PedAM
Pediatric Disease Annotations & Medicines
| lichen planus | ||||
| Disease ID | 266 |
|---|---|
| Disease | lichen planus |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:38) C2364133 | infection C2186532 | liver disease C1420725 | thymoma C1290886 | chronic inflammatory disease C1274790 | cicatrizing conjunctivitis C0878500 | epithelial dysplasia C0850666 | h. pylori infection C0849640 | skin damage C0520463 | active chronic hepatitis C0451641 | urolithiasis C0409974 | lupus erythematosus C0406443 | twenty-nail dystrophy C0271650 | glucose intolerance C0235401 | abnormal glucose tolerance C0221260 | nail dystrophy C0220847 | hepatitis c C0220641 | oral cancer C0151546 | oral carcinomas C0086873 | scarring alopecia C0042900 | vitiligo C0042769 | virus infection C0041408 | turner's syndrome C0037285 | skin manifestations C0037284 | skin lesions C0033860 | psoriasis C0033774 | pruritus C0030805 | bullous pemphigoid C0029166 | oral manifestations C0029166 | oral manifestation C0024141 | le syndrome C0022906 | canalicular obstruction C0022573 | keratoconjunctivitis C0022572 | keratoacanthoma C0021053 | immune disorder C0017677 | benign migratory glossitis C0017577 | desquamative gingivitis C0014866 | oesophageal stricture C0009763 | conjunctivitis |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:10) C0009450 | infection | 11 C0019196 | hepatitis c | 10 C0042769 | virus infection | 5 C0037284 | skin lesions | 2 C0017577 | desquamative gingivitis | 2 C0033774 | pruritus | 1 C0026640 | oral cancer | 1 C0037285 | skin manifestations | 1 C0221260 | nail dystrophy | 1 C0040100 | thymoma | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:1) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0001952 | Abnormal glucose tolerance | MP:0002078 | abnormal glucose homeostasis; | |
Mapped by homologous gene(Total Items:1) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0003765 | Psoriasis | MP:0003410 | abnormal artery development;HP:0001045 | Vitiligo |
Chemical(Total Drugs:3) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0023646 | pimecrolimus | C117268 | - | lichen planus | MESH:D008010 | therapeutic | 16033622 | ||
| C0023646 | tacrolimus | D016559 | 109581-93-3 | lichen planus | MESH:D008010 | therapeutic | 15284791 | ||
| C0023646 | thalidomide | D013792 | 50-35-1 | lichen planus | MESH:D008010 | therapeutic | 17852637 | ||
FDA approved drug and dosage information(Total Drugs:1) | ||||||||
|---|---|---|---|---|---|---|---|---|
| DiseaseID | Drug_name | active_ingredients | strength | Dosage Form/Route | Marketing Status | TE code | RLD | RS |
| MESH:D008010 | elidel | pimecrolimus | 1% | CREAM;TOPICAL | Prescription | None | Yes | Yes |
FDA labeling changes(Total Drugs:1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DiseaseID | Pediatric_Labeling_Date | Trade_Name | Generic_Name_or_Proper_Name | Indications Studied | Label Changes Summary | Product Labeling | BPCA(B) | PREA(P) | BPCA(B) and PREA(P) | Pediatric Rule (R) | Sponsor | Pediatric Exclusivity Granted Date | NNPS |
| MESH:D008010 | 12/13/2001 | elidel | pimecrolimus | Treatment of mild/moderate atopic dermatitis | Indicated for short-term and intermittent long-term therapy for mild to moderate atopic dermatitis in non-immunocompromised patients 2 years and older Not recommended for use in pediatric patients less than 2 years of age. Infants on Elidel Cream had an increased incidence of some adverse events compared to vehicle which included pyrexia, URI, nasopharyngitis, gastroenteritis, otitis media, and diarrhea. | Labeling | B | - | - | - | Novartis | 09/24/2001 | FALSE' |