All Snps(Total Genotypes:129) |
|---|
| snpId |
pubmedId |
geneId |
geneSymbol |
diseaseId |
sourceId |
sentence |
score |
Year |
geneSymbol_dbSNP |
CHROMOSOME |
POS |
REF |
ALT |
| rs1140409 | 20022962 | 1655 | DDX5 | umls:C0023890 | BeFree | We recently identified a missense single nucleotide polymorphism (SNP) in DDX5 (rs1140409, p.S480A) that enhances the risk of developing cirrhosis. | 0.002995792 | 2010 | DDX5;MIR3064 | 17 | 64500552 | A | C |
| rs1140409 | 20022962 | 1655 | DDX5 | umls:C1623038 | BeFree | We recently identified a missense single nucleotide polymorphism (SNP) in DDX5 (rs1140409, p.S480A) that enhances the risk of developing cirrhosis. | 0.000271442 | 2010 | DDX5;MIR3064 | 17 | 64500552 | A | C |
| rs11557880 | 15941661 | 183 | AGT | umls:C1623038 | BeFree | In this respect, we investigated the impact of functional genetic polymorphisms of TGF-beta1 (codon 10 Leu/Pro, codon 25 Arg/Pro), TNF-alpha (-308 G/A, -238 G/A) and angiotensinogen (-6 G/A) on the development of cirrhosis in HHC. | 0.000271442 | 2005 | AGT | 1 | 230714088 | T | C |
| rs11557880 | 15941661 | 183 | AGT | umls:C0023890 | BeFree | In this respect, we investigated the impact of functional genetic polymorphisms of TGF-beta1 (codon 10 Leu/Pro, codon 25 Arg/Pro), TNF-alpha (-308 G/A, -238 G/A) and angiotensinogen (-6 G/A) on the development of cirrhosis in HHC. | 0.217826744 | 2005 | AGT | 1 | 230714088 | T | C |
| rs12304647 | 24248733 | 84668 | FAM126A | umls:C0023890 | BeFree | In conclusion, the miR-196a-2 rs12304647 CC genotype had a protective effect against development of HCC in comparison to the AA or AC genotypes in patients with chronic hepatitis and cirrhosis. | 0.017643722 | 2013 | MIR196A2 | 12 | 53991163 | A | C |
| rs12304647 | 24248733 | 84668 | FAM126A | umls:C1623038 | BeFree | In conclusion, the miR-196a-2 rs12304647 CC genotype had a protective effect against development of HCC in comparison to the AA or AC genotypes in patients with chronic hepatitis and cirrhosis. | 0.011672 | 2013 | MIR196A2 | 12 | 53991163 | A | C |
| rs12979860 | 21146242 | 282617 | IFNL3 | umls:C1623038 | BeFree | IL-28B rs12979860 C/T polymorphism T allele is more prevalent in patients with viral cirrhosis due to HCV in comparison to other aetiologies and to patients with mild chronic hepatitis C. Among OLT patients, carriage of this allele seems to augment the risk of developing HCC. | 0.005157396 | 2011 | IFNL3;IFNL4 | 19 | 39248147 | C | T |
| rs12979860 | 25420838 | 282617 | IFNL3 | umls:C1623038 | BeFree | CC genotype at rs12979860 of IL28B is associated with lower risk of new-onset diabetes after transplantation in adult patients with liver transplantation for hepatitis C cirrhosis. | 0.005157396 | 2015 | IFNL3;IFNL4 | 19 | 39248147 | C | T |
| rs12979860 | 24026885 | 282617 | IFNL3 | umls:C0023890 | BeFree | Carriage of IL28B rs12979860 CC genotype was associated with an increased risk for developing liver cirrhosis among patients with HBV infection (CC vs CT + TT: OR = 1.39, 95 % CI = 1.04-1.85). | 0.008338753 | 2013 | IFNL3;IFNL4 | 19 | 39248147 | C | T |
| rs12979860 | 21146242 | 282617 | IFNL3 | umls:C0023890 | BeFree | IL-28B rs12979860 C/T allele distribution in patients with liver cirrhosis: role in the course of chronic viral hepatitis and the development of HCC. | 0.008338753 | 2011 | IFNL3;IFNL4 | 19 | 39248147 | C | T |
| rs12979860 | 25504078 | 80339 | PNPLA3 | umls:C1623038 | BeFree | Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown. | 0.005428837 | 2014 | IFNL3;IFNL4 | 19 | 39248147 | C | T |
| rs12979860 | 25504078 | 1950 | EGF | umls:C1623038 | BeFree | Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown. | 0.001900093 | 2014 | IFNL3;IFNL4 | 19 | 39248147 | C | T |
| rs12979860 | 25504078 | 80339 | PNPLA3 | umls:C0023890 | BeFree | Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown. | 0.008067311 | 2014 | IFNL3;IFNL4 | 19 | 39248147 | C | T |
| rs12979860 | 25420838 | 282617 | IFNL3 | umls:C0023890 | BeFree | CC genotype at rs12979860 of IL28B is associated with lower risk of new-onset diabetes after transplantation in adult patients with liver transplantation for hepatitis C cirrhosis. | 0.008338753 | 2015 | IFNL3;IFNL4 | 19 | 39248147 | C | T |
| rs12979860 | 25504078 | 1950 | EGF | umls:C0023890 | BeFree | Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown. | 0.007262917 | 2014 | IFNL3;IFNL4 | 19 | 39248147 | C | T |
| rs12979860 | 21813376 | 282617 | IFNL3 | umls:C1623038 | BeFree | Recently, the rs12979860 C/T polymorphism in the IL28B gene has been linked to progression towards cirrhosis in HCV mono-infected patients and to treatment response of HCV-infection in HIV/HCV co-infected patients. | 0.005157396 | 2011 | IFNL3;IFNL4 | 19 | 39248147 | C | T |
| rs12979860 | 21813376 | 282617 | IFNL3 | umls:C0023890 | BeFree | Recently, the rs12979860 C/T polymorphism in the IL28B gene has been linked to progression towards cirrhosis in HCV mono-infected patients and to treatment response of HCV-infection in HIV/HCV co-infected patients. | 0.008338753 | 2011 | IFNL3;IFNL4 | 19 | 39248147 | C | T |
| rs1799945 | 12586300 | 3077 | HFE | umls:C0023890 | BeFree | HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis. | 0.089879864 | 2003 | HFE | 6 | 26090951 | C | G |
| rs1799945 | 11473464 | 3077 | HFE | umls:C1623038 | BeFree | The possibility of cirrhosis-associated hemosiderosis secondary to an iron metabolism abnormality associated with the H63D mutation of the HFE gene is proposed. | 0.014430026 | 2001 | HFE | 6 | 26090951 | C | G |
| rs1799945 | 11473464 | 3077 | HFE | umls:C0023890 | BeFree | The possibility of cirrhosis-associated hemosiderosis secondary to an iron metabolism abnormality associated with the H63D mutation of the HFE gene is proposed. | 0.089879864 | 2001 | HFE | 6 | 26090951 | C | G |
| rs1799945 | 12586300 | 3077 | HFE | umls:C1623038 | BeFree | HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis. | 0.014430026 | 2003 | HFE | 6 | 26090951 | C | G |
| rs1800562 | 12591066 | 3077 | HFE | umls:C0023890 | BeFree | Except for C282Y homozygotes, HFE gene mutations do not increase the risk to develop HCC in patients with cirrhosis. | 0.089879864 | 2003 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 20583211 | 3077 | HFE | umls:C1623038 | BeFree | Most clinical cases are homozygous for the Cys282Tyr (C282Y) mutation in the HFE gene, with serum ferritin (SF) concentration >1000 microg/L as the strongest predictor of cirrhosis. | 0.014430026 | 2010 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 20673159 | 4353 | MPO | umls:C1623038 | BeFree | We assessed the influence of Ala16Val-superoxide dismutase 2, Pro198Leu-glutathione peroxidase 1, and -463G/A-myeloperoxidase genotypes (high activity for the Ala, Pro, and G alleles, respectively) on the risks of cirrhosis and hepatocellular carcinoma (HCC) in patients homozygous for the C282Y-hemochromatosis (HFE) gene mutation. | 0.003181358 | 2011 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 20673159 | 3077 | HFE | umls:C0023890 | BeFree | We assessed the influence of Ala16Val-superoxide dismutase 2, Pro198Leu-glutathione peroxidase 1, and -463G/A-myeloperoxidase genotypes (high activity for the Ala, Pro, and G alleles, respectively) on the risks of cirrhosis and hepatocellular carcinoma (HCC) in patients homozygous for the C282Y-hemochromatosis (HFE) gene mutation. | 0.089879864 | 2011 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 23990522 | 3077 | HFE | umls:C0023890 | BeFree | RESEARCH DESIGN AND METHODS We studied these 16 variables in 159 nonscreening hemochromatosis probands with HFE C282Y homozygosity: age; sex; BMI; diabetes reports in first-degree family members (dichotomous); heavy ethanol consumption; cigarette smoking; elevated serum alanine aminotransferase/aspartate aminotransferase levels; nonalcoholic fatty liver; chronic viral hepatitis; cirrhosis; hand arthropathy; iron removed by phlebotomy; and positivity for HLA-A*01, B*08; A*03, B*07; and A*03, B*14 haplotypes. | 0.089879864 | 2015 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 14557859 | 3077 | HFE | umls:C1623038 | BeFree | In HCV-infected patients, heterozygosity for the C282Y mutation in HFE was significantly associated with elevated serum ferritin levels, stainable liver iron, and advanced fibrosis or cirrhosis (F2-F4). | 0.014430026 | 2003 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 17710673 | 3077 | HFE | umls:C0023890 | GAD | [A small but significant number of Norwegian male C282Y homozygotes will contract liver cirrhosis if their hemochromatosis is not diagnosed and treated in time.] | 0.089879864 | 2007 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 12957298 | 3077 | HFE | umls:C1623038 | BeFree | Other recent evidence indicates that the prevalence of HFE gene mutations is increased in chronic viral hepatitis and that patients with chronic hepatitis C harboring especially the C282Y mutation are more likely to suffer from advanced hepatic fibrosis or cirrhosis and to do so at younger ages. | 0.014430026 | 2003 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 19930418 | 3077 | HFE | umls:C0023890 | BeFree | Hereditary hemochromatosis (HH), most often due to HFE C282Y homozygosity, is an iron overload disorder that can result in severe morbidity including hepatic cirrhosis. | 0.089879864 | 2010 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 11168438 | 3077 | HFE | umls:C0023890 | BeFree | The results indicate that HH patients with the HFE C282Y mutation and low numbers of CD8+ cells in the liver lobuli have higher iron stores and are more prone to develop liver cirrhosis. | 0.089879864 | 2001 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 10980924 | 3077 | HFE | umls:C0023890 | BeFree | It is less well established that the prevalence of the HFE mutations is increased in alcoholic liver disease and in chronic viral hepatitis, but in both conditions, patients harboring one of these mutations, especially C282Y, are more likely to have advanced hepatic fibrosis or cirrhosis. | 0.089879864 | 1999 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 18705322 | 3077 | HFE | umls:C0023890 | GAD | [The finding of iron deposits in routinely obtained liver specimen correlates with occurrence of the different HFE gene mutations.] | 0.089879864 | 2008 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 24556216 | 3077 | HFE | umls:C0023890 | BeFree | PCSK7 variant rs236918 is a risk factor for cirrhosis in HH patients homozygous for the HFE C282Y mutation. | 0.089879864 | 2015 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 20583211 | 3077 | HFE | umls:C0023890 | BeFree | Most clinical cases are homozygous for the Cys282Tyr (C282Y) mutation in the HFE gene, with serum ferritin (SF) concentration >1000 microg/L as the strongest predictor of cirrhosis. | 0.089879864 | 2010 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 10980924 | 3077 | HFE | umls:C1623038 | BeFree | It is less well established that the prevalence of the HFE mutations is increased in alcoholic liver disease and in chronic viral hepatitis, but in both conditions, patients harboring one of these mutations, especially C282Y, are more likely to have advanced hepatic fibrosis or cirrhosis. | 0.014430026 | 1999 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 22265917 | 3077 | HFE | umls:C1623038 | BeFree | In hemochromatosis probands homozygous for HFE C282Y, serum levels of ferritin greater than 1000 μg/L at diagnosis were positively associated with male sex and cirrhosis. | 0.014430026 | 2012 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 12957298 | 3077 | HFE | umls:C0023890 | BeFree | Other recent evidence indicates that the prevalence of HFE gene mutations is increased in chronic viral hepatitis and that patients with chronic hepatitis C harboring especially the C282Y mutation are more likely to suffer from advanced hepatic fibrosis or cirrhosis and to do so at younger ages. | 0.089879864 | 2003 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 24556216 | 3077 | HFE | umls:C1623038 | BeFree | PCSK7 variant rs236918 is a risk factor for cirrhosis in HH patients homozygous for the HFE C282Y mutation. | 0.014430026 | 2015 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 12591066 | 3077 | HFE | umls:C1623038 | BeFree | Except for C282Y homozygotes, HFE gene mutations do not increase the risk to develop HCC in patients with cirrhosis. | 0.014430026 | 2003 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 20190684 | 3077 | HFE | umls:C0023890 | GAD | [Iron overload was frequently detected in patients with CHC, and was associated only with C282Y alleles. Biochemical markers of iron overload and HFE gene mutations were negative prognostic factors of antiviral treatment.] | 0.089879864 | 2010 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 14557859 | 3077 | HFE | umls:C0023890 | BeFree | In HCV-infected patients, heterozygosity for the C282Y mutation in HFE was significantly associated with elevated serum ferritin levels, stainable liver iron, and advanced fibrosis or cirrhosis (F2-F4). | 0.089879864 | 2003 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 22265917 | 3077 | HFE | umls:C0023890 | BeFree | In hemochromatosis probands homozygous for HFE C282Y, serum levels of ferritin greater than 1000 μg/L at diagnosis were positively associated with male sex and cirrhosis. | 0.089879864 | 2012 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 12109859 | 3077 | HFE | umls:C0023890 | BeFree | Heavy HIOL was noted in C282Y homozygotes and 1 patient with cirrhosis without either HFE mutation. | 0.089879864 | 2002 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 20673159 | 3077 | HFE | umls:C1623038 | BeFree | We assessed the influence of Ala16Val-superoxide dismutase 2, Pro198Leu-glutathione peroxidase 1, and -463G/A-myeloperoxidase genotypes (high activity for the Ala, Pro, and G alleles, respectively) on the risks of cirrhosis and hepatocellular carcinoma (HCC) in patients homozygous for the C282Y-hemochromatosis (HFE) gene mutation. | 0.014430026 | 2011 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 20673159 | 4353 | MPO | umls:C0023890 | BeFree | We assessed the influence of Ala16Val-superoxide dismutase 2, Pro198Leu-glutathione peroxidase 1, and -463G/A-myeloperoxidase genotypes (high activity for the Ala, Pro, and G alleles, respectively) on the risks of cirrhosis and hepatocellular carcinoma (HCC) in patients homozygous for the C282Y-hemochromatosis (HFE) gene mutation. | 0.000814326 | 2011 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 12586300 | 3077 | HFE | umls:C0023890 | BeFree | HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis. | 0.089879864 | 2003 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 24556216 | 7036 | TFR2 | umls:C0023890 | BeFree | Genetic loci associated with iron metabolism (TF, TMPRSS6, PCSK7, TFR2 and Chr2p14) in recent GWAS and liver fibrosis (PNPLA3) in recent meta-analysis were analyzed for association with either liver cirrhosis or advanced fibrosis in 148 German HFE C282Y homozygotes. | 0.000542884 | 2015 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 12109859 | 3077 | HFE | umls:C1623038 | BeFree | Heavy HIOL was noted in C282Y homozygotes and 1 patient with cirrhosis without either HFE mutation. | 0.014430026 | 2002 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 20814896 | 3077 | HFE | umls:C1623038 | BeFree | Patients with HH carrying the HFE gene who were homozygous for the Cys282Tyr mutation, serum ferritin levels of 300-2000 ng/mL, transferrin saturation ≥ 45%, and no known history of cirrhosis were enrolled in this dose-escalation study to characterize the safety and efficacy of deferasirox, comprising a core and an extension phase (each 24 weeks). | 0.014430026 | 2010 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 24556216 | 9159 | PCSK7 | umls:C1623038 | BeFree | PCSK7 variant rs236918 is a risk factor for cirrhosis in HH patients homozygous for the HFE C282Y mutation. | 0.000271442 | 2015 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 20814896 | 3077 | HFE | umls:C0023890 | BeFree | Patients with HH carrying the HFE gene who were homozygous for the Cys282Tyr mutation, serum ferritin levels of 300-2000 ng/mL, transferrin saturation ≥ 45%, and no known history of cirrhosis were enrolled in this dose-escalation study to characterize the safety and efficacy of deferasirox, comprising a core and an extension phase (each 24 weeks). | 0.089879864 | 2010 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 12586300 | 3077 | HFE | umls:C1623038 | BeFree | HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis. | 0.014430026 | 2003 | HFE | 6 | 26092913 | G | A |
| rs1800562 | 23990522 | 3077 | HFE | umls:C1623038 | BeFree | RESEARCH DESIGN AND METHODS We studied these 16 variables in 159 nonscreening hemochromatosis probands with HFE C282Y homozygosity: age; sex; BMI; diabetes reports in first-degree family members (dichotomous); heavy ethanol consumption; cigarette smoking; elevated serum alanine aminotransferase/aspartate aminotransferase levels; nonalcoholic fatty liver; chronic viral hepatitis; cirrhosis; hand arthropathy; iron removed by phlebotomy; and positivity for HLA-A*01, B*08; A*03, B*07; and A*03, B*14 haplotypes. | 0.014430026 | 2015 | HFE | 6 | 26092913 | G | A |
| rs2070874 | 25295591 | 3565 | IL4 | umls:C0023890 | BeFree | IL-4 -590C/T and -33C/T polymorphisms were examined in 154 patients with HBV-related HCC, 62 patients with HBV-induced liver cirrhosis (LC), 129 patients with chronic hepatitis B (CHB), and 94 healthy controls, using the polymerase chain reaction-restriction fragment length polymorphism method and DNA sequencing. | 0.00554839 | 2014 | IL4 | 5 | 132674018 | C | T |
| rs236918 | 24556216 | 3077 | HFE | umls:C1623038 | BeFree | PCSK7 variant rs236918 is a risk factor for cirrhosis in HH patients homozygous for the HFE C282Y mutation. | 0.014430026 | 2015 | PCSK7 | 11 | 117220893 | G | C |
| rs236918 | 24556216 | 3077 | HFE | umls:C0023890 | BeFree | PCSK7 variant rs236918 is a risk factor for cirrhosis in HH patients homozygous for the HFE C282Y mutation. | 0.089879864 | 2015 | PCSK7 | 11 | 117220893 | G | C |
| rs236918 | 24556216 | 9159 | PCSK7 | umls:C1623038 | BeFree | PCSK7 variant rs236918 is a risk factor for cirrhosis in HH patients homozygous for the HFE C282Y mutation. | 0.000271442 | 2015 | PCSK7 | 11 | 117220893 | G | C |
| rs25487 | 24018491 | 7515 | XRCC1 | umls:C0023890 | BeFree | The X-ray repair cross complementing protein 1 (XRCC1) rs25487 polymorphism and susceptibility to cirrhosis in Brazilian patients with chronic viral hepatitis. | 0.000542884 | 2014 | XRCC1 | 19 | 43551574 | T | C |
| rs28934571 | 22675488 | 7157 | TP53 | umls:C0023890 | BeFree | Aflatoxin-induced TP53 R249S mutation in hepatocellular carcinoma in Thailand: association with tumors developing in the absence of liver cirrhosis. | 0.012072926 | 2012 | TP53 | 17 | 7674216 | C | A |
| rs3135363 | 23321320 | 3118 | HLA-DQA2 | umls:C0023890 | BeFree | Multiple logistic regression analysis revealed that rs3135363, rs910049, and HLA-DQA1(*)0601 were independently associated with the risk of HCV-induced LC. | 0.000542884 | 2012 | NA | 6 | 32421871 | A | G |
| rs343064 | 20708005 | 57057 | TBX20 | umls:C0023890 | GAD | [A GWAS significantly associated genetic variants with features of hepatic histology in patients with NAFLD. These findings should be validated in larger and more diverse cohorts.] | 0.002367032 | 2010 | NA | 7 | 35515178 | C | T |
| rs3732378 | 18078680 | 1524 | CX3CR1 | umls:C0023890 | GAD | [The results identify the fractalkine receptor CX3CR1 as susceptibility a gene for hepatic fibrosis in HCV infection.] | 0.005091382 | 2008 | CX3CR1 | 3 | 39265671 | G | A |
| rs3775290 | 26024592 | 7098 | TLR3 | umls:C0023890 | BeFree | Association analysis showed that the TT genotype of TLR3 rs3775290 was associated with a decreased risk for CHB, HBV-related LC, and HCC (OR=0.52, 95% CI: 0.27-0.99, P=0.048; OR=0.32, 95% CI: 0.14-0.76, P=0.010; OR=0.49, 95% CI: 0.26-0.92, P=0.027). | 0.000814326 | 2015 | TLR3 | 4 | 186083063 | C | T,A |
| rs386586050 | 21839239 | 7098 | TLR3 | umls:C0023890 | BeFree | Toll-like receptor 3 L412F polymorphism may protect against acute graft rejection in adult patients undergoing liver transplantation for hepatitis C-related cirrhosis. | 0.000814326 | 2011 | NA | NA | NA | NA | NA |
| rs4074 | 22173151 | 7097 | TLR2 | umls:C1623038 | BeFree | The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients. | 0.001357209 | 2012 | CXCL1 | 4 | 73870427 | A | G |
| rs4074 | 22173151 | 2919 | CXCL1 | umls:C1623038 | BeFree | The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients. | 0.000542884 | 2012 | CXCL1 | 4 | 73870427 | A | G |
| rs4074 | 22173151 | 2919 | CXCL1 | umls:C0023890 | BeFree | The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients. | 0.000542884 | 2012 | CXCL1 | 4 | 73870427 | A | G |
| rs4074 | 24260493 | 2919 | CXCL1 | umls:C1623038 | BeFree | Accordingly, the frequency of the CXCL1 rs4074 A allele was significantly higher in the cirrhotic patients than in the subjects without cirrhosis (41.4% vs. 33.9%, OR=1.38, 95% CI:1.14-1.66, p=0.001). | 0.000542884 | 2013 | CXCL1 | 4 | 73870427 | A | G |
| rs4074 | 22173151 | 7097 | TLR2 | umls:C0023890 | BeFree | The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients. | 0.001900093 | 2012 | CXCL1 | 4 | 73870427 | A | G |
| rs4074 | 24260493 | 2919 | CXCL1 | umls:C0023890 | BeFree | Accordingly, the frequency of the CXCL1 rs4074 A allele was significantly higher in the cirrhotic patients than in the subjects without cirrhosis (41.4% vs. 33.9%, OR=1.38, 95% CI:1.14-1.66, p=0.001). | 0.000542884 | 2013 | CXCL1 | 4 | 73870427 | A | G |
| rs430397 | 21779363 | 3309 | HSPA5 | umls:C1623038 | BeFree | Our previous study indicated that a common variant (rs430397 G>A) in the intron 5 of glucose-regulated protein 78 (GRP78) gene was associated with risk and prognosis of primary hepatocellular carcinoma (HCC), including HBV- and cirrhosis-related HCC. | 0.000271442 | 2011 | HSPA5 | 9 | 125238840 | C | T |
| rs4444903 | 25504078 | 80339 | PNPLA3 | umls:C1623038 | BeFree | Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown. | 0.005428837 | 2014 | EGF | 4 | 109912954 | A | G |
| rs4444903 | 22122913 | 1950 | EGF | umls:C1623038 | BeFree | The epidermal growth factor (EGF) rs4444903 A>G polymorphism has been associated with the development of liver cancer, which commonly complicates cirrhosis of viral origin; however, whether this polymorphism might be associated with fibrosis progression in chronic viral hepatitis is unknown. | 0.001900093 | 2012 | EGF | 4 | 109912954 | A | G |
| rs4444903 | 25504078 | 1950 | EGF | umls:C0023890 | BeFree | Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown. | 0.007262917 | 2014 | EGF | 4 | 109912954 | A | G |
| rs4444903 | 22122913 | 1950 | EGF | umls:C0023890 | BeFree | The epidermal growth factor (EGF) rs4444903 A>G polymorphism has been associated with the development of liver cancer, which commonly complicates cirrhosis of viral origin; however, whether this polymorphism might be associated with fibrosis progression in chronic viral hepatitis is unknown. | 0.007262917 | 2012 | EGF | 4 | 109912954 | A | G |
| rs4444903 | 25504078 | 1950 | EGF | umls:C1623038 | BeFree | Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown. | 0.001900093 | 2014 | EGF | 4 | 109912954 | A | G |
| rs4444903 | 25504078 | 80339 | PNPLA3 | umls:C0023890 | BeFree | Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown. | 0.008067311 | 2014 | EGF | 4 | 109912954 | A | G |
| rs4444903 | 22236006 | 1950 | EGF | umls:C1623038 | BeFree | In conclusion, the EGF rs4444903 A > G polymorphism appears to be associated with an unfavourable disease course of chronic HBV infection and cirrhosis development. | 0.001900093 | 2012 | EGF | 4 | 109912954 | A | G |
| rs4444903 | 22236006 | 1950 | EGF | umls:C0023890 | BeFree | In conclusion, the EGF rs4444903 A > G polymorphism appears to be associated with an unfavourable disease course of chronic HBV infection and cirrhosis development. | 0.007262917 | 2012 | EGF | 4 | 109912954 | A | G |
| rs4898 | 23563628 | 7077 | TIMP2 | umls:C0023890 | BeFree | We used PCR to analyze 188 patients with HCV-related liver disease (95 with chronic hepatitis and 93 with cirrhosis) for TIMP-1 372 T/C and TIMP-2 -418 G/C polymorphisms. | 0.002909916 | 2012 | SYN1;TIMP1;MIR4769 | X | 47585586 | T | C |
| rs4986790 | 18666712 | 7099 | TLR4 | umls:C1623038 | BeFree | The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphisms (base pair -159 and -260) with HBV-related cirrhosis in Chinese Han patients. | 0.002442977 | 2008 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 18666712 | 7099 | TLR4 | umls:C0023890 | BeFree | The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphisms (base pair -159 and -260) with HBV-related cirrhosis in Chinese Han patients. | 0.010086957 | 2008 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 18666712 | 929 | CD14 | umls:C0023890 | BeFree | The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphisms (base pair -159 and -260) with HBV-related cirrhosis in Chinese Han patients. | 0.126634157 | 2008 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 18666712 | 4695 | NDUFA2 | umls:C1623038 | BeFree | The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphisms (base pair -159 and -260) with HBV-related cirrhosis in Chinese Han patients. | 0.000814326 | 2008 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 18666712 | 929 | CD14 | umls:C1623038 | BeFree | The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphisms (base pair -159 and -260) with HBV-related cirrhosis in Chinese Han patients. | 0.003181358 | 2008 | TLR4 | 9 | 117713024 | A | G |
| rs4986790 | 18666712 | 4695 | NDUFA2 | umls:C0023890 | BeFree | The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphisms (base pair -159 and -260) with HBV-related cirrhosis in Chinese Han patients. | 0.001900093 | 2008 | TLR4 | 9 | 117713024 | A | G |
| rs4986791 | 18666712 | 7099 | TLR4 | umls:C1623038 | BeFree | The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphisms (base pair -159 and -260) with HBV-related cirrhosis in Chinese Han patients. | 0.002442977 | 2008 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 18666712 | 4695 | NDUFA2 | umls:C1623038 | BeFree | The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphisms (base pair -159 and -260) with HBV-related cirrhosis in Chinese Han patients. | 0.000814326 | 2008 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 18666712 | 929 | CD14 | umls:C0023890 | BeFree | The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphisms (base pair -159 and -260) with HBV-related cirrhosis in Chinese Han patients. | 0.126634157 | 2008 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 18666712 | 929 | CD14 | umls:C1623038 | BeFree | The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphisms (base pair -159 and -260) with HBV-related cirrhosis in Chinese Han patients. | 0.003181358 | 2008 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 18666712 | 4695 | NDUFA2 | umls:C0023890 | BeFree | The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphisms (base pair -159 and -260) with HBV-related cirrhosis in Chinese Han patients. | 0.001900093 | 2008 | TLR4 | 9 | 117713324 | C | T |
| rs4986791 | 18666712 | 7099 | TLR4 | umls:C0023890 | BeFree | The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphisms (base pair -159 and -260) with HBV-related cirrhosis in Chinese Han patients. | 0.010086957 | 2008 | TLR4 | 9 | 117713324 | C | T |
| rs7080536 | 19105210 | 3026 | HABP2 | umls:C0023890 | BeFree | The G534E variant of FSAP is a risk locus for HCV-induced liver fibrosis and cirrhosis by determining PDGF-BB-mediated hepatic stellate cell proliferation through a single amino acid substitution in FSAP. | 0.002638474 | 2009 | HABP2 | 10 | 113588287 | G | A |
| rs7080536 | 19105210 | 3026 | HABP2 | umls:C1623038 | BeFree | The G534E variant of FSAP is a risk locus for HCV-induced liver fibrosis and cirrhosis by determining PDGF-BB-mediated hepatic stellate cell proliferation through a single amino acid substitution in FSAP. | 0.000271442 | 2009 | HABP2 | 10 | 113588287 | G | A |
| rs738409 | 25504078 | 80339 | PNPLA3 | umls:C0023890 | BeFree | Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown. | 0.008067311 | 2014 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 25378656 | 80339 | PNPLA3 | umls:C0023890 | BeFree | The rs738409 (I148M) variant of the PNPLA3 gene and cirrhosis: a meta-analysis. | 0.008067311 | 2015 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 22863264 | 5743 | PTGS2 | umls:C0023890 | BeFree | The -1195GG genotype of single nucleotide polymorphism (SNP) in COX-2 promoter was associated with low platelet counts in patients with chronic hepatitis C. Polymorphism of patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene (rs738409 C>G) have been reported to be associated with cirrhosis, and the major genotype of SNPs near interleukin (IL)28B are related to viral clearance. | 0.001357209 | 2012 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 22719190 | 80339 | PNPLA3 | umls:C1623038 | BeFree | The association of the PNPLA3 I148M protein variant (p.I148M) with steatosis, fibrosis stage, and cirrhosis was evaluated by logistic regression analysis. | 0.005428837 | 2012 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 24114809 | 80339 | PNPLA3 | umls:C0023890 | BeFree | Overall, these results suggest that rs738409 exerts a marked influence on hepatocarcinogenesis in patients with cirrhosis of European descent and provide a strong argument for performing further mechanistic studies to better understand the role of PNPLA3 in HCC development. | 0.008067311 | 2013 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 24978903 | 80339 | PNPLA3 | umls:C1623038 | BeFree | Furthermore, using two histologically characterized cohorts encompassing steatosis, steatohepatitis, fibrosis and cirrhosis (combined n=1,074), we demonstrate a new association, independent of potential confounding factors (age, BMI, type 2 diabetes mellitus and PNPLA3 rs738409 genotype), with advanced hepatic fibrosis/cirrhosis. | 0.005428837 | 2014 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 22863264 | 80339 | PNPLA3 | umls:C0023890 | BeFree | The -1195GG genotype of single nucleotide polymorphism (SNP) in COX-2 promoter was associated with low platelet counts in patients with chronic hepatitis C. Polymorphism of patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene (rs738409 C>G) have been reported to be associated with cirrhosis, and the major genotype of SNPs near interleukin (IL)28B are related to viral clearance. | 0.008067311 | 2012 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 24978903 | 80339 | PNPLA3 | umls:C0023890 | BeFree | Furthermore, using two histologically characterized cohorts encompassing steatosis, steatohepatitis, fibrosis and cirrhosis (combined n=1,074), we demonstrate a new association, independent of potential confounding factors (age, BMI, type 2 diabetes mellitus and PNPLA3 rs738409 genotype), with advanced hepatic fibrosis/cirrhosis. | 0.008067311 | 2014 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 23069476 | 80339 | PNPLA3 | umls:C0023890 | BeFree | PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis. | 0.008067311 | 2013 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 25504078 | 1950 | EGF | umls:C1623038 | BeFree | Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown. | 0.001900093 | 2014 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 22087248 | 80339 | PNPLA3 | umls:C0023890 | BeFree | The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis. | 0.008067311 | 2011 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 21745286 | 80339 | PNPLA3 | umls:C1623038 | BeFree | PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence. | 0.005428837 | 2011 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 21745286 | 80339 | PNPLA3 | umls:C0023890 | BeFree | PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence. | 0.008067311 | 2011 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 22863264 | 80339 | PNPLA3 | umls:C1623038 | BeFree | The -1195GG genotype of single nucleotide polymorphism (SNP) in COX-2 promoter was associated with low platelet counts in patients with chronic hepatitis C. Polymorphism of patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene (rs738409 C>G) have been reported to be associated with cirrhosis, and the major genotype of SNPs near interleukin (IL)28B are related to viral clearance. | 0.005428837 | 2012 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 22863264 | 5743 | PTGS2 | umls:C1623038 | BeFree | The -1195GG genotype of single nucleotide polymorphism (SNP) in COX-2 promoter was associated with low platelet counts in patients with chronic hepatitis C. Polymorphism of patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene (rs738409 C>G) have been reported to be associated with cirrhosis, and the major genotype of SNPs near interleukin (IL)28B are related to viral clearance. | 0.001085767 | 2012 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 21319195 | 80339 | PNPLA3 | umls:C1623038 | BeFree | The rs738409 PNPLA3 genotype influences steatosis development in CHC and is independently associated with cirrhosis and other steatosis-related clinical outcomes, such as lack of response to antiviral treatment and possibly HCC. | 0.005428837 | 2011 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 25504078 | 80339 | PNPLA3 | umls:C1623038 | BeFree | Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown. | 0.005428837 | 2014 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 25378656 | 80339 | PNPLA3 | umls:C1623038 | BeFree | The rs738409 (I148M) variant of the PNPLA3 gene and cirrhosis: a meta-analysis. | 0.005428837 | 2015 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 25504078 | 1950 | EGF | umls:C0023890 | BeFree | Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown. | 0.007262917 | 2014 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 21254164 | 80339 | PNPLA3 | umls:C1623038 | BeFree | The population attributable risk of cirrhosis in alcoholic carriers of allele PNPLA3 rs738409(G) was estimated at 26.6%. | 0.005428837 | 2011 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 22978414 | 80339 | PNPLA3 | umls:C0023890 | BeFree | Previous studies of the PNPLA3 I148M sequence variant in HCV infected individuals have reported an association between this variant and prevalence of steatosis, fibrosis, and cirrhosis. | 0.008067311 | 2012 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 23069476 | 80339 | PNPLA3 | umls:C1623038 | BeFree | PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis. | 0.005428837 | 2013 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 22978414 | 80339 | PNPLA3 | umls:C1623038 | BeFree | Previous studies of the PNPLA3 I148M sequence variant in HCV infected individuals have reported an association between this variant and prevalence of steatosis, fibrosis, and cirrhosis. | 0.005428837 | 2012 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 22087248 | 80339 | PNPLA3 | umls:C1623038 | BeFree | The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis. | 0.005428837 | 2011 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 24349054 | 80339 | PNPLA3 | umls:C0023890 | BeFree | No correlation between PNPLA3 rs738409 genotype and fatty liver and hepatic cirrhosis in Japanese patients with HCV. | 0.008067311 | 2013 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 21254164 | 80339 | PNPLA3 | umls:C0023890 | BeFree | The population attributable risk of cirrhosis in alcoholic carriers of allele PNPLA3 rs738409(G) was estimated at 26.6%. | 0.008067311 | 2011 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 22719190 | 80339 | PNPLA3 | umls:C0023890 | BeFree | The association of the PNPLA3 I148M protein variant (p.I148M) with steatosis, fibrosis stage, and cirrhosis was evaluated by logistic regression analysis. | 0.008067311 | 2012 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 21319195 | 80339 | PNPLA3 | umls:C0023890 | BeFree | The rs738409 PNPLA3 genotype influences steatosis development in CHC and is independently associated with cirrhosis and other steatosis-related clinical outcomes, such as lack of response to antiviral treatment and possibly HCC. | 0.008067311 | 2011 | PNPLA3 | 22 | 43928847 | C | G |
| rs738409 | 24114809 | 80339 | PNPLA3 | umls:C1623038 | BeFree | Overall, these results suggest that rs738409 exerts a marked influence on hepatocarcinogenesis in patients with cirrhosis of European descent and provide a strong argument for performing further mechanistic studies to better understand the role of PNPLA3 in HCC development. | 0.005428837 | 2013 | PNPLA3 | 22 | 43928847 | C | G |
| rs7536540 | 22658643 | 406893 | MIR101-1 | umls:C0023890 | BeFree | We find that the rs7536540 polymorphism in miR-101-1 is significantly associated with development of liver cirrhosis and hepatocellular carcinoma occurrence. | 0.000271442 | 2012 | MIR101-1;MIR3671 | 1 | 65058899 | C | G |
| rs769217 | 25837767 | 847 | CAT | umls:C0023890 | BeFree | Our findings suggest that the CAT rs769217 T allele is associated with increased risk of CHB, HBV-LC, and HBV-HCC in Guangxi population. | 0.000271442 | 2015 | CAT | 11 | 34461361 | C | T |
| rs8099917 | 24117654 | 282617 | IFNL3 | umls:C1623038 | BeFree | Multivariable analysis identified four independent factors that were significantly associated with SVR: IL28B SNP rs8099917 genotype (P = 6.90 × 10(-5) ), pre-existence of cirrhosis (P = 3.99 × 10(-3) ), prior treatment response (P = 0.0126), and rapid virological response (P = 0.0239). | 0.005157396 | 2013 | NA | 19 | 39252525 | T | G |
| rs8099917 | 24117654 | 282617 | IFNL3 | umls:C0023890 | BeFree | Multivariable analysis identified four independent factors that were significantly associated with SVR: IL28B SNP rs8099917 genotype (P = 6.90 × 10(-5) ), pre-existence of cirrhosis (P = 3.99 × 10(-3) ), prior treatment response (P = 0.0126), and rapid virological response (P = 0.0239). | 0.008338753 | 2013 | NA | 19 | 39252525 | T | G |
| rs910049 | 23321320 | 3118 | HLA-DQA2 | umls:C0023890 | BeFree | Multiple logistic regression analysis revealed that rs3135363, rs910049, and HLA-DQA1(*)0601 were independently associated with the risk of HCV-induced LC. | 0.000542884 | 2012 | C6orf10;LOC101929163 | 6 | 32347950 | T | C |
