| IRS1 \| DISEASES 3596 \| IL13 \| DISEASES 7363 \| UGT2B4 \| DISEASES 1051 \| CEBPB \| DISEASES 8862 \| APLN \| DISEASES 3627 \| CXCL10 \| DISEASES 7399 \| USH2A \| DISEASES 6579 \| SLCO1A2 \| DISEASES 5066 \| PAM \| DISEASES 3575 \| IL7R \| DISEASES 2353 \| FOS \| DISEASES 149603 \| RNF187 \| DISEASES 4968 \| OGG1 \| DISEASES 3669 \| ISG20 \| DISEASES 125 \| ADH1B \| DISEASES 56246 \| MRAP \| DISEASES 6373 \| CXCL11 \| DISEASES 646 \| BNC1 \| DISEASES 435 \| ASL \| DISEASES 9451 \| EIF2AK3 \| DISEASES 54205 \| CYCS \| DISEASES 27087 \| B3GAT1 \| DISEASES 2752 \| GLUL \| DISEASES 4323 \| MMP14 \| DISEASES 150684 \| COMMD1 \| DISEASES 197259 \| MLKL \| DISEASES 64081 \| PBLD \| DISEASES 2147 \| F2 \| DISEASES 9940 \| DLEC1 \| DISEASES 5897 \| RAG2 \| DISEASES 3626 \| INHBC \| DISEASES 5644 \| PRSS1 \| DISEASES 344561 \| GPR148 \| DISEASES 5340 \| PLG \| DISEASES 211 \| ALAS1 \| DISEASES 1212 \| CLTB \| DISEASES 125988 \| C19orf70 \| DISEASES 7015 \| TERT \| DISEASES 4023 \| LPL \| DISEASES 3265 \| HRAS \| DISEASES 6868 \| ADAM17 \| DISEASES 947 \| CD34 \| DISEASES 3661 \| IRF3 \| DISEASES 22885 \| ABLIM3 \| DISEASES 2829 \| XCR1 \| DISEASES 27243 \| CHMP2A \| DISEASES 27257 \| LSM1 \| DISEASES 225 \| ABCD2 \| DISEASES 9420 \| CYP7B1 \| DISEASES 2286 \| FKBP2 \| DISEASES 11037 \| STON1 \| DISEASES 836 \| CASP3 \| DISEASES 1579 \| CYP4A11 \| DISEASES 358 \| AQP1 \| DISEASES 148229 \| ATP8B3 \| DISEASES 118430 \| MUCL1 \| DISEASES 2944 \| GSTM1 \| DISEASES 22949 \| PTGR1 \| DISEASES 84868 \| HAVCR2 \| DISEASES 7351 \| UCP2 \| DISEASES 8639 \| AOC3 \| DISEASES 134083 \| OR2Y1 \| DISEASES 8837 \| CFLAR \| DISEASES 80194 \| TMEM134 \| DISEASES 3952 \| LEP \| DISEASES 23166 \| STAB1 \| DISEASES 3172 \| HNF4A \| DISEASES 11322 \| TMC6 \| DISEASES 5257 \| PHKB \| DISEASES 51593 \| SRRT \| DISEASES 285 \| ANGPT2 \| DISEASES 9153 \| SLC28A2 \| DISEASES 1909 \| EDNRA \| DISEASES 1191 \| CLU \| DISEASES 30835 \| CD209 \| DISEASES 6773 \| STAT2 \| DISEASES 3170 \| FOXA2 \| DISEASES 10332 \| CLEC4M \| DISEASES 8560 \| DEGS1 \| DISEASES 65987 \| KCTD14 \| DISEASES 10170 \| DHRS9 \| DISEASES 3291 \| HSD11B2 \| DISEASES 475 \| ATOX1 \| DISEASES 4233 \| MET \| DISEASES 8824 \| CES2 \| DISEASES 9475 \| ROCK2 \| DISEASES 4684 \| NCAM1 \| DISEASES 23621 \| BACE1 \| DISEASES 7173 \| TPO \| DISEASES 1582 \| CYP8B1 \| DISEASES 79901 \| CYBRD1 \| DISEASES 26973 \| CHORDC1 \| DISEASES 84967 \| LSM10 \| DISEASES 29851 \| ICOS \| DISEASES 3579 \| CXCR2 \| DISEASES 63951 \| DMRTA1 \| DISEASES 1728 \| NQO1 \| DISEASES 80381 \| CD276 \| DISEASES 8289 \| ARID1A \| DISEASES 9370 \| ADIPOQ \| DISEASES 811 \| CALR \| DISEASES 51085 \| MLXIPL \| DISEASES 23765 \| IL17RA \| DISEASES 6863 \| TAC1 \| DISEASES 25898 \| RCHY1 \| DISEASES 6888 \| TALDO1 \| DISEASES 4018 \| LPA \| DISEASES 51582 \| AZIN1 \| DISEASES 3615 \| IMPDH2 \| DISEASES 10611 \| PDLIM5 \| DISEASES 6014 \| RIT2 \| DISEASES 5345 \| SERPINF2 \| DISEASES 6181 \| RPLP2 \| DISEASES 3039 \| HBA1 \| DISEASES 3157 \| HMGCS1 \| DISEASES 4312 \| MMP1 \| DISEASES 55 \| ACPP \| DISEASES 27036 \| SIGLEC7 \| DISEASES 8706 \| B3GALNT1 \| DISEASES 2837 \| UTS2R \| DISEASES 2 \| A2M \| DISEASES 3309 \| HSPA5 \| DISEASES 56252 \| YLPM1 \| DISEASES 2314 \| FLII \| DISEASES 1555 \| CYP2B6 \| DISEASES 9235 \| IL32 \| DISEASES 6794 \| STK11 \| DISEASES 147138 \| TMC8 \| DISEASES 9159 \| PCSK7 \| DISEASES 9622 \| KLK4 \| DISEASES 117584 \| RFFL \| DISEASES 51330 \| TNFRSF12A \| DISEASES 9015 \| TAF1A \| DISEASES 4843 \| NOS2 \| DISEASES 9582 \| APOBEC3B \| DISEASES 1435 \| CSF1 \| DISEASES 339390 \| CLEC4G \| DISEASES 26276 \| VPS33B \| DISEASES 5034 \| P4HB \| DISEASES 9241 \| NOG \| DISEASES 1789 \| DNMT3B \| DISEASES 9074 \| CLDN6 \| DISEASES 147719 \| LYPD4 \| DISEASES 706 \| TSPO \| DISEASES 3855 \| KRT7 \| DISEASES 6906 \| SERPINA7 \| DISEASES 50616 \| IL22 \| DISEASES 3665 \| IRF7 \| DISEASES 8651 \| SOCS1 \| DISEASES 842 \| CASP9 \| DISEASES 9021 \| SOCS3 \| DISEASES 5155 \| PDGFB \| DISEASES 3953 \| LEPR \| DISEASES 493753 \| COA5 \| DISEASES 8519 \| IFITM1 \| DISEASES 2520 \| GAST \| DISEASES 54328 \| GPR173 \| DISEASES 6401 \| SELE \| DISEASES 796 \| CALCA \| DISEASES 64782 \| AEN \| DISEASES 942 \| CD86 \| DISEASES 8694 \| DGAT1 \| DISEASES 9145 \| SYNGR1 \| DISEASES 212 \| ALAS2 \| DISEASES 1553 \| CYP2A13 \| DISEASES 286410 \| ATP11C \| DISEASES 256933 \| NPB \| DISEASES 4088 \| SMAD3 \| DISEASES 5104 \| SERPINA5 \| DISEASES 3916 \| LAMP1 \| DISEASES 682 \| BSG \| DISEASES 151888 \| BTLA \| DISEASES 3043 \| HBB \| DISEASES 2152 \| F3 \| DISEASES 220001 \| VWCE \| DISEASES 120227 \| CYP2R1 \| DISEASES 5133 \| PDCD1 \| DISEASES 51738 \| GHRL \| DISEASES 3320 \| HSP90AA1 \| DISEASES 123264 \| SLC51B \| DISEASES 2938 \| GSTA1 \| DISEASES 885 \| CCK \| DISEASES 8856 \| NR1I2 \| DISEASES 468 \| ATF4 \| DISEASES 2266 \| FGG \| DISEASES 148738 \| HFE2 \| DISEASES 1908 \| EDN3 \| DISEASES 3988 \| LIPA \| DISEASES 114548 \| NLRP3 \| DISEASES 112744 \| IL17F \| DISEASES 1551 \| CYP3A7 \| DISEASES 4842 \| NOS1 \| DISEASES 84324 \| SARNP \| DISEASES 57104 \| PNPLA2 \| DISEASES 3932 \| LCK \| DISEASES 57142 \| RTN4 \| DISEASES 1576 \| CYP3A4 \| DISEASES 3363 \| HTR7 \| DISEASES 3091 \| HIF1A \| DISEASES 554 \| AVPR2 \| DISEASES 3824 \| KLRD1 \| DISEASES 23436 \| CELA3B \| DISEASES 3141 \| HLCS \| DISEASES 23583 \| SMUG1 \| DISEASES 7360 \| UGP2 \| DISEASES 3572 \| IL6ST \| DISEASES 2686 \| GGT7 \| DISEASES 3266 \| ERAS \| DISEASES 857 \| CAV1 \| DISEASES 54878 \| DPP8 \| DISEASES 5329 \| PLAUR \| DISEASES 3117 \| HLA-DQA1 \| DISEASES 8835 \| SOCS2 \| DISEASES 2309 \| FOXO3 \| DISEASES 200810 \| ALG1L \| DISEASES 3329 \| HSPD1 \| DISEASES 7100 \| TLR5 \| DISEASES 8788 \| DLK1 \| DISEASES 6609 \| SMPD1 \| DISEASES 23193 \| GANAB \| DISEASES 113675 \| SDSL \| DISEASES 6776 \| STAT5A \| DISEASES 8717 \| TRADD \| DISEASES 4306 \| NR3C2 \| DISEASES 54681 \| P4HTM \| DISEASES 4089 \| SMAD4 \| DISEASES 1528 \| CYB5A \| DISEASES 51094 \| ADIPOR1 \| DISEASES 1544 \| CYP1A2 \| DISEASES 9588 \| PRDX6 \| DISEASES 1508 \| CTSB \| DISEASES 6692 \| SPINT1 \| DISEASES 145264 \| SERPINA12 \| DISEASES 259197 \| NCR3 \| DISEASES 3804 \| KIR2DL3 \| DISEASES 4939 \| OAS2 \| DISEASES 2537 \| IFI6 \| DISEASES 921 \| CD5 \| DISEASES 866 \| SERPINA6 \| DISEASES 6672 \| SP100 \| DISEASES 3146 \| HMGB1 \| DISEASES 3716 \| JAK1 \| DISEASES 54575 \| UGT1A10 \| DISEASES 2100 \| ESR2 \| DISEASES 3455 \| IFNAR2 \| DISEASES 127665 \| ZNF648 \| DISEASES 3605 \| IL17A \| DISEASES 8720 \| MBTPS1 \| DISEASES 285193 \| DUSP28 \| DISEASES 1499 \| CTNNB1 \| DISEASES 875 \| CBS \| DISEASES 31 \| ACACA \| DISEASES 26762 \| HAVCR1 \| DISEASES 3516 \| RBPJ \| DISEASES 84706 \| GPT2 \| DISEASES 25813 \| SAMM50 \| DISEASES 3767 \| KCNJ11 \| DISEASES 1861 \| TOR1A \| DISEASES 538 \| ATP7A \| DISEASES 1811 \| SLC26A3 \| DISEASES 302 \| ANXA2 \| DISEASES 6275 \| S100A4 \| DISEASES 23481 \| PES1 \| DISEASES 54600 \| UGT1A9 \| DISEASES 2335 \| FN1 \| DISEASES 2873 \| GPS1 \| DISEASES 100506658 \| OCLN \| DISEASES 3792 \| KEL \| DISEASES 331 \| XIAP \| DISEASES 8764 \| TNFRSF14 \| DISEASES 355 \| FAS \| DISEASES 5265 \| SERPINA1 \| DISEASES 6720 \| SREBF1 \| DISEASES 2074 \| ERCC6 \| DISEASES 3240 \| HP \| DISEASES 6898 \| TAT \| DISEASES 51155 \| HN1 \| DISEASES 79876 \| UBA5 \| DISEASES 6288 \| SAA1 \| DISEASES 2224 \| FDPS \| DISEASES 4100 \| MAGEA1 \| DISEASES 3683 \| ITGAL \| DISEASES 246778 \| IL27 \| DISEASES 3482 \| IGF2R \| DISEASES 801 \| CALM1 \| DISEASES 11186 \| RASSF1 \| DISEASES 79602 \| ADIPOR2 \| DISEASES 3663 \| IRF5 \| DISEASES 60 \| ACTB \| DISEASES 10803 \| CCR9 \| DISEASES 5169 \| ENPP3 \| DISEASES 871 \| SERPINH1 \| DISEASES 26136 \| TES \| DISEASES 6714 \| SRC \| DISEASES 51643 \| TMBIM4 \| DISEASES 1524 \| CX3CR1 \| DISEASES 1969 \| EPHA2 \| DISEASES 6775 \| STAT4 \| DISEASES 841 \| CASP8 \| DISEASES 2996 \| GYPE \| DISEASES 9652 \| TTC37 \| DISEASES 112476 \| PRRT2 \| DISEASES 6364 \| CCL20 \| DISEASES 92689 \| FAM114A1 \| DISEASES 23644 \| EDC4 \| DISEASES 7048 \| TGFBR2 \| DISEASES 3821 \| KLRC1 \| DISEASES 9332 \| CD163 \| DISEASES 617 \| BCS1L \| DISEASES 4151 \| MB \| DISEASES 79892 \| MCMBP \| DISEASES 3123 \| HLA-DRB1 \| DISEASES 79947 \| DHDDS \| DISEASES 7037 \| TFRC \| DISEASES 2157 \| F8 \| DISEASES 4478 \| MSN \| DISEASES 3135 \| HLA-G \| DISEASES 1366 \| CLDN7 \| DISEASES 5599 \| MAPK8 \| DISEASES 4311 \| MME \| DISEASES 1066 \| CES1 \| DISEASES 1803 \| DPP4 \| DISEASES 58506 \| SCAF1 \| DISEASES 1565 \| CYP2D6 \| DISEASES 54106 \| TLR9 \| DISEASES 26580 \| BSCL2 \| DISEASES 6533 \| SLC6A6 \| DISEASES 2673 \| GFPT1 \| DISEASES 6772 \| STAT1 \| DISEASES 10367 \| MICU1 \| DISEASES 6721 \| SREBF2 \| DISEASES 4512 \| MT-CO1 \| DISEASES 2475 \| MTOR \| DISEASES 5742 \| PTGS1 \| DISEASES 10724 \| MGEA5 \| DISEASES 2705 \| GJB1 \| DISEASES 4283 \| CXCL9 \| DISEASES 7096 \| TLR1 \| DISEASES 4514 \| MT-CO3 \| DISEASES 3880 \| KRT19 \| DISEASES 8678 \| BECN1 \| DISEASES 23038 \| WDTC1 \| DISEASES 7052 \| TGM2 \| DISEASES 27350 \| APOBEC3C \| DISEASES 84284 \| NTPCR \| DISEASES 8443 \| GNPAT \| DISEASES 183 \| AGT \| DISEASES 22796 \| COG2 \| DISEASES 58 \| ACTA1 \| DISEASES 28514 \| DLL1 \| DISEASES 116841 \| SNAP47 \| DISEASES 142 \| PARP1 \| DISEASES 55532 \| SLC30A10 \| DISEASES 7042 \| TGFB2 \| DISEASES 1063 \| CENPF \| DISEASES 3664 \| IRF6 \| DISEASES 1378 \| CR1 \| DISEASES 6993 \| DYNLT1 \| DISEASES 7432 \| VIP \| DISEASES 59349 \| KLHL12 \| DISEASES 2494 \| NR5A2 \| DISEASES 5788 \| PTPRC \| DISEASES 3075 \| CFH \| DISEASES 6738 \| TROVE2 \| DISEASES 5743 \| PTGS2 \| DISEASES 1660 \| DHX9 \| DISEASES 6041 \| RNASEL \| DISEASES 462 \| SERPINC1 \| DISEASES 356 \| FASLG \| DISEASES 2153 \| F5 \| DISEASES 22926 \| ATF6 \| DISEASES 2214 \| FCGR3A \| DISEASES 1490 \| CTGF \| DISEASES 9970 \| NR1I3 \| DISEASES 336 \| APOA2 \| DISEASES 4720 \| NDUFS2 \| DISEASES 51744 \| CD244 \| DISEASES 1314 \| COPA \| DISEASES 383 \| ARG1 \| DISEASES 9447 \| AIM2 \| DISEASES 911 \| CD1C \| DISEASES 912 \| CD1D \| DISEASES 922 \| CD5L \| DISEASES 632 \| BGLAP \| DISEASES 4582 \| MUC1 \| DISEASES 55974 \| SLC50A1 \| DISEASES 103 \| ADAR \| DISEASES 3570 \| IL6R \| DISEASES 57198 \| ATP8B2 \| DISEASES 1892 \| ECHS1 \| DISEASES 119467 \| CLRN3 \| DISEASES 6280 \| S100A9 \| DISEASES 284486 \| THEM5 \| DISEASES 4942 \| OAT \| DISEASES 79626 \| TNFAIP8L2 \| DISEASES 246269 \| LACE1 \| DISEASES 5550 \| PREP \| DISEASES 914 \| CD2 \| DISEASES 965 \| CD58 \| DISEASES 1268 \| CNR1 \| DISEASES 4893 \| NRAS \| DISEASES 8517 \| IKBKG \| DISEASES 2316 \| FLNA \| DISEASES 8729 \| GBF1 \| DISEASES 8771 \| TNFRSF6B \| DISEASES 1629 \| DBT \| DISEASES 2730 \| GCLM \| DISEASES 6319 \| SCD \| DISEASES 1244 \| ABCC2 \| DISEASES 4923 \| NTSR1 \| DISEASES 2805 \| GOT1 \| DISEASES 959 \| CD40LG \| DISEASES 55361 \| PI4K2A \| DISEASES 10964 \| IFI44L \| DISEASES 1491 \| CTH \| DISEASES 2941 \| GSTA4 \| DISEASES 5314 \| PKHD1 \| DISEASES 1791 \| DNTT \| DISEASES 953 \| ENTPD1 \| DISEASES 3725 \| JUN \| DISEASES 1558 \| CYP2C8 \| DISEASES 1557 \| CYP2C19 \| DISEASES 5950 \| RBP4 \| DISEASES 55268 \| ECHDC2 \| DISEASES 11253 \| MAN1B1 \| DISEASES 2030 \| SLC29A1 \| DISEASES 64170 \| CARD9 \| DISEASES 3434 \| IFIT1 \| DISEASES 3437 \| IFIT3 \| DISEASES 11093 \| ADAMTS13 \| DISEASES 5728 \| PTEN \| DISEASES 7422 \| VEGFA \| DISEASES 4143 \| MAT1A \| DISEASES 958 \| CD40 \| DISEASES 4318 \| MMP9 \| DISEASES 9682 \| KDM4A \| DISEASES 4352 \| MPL \| DISEASES 4904 \| YBX1 \| DISEASES 10864 \| SLC22A7 \| DISEASES 5328 \| PLAU \| DISEASES 27232 \| GNMT \| DISEASES 100 \| ADA \| DISEASES 51021 \| MRPS16 \| DISEASES 84647 \| PLA2G12B \| DISEASES 9436 \| NCR2 \| DISEASES 2022 \| ENG \| DISEASES 2740 \| GLP1R \| DISEASES 1025 \| CDK9 \| DISEASES 54657 \| UGT1A4 \| DISEASES 54577 \| UGT1A7 \| DISEASES 5292 \| PIM1 \| DISEASES 2833 \| CXCR3 \| DISEASES 2170 \| FABP3 \| DISEASES 4153 \| MBL2 \| DISEASES 22943 \| DKK1 \| DISEASES 7099 \| TLR4 \| DISEASES 9966 \| TNFSF15 \| DISEASES 23585 \| TMEM50A \| DISEASES 240 \| ALOX5 \| DISEASES 1269 \| CNR2 \| DISEASES 7295 \| TXN \| DISEASES 158833 \| AWAT1 \| DISEASES 1896 \| EDA \| DISEASES 3339 \| HSPG2 \| DISEASES 11326 \| VSIG4 \| DISEASES 249 \| ALPL \| DISEASES 229 \| ALDOB \| DISEASES 5696 \| PSMB8 \| DISEASES 3127 \| HLA-DRB5 \| DISEASES 7046 \| TGFBR1 \| DISEASES 4855 \| NOTCH4 \| DISEASES 221527 \| ZBTB12 \| DISEASES 2159 \| F10 \| DISEASES 2155 \| F7 \| DISEASES 728239 \| MAGED4 \| DISEASES 3303 \| HSPA1A \| DISEASES 57819 \| LSM2 \| DISEASES 6850 \| SYK \| DISEASES 388595 \| TMEM82 \| DISEASES 23564 \| DDAH2 \| DISEASES 53358 \| SHC3 \| DISEASES 3055 \| HCK \| DISEASES 10673 \| TNFSF13B \| DISEASES 79070 \| KDELC1 \| DISEASES 50943 \| FOXP3 \| DISEASES 100507436 \| MICA \| DISEASES 3107 \| HLA-C \| DISEASES 64078 \| SLC28A3 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 3190 \| HNRNPK \| DISEASES 1041 \| CDSN \| DISEASES 729956 \| SHISA7 \| DISEASES 4879 \| NPPB \| DISEASES 4878 \| NPPA \| DISEASES 4524 \| MTHFR \| DISEASES 3105 \| HLA-A \| DISEASES 23412 \| COMMD3 \| DISEASES 10257 \| ABCC4 \| DISEASES 1471 \| CST3 \| DISEASES 10537 \| UBD \| DISEASES 114798 \| SLITRK1 \| DISEASES 7056 \| THBD \| DISEASES 1910 \| EDNRB \| DISEASES 3274 \| HRH2 \| DISEASES 2512 \| FTL \| DISEASES 3604 \| TNFRSF9 \| DISEASES 6461 \| SHB \| DISEASES 8718 \| TNFRSF25 \| DISEASES 4609 \| MYC \| DISEASES 414062 \| CCL3L3 \| DISEASES 3980 \| LIG3 \| DISEASES 2098 \| ESD \| DISEASES 9308 \| CD83 \| DISEASES 5251 \| PHEX \| DISEASES 1906 \| EDN1 \| DISEASES 3096 \| HIVEP1 \| DISEASES 9636 \| ISG15 \| DISEASES 444 \| ASPH \| DISEASES 2308 \| FOXO1 \| DISEASES 1543 \| CYP1A1 \| DISEASES 1059 \| CENPB \| DISEASES 23586 \| DDX58 \| DISEASES 25820 \| ARIH1 \| DISEASES 203102 \| ADAM32 \| DISEASES 5256 \| PHKA2 \| DISEASES 3559 \| IL2RA \| DISEASES 10346 \| TRIM22 \| DISEASES 7010 \| TEK \| DISEASES 91828 \| EXOC3L4 \| DISEASES 3704 \| ITPA \| DISEASES 3440 \| IFNA2 \| DISEASES 3456 \| IFNB1 \| DISEASES 551 \| AVP \| DISEASES 3045 \| HBD \| DISEASES 6462 \| SHBG \| DISEASES 5277 \| PIGA \| DISEASES 7114 \| TMSB4X \| DISEASES 3030 \| HADHA \| DISEASES 51284 \| TLR7 \| DISEASES 1646 \| AKR1C2 \| DISEASES 1645 \| AKR1C1 \| DISEASES 3486 \| IGFBP3 \| DISEASES 4267 \| CD99 \| DISEASES 11082 \| ESM1 \| DISEASES 90865 \| IL33 \| DISEASES 53919 \| SLCO1C1 \| DISEASES 29126 \| CD274 \| DISEASES 3717 \| JAK2 \| DISEASES 192668 \| CYS1 \| DISEASES 3822 \| KLRC2 \| DISEASES 91543 \| RSAD2 \| DISEASES 51091 \| SEPSECS \| DISEASES 9681 \| DEPDC5 \| DISEASES 23410 \| SIRT3 \| DISEASES 3083 \| HGFAC \| DISEASES 2235 \| FECH \| DISEASES 6736 \| SRY \| DISEASES 51280 \| GOLM1 \| DISEASES 2878 \| GPX3 \| DISEASES 3875 \| KRT18 \| DISEASES 55576 \| STAB2 \| DISEASES 94 \| ACVRL1 \| DISEASES 238 \| ALK \| DISEASES 4017 \| LOXL2 \| DISEASES 53345 \| TM6SF2 \| DISEASES 2877 \| GPX2 \| DISEASES 8878 \| SQSTM1 \| DISEASES 28227 \| PPP2R3B \| DISEASES 79866 \| BORA \| DISEASES 3811 \| KIR3DL1 \| DISEASES 250 \| ALPP \| DISEASES 11262 \| SP140 \| DISEASES 29994 \| BAZ2B \| DISEASES 51466 \| EVL \| DISEASES 12 \| SERPINA3 \| DISEASES 10018 \| BCL2L11 \| DISEASES 114898 \| C1QTNF2 \| DISEASES 2172 \| FABP6 \| DISEASES 5627 \| PROS1 \| DISEASES 2719 \| GPC3 \| DISEASES 51520 \| LARS \| DISEASES 9560 \| CCL4L2 \| DISEASES 6355 \| CCL8 \| DISEASES 130 \| ADH6 \| DISEASES 4891 \| SLC11A2 \| DISEASES 2875 \| GPT \| DISEASES 6696 \| SPP1 \| DISEASES 3965 \| LGALS9 \| DISEASES 2643 \| GCH1 \| DISEASES 4239 \| MFAP4 \| DISEASES 2919 \| CXCL1 \| DISEASES 174 \| AFP \| DISEASES 6387 \| CXCL12 \| DISEASES 27327 \| TNRC6A \| DISEASES 655 \| BMP7 \| DISEASES 10379 \| IRF9 \| DISEASES 4780 \| NFE2L2 \| DISEASES 80380 \| PDCD1LG2 \| DISEASES 5609 \| MAP2K7 \| DISEASES 594857 \| NPS \| DISEASES 4599 \| MX1 \| DISEASES 2950 \| GSTP1 \| DISEASES 1859 \| DYRK1A \| DISEASES 3119 \| HLA-DQB1 \| DISEASES 1763 \| DNA2 \| DISEASES 10410 \| IFITM3 \| DISEASES 1654 \| DDX3X \| DISEASES 8091 \| HMGA2 \| DISEASES 5970 \| RELA \| DISEASES 6654 \| SOS1 \| DISEASES 2160 \| F11 \| DISEASES 60489 \| APOBEC3G \| DISEASES 202018 \| TAPT1 \| DISEASES 728441 \| GGT2 \| DISEASES 164668 \| APOBEC3H \| DISEASES 2011 \| MARK2 \| DISEASES 7018 \| TF \| DISEASES 1363 \| CPE \| DISEASES 210 \| ALAD \| DISEASES 7852 \| CXCR4 \| DISEASES 3655 \| ITGA6 \| DISEASES 100190949 \| C5orf52 \| DISEASES 501 \| ALDH7A1 \| DISEASES 10989 \| IMMT \| DISEASES 23066 \| CAND2 \| DISEASES 2641 \| GCG \| DISEASES 4938 \| OAS1 \| DISEASES 4295 \| MLN \| DISEASES 55577 \| NAGK \| DISEASES 5601 \| MAPK9 \| DISEASES 6916 \| TBXAS1 \| DISEASES 91147 \| TMEM67 \| DISEASES 3120 \| HLA-DQB2 \| DISEASES 51099 \| ABHD5 \| DISEASES 3481 \| IGF2 \| DISEASES 10134 \| BCAP31 \| DISEASES 8671 \| SLC4A4 \| DISEASES 3113 \| HLA-DPA1 \| DISEASES 648791 \| PPP1R3G \| DISEASES 197 \| AHSG \| DISEASES 23210 \| JMJD6 \| DISEASES 85443 \| DCLK3 \| DISEASES 1029 \| CDKN2A \| DISEASES 720 \| C4A \| DISEASES 55665 \| URGCP \| DISEASES 93349 \| SP140L \| DISEASES 9080 \| CLDN9 \| DISEASES 79094 \| CHAC1 \| DISEASES 960 \| CD44 \| DISEASES 3702 \| ITK \| DISEASES 7124 \| TNF \| DISEASES 7264 \| TSTA3 \| DISEASES 3106 \| HLA-B \| DISEASES 10165 \| SLC25A13 \| DISEASES 387 \| RHOA \| DISEASES 4615 \| MYD88 \| DISEASES 57506 \| MAVS \| DISEASES 5817 \| PVR \| DISEASES 4049 \| LTA \| DISEASES 388372 \| CCL4L1 \| DISEASES 6522 \| SLC4A2 \| DISEASES 9498 \| SLC4A8 \| DISEASES 3276 \| PRMT1 \| DISEASES 2876 \| GPX1 \| DISEASES 5830 \| PEX5 \| DISEASES 3115 \| HLA-DPB1 \| DISEASES 1154 \| CISH \| DISEASES 834 \| CASP1 \| DISEASES 4050 \| LTB \| DISEASES 2632 \| GBE1 \| DISEASES 3451 \| IFNA17 \| DISEASES 3586 \| IL10 \| DISEASES 3441 \| IFNA4 \| DISEASES 26065 \| LSM14A \| DISEASES 5682 \| PSMA1 \| DISEASES 8842 \| PROM1 \| DISEASES 133396 \| IL31RA \| DISEASES 721 \| C4B \| DISEASES 57553 \| MICAL3 \| DISEASES 4193 \| MDM2 \| DISEASES 3077 \| HFE \| DISEASES 374308 \| PTCHD3 \| DISEASES 338376 \| IFNE \| DISEASES 3712 \| IVD \| DISEASES 54659 \| UGT1A3 \| DISEASES 4700 \| NDUFA6 \| DISEASES 5478 \| PPIA \| DISEASES 10209 \| EIF1 \| DISEASES 6256 \| RXRA \| DISEASES 1316 \| KLF6 \| DISEASES 30816 \| ERVW-1 \| DISEASES 846 \| CASR \| DISEASES 131 \| ADH7 \| DISEASES 7019 \| TFAM \| DISEASES 2638 \| GC \| DISEASES 51428 \| DDX41 \| DISEASES 100506742 \| CASP12 \| DISEASES 26064 \| RAI14 \| DISEASES 2920 \| CXCL2 \| DISEASES 1050 \| CEBPA \| DISEASES 2994 \| GYPB \| DISEASES 284 \| ANGPT1 \| DISEASES 151306 \| GPBAR1 \| DISEASES 51312 \| SLC25A37 \| DISEASES 4147 \| MATN2 \| DISEASES 9843 \| HEPH \| DISEASES 3551 \| IKBKB \| DISEASES 7033 \| TFF3 \| DISEASES 503542 \| SPRN \| DISEASES 930 \| CD19 \| DISEASES 9414 \| TJP2 \| DISEASES 83695 \| RHNO1 \| DISEASES 441864 \| TARM1 \| DISEASES 3684 \| ITGAM \| DISEASES 8284 \| KDM5D \| DISEASES 11153 \| FICD \| DISEASES 9971 \| NR1H4 \| DISEASES 7421 \| VDR \| DISEASES 8972 \| MGAM \| DISEASES 1649 \| DDIT3 \| DISEASES 84525 \| HOPX \| DISEASES 26037 \| SIPA1L1 \| DISEASES 5228 \| PGF \| DISEASES 8742 \| TNFSF12 \| DISEASES 567 \| B2M \| DISEASES 11245 \| GPR176 \| DISEASES 101 \| ADAM8 \| DISEASES 3949 \| LDLR \| DISEASES 5261 \| PHKG2 \| DISEASES 388588 \| SMIM1 \| DISEASES 820 \| CAMP \| DISEASES 1506 \| CTRL \| DISEASES 11201 \| POLI \| DISEASES 84823 \| LMNB2 \| DISEASES 7138 \| TNNT1 \| DISEASES 284424 \| MIR7-3HG \| DISEASES 246734 \| NPCDR1 \| DISEASES 6689 \| SPIB \| DISEASES 6625 \| SNRNP70 \| DISEASES 7012 \| TERC \| DISEASES 101669766 \| ZNF350-AS1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	675
Disease	liver disease
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:226) HP:0001394 \| Hepatic cirrhosis \| 175 HP:0012115 \| Liver inflammation \| 144 HP:0001513 \| Obesity \| 83 HP:0001402 \| Hepatocellular carcinoma \| 81 HP:0000855 \| Insulin resistance \| 75 HP:0030731 \| Carcinoma \| 64 HP:0000822 \| Hypertension \| 62 HP:0200123 \| Chronic liver inflammation \| 55 HP:0001409 \| Portal hypertension \| 54 HP:0001397 \| Hepatic steatosis \| 52 HP:0001395 \| Hepatic fibrosis \| 39 HP:0001541 \| Ascites \| 32 HP:0001298 \| Encephalopathy \| 31 HP:0001399 \| Liver failure \| 30 HP:0001873 \| Low platelet count \| 25 HP:0000819 \| Diabetes mellitus \| 24 HP:0003256 \| Coagulopathy \| 21 HP:0006562 \| Viral hepatitis \| 19 HP:0002480 \| Hepatic encephalopathy \| 19 HP:0000952 \| Yellow skin \| 19 HP:0001677 \| Coronary artery disease \| 16 HP:0002240 \| Enlarged liver \| 15 HP:0000083 \| Renal insufficiency \| 14 HP:0002664 \| Neoplasia \| 14 HP:0100512 \| Vitamin D deficiency \| 12 HP:0000989 \| pruritis \| 12 HP:0002910 \| Elevated transaminases \| 11 HP:0004395 \| Malnutrition \| 11 HP:0002621 \| Atherosclerosis \| 11 HP:0002721 \| Immunodeficiency \| 10 HP:0000939 \| Osteoporosis \| 10 HP:0002239 \| Gastrointestinal hemorrhage \| 9 HP:0001907 \| Thromboembolic disease \| 9 HP:0002584 \| Intestinal hemorrhage \| 9 HP:0002896 \| Liver cancer \| 9 HP:0000716 \| Depression \| 8 HP:0003774 \| End-stage renal failure \| 8 HP:0002092 \| Pulmonary artery hypertension \| 8 HP:0001396 \| Cholestasis \| 8 HP:0001903 \| Anemia \| 8 HP:0001824 \| Weight loss \| 7 HP:0001410 \| Decreased liver function \| 7 HP:0006554 \| Acute hepatic failure \| 7 HP:0000147 \| Sclerocystic ovaries \| 7 HP:0012622 \| Chronic kidney disease \| 6 HP:0002608 \| Celiac disease \| 6 HP:0003074 \| High blood glucose \| 5 HP:0100626 \| Chronic hepatic failure \| 5 HP:0001744 \| Splenomegaly \| 5 HP:0005912 \| Biliary duct atresia \| 5 HP:0030151 \| Cholangitis \| 5 HP:0000821 \| Underactive thyroid \| 5 HP:0002725 \| Systemic lupus erythematosus \| 5 HP:0200119 \| Acute liver inflammation \| 5 HP:0001635 \| Congestive heart failure \| 4 HP:0000833 \| Glucose intolerance \| 4 HP:0002902 \| Hyponatremia \| 4 HP:0012531 \| Pain \| 4 HP:0100806 \| Sepsis \| 4 HP:0002090 \| Pneumonia \| 4 HP:0001971 \| Hypersplenism \| 4 HP:0001919 \| Acute renal failure \| 4 HP:0012418 \| Low blood oxygen level \| 4 HP:0002904 \| High blood bilirubin levels \| 4 HP:0012378 \| Fatigue \| 4 HP:0002202 \| Pleural effusion \| 3 HP:0002716 \| Lymph node hyperplasia \| 3 HP:0001548 \| Overgrowth \| 3 HP:0000969 \| Dropsy \| 3 HP:0001945 \| Fever \| 3 HP:0001537 \| Umbilical hernias \| 3 HP:0000846 \| Hypoadrenalism \| 3 HP:0000113 \| Polycystic kidney dysplasia \| 3 HP:0002613 \| Biliary cirrhosis \| 3 HP:0000938 \| Decreased bone mineral density \| 3 HP:0000739 \| Anxiety \| 3 HP:0030153 \| Cholangiocarcinoma \| 3 HP:0100790 \| Hernia \| 3 HP:0030242 \| Blood clot in portal vein \| 3 HP:0002094 \| Dyspnea \| 3 HP:0002870 \| Obstructive sleep apnea \| 3 HP:0012743 \| Central obesity \| 3 HP:0010535 \| Sleep apnea \| 3 HP:0001878 \| Haemolytic anaemia \| 2 HP:0004936 \| Blood clot in vein \| 2 HP:0001259 \| Coma \| 2 HP:0001987 \| Hyperammonemia \| 2 HP:0000842 \| Elevated insulin level \| 2 HP:0001297 \| Cerebral vascular events \| 2 HP:0002615 \| Low blood pressure \| 2 HP:0002586 \| Peritonitis \| 2 HP:0002639 \| Budd-Chiari syndrome \| 2 HP:0003002 \| Breast carcinoma \| 2 HP:0000979 \| Purpura \| 2 HP:0002024 \| Intestinal malabsorption \| 2 HP:0003765 \| Psoriasis \| 2 HP:0001717 \| Coronary artery calcification \| 2 HP:0100753 \| Schizophrenia \| 2 HP:0002960 \| Autoimmune condition \| 2 HP:0002301 \| Hemiplegia \| 2 HP:0100324 \| Progressive systemic scleroderma \| 2 HP:0100543 \| Cognitive deficits \| 2 HP:0002104 \| Absence of spontaneous respiration \| 2 HP:0001928 \| Abnormal blood coagulation studies \| 2 HP:0000112 \| Nephropathy \| 2 HP:0001081 \| Gallstones \| 2 HP:0003077 \| Hyperlipidemia \| 2 HP:0012164 \| Asterixis \| 2 HP:0005202 \| Helicobacter pylori infection \| 2 HP:0002181 \| Cerebral edema \| 2 HP:0002020 \| Heartburn \| 2 HP:0002583 \| Colitis \| 2 HP:0000421 \| Bloody nose \| 2 HP:0003270 \| Distended abdomen \| 1 HP:0012578 \| Membranous glomerulonephritis \| 1 HP:0040171 \| Low serum testosterone levels \| 1 HP:0200063 \| Colorectal polyposis \| 1 HP:0001406 \| Intrahepatic cholestasis \| 1 HP:0002605 \| Hepatic necrosis \| 1 HP:0000802 \| Erectile dysfunction \| 1 HP:0002905 \| Hyperphosphatemia \| 1 HP:0012126 \| Gastric cancer \| 1 HP:0100602 \| Pre-eclampsia \| 1 HP:0012594 \| High urine albumin levels \| 1 HP:0100279 \| Ulcerative colitis \| 1 HP:0011675 \| Arrhythmias \| 1 HP:0100584 \| Endocarditis \| 1 HP:0002248 \| Vomitting blood \| 1 HP:0040184 \| Oral hemorrhage \| 1 HP:0000859 \| Mineralocorticoid excess \| 1 HP:0003394 \| Muscle cramps \| 1 HP:0003231 \| Increased tyrosine in blood \| 1 HP:0001272 \| Cerebellar atrophy \| 1 HP:0001875 \| Neutropenia \| 1 HP:0001712 \| Left ventricular hypertrophy \| 1 HP:0007634 \| Nonarteritic anterior ischemic optic neuropathy \| 1 HP:0002630 \| Fat malabsorption \| 1 HP:0012490 \| Inflammation of fat tissue \| 1 HP:0000967 \| Petechiae \| 1 HP:0011921 \| Exudative pleural effusion \| 1 HP:0100614 \| Muscle inflammation \| 1 HP:0004844 \| Coombs-positive hemolytic anemia \| 1 HP:0003155 \| Hyperphosphatasia \| 1 HP:0002633 \| Vasculitis \| 1 HP:0000752 \| Hyperactive behavior \| 1 HP:0002901 \| Hypocalcemia \| 1 HP:0002908 \| Conjugated hyperbilirubinemia \| 1 HP:0000206 \| Inflammation of the tongue \| 1 HP:0001880 \| Eosinophilia \| 1 HP:0002140 \| Ischemic stroke \| 1 HP:0003261 \| Elevated IgA \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0001892 \| Bleeding diathesis \| 1 HP:0007302 \| Bipolar disorder \| 1 HP:0000488 \| Noninflammatory retina disease \| 1 HP:0002955 \| Granulomatosis \| 1 HP:0008356 \| Combined hyperlipidaemia \| 1 HP:0002013 \| Emesis \| 1 HP:0002835 \| Aspiration \| 1 HP:0008282 \| Unconjugated hyperbilirubinemia \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0009125 \| Lipodystrophy \| 1 HP:0010562 \| Keloids \| 1 HP:0004448 \| Fulminant hepatic failure \| 1 HP:0100009 \| Intracranial meningioma \| 1 HP:0004387 \| Enterocolitis \| 1 HP:0010702 \| Hypergammaglobulinaemia \| 1 HP:0002757 \| Multiple fractures \| 1 HP:0005978 \| Noninsulin dependent diabetes mellitus \| 1 HP:0012532 \| Chronic pain \| 1 HP:0000602 \| Ophthalmoplegia \| 1 HP:0001882 \| Decreased blood leukocyte number \| 1 HP:0001942 \| Metabolic acidosis \| 1 HP:0100778 \| Cryoglobulinemia \| 1 HP:0001622 \| Premature delivery \| 1 HP:0001251 \| Ataxia \| 1 HP:0001250 \| Seizures \| 1 HP:0100727 \| Histiocytosis \| 1 HP:0002749 \| Osteomalacia \| 1 HP:0001714 \| Ventricular hypertrophy \| 1 HP:0000988 \| Exanthem \| 1 HP:0002014 \| Diarrhea \| 1 HP:0002099 \| Asthma \| 1 HP:0030830 \| Crackles \| 1 HP:0001138 \| Damaged optic nerve \| 1 HP:0011106 \| Depleted blood volume \| 1 HP:0000166 \| Severe periodontal disease \| 1 HP:0012197 \| Insulinoma \| 1 HP:0001262 \| Somnolence \| 1 HP:0003202 \| Neurogenic muscle atrophy, especially in the lower limbs \| 1 HP:0100699 \| Scarring \| 1 HP:0001369 \| Arthritis \| 1 HP:0100723 \| Gastrointestinal stroma tumor \| 1 HP:0004929 \| Coronary artherosclerosis \| 1 HP:0001997 \| Gout \| 1 HP:0002829 \| Arthralgias \| 1 HP:0002360 \| Sleep disturbance \| 1 HP:0002624 \| Abnormal vein \| 1 HP:0001876 \| Low blood cell count \| 1 HP:0006280 \| Chronic pancreas inflammation \| 1 HP:0004787 \| Fulminant hepatitis \| 1 HP:0100724 \| Hypercoagulability \| 1 HP:0000107 \| Renal cyst \| 1 HP:0100896 \| Rectal polyps \| 1 HP:0001973 \| Autoimmune thrombocytopenia \| 1 HP:0001871 \| Abnormality of blood and blood-forming tissues \| 1 HP:0003201 \| Rhabdomyolysis \| 1 HP:0002189 \| Excessive daytime sleepiness \| 1 HP:0001342 \| Intracerebral hemorrhage \| 1 HP:0006580 \| Portal fibrosis \| 1 HP:0100537 \| Inflammation of the fascia \| 1 HP:0002597 \| Abnormality of blood vessels \| 1 HP:0100033 \| Tic disorder \| 1 HP:0006561 \| Lipid accumulation in hepatocytes \| 1 HP:0001300 \| Parkinsonism \| 1 HP:0005523 \| Lymphoproliferative disorder \| 1 HP:0000824 \| Growth hormone deficiency \| 1 HP:0002878 \| Respiratory failure \| 1 HP:0002578 \| Gastroparesis \| 1 HP:0002617 \| Aneurysmal dilatation \| 1 HP:0003075 \| Hypoproteinemia \| 1 HP:0005681 \| Juvenile idiopathic arthritis \| 1 HP:0001650 \| Valvular aortic stenosis \| 1 HP:0000978 \| Bruisability \| 1 HP:0001941 \| acidemia \| 1 HP:0030049 \| Brain abscess \| 1

Disease ID	675
Disease	liver disease
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:81) C0023890 \| cirrhosis \| 175 C0009450 \| infection \| 152 C0239946 \| liver fibrosis \| 87 C0019196 \| hepatitis c \| 69 C0011847 \| diabetes \| 69 C0796095 \| c syndrome \| 56 C0020541 \| portal hypertension \| 54 C0239946 \| hepatic fibrosis \| 39 C0085584 \| encephalopathy \| 31 C0021311 \| infections \| 31 C0426768 \| o sign \| 27 C0085605 \| liver failure \| 24 C0011849 \| diabetes mellitus \| 24 C0040034 \| thrombocytopenia \| 22 C0005779 \| coagulopathy \| 21 C0019151 \| hepatic encephalopathy \| 19 C0042769 \| virus infection \| 15 C0282193 \| iron overload \| 13 C0042870 \| vitamin d deficiency \| 12 C0033774 \| pruritus \| 12 C0004153 \| atherosclerosis \| 11 C0162429 \| malnutrition \| 11 C0035078 \| renal failure \| 10 C0040053 \| thrombosis \| 10 C0029456 \| osteoporosis \| 10 C0014867 \| esophageal varices \| 9 C0040038 \| thromboembolism \| 9 C0022658 \| renal disease \| 9 C0267373 \| intestinal bleeding \| 9 C0019080 \| hemorrhage \| 8 C0008370 \| cholestasis \| 8 C0235378 \| hepatotoxicity \| 8 C0020542 \| pulmonary hypertension \| 8 C0002871 \| anemia \| 7 C0019202 \| wilson's disease \| 5 C0036690 \| sepsis \| 4 C0001973 \| alcoholism \| 4 C0235950 \| zinc deficiency \| 4 C0015672 \| fatigue \| 4 C1393529 \| vascular complications \| 3 C0019163 \| hepatitis b infection \| 3 C0341697 \| renal impairment \| 3 C0001623 \| adrenal insufficiency \| 3 C0024228 \| lymphadenopathy \| 3 C0019322 \| umbilical hernia \| 3 C0442874 \| neuropathy \| 2 C0024523 \| malabsorption \| 2 C0004610 \| bacteremia \| 2 C0005944 \| metabolic bone disease \| 2 C0005779 \| coagulation disorders \| 2 C0004623 \| bacterial infections \| 2 C1619692 \| nephrogenic systemic fibrosis \| 2 C0027765 \| neurological disorder \| 2 C0005779 \| coagulopathies \| 2 C0022658 \| nephropathy \| 2 C0031154 \| peritonitis \| 2 C0162429 \| nutritional deficiencies \| 1 C0024115 \| lung disease \| 1 C0233401 \| psychiatric symptoms \| 1 C0005940 \| bone disorders \| 1 C0271650 \| glucose intolerance \| 1 C0014009 \| empyema \| 1 C0021053 \| immune disorders \| 1 C0235394 \| wasting \| 1 C0687751 \| spur cell anemia \| 1 C0004623 \| bacterial infection \| 1 C0008350 \| gallstones \| 1 C0037090 \| respiratory symptoms \| 1 C0268307 \| conjugated hyperbilirubinemia \| 1 C0002878 \| haemolytic anaemia \| 1 C0005750 \| stasis syndrome \| 1 C0002878 \| hemolytic anemia \| 1 C0022660 \| acute renal failure \| 1 C0020488 \| sodium retention \| 1 C0242350 \| erectile dysfunction \| 1 C1527311 \| brain edema \| 1 C0009324 \| ulcerative colitis \| 1 C0162316 \| iron deficiency \| 1 C0259749 \| autonomic neuropathy \| 1 C0221757 \| alpha-1-antitrypsin deficiency \| 1 C1839611 \| n syndrome \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:40)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs104894422	18199861	6445	SGCG	umls:C0023895	BeFree	Male C282Y homozygotes with a serum ferritin level of 1000 mug per liter or more were more likely to report fatigue, use of arthritis medicine, and a history of liver disease than were men who had the wild-type gene.	0.000271442	2008	SGCG	13	23324513	G	A
rs121434622	20011099	2332	FMR1	umls:C0023895	BeFree	This patient harbors an isoleucine to asparagine mutation (I304N) in the second FMRP KH-type RNA-binding domain, however, this single case report was complicated because the patient harbored a superimposed familial liver disease.	0.000271442	2009	FMR1	X	147936534	T	A
rs1229984	22048268	125	ADH1B	umls:C0023895	BeFree	The aim of this study was to analyze the combined effect of the most frequent alcohol dehydrogenase polymorphisms (Arg48His and Arg370Cys in ADH1B, Arg272Gln and Ile350Val in ADH1C) on the alcohol use habits, alcohol dependence and chronic liver diseases in Hungary.	0.003724241	2011	ADH1B	4	99318162	T	C
rs12979860	24914551	282617	IFNL3	umls:C0023895	BeFree	Impact of host IL28B rs12979860, rs8099917 in interferon responsiveness and advanced liver disease in chronic genotype 3 hepatitis C patients.	0.002442977	2014	IFNL3;IFNL4	19	39248147	C	T
rs12979860	25740255	101180976	IFNL4	umls:C0023895	BeFree	Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner.	0.000271442	2015	IFNL3;IFNL4	19	39248147	C	T
rs150495372	22048268	125	ADH1B	umls:C0023895	BeFree	The aim of this study was to analyze the combined effect of the most frequent alcohol dehydrogenase polymorphisms (Arg48His and Arg370Cys in ADH1B, Arg272Gln and Ile350Val in ADH1C) on the alcohol use habits, alcohol dependence and chronic liver diseases in Hungary.	0.003724241	2011	ADH1B	4	99313834	C	T
rs1693482	22048268	125	ADH1B	umls:C0023895	BeFree	The aim of this study was to analyze the combined effect of the most frequent alcohol dehydrogenase polymorphisms (Arg48His and Arg370Cys in ADH1B, Arg272Gln and Ile350Val in ADH1C) on the alcohol use habits, alcohol dependence and chronic liver diseases in Hungary.	0.003724241	2011	ADH1C	4	99342808	C	T
rs1799945	10925986	3077	HFE	umls:C0023895	BeFree	This study assessed liver biopsies containing stainable iron from 103 patients with various liver diseases; clinical information included hepatic iron concentration and HFE genotype (C282Y, H63D).	0.053636003	2000	HFE	6	26090951	C	G
rs1799945	17160239	3077	HFE	umls:C0023895	BeFree	Mutation of the hemochromatosis gene (C282Y and/or H63D) was diagnosed in 16 (55.2%) patients with nonalcoholic steatohepatitis, in 12 (60%) patients with hepatitis C and in 8 (40%) patients with no liver disease.	0.053636003	2006	HFE	6	26090951	C	G
rs1799945	12678056	3077	HFE	umls:C0023895	BeFree	Our results show that the C282Y and H63D mutations of the HFE gene associated with hemochromatosis have measurable and consistent effects on iron indicators and are associated with liver disorders, but have no measurable effect on other iron overload-related symptoms and life-expectancy.	0.053636003	2002	HFE	6	26090951	C	G
rs1800562	19892936	9843	HEPH	umls:C0023895	BeFree	Duodenal biopsy samples were analyzed using real-time PCR for expression of DMT1, FPN1, DCYTB, and HEPH relative to GAPDH from 23 C282Y homozygotes, including 5 nonexpressors (serum ferritin < upper limit of normal and absence of phenotypic features of hemochromatosis) and 18 expressors. Four subjects of wild type for HFE mutations without iron overload or liver disease served as controls.	0.000271442	2010	HFE	6	26092913	G	A
rs1800562	17904763	3077	HFE	umls:C0023895	BeFree	Hereditary hemochromatosis (HH) is a genetic disease associated with iron overload, in which individuals homozygous for the mutant C282Y HFE associated allele are at risk of developing liver disease, diabetes and arthritis.	0.053636003	2008	HFE	6	26092913	G	A
rs1800562	19892936	3077	HFE	umls:C0023895	BeFree	Duodenal biopsy samples were analyzed using real-time PCR for expression of DMT1, FPN1, DCYTB, and HEPH relative to GAPDH from 23 C282Y homozygotes, including 5 nonexpressors (serum ferritin < upper limit of normal and absence of phenotypic features of hemochromatosis) and 18 expressors. Four subjects of wild type for HFE mutations without iron overload or liver disease served as controls.	0.053636003	2010	HFE	6	26092913	G	A
rs1800562	9620344	3077	HFE	umls:C0023895	BeFree	We evaluated whether the recently described C282Y mutation of the hemochromatosis gene, designated HFE (responsible for at least 83% of hereditary hemochromatosis), was associated with more advanced liver disease in chronic hepatitis C. One hundred thirty-seven patients with biopsy-proven chronic hepatitis C were studied and liver biopsies scored for necroinflammation (grade 0-18) and fibrosis (stage 0-6).	0.053636003	1998	HFE	6	26092913	G	A
rs1800562	10925986	3077	HFE	umls:C0023895	BeFree	This study assessed liver biopsies containing stainable iron from 103 patients with various liver diseases; clinical information included hepatic iron concentration and HFE genotype (C282Y, H63D).	0.053636003	2000	HFE	6	26092913	G	A
rs1800562	17160239	3077	HFE	umls:C0023895	BeFree	Mutation of the hemochromatosis gene (C282Y and/or H63D) was diagnosed in 16 (55.2%) patients with nonalcoholic steatohepatitis, in 12 (60%) patients with hepatitis C and in 8 (40%) patients with no liver disease.	0.053636003	2006	HFE	6	26092913	G	A
rs1800562	12678056	3077	HFE	umls:C0023895	BeFree	Our results show that the C282Y and H63D mutations of the HFE gene associated with hemochromatosis have measurable and consistent effects on iron indicators and are associated with liver disorders, but have no measurable effect on other iron overload-related symptoms and life-expectancy.	0.053636003	2002	HFE	6	26092913	G	A
rs1800562	15858186	3077	HFE	umls:C0023895	BeFree	Among men, C282Y homozygotes and compound heterozygotes were more likely to report a history of liver disease than were participants without HFE mutations.	0.053636003	2005	HFE	6	26092913	G	A
rs35385902	22048268	125	ADH1B	umls:C0023895	BeFree	The aim of this study was to analyze the combined effect of the most frequent alcohol dehydrogenase polymorphisms (Arg48His and Arg370Cys in ADH1B, Arg272Gln and Ile350Val in ADH1C) on the alcohol use habits, alcohol dependence and chronic liver diseases in Hungary.	0.003724241	2011	ADH1C	4	99347122	C	T,A
rs386626619	22684349	3717	JAK2	umls:C0023895	BeFree	The aim of this study was to describe the prevalence of main hereditary thrombophilias, Janus kinase 2 (JAK2) V617F mutation, antiphospholipid antibody syndrome (APS), and hyperhomocysteinemia in Brazilian children and adolescents diagnosed with portal vein thrombosis (PVT) without associated hepatic disease.	0.000271442	2012	NA	NA	NA	NA	NA
rs4074	24260493	2919	CXCL1	umls:C0023895	BeFree	Patients with alcohol-induced cirrhosis were significantly more often carriers of the CXCL1 rs4074 A allele (65.3%) than alcoholics without liver disease (54.8%, OR=1.55; 95%CI=1.025-2.350; p=0.04) and healthy controls (53.8%, OR=1.62; 95%CI=1.212-2.151; p=0.001).	0.000271442	2013	CXCL1	4	73870427	A	G
rs4898	23563628	7076	TIMP1	umls:C0023895	BeFree	We used PCR to analyze 188 patients with HCV-related liver disease (95 with chronic hepatitis and 93 with cirrhosis) for TIMP-1 372 T/C and TIMP-2 -418 G/C polymorphisms.	0.000814326	2012	SYN1;TIMP1;MIR4769	X	47585586	T	C
rs55868078	22048268	125	ADH1B	umls:C0023895	BeFree	The aim of this study was to analyze the combined effect of the most frequent alcohol dehydrogenase polymorphisms (Arg48His and Arg370Cys in ADH1B, Arg272Gln and Ile350Val in ADH1C) on the alcohol use habits, alcohol dependence and chronic liver diseases in Hungary.	0.003724241	2011	NA	NA	NA	NA	NA
rs56061981	24023775	3627	CXCL10	umls:C0023895	BeFree	G-201A in promoter region of IP-10 gene was associated with liver disease progression in patients with HBV infection through up-regulating IP-10 expression.	0.001085767	2013	ART3;CXCL10	4	76023632	C	T
rs67420531	22048268	125	ADH1B	umls:C0023895	BeFree	The aim of this study was to analyze the combined effect of the most frequent alcohol dehydrogenase polymorphisms (Arg48His and Arg370Cys in ADH1B, Arg272Gln and Ile350Val in ADH1C) on the alcohol use habits, alcohol dependence and chronic liver diseases in Hungary.	0.003724241	2011	ADH1C	4	99336772	G	A,C
rs698	22048268	125	ADH1B	umls:C0023895	BeFree	The aim of this study was to analyze the combined effect of the most frequent alcohol dehydrogenase polymorphisms (Arg48His and Arg370Cys in ADH1B, Arg272Gln and Ile350Val in ADH1C) on the alcohol use habits, alcohol dependence and chronic liver diseases in Hungary.	0.003724241	2011	ADH1C	4	99339632	T	C,A
rs699	19473084	183	AGT	umls:C0023895	BeFree	Evaluation of angiotensinogen c.1-44G>A and p.M268T variants as risk factors for fibrosis progression in chronic hepatitis C and liver diseases of various etiologies.	0.002909916	2009	AGT	1	230710048	A	G
rs738409	23069476	80339	PNPLA3	umls:C0023895	BeFree	Several studies have reported an association between the genetic variant rs738409 (G) in the PNPLA3 gene and the risk of cirrhosis in various liver diseases.	0.007524428	2013	PNPLA3	22	43928847	C	G
rs738409	21745286	80339	PNPLA3	umls:C0023895	BeFree	PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence.	0.007524428	2011	PNPLA3	22	43928847	C	G
rs738409	22898488	80339	PNPLA3	umls:C0023895	BeFree	Aim of this study was to evaluate whether the I148M PNPLA3 polymorphism influences serum adiponectin in liver diseases and healthy controls.	0.007524428	2012	PNPLA3	22	43928847	C	G
rs738409	23564580	80339	PNPLA3	umls:C0023895	BeFree	Recently, the rs738409 I148M patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism has been demonstrated to influence steatosis susceptibility and fibrosis progression in patients with different liver diseases, but no data are yet available for CHB.	0.007524428	2013	PNPLA3	22	43928847	C	G
rs738409	23872669	80339	PNPLA3	umls:C0023895	BeFree	The G-allele in position rs738409 of patatin-like phospholipase domain-containing protein 3 (PNPLA3) is associated with an increased hepatic concentration of triglyceride and is a risk factor for advanced liver disease.	0.007524428	2013	PNPLA3	22	43928847	C	G
rs738409	24114809	80339	PNPLA3	umls:C0023895	BeFree	A variant (rs738409 C>G, encoding for p.I148M) in the PNPLA3 gene is associated with liver damage in chronic liver diseases.	0.007524428	2013	PNPLA3	22	43928847	C	G
rs738409	24222941	80339	PNPLA3	umls:C0023895	BeFree	PNPLA3 I148M polymorphism and progressive liver disease.	0.007524428	2013	PNPLA3	22	43928847	C	G
rs738409	23333103	80339	PNPLA3	umls:C0023895	BeFree	The rs738409 genetic variant in the patatin-like phospholipase domain-containing 3 (PNPLA3, adiponutrin) gene has been implicated as a genetic determinant of the entire spectrum of liver diseases, ranging from steatosis, chronic hepatitis, cirrhosis and ultimately to HCC.	0.007524428	2012	PNPLA3	22	43928847	C	G
rs738409	22869157	80339	PNPLA3	umls:C0023895	BeFree	This study was conducted to determine whether PNPLA3 rs738409 SNPs affect development and prognosis of hepatocellular carcinoma (HCC) in patients with various liver diseases.	0.007524428	2013	PNPLA3	22	43928847	C	G
rs738409	25378656	80339	PNPLA3	umls:C0023895	BeFree	The human patatin-like phospholipase domain-containing-3 (PNPLA3) gene rs738409 C>G polymorphism is associated with several types of liver disease.	0.007524428	2015	PNPLA3	22	43928847	C	G
rs738409	25624712	80339	PNPLA3	umls:C0023895	BeFree	Various studies have established a strong link between the 148 isoleucine to methionine protein variant (I148M) of PNPLA3 and liver diseases, including nonalcoholic fatty liver disease (NAFLD).	0.007524428	2014	PNPLA3	22	43928847	C	G
rs77375493	22684349	3717	JAK2	umls:C0023895	BeFree	The aim of this study was to describe the prevalence of main hereditary thrombophilias, Janus kinase 2 (JAK2) V617F mutation, antiphospholipid antibody syndrome (APS), and hyperhomocysteinemia in Brazilian children and adolescents diagnosed with portal vein thrombosis (PVT) without associated hepatic disease.	0.000271442	2012	JAK2;INSL6	9	5073770	G	A,T
rs8099917	24914551	282617	IFNL3	umls:C0023895	BeFree	Impact of host IL28B rs12979860, rs8099917 in interferon responsiveness and advanced liver disease in chronic genotype 3 hepatitis C patients.	0.002442977	2014	NA	19	39252525	T	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:174)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	16505320	rs1497406	A	G	rs1497406	22001757	3.00E-19	NA	3.8	[2.70-4.80] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs1497406-G	NA
1	21766453	rs1976403	A	C	rs1976403	22001757	2.00E-50	NA	3.6	[3.0-4.2] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alkaline phosphatase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004533	alkaline phosphatase measurement	Liver disease	rs1976403-C	NA
1	21821757	rs1780324	A	G	rs1780324	18940312	7.00E-15	ALP	0.03	[0.023-0.039] U/L increase	7,751 European ancestry individuals	European(7751)	ALL(7751)	EUR(7751)	ALL(7751)	Liver enzyme levels	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004582	alkaline phosphatase measurement	Liver disease	rs1780324-T	Research Support, Non-U.S. Gov't	Research Support, N.I.H., Intramural	C
1	67719129	rs1343151	G	A	rs1343151	21177773	1.91E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
1	76899464	rs4949718	T	C	rs4949718	24124411	1.00E-06	NA	0.03	[0.016-0.036] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (aspartate transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	NA	NA	Liver disease	rs4949718-A	NA	T	ST6GALNAC3
1	76899464	rs4949718	T	C	rs4949718	24124411	2.00E-07	NA	0.05	[0.033-0.073] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs4949718-A	NA	T	ST6GALNAC3
1	89146234	rs12145922	C	A	rs12145922	22001757	4.00E-11	NA	2.8	[2.20-3.40] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs12145922-A	NA
1	111684276	rs1335645	A	G	rs1335645	22001757	7.00E-09	NA	4.3	[3.50-5.20] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs1335645-A	NA
1	155126948	rs10908458	T	C	rs10908458	22001757	2.00E-15	NA	3.7	[3.10-4.20] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs10908458-T	NA
1	163142555	rs12035879	G	A	rs12035879	24124411	4.00E-06	NA	0.05	[0.028-0.068] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs12035879-A	NA	A	RGS5
1	165175515	rs1354510	A	G	rs1354510	21177773	7.78E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
1	165180089	rs1532815	T	A	rs1532815	21177773	6.00E-07	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
1	167156500	rs9803659	T	C	rs9803659	18940312	4.00E-06	ALT	0.03	[0.018-0.042] U/L decrease	7,751 European ancestry individuals	European(7751)	ALL(7751)	EUR(7751)	ALL(7751)	Liver enzyme levels	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004582	alkaline phosphatase measurement	Liver disease	rs9803659-C	Research Support, Non-U.S. Gov't	Research Support, N.I.H., Intramural	C
1	204112984	rs3795578	G	A	rs3795578	21177773	7.00E-06	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
1	205554085	rs7526132	G	C	rs7526132	21177773	3.87E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
2	27730940	rs1260326	T	C	rs1260326	22001757	4.00E-13	NA	3.2	[2.40-4.0] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs1260326-T	NA
2	137873347	rs892877	A	G	rs892877	24124411	4.00E-06	NA	0.03	[0.018-0.046] unit decrease	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (aspartate transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	NA	NA	Liver disease	rs892877-A	NA	C	THSD7B
2	137898753	rs984295	G	A	rs984295	24124411	5.86E-06	NA	0.03	[0.02-0.04] unit decrease	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (aspartate transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	NA	NA	Liver disease	rs984295-G	NA	A	THSD7B
2	150564484	rs17801127	C	T	rs17801127	24124411	2.00E-07	NA	0.15	[0.097-0.211] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs17801127-A	NA	C	NA
2	152481977	rs10186482	A	G	rs10186482	21177773	6.87E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
2	155234318	rs12621256	A	G	rs12621256	24124411	4.00E-06	NA	0.09	[0.053-0.131] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs12621256-G	NA	A	GALNT13
2	155647819	rs17640676	G	T	rs17640676	21177773	2.09E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
2	169840574	rs16856332	T	G	rs16856332	22001757	2.00E-09	NA	3.9	[1.20-6.70] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alkaline phosphatase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004533	alkaline phosphatase measurement	Liver disease	rs16856332-T	NA
2	192117238	rs13030978	C	T	rs13030978	22001757	1.00E-11	NA	3.7	[2.80-4.6] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs13030978-T	NA
2	203062103	rs13015146	T	C	rs13015146	21177773	9.49E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
2	215024392	rs16851554	T	G	rs16851554	21177773	2.46E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
2	233513175	rs2140773	C	A	rs2140773	22001757	1.00E-09	NA	2.9	[2.30-3.50] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs2140773-A	NA
2	240216021	rs6737742	G	A	rs6737742	21177773	5.53E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
2	240217522	rs908262	C	A	rs908262	21177773	3.71E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
3	23712616	rs11129122	A	G	rs11129122	21177773	4.97E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
3	52532118	rs13326165	A	G	rs13326165	21177773	7.92E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
3	64536648	rs80311637	C	T	rs80311637	24124411	2.00E-06	NA	0.08	[0.047-0.109] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (aspartate transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	NA	NA	Liver disease	rs80311637-A	NA	C	ADAMTS9
3	64536648	rs80311637	C	T	rs80311637	24124411	7.00E-06	NA	0.14	[0.078-0.196] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs80311637-A	NA	C	ADAMTS9
3	79604064	rs7617400	C	T	rs7617400	24124411	6.00E-06	NA	0.03	[0.02-0.048] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (aspartate transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	NA	NA	Liver disease	rs7617400-A	NA	C	ROBO1
3	79610625	rs11924965	C	T	rs11924965	24124411	6.16E-06	NA	0.03	[0.02-0.05] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (aspartate transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	NA	NA	Liver disease	rs11924965-A	NA	T	ROBO1
3	79646157	rs7644918	A	C	rs7644918	24124411	6.97E-06	NA	0.03	[0.02-0.05] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (aspartate transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	NA	NA	Liver disease	rs7644918-C	NA	C	ROBO1
3	88479786	rs4563418	G	A	rs4563418	21177773	3.87E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
3	88524175	rs2880961	C	T	rs2880961	21177773	2.00E-07	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
3	104446688	rs777952	C	T	rs777952	21177773	5.73E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
3	107589551	rs6789170	G	T	rs6789170	21177773	3.63E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
3	170725542	rs10513686	G	A	rs10513686	22001757	6.00E-11	NA	4.9	[4.00-5.70] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs10513686-A	NA
4	20515670	rs6810790	G	A	rs6810790	21177773	8.17E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
4	31208611	rs9997440	A	T	rs9997440	21177773	3.83E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
4	88213808	rs6834314	A	G	rs6834314	22001757	3.00E-09	NA	2.6	[1.90-3.40] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs6834314-A	NA
4	126939153	rs4495049	A	C	rs4495049	21177773	9.43E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
4	146794621	rs4547811	T	C	rs4547811	22001757	3.00E-27	NA	6.4	[5.00-7.90] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs4547811-C	NA
4	175300604	rs6553786	C	T	rs6553786	21177773	8.16E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
4	175300779	rs6852435	T	C	rs6852435	21177773	6.00E-06	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
4	175325686	rs7665426	G	T	rs7665426	21177773	2.17E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
4	179675395	rs2082603	C	T	rs2082603	21177773	3.43E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
5	31020521	rs6888304	A	G	rs6888304	22001757	1.00E-09	NA	2.7	[2.00-3.50] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs6888304-A	NA
5	31113414	rs16900696	C	G	rs16900696	21177773	7.12E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
5	52193125	rs4074793	A	G	rs4074793	22001757	3.00E-10	NA	5.5	[3.30-7.70] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs4074793-G	NA
5	86122767	rs7726138	A	G	rs7726138	21177773	5.44E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
5	94425542	rs4869233	T	C	rs4869233	21177773	2.28E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
5	116207905	rs6878801	C	T	rs6878801	21177773	6.77E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
5	134250146	rs319594	C	T	rs319594	21177773	6.51E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
5	134254788	rs319590	G	T	rs319590	21177773	2.76E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
5	134267557	rs10515465	G	C	rs10515465	21177773	4.69E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
6	21946612	rs13204006	A	G	rs13204006	21177773	7.85E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
6	24441746	rs9467160	G	A	rs9467160	18940312	1.00E-11	ALP	0.03	[0.024-0.044] U/L increase	7,751 European ancestry individuals	European(7751)	ALL(7751)	EUR(7751)	ALL(7751)	Liver enzyme levels	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004582	alkaline phosphatase measurement	Liver disease	rs9467160-A	Research Support, Non-U.S. Gov't	Research Support, N.I.H., Intramural	G
6	24489652	rs1126617	C	T	rs1126617	22001757	1.80E-14	NA	NA	NA	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	NA	NA
6	24491475	rs1883415	A	C	rs1883415	22001757	6.00E-26	NA	3.1	[2.50-3.70] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alkaline phosphatase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004533	alkaline phosphatase measurement	Liver disease	rs1883415-C	NA
6	32305979	rs3129900	G	T	rs3129900	20639878	7.00E-25	NA	7.5	[5.00-11.30]	41 cases; 176 controls	NOPOP(217)	ALL(217)	NOPOP(217)	ALL(217)	Lumiracoxib-related liver injury	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004228	drug-induced liver injury	Liver disease	NA	NA	T	C6orf10
6	50834157	rs9473924	G	T	rs9473924	21177773	8.49E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
6	50857995	rs9473932	G	A	rs9473932	21177773	3.26E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
6	50865820	rs943005	C	T	rs943005	21177773	7.78E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
6	50897251	rs4715210	C	T	rs4715210	21177773	7.75E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
6	50905067	rs3857596	C	T	rs3857596	21177773	7.75E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
6	53924697	rs9296736	T	C	rs9296736	22001757	3.00E-09	NA	3	[2.10-4.00] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs9296736-T	NA
6	67497830	rs4710625	C	G	rs4710625	21177773	8.39E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
6	88916603	rs7738812	A	T	rs7738812	21177773	8.52E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
6	112573289	rs3208829	C	G	rs3208829	21177773	2.54E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
6	112578384	rs11153350	G	A	rs11153350	21177773	2.54E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
6	116128906	rs10485114	C	T	rs10485114	21177773	4.01E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
6	125574509	rs3799732	T	C	rs3799732	21177773	6.49E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
7	22763009	rs12700386	C	G	rs12700386	21177773	6.20E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
7	49519619	rs11766607	A	G	rs11766607	21177773	2.06E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
7	49534244	rs6949916	A	G	rs6949916	21177773	8.53E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
7	49556594	rs4289753	A	G	rs4289753	21177773	7.19E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
7	73026378	rs17145750	C	T	rs17145750	22001757	3.00E-09	NA	4.5	[2.90-6.30] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs17145750-C	NA
7	77985583	rs17413355	C	T	rs17413355	21177773	8.50E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
7	134564363	rs2218988	T	C	rs2218988	21177773	9.50E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
8	9178268	rs6984305	A	T	rs6984305	22001757	2.00E-10	NA	2.7	[1.10-4.40] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alkaline phosphatase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004533	alkaline phosphatase measurement	Liver disease	rs6984305-A	NA
8	21102896	rs718068	T	C	rs718068	21177773	5.25E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
8	21104408	rs1380292	A	G	rs1380292	21177773	7.64E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
8	21118224	rs1599096	C	T	rs1599096	21177773	6.86E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
8	27583328	rs17469886	C	A	rs17469886	21177773	3.52E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
8	36847115	rs10110651	T	C	rs10110651	21177773	2.14E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
8	57926726	rs2089515	C	T	rs2089515	21177773	9.91E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
8	68734769	rs4585742	G	A	rs4585742	21177773	6.05E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
8	126482077	rs2954021	A	G	rs2954021	22001757	2.00E-13	NA	1.4	[0.50-2.30] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alkaline phosphatase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004533	alkaline phosphatase measurement	Liver disease	rs2954021-A	NA
8	126482077	rs2954021	A	G	rs2954021	22001757	5.00E-09	NA	1.6	[0.60-2.60] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs2954021-A	NA
8	129083459	rs2720666	G	A	rs2720666	21177773	6.93E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
8	129083584	rs2720667	G	A	rs2720667	21177773	5.73E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
9	953057	rs279874	C	G	rs279874	21177773	9.13E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
9	104223233	rs10819937	C	G	rs10819937	22001757	1.00E-09	NA	2.5	[1.40-3.60] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alkaline phosphatase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004533	alkaline phosphatase measurement	Liver disease	rs10819937-C	NA
9	136139265	rs657152	C	A	rs657152	18940312	2.00E-30	ALP	0.05	[0.039-0.055] U/L decrease	7,751 European ancestry individuals	European(7751)	ALL(7751)	EUR(7751)	ALL(7751)	Liver enzyme levels	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004582	alkaline phosphatase measurement	Liver disease	rs657152-T	Research Support, Non-U.S. Gov't	Research Support, N.I.H., Intramural	T
9	136154168	rs579459	T	C	rs579459	22001757	3.00E-123	NA	8.8	[7.40-10.2] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alkaline phosphatase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004533	alkaline phosphatase measurement	Liver disease	rs579459-T	NA
9	136323754	rs4962153	A	G	rs4962153	18940312	8.00E-21	ALP	0.06	[0.048-0.072] U/L decrease	7,751 European ancestry individuals	European(7751)	ALL(7751)	EUR(7751)	ALL(7751)	Liver enzyme levels	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004582	alkaline phosphatase measurement	Liver disease	rs4962153-A	Research Support, Non-U.S. Gov't	Research Support, N.I.H., Intramural	G
10	1675548	rs12267329	A	G	rs12267329	21177773	6.71E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
10	11224665	rs596406	T	C	rs596406	24124411	4.00E-07	NA	0.07	[0.042-0.092] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (aspartate transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	NA	NA	Liver disease	rs596406-G	NA	T	CELF2
10	11224665	rs596406	T	C	rs596406	24124411	9.00E-06	NA	0.11	[0.063-0.157] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs596406-G	NA	T	CELF2
10	65121565	rs12355784	C	A	rs12355784	18940312	5.00E-10	ALP	0.03	[0.017-0.033] U/L increase	7,751 European ancestry individuals	European(7751)	ALL(7751)	EUR(7751)	ALL(7751)	Liver enzyme levels	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004582	alkaline phosphatase measurement	Liver disease	rs12355784-A	Research Support, Non-U.S. Gov't	Research Support, N.I.H., Intramural	C
10	65133822	rs7923609	A	G	rs7923609	22001757	6.00E-23	NA	2.2	[1.70-2.70] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alkaline phosphatase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004533	alkaline phosphatase measurement	Liver disease	rs7923609-G	NA
10	65274927	rs10761779	A	G	rs10761779	18940312	7.00E-10	ALP	0.03	[0.017-0.033] U/L increase	7,751 European ancestry individuals	European(7751)	ALL(7751)	EUR(7751)	ALL(7751)	Liver enzyme levels	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004582	alkaline phosphatase measurement	Liver disease	rs10761779-G	Research Support, Non-U.S. Gov't	Research Support, N.I.H., Intramural	A
10	79680434	rs754466	A	T	rs754466	22001757	6.00E-10	NA	3.5	[2.20-4.80] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs754466-T	NA
10	101157438	rs76850691	G	C	rs76850691	24124411	9.00E-07	NA	0.1	[0.06-0.138] unit decrease	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (aspartate transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	NA	NA	Liver disease	rs76850691-C	NA	G	GOT1
10	101795361	rs10883437	T	A	rs10883437	22001757	4.00E-09	NA	2.3	[1.40-3.10] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs10883437-T	NA
10	101861435	rs11597390	G	A	rs11597390	18940312	2.00E-08	ALT	0.04	[0.025-0.053] U/L decrease	7,751 European ancestry individuals	European(7751)	ALL(7751)	EUR(7751)	ALL(7751)	Liver enzyme levels	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004582	alkaline phosphatase measurement	Liver disease	rs11597390-A	Research Support, Non-U.S. Gov't	Research Support, N.I.H., Intramural	A
11	61623140	rs174601	C	T	rs174601	22001757	3.00E-09	NA	1.7	[0.80-2.60] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alkaline phosphatase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004533	alkaline phosphatase measurement	Liver disease	rs174601-T	NA
11	61687674	rs2524290	G	A	rs2524290	21177773	6.19E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
11	126283785	rs2236653	C	T	rs2236653	22001757	2.00E-09	NA	1.5	[0.60-2.50] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alkaline phosphatase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004533	alkaline phosphatase measurement	Liver disease	rs2236653-T	NA
11	130698539	rs948999	C	T	rs948999	21177773	6.95E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
12	6327008	rs10849421	A	G	rs10849421	21177773	4.15E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
12	6327989	rs4764486	T	C	rs4764486	21177773	5.27E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
12	41721235	rs1880889	A	C	rs1880889	23696881	1.96E-08	NA	NA	NA	1210 individuals	NOPOP(1210)	ALL(1210)	NOPOP(1210)	ALL(1210)	Alkaline phosphatase (ALP)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	NA	NA	NA	NA	Liver disease	NA	Research Support, Non-U.S. Gov't	G	PDZRN4
12	97685364	rs11611637	T	C	rs11611637	21177773	8.78E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
12	121424861	rs7310409	A	G	rs7310409	22001757	7.00E-45	NA	6.8	[5.70-7.80] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs7310409-G	NA
12	121442670	rs1169313	T	A,C	rs1169313	18940312	2.00E-10	GGT	0.01	[0.003-0.007] U/L decrease	7,751 European ancestry individuals	European(7751)	ALL(7751)	EUR(7751)	ALL(7751)	Liver enzyme levels	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004582	alkaline phosphatase measurement	Liver disease	rs1169313-C	Research Support, Non-U.S. Gov't	Research Support, N.I.H., Intramural	C
13	29558694	rs9508207	C	T	rs9508207	21177773	6.79E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
13	39675022	rs2209631	G	A	rs2209631	21177773	7.28E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
13	39675421	rs1536343	T	C	rs1536343	21177773	7.28E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
14	26488467	rs862946	T	C	rs862946	24124411	2.00E-07	NA	0.04	[0.027-0.059] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (aspartate transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	NA	NA	Liver disease	rs862946-A	NA	G	NA
14	95911835	rs10144421	T	C	rs10144421	21177773	8.77E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
14	103572815	rs944002	A	G	rs944002	22001757	6.00E-29	NA	6.3	[4.90-7.70] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs944002-G	NA
15	60883281	rs339969	C	A	rs339969	22001757	7.00E-20	NA	4.5	[3.90-5.10] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs339969-A	NA
15	73978337	rs8038465	C	T	rs8038465	22001757	1.00E-09	NA	2.4	[1.80-3.00] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs8038465-T	NA
15	101445900	rs3825924	G	A	rs3825924	21177773	1.73E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
16	1241997	rs11248859	G	A	rs11248859	21177773	6.18E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
16	50437528	rs9941219	C	T	rs9941219	24124411	4.00E-06	NA	0.15	[0.089-0.219] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs9941219-A	NA	C	NA
16	50441208	rs731660	C	A	rs731660	24124411	4.06E-06	NA	0.15	[0.09-0.22] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs731660-A	NA	G	NA
16	72220373	rs7186908	G	C	rs7186908	22001757	5.00E-09	NA	2	[1.10-2.90] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alkaline phosphatase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004533	alkaline phosphatase measurement	Liver disease	rs7186908-C	NA
16	80497601	rs4581712	C	A	rs4581712	22001757	3.00E-09	NA	3.2	[2.50-3.90] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs4581712-A	NA
17	2729652	rs6502555	T	C	rs6502555	21177773	3.11E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
17	6686566	rs8081984	T	G	rs8081984	21177773	7.46E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
17	6692841	rs10852886	T	A	rs10852886	21177773	7.50E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
17	7091650	rs314253	T	C	rs314253	22001757	8.00E-12	NA	2.1	[1.50-2.80] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alkaline phosphatase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004533	alkaline phosphatase measurement	Liver disease	rs314253-C	NA
17	70098161	rs9913711	G	C	rs9913711	22001757	1.00E-09	NA	2.4	[1.80-3.00] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs9913711-C	NA
17	70692740	rs2567513	C	T	rs2567513	21177773	6.66E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
17	71061934	rs903107	T	C	rs903107	24124411	6.00E-06	NA	0.1	[0.059-0.149] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs903107-G	NA	A	SLC39A11
17	72956124	rs3744198	G	A	rs3744198	21177773	3.40E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
18	28017919	rs1372940	C	T	rs1372940	21177773	5.74E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
18	55322502	rs12968116	C	T	rs12968116	22001757	9.00E-10	NA	4.8	[2.80-6.70] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs12968116-C	NA
18	56084054	rs4503880	T	C	rs4503880	22001757	3.00E-12	NA	3.6	[2.50-4.70] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs4503880-T	NA
18	66544755	rs1539893	G	A	rs1539893	24124411	3.00E-06	NA	0.06	[0.035-0.085] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs1539893-G	NA	T	CCDC102B
19	49206172	rs516246	C	T	rs516246	22001757	8.00E-10	NA	2.3	[1.80-2.90] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs516246-T	NA
19	49206603	rs281377	C	T	rs281377	22001757	1.00E-15	NA	1.8	[0.80-2.80] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alkaline phosphatase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004533	alkaline phosphatase measurement	Liver disease	rs281377-T	NA
19	49206674	rs601338	G	A	rs601338	22001757	1.40E-08	NA	NA	NA	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	NA	NA
20	1929542	rs6035126	C	T	rs6035126	24124411	5.00E-06	NA	0.18	[0.1-0.25] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs6035126-A	NA	C	NA
20	1931500	rs13433286	A	G	rs13433286	24124411	4.94E-06	NA	0.18	[0.1-0.25] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs13433286-G	NA	A	NA
20	23141445	rs844914	A	C	rs844914	24124411	5.98E-06	NA	0.11	[0.06-0.16] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs844914-A	NA	C	NA
20	23141655	rs844917	T	C	rs844917	24124411	6.00E-06	NA	0.11	[0.064-0.158] unit increase	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs844917-A	NA	C	NA
20	23863795	rs6083315	G	A	rs6083315	21177773	7.52E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
20	25298087	rs7267979	A	G	rs7267979	22001757	7.00E-10	NA	1.5	[0.90-2.0] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alkaline phosphatase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004533	alkaline phosphatase measurement	Liver disease	rs7267979-G	NA
20	44403710	rs2064504	A	G	rs2064504	21177773	8.52E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
20	44404647	rs6124741	C	T	rs6124741	21177773	8.31E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
20	44422705	rs6032545	G	T	rs6032545	21177773	6.48E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
21	28657949	rs457603	C	T	rs457603	24124411	5.00E-06	NA	0.07	[0.041-0.099] unit decrease	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (aspartate transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	NA	NA	Liver disease	rs457603-G	NA	T	NA
21	28659396	rs452621	T	C	rs452621	24124411	4.57E-06	NA	0.07	[0.04-0.1] unit decrease	484 Korean ancestry children	Korean(484)	ALL(484)	ASN(484)	ALL(484)	Liver enzyme levels (aspartate transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	NA	NA	Liver disease	rs452621-A	NA	C	NA
21	42884031	rs9984523	C	T	rs9984523	21177773	8.76E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
21	43822402	rs11909987	C	A	rs11909987	21177773	3.62E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
21	43823736	rs9784215	C	A	rs9784215	21177773	2.73E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
21	43826344	rs3746923	C	T	rs3746923	21177773	2.56E-05	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease
22	18439958	rs1076540	C	T	rs1076540	22001757	1.00E-16	NA	4.8	[3.50-6.10] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs1076540-C	NA
22	24295286	rs2739330	T	C	rs2739330	22001757	2.00E-09	NA	3.7	[2.70-4.60] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs2739330-T	NA
22	24990213	rs4820599	A	G	rs4820599	18940312	4.00E-11	GGT	0.01	[0.005-0.009] U/L increase	7,751 European ancestry individuals	European(7751)	ALL(7751)	EUR(7751)	ALL(7751)	Liver enzyme levels	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004582	alkaline phosphatase measurement	Liver disease	rs4820599-G	Research Support, Non-U.S. Gov't	Research Support, N.I.H., Intramural	G
22	24995756	rs2006227	C	A	rs2006227	23696881	0.000000017	NA	NA	NA	1210 individuals	NOPOP(1210)	ALL(1210)	NOPOP(1210)	ALL(1210)	Gamma-glutamyl transferase (GGT)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	NA	NA	NA	NA	Liver disease	NA	Research Support, Non-U.S. Gov't	C	GGT1
22	24996582	rs2330795	G	A	rs2330795	22001757	8.80E-18	NA	NA	NA	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	NA	NA
22	24997309	rs2017869	G	C	rs2017869	23696881	7.94E-08	NA	NA	NA	1210 individuals	NOPOP(1210)	ALL(1210)	NOPOP(1210)	ALL(1210)	Gamma-glutamyl transferase (GGT)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	NA	NA	NA	NA	Liver disease	NA	Research Support, Non-U.S. Gov't	C	GGT1
22	24999104	rs2073398	C	G	rs2073398	22001757	1.00E-109	NA	12.3	[10.90-13.70] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (gamma-glutamyl transferase)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056486	Drug-Induced Liver Injury	EFOID:0004532	serum gamma-glutamyl transferase measurement	Liver disease	rs2073398-G	NA
22	44324727	rs738409	C	G	rs738409	22001757	1.00E-45	NA	6	[5.0-7.0] % increase	Up to 52,350 European ancestry individuals; up to 8,739 Indian Asian individuals	European(52350)	Indian Asian(8739)	ALL(61089)	EUR(52350)	SAN(8739)	ALL(61089)	Liver enzyme levels (alanine transaminase)	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004735	serum alanine aminotransferase measurement	Liver disease	rs738409-G	NA
22	44332570	rs2281135	G	A	rs2281135	18940312	8.00E-16	ALT	0.06	[0.046-0.074] U/L increase	7,751 European ancestry individuals	European(7751)	ALL(7751)	EUR(7751)	ALL(7751)	Liver enzyme levels	HPOID:0001410	Decreased liver function	DOID:409	liver disease	NA	NA	EFOID:0004582	alkaline phosphatase measurement	Liver disease	rs2281135-T	Research Support, Non-U.S. Gov't	Research Support, N.I.H., Intramural	T
X	147324256	rs5936441	C	T	rs5936441	21177773	5.00E-06	NA	NA	NA	60 Caucasian American lymphoblastoid cell lines; 56 African American lymphoblastoid cell lines; 60 Han Chinese American lymphoblastoid cell lines	Han Chinese American(60)	Caucasian American(60)	African American(56)	ALL(176)	ASN(60)	AFR(56)	EUR(60)	ALL(176)	Response to acetaminophen (hepatotoxicity)	HPOID:0001392	Abnormality of the liver	DOID:409	liver disease	D056487	Drug-Induced Liver Injury, Chronic	NA	NA	Liver disease

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:67)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0023895	acetaminophen	D000082	103-90-2	liver diseases	MESH:D008107	marker/mechanism	11587558
C0023895	acetylcysteine	D000111	616-91-1	liver diseases	MESH:D008107	therapeutic	16922458
C0023895	s-adenosylmethionine	D012436	29908-03-0	liver diseases	MESH:D008107	therapeutic	1327655
C0023895	amphetamine	D000661	300-62-9	liver diseases	MESH:D008107	marker/mechanism	8099372
C0023895	busulfan	D002066	55-98-1	liver diseases	MESH:D008107	marker/mechanism	10955873
C0023895	capsaicin	D002211	404-86-4	liver diseases	MESH:D008107	therapeutic	16956363
C0023895	carmustine	D002330	154-93-8	liver diseases	MESH:D008107	marker/mechanism	10918425
C0023895	ceftazidime	D002442	78439-06-2	liver diseases	MESH:D008107	therapeutic	21227004
C0023895	celecoxib	D000068579	-	liver diseases	MESH:D008107	marker/mechanism	19007904
C0023895	cephalexin	D002506	15686-71-2	liver diseases	MESH:D008107	marker/mechanism	7479194
C0023895	chlorpromazine	D002746	50-53-3	liver diseases	MESH:D008107	marker/mechanism	1175890
C0023895	cholic acid	D019826	81-25-4	liver diseases	MESH:D008107	marker/mechanism	25344563
C0023895	cimetidine	D002927	51481-61-9	liver diseases	MESH:D008107	therapeutic	6141900
C0023895	clozapine	D003024	5786-21-0	liver diseases	MESH:D008107	marker/mechanism	8121527
C0023895	colchicine	D003078	64-86-8	liver diseases	MESH:D008107	marker/mechanism	10455999
C0023895	cyclophosphamide	D003520	50-18-0	liver diseases	MESH:D008107	marker/mechanism	17580253
C0023895	cyclosporine	D016572	59865-13-3	liver diseases	MESH:D008107	marker/mechanism	10455999
C0023895	dapsone	D003622	80-08-0	liver diseases	MESH:D008107	marker/mechanism	15947852
C0023895	daptomycin	D017576	103060-53-3	liver diseases	MESH:D008107	marker/mechanism	18381844
C0023895	diclofenac	D004008	15307-86-5	liver diseases	MESH:D008107	marker/mechanism	14566034
C0023895	diltiazem	D004110	42399-41-7	liver diseases	MESH:D008107	therapeutic	1472086
C0023895	disopyramide	D004206	3737/9/5	liver diseases	MESH:D008107	marker/mechanism	6834895
C0023895	doxycycline	D004318	564-25-0	liver diseases	MESH:D008107	marker/mechanism	13130401
C0023895	enalapril	D004656	75847-73-3	liver diseases	MESH:D008107	marker/mechanism	1880490
C0023895	enflurane	D004737	13838-16-9	liver diseases	MESH:D008107	marker/mechanism	7647582
C0023895	ethambutol	D004977	74-55-5	liver diseases	MESH:D008107	marker/mechanism	10599213
C0023895	ethosuximide	D005013	77-67-8	liver diseases	MESH:D008107	marker/mechanism	6847455
C0023895	floxuridine	D005467	50-91-9	liver diseases	MESH:D008107	marker/mechanism	2522675
C0023895	fluconazole	D015725	86386-73-4	liver diseases	MESH:D008107	marker/mechanism	14966256
C0023895	fluconazole	D015725	86386-73-4	liver diseases	MESH:D008107	therapeutic	17580253
C0023895	fluorouracil	D005472	51-21-8	liver diseases	MESH:D008107	marker/mechanism	8862076
C0023895	flutamide	D005485	13311-84-7	liver diseases	MESH:D008107	marker/mechanism	10431581
C0023895	fluvoxamine	D016666	54739-18-3	liver diseases	MESH:D008107	marker/mechanism	15349014
C0023895	folic acid	D005492	59-30-3	liver diseases	MESH:D008107	marker/mechanism	16877991
C0023895	fosinopril	D017328	98048-97-6	liver diseases	MESH:D008107	marker/mechanism	11941910
C0023895	haloperidol	D006220	52-86-8	liver diseases	MESH:D008107	marker/mechanism	595591
C0023895	hemin	D006427	16009-13-5	liver diseases	MESH:D008107	therapeutic	17173083
C0023895	imatinib mesylate	D000068877	-	liver diseases	MESH:D008107	marker/mechanism	17364993
C0023895	indomethacin	D007213	53-86-1	liver diseases	MESH:D008107	marker/mechanism	15784032
C0023895	labetalol	D007741	36894-69-6	liver diseases	MESH:D008107	marker/mechanism	8124849
C0023895	lindane	D001556	58-89-9	liver diseases	MESH:D008107	marker/mechanism	1715830
C0023895	mebendazole	D008463	31431-39-7	liver diseases	MESH:D008107	marker/mechanism	21254932
C0023895	melphalan	D008558	148-82-3	liver diseases	MESH:D008107	marker/mechanism	10955873
C0023895	metformin	D008687	657-24-9	liver diseases	MESH:D008107	marker/mechanism	10216414
C0023895	methotrexate	D008727	1959/5/2	liver diseases	MESH:D008107	marker/mechanism	1058041
C0023895	mitoxantrone	D008942	65271-80-9	liver diseases	MESH:D008107	marker/mechanism	20427751
C0023895	nevirapine	D019829	129618-40-2	liver diseases	MESH:D008107	marker/mechanism	18261327
C0023895	nicotine	D009538	-	liver diseases	MESH:D008107	marker/mechanism	15925865
C0023895	phenytoin	D010672	57-41-0	liver diseases	MESH:D008107	marker/mechanism	14986274
C0023895	piroxicam	D010894	36322-90-4	liver diseases	MESH:D008107	marker/mechanism	16867024
C0023895	propranolol	D011433	525-66-6	liver diseases	MESH:D008107	therapeutic	11193444
C0023895	rifampin	D012293	13292-46-1	liver diseases	MESH:D008107	marker/mechanism	10599213
C0023895	ritonavir	D019438	-	liver diseases	MESH:D008107	marker/mechanism	20003457
C0023895	rofecoxib	C116926	-	liver diseases	MESH:D008107	marker/mechanism	15834531
C0023895	rosiglitazone	C089730	-	liver diseases	MESH:D008107	marker/mechanism	14562008
C0023895	streptozocin	D013311	18883-66-4	liver diseases	MESH:D008107	marker/mechanism	135666
C0023895	sulindac	D013467	38194-50-2	liver diseases	MESH:D008107	marker/mechanism	14566034
C0023895	tenoxicam	C032801	59804-37-4	liver diseases	MESH:D008107	marker/mechanism	16867024
C0023895	thiotepa	D013852	52-24-4	liver diseases	MESH:D008107	marker/mechanism	10918425
C0023895	ticlopidine	D013988	55142-85-3	liver diseases	MESH:D008107	marker/mechanism	9798669
C0023895	tretinoin	D014212	302-79-4	liver diseases	MESH:D008107	marker/mechanism	18275266
C0023895	trimethoprim	D014295	738-70-5	liver diseases	MESH:D008107	marker/mechanism	7479194
C0023895	valproic acid	D014635	99-66-1	liver diseases	MESH:D008107	marker/mechanism	3092003
C0023895	vincristine	D014750	-	liver diseases	MESH:D008107	marker/mechanism	169340
C0023895	vitamin a	D014801	11103-57-4	liver diseases	MESH:D008107	marker/mechanism	10424294
C0023895	vitamin e	D014810	1406-18-4	liver diseases	MESH:D008107	therapeutic	18377885
C0023895	zidovudine	D015215	30516-87-1	liver diseases	MESH:D008107	marker/mechanism	8004891

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)