PedAM

Pediatric Disease Annotations & Medicines


	liposarcoma

Disease ID	311
Disease	liposarcoma
Definition	A malignant tumor derived from primitive or embryonal lipoblastic cells. It may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid (LIPOSARCOMA, MYXOID), round-celled, or pleomorphic, usually in association with a rich network of capillaries. Recurrences are common and dedifferentiated liposarcomas metastasize to the lungs or serosal surfaces. (From Dorland, 27th ed; Stedman, 25th ed)
Synonym	[m]liposarcoma nos [m]liposarcoma nos (morphologic abnormality) fibroliposarcoma liposarcoma (disorder) liposarcoma (morphologic abnormality) liposarcoma [disease/finding] liposarcoma morphology liposarcoma not otherwise specified liposarcoma, malignant liposarcoma, no icd-o subtype liposarcoma, no icd-o subtype (morphologic abnormality) liposarcoma, no international classification of diseases for oncology subtype liposarcoma, no international classification of diseases for oncology subtype (morphologic abnormality) liposarcoma, nos liposarcomas
Orphanet	ORPHANET:69078
DOID	DOID:3382
UMLS	C0023827
MeSH	D008080
SNOMED-CT	SNOMEDCT_US_2016_09_01:254829001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:26) C0023798 \| lipoma \| 4 C0007134 \| renal cell carcinoma \| 3 C1261473 \| sarcoma \| 2 C0039101 \| synovial sarcoma \| 2 C1261473 \| sarcomas \| 2 C0040053 \| thrombus \| 1 C0494165 \| hepatic metastasis \| 1 C0206632 \| angiolipoma \| 1 C0024305 \| non-hodgkin lymphoma \| 1 C0021845 \| bowel perforation \| 1 C0019829 \| hodgkin lymphoma \| 1 C0600139 \| prostatic carcinoma \| 1 C0036220 \| kaposi's sarcoma \| 1 C0334121 \| inflammatory pseudotumor \| 1 C0334492 \| malignant mesenchymoma \| 1 C0029463 \| osteosarcoma \| 1 C0085113 \| neurofibromatosis \| 1 C0153676 \| pulmonary metastases \| 1 C0740457 \| renal cancer \| 1 C0010346 \| crohn's disease \| 1 C1266042 \| chromophobe renal cell carcinoma \| 1 C0334121 \| inflammatory myofibroblastic tumor \| 1 C0007112 \| prostatic adenocarcinoma \| 1 C0025464 \| mesenchymoma \| 1 C0019294 \| inguinal hernia \| 1 C0751483 \| hereditary retinoblastoma \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) NF1 \| 4763 \| CTD_human CDK4 \| 1019 \| CTD_human FASN \| 2194 \| CTD_human YEATS4 \| 8089 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:237) 340533 \| KIAA2022 \| DISEASES 4826 \| NNAT \| DISEASES 84699 \| CREB3L3 \| DISEASES 10777 \| ARPP21 \| DISEASES 78990 \| OTUB2 \| DISEASES 6767 \| ST13 \| DISEASES 6790 \| AURKA \| DISEASES 25878 \| MXRA5 \| DISEASES 4150 \| MAZ \| DISEASES 708 \| C1QBP \| DISEASES 1277 \| COL1A1 \| DISEASES 1075 \| CTSC \| DISEASES 1389 \| CREBL2 \| DISEASES 57122 \| NUP107 \| DISEASES 84519 \| ACRBP \| DISEASES 2026 \| ENO2 \| DISEASES 4188 \| MDFI \| DISEASES 5754 \| PTK7 \| DISEASES 3910 \| LAMA4 \| DISEASES 1894 \| ECT2 \| DISEASES 4436 \| MSH2 \| DISEASES 5396 \| PRRX1 \| DISEASES 23435 \| TARDBP \| DISEASES 4656 \| MYOG \| DISEASES 3229 \| HOXC13 \| DISEASES 4035 \| LRP1 \| DISEASES 11017 \| SNRNP27 \| DISEASES 3991 \| LIPE \| DISEASES 55831 \| EMC3 \| DISEASES 2806 \| GOT2 \| DISEASES 8698 \| S1PR4 \| DISEASES 9787 \| DLGAP5 \| DISEASES 30848 \| CTAG2 \| DISEASES 8089 \| YEATS4 \| DISEASES 7533 \| YWHAH \| DISEASES 4654 \| MYOD1 \| DISEASES 9098 \| USP6 \| DISEASES 968 \| CD68 \| DISEASES 1036 \| CDO1 \| DISEASES 2872 \| MKNK2 \| DISEASES 9119 \| KRT75 \| DISEASES 2521 \| FUS \| DISEASES 22856 \| CHSY1 \| DISEASES 2167 \| FABP4 \| DISEASES 5156 \| PDGFRA \| DISEASES 1019 \| CDK4 \| DISEASES 6302 \| TSPAN31 \| DISEASES 2799 \| GNS \| DISEASES 7057 \| THBS1 \| DISEASES 4069 \| LYZ \| DISEASES 5159 \| PDGFRB \| DISEASES 4141 \| MARS \| DISEASES 466 \| ATF1 \| DISEASES 22858 \| ICK \| DISEASES 6598 \| SMARCB1 \| DISEASES 25978 \| CHMP2B \| DISEASES 3791 \| KDR \| DISEASES 5317 \| PKP1 \| DISEASES 5290 \| PIK3CA \| DISEASES 1021 \| CDK6 \| DISEASES 29999 \| FSCN3 \| DISEASES 1616 \| DAXX \| DISEASES 23598 \| PATZ1 \| DISEASES 374462 \| PTPRQ \| DISEASES 144193 \| AMDHD1 \| DISEASES 3480 \| IGF1R \| DISEASES 7157 \| TP53 \| DISEASES 6647 \| SOD1 \| DISEASES 57410 \| SCYL1 \| DISEASES 207 \| AKT1 \| DISEASES 5546 \| PRCC \| DISEASES 3756 \| KCNH1 \| DISEASES 148327 \| CREB3L4 \| DISEASES 2044 \| EPHA5 \| DISEASES 91937 \| TIMD4 \| DISEASES 1956 \| EGFR \| DISEASES 85417 \| CCNB3 \| DISEASES 9258 \| MFHAS1 \| DISEASES 123 \| PLIN2 \| DISEASES 9538 \| EI24 \| DISEASES 5805 \| PTS \| DISEASES 7069 \| THRSP \| DISEASES 2321 \| FLT1 \| DISEASES 7545 \| ZIC1 \| DISEASES 5801 \| PTPRR \| DISEASES 221895 \| JAZF1 \| DISEASES 5922 \| RASA2 \| DISEASES 5468 \| PPARG \| DISEASES 348174 \| CLEC18A \| DISEASES 3815 \| KIT \| DISEASES 26060 \| APPL1 \| DISEASES 2256 \| FGF11 \| DISEASES 6051 \| RNPEP \| DISEASES 3148 \| HMGB2 \| DISEASES 7373 \| COL14A1 \| DISEASES 120114 \| FAT3 \| DISEASES 4108 \| MAGEA9 \| DISEASES 55027 \| HEATR3 \| DISEASES 10818 \| FRS2 \| DISEASES 5346 \| PLIN1 \| DISEASES 4665 \| NAB2 \| DISEASES 6778 \| STAT6 \| DISEASES 7846 \| TUBA1A \| DISEASES 558 \| AXL \| DISEASES 1051 \| CEBPB \| DISEASES 10655 \| DMRT2 \| DISEASES 794 \| CALB2 \| DISEASES 57124 \| CD248 \| DISEASES 7015 \| TERT \| DISEASES 3265 \| HRAS \| DISEASES 947 \| CD34 \| DISEASES 10290 \| SPEG \| DISEASES 79850 \| FAM57A \| DISEASES 5553 \| PRG2 \| DISEASES 10102 \| TSFM \| DISEASES 8092 \| ALX1 \| DISEASES 23512 \| SUZ12 \| DISEASES 4026 \| LPP \| DISEASES 4684 \| NCAM1 \| DISEASES 23786 \| BCL2L13 \| DISEASES 8490 \| RGS5 \| DISEASES 55342 \| STRBP \| DISEASES 3039 \| HBA1 \| DISEASES 2314 \| FLII \| DISEASES 154141 \| MBOAT1 \| DISEASES 5324 \| PLAG1 \| DISEASES 64332 \| NFKBIZ \| DISEASES 5499 \| PPP1CA \| DISEASES 2300 \| FOXL1 \| DISEASES 283971 \| CLEC18C \| DISEASES 3052 \| HCCS \| DISEASES 5074 \| PAWR \| DISEASES 53637 \| S1PR5 \| DISEASES 9074 \| CLDN6 \| DISEASES 64764 \| CREB3L2 \| DISEASES 5155 \| PDGFB \| DISEASES 7490 \| WT1 \| DISEASES 1675 \| CFD \| DISEASES 1485 \| CTAG1B \| DISEASES 9939 \| RBM8A \| DISEASES 8013 \| NR4A3 \| DISEASES 91156 \| IGFN1 \| DISEASES 5501 \| PPP1CC \| DISEASES 283 \| ANG \| DISEASES 9138 \| ARHGEF1 \| DISEASES 23583 \| SMUG1 \| DISEASES 57496 \| MKL2 \| DISEASES 1368 \| CPM \| DISEASES 29102 \| DROSHA \| DISEASES 23193 \| GANAB \| DISEASES 6187 \| RPS2 \| DISEASES 8445 \| DYRK2 \| DISEASES 1499 \| CTNNB1 \| DISEASES 1102 \| RCBTB2 \| DISEASES 64218 \| SEMA4A \| DISEASES 55107 \| ANO1 \| DISEASES 5979 \| RET \| DISEASES 85236 \| HIST1H2BK \| DISEASES 26052 \| DNM3 \| DISEASES 4763 \| NF1 \| DISEASES 4151 \| MB \| DISEASES 4311 \| MME \| DISEASES 6663 \| SOX10 \| DISEASES 55705 \| IPO9 \| DISEASES 800 \| CALD1 \| DISEASES 50486 \| G0S2 \| DISEASES 1380 \| CR2 \| DISEASES 4194 \| MDM4 \| DISEASES 23612 \| PHLDA3 \| DISEASES 6675 \| UAP1 \| DISEASES 23097 \| CDK19 \| DISEASES 10360 \| NPM3 \| DISEASES 84795 \| PYROXD2 \| DISEASES 10561 \| IFI44 \| DISEASES 5236 \| PGM1 \| DISEASES 81030 \| ZBP1 \| DISEASES 3725 \| JUN \| DISEASES 5728 \| PTEN \| DISEASES 154796 \| AMOT \| DISEASES 10103 \| TSPAN1 \| DISEASES 4904 \| YBX1 \| DISEASES 2356 \| FPGS \| DISEASES 546 \| ATRX \| DISEASES 7321 \| UBE2D1 \| DISEASES 9968 \| MED12 \| DISEASES 4303 \| FOXO4 \| DISEASES 58476 \| TP53INP2 \| DISEASES 5081 \| PAX7 \| DISEASES 727837 \| SSX2B \| DISEASES 10927 \| SPIN1 \| DISEASES 2259 \| FGF14 \| DISEASES 400736 \| PRAMEF13 \| DISEASES 6756 \| SSX1 \| DISEASES 11166 \| SOX21 \| DISEASES 4609 \| MYC \| DISEASES 1874 \| E2F4 \| DISEASES 2308 \| FOXO1 \| DISEASES 2874 \| GPS2 \| DISEASES 4267 \| CD99 \| DISEASES 2315 \| MLANA \| DISEASES 11172 \| INSL6 \| DISEASES 131405 \| TRIM71 \| DISEASES 238 \| ALK \| DISEASES 9055 \| PRC1 \| DISEASES 10379 \| IRF9 \| DISEASES 4338 \| MOCS2 \| DISEASES 29911 \| HOOK2 \| DISEASES 23532 \| PRAME \| DISEASES 8091 \| HMGA2 \| DISEASES 2199 \| FBLN2 \| DISEASES 8115 \| TCL1A \| DISEASES 2115 \| ETV1 \| DISEASES 29072 \| SETD2 \| DISEASES 2260 \| FGFR1 \| DISEASES 1029 \| CDKN2A \| DISEASES 10499 \| NCOA2 \| DISEASES 2130 \| EWSR1 \| DISEASES 55611 \| OTUB1 \| DISEASES 2195 \| FAT1 \| DISEASES 6760 \| SS18 \| DISEASES 4193 \| MDM2 \| DISEASES 5515 \| PPP2CA \| DISEASES 1316 \| KLF6 \| DISEASES 10772 \| SRSF10 \| DISEASES 26064 \| RAI14 \| DISEASES 1050 \| CEBPA \| DISEASES 4168 \| MCF2 \| DISEASES 149685 \| ADIG \| DISEASES 996 \| CDC27 \| DISEASES 10480 \| EIF3M \| DISEASES 488 \| ATP2A2 \| DISEASES 89795 \| NAV3 \| DISEASES 1649 \| DDIT3 \| DISEASES 7786 \| MAP3K12 \| DISEASES 8437 \| RASAL1 \| DISEASES 8148 \| TAF15 \| DISEASES 25804 \| LSM4 \| DISEASES
Locus	(Waiting for update.)

Disease ID	311
Disease	liposarcoma
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:9) HP:0100242 \| Sarcoma HP:0001824 \| Weight loss HP:0012378 \| Fatigue HP:0002619 \| Varicose veins HP:0002017 \| Nausea and vomiting HP:0001482 \| Subcutaneous nodule HP:0003401 \| Paresthesia HP:0002027 \| Abdominal pain HP:0000077 \| Abnormality of the kidney
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:19) HP:0002664 \| Neoplasia \| 11 HP:0030731 \| Carcinoma \| 5 HP:0012032 \| Lipoma \| 4 HP:0005584 \| Renal cell carcinoma \| 3 HP:0100242 \| Sarcoma \| 2 HP:0012570 \| Synovial sarcoma \| 2 HP:0002669 \| Osteosarcoma \| 1 HP:0100013 \| Tumours of the breast \| 1 HP:0001067 \| Neurofibromas \| 1 HP:0100790 \| Hernia \| 1 HP:0100544 \| Heart tumor \| 1 HP:0001289 \| Confusion \| 1 HP:0012539 \| Non-Hodgkin lymphoma \| 1 HP:0100280 \| Morbus Crohn \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0000023 \| Inguinal hernia \| 1 HP:0002094 \| Dyspnea \| 1 HP:0100726 \| Kaposi's sarcoma \| 1 HP:0000718 \| Aggressive behaviour \| 1

Disease ID	311
Disease	liposarcoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:9) C2248595 \| dedifferentiation C1704231 \| meningeal metastases C0686377 \| central nervous system metastasis C0346976 \| pancreatic metastasis C0153685 \| renal metastases C0153676 \| pulmonary metastasis C0085077 \| sweet syndrome C0023798 \| lipoma C0021843 \| intestinal obstruction
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0002793 \| dedifferentiation \| 6 C0023798 \| lipoma \| 4

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:4)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0023827	nelfinavir	D019888	159989-64-7	liposarcoma	MESH:D008080	therapeutic	21355074
C0023827	paclitaxel	D017239	-	liposarcoma	MESH:D008080	therapeutic	17353645
C0023827	sorafenib	C471405	-	liposarcoma	MESH:D008080	therapeutic	21610706
C0023827	troglitazone	C057693	97322-87-7	liposarcoma	MESH:D008080	therapeutic	10097144

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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