PedAM

Pediatric Disease Annotations & Medicines


	lipoid nephrosis

Disease ID	467
Disease	lipoid nephrosis
Definition	A kidney disease with no or minimal histological glomerular changes on light microscopy and with no immune deposits. It is characterized by lipid accumulation in the epithelial cells of KIDNEY TUBULES and in the URINE. Patients usually show NEPHROTIC SYNDROME indicating the presence of PROTEINURIA with accompanying EDEMA.
Synonym	change disease minimal change diseases minimal change diseases, minimal change glomerulonephritis minimal changes glomerulonephritis minimal disease nils disease, minimal change diseases, minimal change foot process disease glomerulopathies, minimal change glomerulopathy, minimal change idiopathic minimal change nephrotic syndrome light negative glomerulonephritis lipid nephrosis lipoid nephroses mcd - minimal change disease mcgn - minimal change glomerulonephritis mcn - minimal change nephropathy minimal change disease minimal change disease (disorder) minimal change diseases minimal change glomerulonephritis minimal change glomerulopathy minimal change nephropathies minimal change nephropathy nephropathies, minimal change nephropathy, minimal change nephroses, lipoid nephrosis lipoid nephrosis, lipoid nephrosis, lipoid [disease/finding] nil disease
DOID	DOID:10966
UMLS	C0027721
MeSH	D009402
SNOMED-CT	SNOMEDCT_US_2016_09_01:44785005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:1) C0017665 \| membranous nephropathy \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) NPHS1 \| 4868 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) 3105 \| HLA-A \| infer 3106 \| HLA-B \| infer 4842 \| NOS1 \| infer 4846 \| NOS3 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:124) 3675 \| ITGA3 \| DISEASES 2217 \| FCGRT \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 113263 \| GLCCI1 \| DISEASES 6347 \| CCL2 \| DISEASES 3558 \| IL2 \| DISEASES 2597 \| GAPDH \| DISEASES 3565 \| IL4 \| DISEASES 2908 \| NR3C1 \| DISEASES 7043 \| TGFB3 \| DISEASES 718 \| C3 \| DISEASES 10047 \| CST8 \| DISEASES 6945 \| MLX \| DISEASES 5199 \| CFP \| DISEASES 968 \| CD68 \| DISEASES 3998 \| LMAN1 \| DISEASES 81 \| ACTN4 \| DISEASES 9590 \| AKAP12 \| DISEASES 4608 \| MYBPH \| DISEASES 2799 \| GNS \| DISEASES 27283 \| TINAG \| DISEASES 9099 \| USP2 \| DISEASES 51196 \| PLCE1 \| DISEASES 4069 \| LYZ \| DISEASES 4092 \| SMAD7 \| DISEASES 23523 \| CABIN1 \| DISEASES 4036 \| LRP2 \| DISEASES 941 \| CD80 \| DISEASES 5443 \| POMC \| DISEASES 306 \| ANXA3 \| DISEASES 3263 \| HPX \| DISEASES 26277 \| TINF2 \| DISEASES 6687 \| SPG7 \| DISEASES 3934 \| LCN2 \| DISEASES 5800 \| PTPRO \| DISEASES 22925 \| PLA2R1 \| DISEASES 55079 \| FEZF2 \| DISEASES 7345 \| UCHL1 \| DISEASES 4091 \| SMAD6 \| DISEASES 4690 \| NCK1 \| DISEASES 54361 \| WNT4 \| DISEASES 1636 \| ACE \| DISEASES 6352 \| CCL5 \| DISEASES 213 \| ALB \| DISEASES 28999 \| KLF15 \| DISEASES 7098 \| TLR3 \| DISEASES 5885 \| RAD21 \| DISEASES 11244 \| ZHX1 \| DISEASES 717 \| C2 \| DISEASES 1398 \| CRK \| DISEASES 51129 \| ANGPTL4 \| DISEASES 116844 \| LRG1 \| DISEASES 1493 \| CTLA4 \| DISEASES 3596 \| IL13 \| DISEASES 4330 \| MN1 \| DISEASES 7369 \| UMOD \| DISEASES 157570 \| ESCO2 \| DISEASES 6383 \| SDC2 \| DISEASES 81793 \| TLR10 \| DISEASES 8658 \| TNKS \| DISEASES 1605 \| DAG1 \| DISEASES 22882 \| ZHX2 \| DISEASES 29851 \| ICOS \| DISEASES 4094 \| MAF \| DISEASES 7490 \| WT1 \| DISEASES 4600 \| MX2 \| DISEASES 342184 \| FMN1 \| DISEASES 5329 \| PLAUR \| DISEASES 7225 \| TRPC6 \| DISEASES 5498 \| PPOX \| DISEASES 26762 \| HAVCR1 \| DISEASES 6275 \| S100A4 \| DISEASES 954 \| ENTPD2 \| DISEASES 4010 \| LMX1B \| DISEASES 1785 \| DNM2 \| DISEASES 5265 \| SERPINA1 \| DISEASES 130013 \| ACMSD \| DISEASES 23556 \| PIGN \| DISEASES 9332 \| CD163 \| DISEASES 23607 \| CD2AP \| DISEASES 6693 \| SPN \| DISEASES 170482 \| CLEC4C \| DISEASES 8828 \| NRP2 \| DISEASES 10724 \| MGEA5 \| DISEASES 7096 \| TLR1 \| DISEASES 88 \| ACTN2 \| DISEASES 1378 \| CR1 \| DISEASES 722 \| C4BPA \| DISEASES 6993 \| DYNLT1 \| DISEASES 9213 \| XPR1 \| DISEASES 7827 \| NPHS2 \| DISEASES 462 \| SERPINC1 \| DISEASES 1490 \| CTGF \| DISEASES 959 \| CD40LG \| DISEASES 7422 \| VEGFA \| DISEASES 958 \| CD40 \| DISEASES 129685 \| TAF8 \| DISEASES 23051 \| ZHX3 \| DISEASES 286204 \| CRB2 \| DISEASES 4153 \| MBL2 \| DISEASES 7099 \| TLR4 \| DISEASES 5420 \| PODXL \| DISEASES 4868 \| NPHS1 \| DISEASES 64423 \| INF2 \| DISEASES 2172 \| FABP6 \| DISEASES 11346 \| SYNPO \| DISEASES 87 \| ACTN1 \| DISEASES 6696 \| SPP1 \| DISEASES 340990 \| OTOG \| DISEASES 25974 \| MMACHC \| DISEASES 10525 \| HYOU1 \| DISEASES 7018 \| TF \| DISEASES 5005 \| ORM2 \| DISEASES 960 \| CD44 \| DISEASES 7124 \| TNF \| DISEASES 389549 \| FEZF1 \| DISEASES 3586 \| IL10 \| DISEASES 56034 \| PDGFC \| DISEASES 930 \| CD19 \| DISEASES 1649 \| DDIT3 \| DISEASES 91056 \| AP5B1 \| DISEASES 6139 \| RPL17 \| DISEASES 348120 \| LINC01193 \| DISEASES
Locus	(Waiting for update.)

Disease ID	467
Disease	lipoid nephrosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:1) HP:0012578 \| Membranous glomerulonephritis \| 1

Disease ID	467
Disease	lipoid nephrosis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:9) C1963137 \| hydrocephalus C1962974 \| chylothorax C1611280 \| allergy C0154251 \| lipid disorders C0032461 \| polycythemia C0031154 \| peritonitis C0030920 \| peptic ulcer C0027726 \| nephrotic syndrome C0020473 \| hyperlipemia
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1570360	21978756	7422	VEGFA	umls:C0027721	BeFree	Finally, we have not proved any significant influence of the polymorphisms at positions -2578 C/A and -1154 G/A of the vascular endothelial growth factor gene promoter on the progression of chronic glomerulonephritides even though our study suggests a negative effect of CC genotype of -2578 C/A polymorphism on the clinical course of minimal change disease/focal segmental glomerulosclerosis.	0.001085767	2011	VEGFA	6	43770093	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:11)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0027721	atenolol	D001262	29122-68-7	nephrosis, lipoid	MESH:D009402	marker/mechanism	3115369
C0027721	chlorambucil	D002699	305-03-3	nephrosis, lipoid	MESH:D009402	therapeutic	19809993
C0027721	chlorthalidone	D002752	77-36-1	nephrosis, lipoid	MESH:D009402	marker/mechanism	3115369
C0027721	cyclophosphamide	D003520	50-18-0	nephrosis, lipoid	MESH:D009402	therapeutic	3802598
C0027721	cyclosporine	D016572	59865-13-3	nephrosis, lipoid	MESH:D009402	therapeutic	17954296
C0027721	diclofenac	D004008	15307-86-5	nephrosis, lipoid	MESH:D009402	marker/mechanism	1630997
C0027721	enalapril	D004656	75847-73-3	nephrosis, lipoid	MESH:D009402	marker/mechanism	9403220
C0027721	fenoprofen	D005279	31879-05-7	nephrosis, lipoid	MESH:D009402	marker/mechanism	6520381
C0027721	piroxicam	D010894	36322-90-4	nephrosis, lipoid	MESH:D009402	marker/mechanism	3993703
C0027721	rifampin	D012293	13292-46-1	nephrosis, lipoid	MESH:D009402	marker/mechanism	10862648
C0027721	tacrolimus	D016559	109581-93-3	nephrosis, lipoid	MESH:D009402	therapeutic	14582073

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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