PedAM

Pediatric Disease Annotations & Medicines


	leukostasis

Disease ID	1544
Disease	leukostasis
Definition	Abnormal intravascular leukocyte aggregation and clumping often seen in leukemia patients. The brain and lungs are the two most commonly affected organs. This acute syndrome requires aggressive cytoreductive modalities including chemotherapy and/or leukophoresis. It is differentiated from LEUKEMIC INFILTRATION which is a neoplastic process where leukemic cells invade organs.
Synonym	leukostases leukostasis (morphologic abnormality) leukostasis [disease/finding] leukostasis syndrome leukostasis syndromes syndrome, leukostasis syndromes, leukostasis
DOID	DOID:12986
UMLS	C0282548
MeSH	D018921
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:13) C0011884 \| diabetic retinopathy \| 2 C0035078 \| renal failure \| 1 C0027051 \| myocardial infarct \| 1 C0041296 \| tuberculosis \| 1 C0085669 \| acute leukemia \| 1 C0035229 \| respiratory insufficiency \| 1 C0027051 \| myocardial infarction \| 1 C0035309 \| retinopathy \| 1 C0034063 \| pulmonary edema \| 1 C0334634 \| mantle cell lymphoma \| 1 C0020456 \| hyperglycemia \| 1 C0024299 \| lymphoma \| 1 C0022116 \| ischemia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) ICAM1 \| 3383 \| CTD_human PPARG \| 5468 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:71) 6376 \| CX3CL1 \| DISEASES 2802 \| GOLGA3 \| DISEASES 50 \| ACO2 \| DISEASES 4353 \| MPO \| DISEASES 6347 \| CCL2 \| DISEASES 6404 \| SELPLG \| DISEASES 6402 \| SELL \| DISEASES 2745 \| GLRX \| DISEASES 1958 \| EGR1 \| DISEASES 3569 \| IL6 \| DISEASES 27179 \| IL36A \| DISEASES 4040 \| LRP6 \| DISEASES 384 \| ARG2 \| DISEASES 5465 \| PPARA \| DISEASES 3553 \| IL1B \| DISEASES 6403 \| SELP \| DISEASES 3791 \| KDR \| DISEASES 3818 \| KLKB1 \| DISEASES 3383 \| ICAM1 \| DISEASES 3827 \| KNG1 \| DISEASES 6507 \| SLC1A3 \| DISEASES 80816 \| ASXL3 \| DISEASES 5972 \| REN \| DISEASES 4319 \| MMP10 \| DISEASES 3948 \| LDHC \| DISEASES 7082 \| TJP1 \| DISEASES 5468 \| PPARG \| DISEASES 1234 \| CCR5 \| DISEASES 246 \| ALOX15 \| DISEASES 178 \| AGL \| DISEASES 7412 \| VCAM1 \| DISEASES 213 \| ALB \| DISEASES 4846 \| NOS3 \| DISEASES 5267 \| SERPINA4 \| DISEASES 27343 \| POLL \| DISEASES 717 \| C2 \| DISEASES 290 \| ANPEP \| DISEASES 4775 \| NFATC3 \| DISEASES 51129 \| ANGPTL4 \| DISEASES 3688 \| ITGB1 \| DISEASES 3627 \| CXCL10 \| DISEASES 6373 \| CXCL11 \| DISEASES 5467 \| PPARD \| DISEASES 7423 \| VEGFB \| DISEASES 8639 \| AOC3 \| DISEASES 23765 \| IL17RA \| DISEASES 51330 \| TNFRSF12A \| DISEASES 6401 \| SELE \| DISEASES 2152 \| F3 \| DISEASES 5170 \| PDPK1 \| DISEASES 100506658 \| OCLN \| DISEASES 3683 \| ITGAL \| DISEASES 142 \| PARP1 \| DISEASES 5788 \| PTPRC \| DISEASES 7422 \| VEGFA \| DISEASES 7099 \| TLR4 \| DISEASES 4814 \| NINJ1 \| DISEASES 5457 \| POU4F1 \| DISEASES 79625 \| NDNF \| DISEASES 7436 \| VLDLR \| DISEASES 84299 \| MIEN1 \| DISEASES 6355 \| CCL8 \| DISEASES 2919 \| CXCL1 \| DISEASES 4773 \| NFATC2 \| DISEASES 3676 \| ITGA4 \| DISEASES 4776 \| NFATC4 \| DISEASES 7124 \| TNF \| DISEASES 834 \| CASP1 \| DISEASES 284 \| ANGPT1 \| DISEASES 3684 \| ITGAM \| DISEASES 64220 \| STRA6 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1544
Disease	leukostasis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:10) HP:0002093 \| progressive respiratory failure \| 2 HP:0003074 \| High blood glucose \| 1 HP:0000969 \| Dropsy \| 1 HP:0002098 \| Respiratory distress \| 1 HP:0000488 \| Noninflammatory retina disease \| 1 HP:0100598 \| Pulmonary oedema \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0002488 \| Acute leukemias \| 1 HP:0000573 \| Retinal hemorrhage \| 1 HP:0001658 \| Myocardial infarction \| 1

Disease ID	1544
Disease	leukostasis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0948755 \| pulmonary failure \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0282548	streptozocin	D013311	18883-66-4	leukostasis	MESH:D018921	marker/mechanism	10485912
C0282548	troglitazone	C057693	97322-87-7	leukostasis	MESH:D018921	therapeutic	12468449

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

Web
Analytics