PedAM

Pediatric Disease Annotations & Medicines


	leukoplakia

Disease ID	1146
Disease	leukoplakia
Definition	A white patch lesion found on a MUCOUS MEMBRANE that cannot be scraped off. Leukoplakia is generally considered a precancerous condition, however its appearance may also result from a variety of HEREDITARY DISEASES.
Synonym	keratotic plaque lesion, leukoplakic lesions, leukoplakic leucoplakia leukokeratosis leukoplakia (disorder) leukoplakia (morphologic abnormality) leukoplakia [disease/finding] leukoplakia, nos leukoplakias leukoplakic lesion leukoplakic lesions
UMLS	C0023531
MeSH	D007971
SNOMED-CT	SNOMEDCT_US_2016_09_01:274134003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:19) C0878500 \| epithelial dysplasia \| 8 C0026640 \| oral cancer \| 5 C0023646 \| lichen planus \| 3 C0870082 \| hyperkeratosis \| 2 C0031099 \| periodontitis \| 2 C0002874 \| aplastic anemia \| 1 C0151546 \| oral carcinoma \| 1 C0153381 \| oral cancers \| 1 C0032305 \| pneumocystis carinii pneumonia \| 1 C0007137 \| squamous cell carcinoma \| 1 C0017168 \| gastroesophageal reflux \| 1 C0032305 \| pneumocystis \| 1 C0042769 \| virus infection \| 1 C0017168 \| esophageal reflux \| 1 C0011334 \| caries \| 1 C0002871 \| anaemia \| 1 C0032285 \| pneumonia \| 1 C0015625 \| fanconi anemia \| 1 C0017168 \| oesophageal reflux \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1146
Disease	leukoplakia
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:13) HP:0002664 \| Neoplasia \| 3 HP:0030731 \| Carcinoma \| 2 HP:0000962 \| Hyperkeratosis \| 2 HP:0000704 \| Pyorrhea \| 2 HP:0002020 \| Heartburn \| 1 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0000670 \| Dental caries \| 1 HP:0001903 \| Anemia \| 1 HP:0002290 \| Poliosis \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0012224 \| Circulating immune complexes \| 1 HP:0002090 \| Pneumonia \| 1 HP:0001915 \| Aplastic anemia \| 1

Disease ID	1146
Disease	leukoplakia
Manually Symptom	UMLS \| Name(Total Manually Symptoms:8) C1608408 \| malignant transformation C1549524 \| mucous membrane C0878500 \| epithelial dysplasia C0857069 \| chronic candidiasis C0265965 \| engman syndrome C0220641 \| oral cancer C0033774 \| pruritis C0006849 \| oral candidiasis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:3) C0878500 \| epithelial dysplasia \| 8 C1608408 \| malignant transformation \| 7 C0026640 \| oral cancer \| 5

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:26)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1052133	21741876	2944	GSTM1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	OGG1;CAMK1	3	9757089	C	G
rs1052133	21741876	2952	GSTT1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	OGG1;CAMK1	3	9757089	C	G
rs1138272	21741876	2952	GSTT1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	GSTP1	11	67586108	C	T
rs1138272	21741876	2944	GSTM1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	GSTP1	11	67586108	C	T
rs12360870	23437280	5591	PRKDC	umls:C0023531	BeFree	Two SNPs (rs12360870 of MRE11A, P-value: 2.37E-07 and rs7003908 of PRKDC, P-value: 7.99E-05) were found to be significantly associated only with leukoplakia.	0.000271442	2013	MRE11A	11	94440881	T	C
rs12360870	23437280	4361	MRE11A	umls:C0023531	BeFree	Two SNPs (rs12360870 of MRE11A, P-value: 2.37E-07 and rs7003908 of PRKDC, P-value: 7.99E-05) were found to be significantly associated only with leukoplakia.	0.000271442	2013	MRE11A	11	94440881	T	C
rs13181	21741876	2952	GSTT1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	ERCC2;KLC3	19	45351661	T	A,G
rs13181	21741876	2944	GSTM1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	ERCC2;KLC3	19	45351661	T	A,G
rs1695	21741876	2944	GSTM1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	GSTP1	11	67585218	A	G
rs1695	21741876	2952	GSTT1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	GSTP1	11	67585218	A	G
rs1799782	21741876	2952	GSTT1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	XRCC1	19	43553422	G	A
rs1799782	21741876	2944	GSTM1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	XRCC1	19	43553422	G	A
rs1799791	21741876	2944	GSTM1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	ERCC2	19	45364545	G	C
rs1799791	21741876	2952	GSTT1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	ERCC2	19	45364545	G	C
rs1799793	21741876	2944	GSTM1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	ERCC2	19	45364001	C	T
rs1799793	21741876	2952	GSTT1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	ERCC2	19	45364001	C	T
rs2031920	21741876	2952	GSTT1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	CYP2E1	10	133526341	C	T
rs2031920	21741876	2944	GSTM1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	CYP2E1	10	133526341	C	T
rs25487	21741876	2944	GSTM1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	XRCC1	19	43551574	T	C
rs25487	21741876	2952	GSTT1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	XRCC1	19	43551574	T	C
rs3813867	21741876	2944	GSTM1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	CYP2E1	10	133526101	G	C
rs3813867	21741876	2952	GSTT1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	CYP2E1	10	133526101	G	C
rs4646903	21741876	2944	GSTM1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	CYP1A1	15	74719300	A	T,G
rs4646903	21741876	2952	GSTT1	umls:C0023531	BeFree	We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls.	0.005819831	2011	CYP1A1	15	74719300	A	T,G
rs7003908	23437280	4361	MRE11A	umls:C0023531	BeFree	Two SNPs (rs12360870 of MRE11A, P-value: 2.37E-07 and rs7003908 of PRKDC, P-value: 7.99E-05) were found to be significantly associated only with leukoplakia.	0.000271442	2013	PRKDC	8	47858141	C	A
rs7003908	23437280	5591	PRKDC	umls:C0023531	BeFree	Two SNPs (rs12360870 of MRE11A, P-value: 2.37E-07 and rs7003908 of PRKDC, P-value: 7.99E-05) were found to be significantly associated only with leukoplakia.	0.000271442	2013	PRKDC	8	47858141	C	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)