PedAM

Pediatric Disease Annotations & Medicines


	leptospirosis

Disease ID	304
Disease	leptospirosis
Definition	Infections with bacteria of the genus LEPTOSPIRA.
Synonym	[x]leptospirosis, unspecified [x]leptospirosis, unspecified (disorder) cane cutter's fever fort bragg fever harvest fever infection due to leptospira infection due to leptospira, nos japanese autumnal fever leptospiroses leptospirosis (disorder) leptospirosis [disease/finding] leptospirosis nos leptospirosis nos (disorder) leptospirosis, nos leptospirosis, unspecified mud fever queensland fever red water fever rice-field worker's disease spirochaetal jaundice spirochetal jaundice stuttgart disease weil disease
Orphanet	ORPHANET:509
DOID	DOID:2297 DOID:5086
ICD10	ICD10CM:A27.9
UMLS	C0023364
MeSH	D007922 D014895
SNOMED-CT	SNOMEDCT_US_2016_09_01:77377001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:34) C0035078 \| renal failure \| 8 C0040034 \| thrombocytopenia \| 6 C0022660 \| acute renal failure \| 6 C0027059 \| myocarditis \| 5 C0030305 \| pancreatitis \| 3 C1145670 \| respiratory failure \| 3 C0019158 \| hepatitis \| 2 C0027697 \| nephritis \| 1 C0022116 \| ischaemia \| 1 C0042164 \| uveitis \| 1 C0008325 \| cholecystitis \| 1 C0027707 \| interstitial nephritis \| 1 C0024198 \| lyme disease \| 1 C0267841 \| acalculous cholecystitis \| 1 C0042164 \| intraocular inflammation \| 1 C0022667 \| papillary necrosis \| 1 C0001973 \| alcoholism \| 1 C0001339 \| acute pancreatitis \| 1 C0041466 \| typhoid fever \| 1 C0032285 \| pneumonitis \| 1 C1704437 \| respiratory distress syndrome \| 1 C0024291 \| hemophagocytic syndrome \| 1 C0031046 \| pericarditis \| 1 C0019101 \| hemorrhagic fever with renal syndrome \| 1 C0035222 \| adult respiratory distress syndrome \| 1 C0001126 \| renal tubular acidosis \| 1 C0155686 \| acute myocarditis \| 1 C0041466 \| typhoid \| 1 C0085293 \| hepatitis e \| 1 C0035222 \| adult respiratory distress syndrome (ards) \| 1 C0041471 \| typhus \| 1 C1565489 \| renal insufficiency \| 1 C0154874 \| neuroretinitis \| 1 C0034155 \| thrombotic thrombocytopenic purpura \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer 7124 \| TNF \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:120) 3937 \| LCP2 \| DISEASES 55808 \| ST6GALNAC1 \| DISEASES 359 \| AQP2 \| DISEASES 5594 \| MAPK1 \| DISEASES 57026 \| PDXP \| DISEASES 10005 \| ACOT8 \| DISEASES 6880 \| TAF9 \| DISEASES 973 \| CD79A \| DISEASES 5444 \| PON1 \| DISEASES 10282 \| BET1 \| DISEASES 858 \| CAV2 \| DISEASES 6348 \| CCL3 \| DISEASES 6347 \| CCL2 \| DISEASES 7448 \| VTN \| DISEASES 3381 \| IBSP \| DISEASES 6484 \| ST3GAL4 \| DISEASES 55856 \| ACOT13 \| DISEASES 51409 \| HEMK1 \| DISEASES 566 \| AZU1 \| DISEASES 6301 \| SARS \| DISEASES 335 \| APOA1 \| DISEASES 56829 \| ZC3HAV1 \| DISEASES 5266 \| PI3 \| DISEASES 718 \| C3 \| DISEASES 2006 \| ELN \| DISEASES 4695 \| NDUFA2 \| DISEASES 1401 \| CRP \| DISEASES 6927 \| HNF1A \| DISEASES 3569 \| IL6 \| DISEASES 7097 \| TLR2 \| DISEASES 10068 \| IL18BP \| DISEASES 16 \| AARS \| DISEASES 9043 \| SPAG9 \| DISEASES 6558 \| SLC12A2 \| DISEASES 8178 \| ELL \| DISEASES 22858 \| ICK \| DISEASES 8578 \| SCARF1 \| DISEASES 3553 \| IL1B \| DISEASES 55669 \| MFN1 \| DISEASES 6550 \| SLC9A3 \| DISEASES 5286 \| PIK3C2A \| DISEASES 5211 \| PFKL \| DISEASES 56006 \| SMG9 \| DISEASES 2044 \| EPHA5 \| DISEASES 3001 \| GZMA \| DISEASES 167410 \| LIX1 \| DISEASES 3934 \| LCN2 \| DISEASES 22934 \| RPIA \| DISEASES 23643 \| LY96 \| DISEASES 132 \| ADK \| DISEASES 27349 \| MCAT \| DISEASES 6352 \| CCL5 \| DISEASES 362 \| AQP5 \| DISEASES 81570 \| CLPB \| DISEASES 84283 \| TMEM79 \| DISEASES 213 \| ALB \| DISEASES 25976 \| TIPARP \| DISEASES 222962 \| SLC29A4 \| DISEASES 90678 \| LRSAM1 \| DISEASES 3627 \| CXCL10 \| DISEASES 4135 \| MAP6 \| DISEASES 2147 \| F2 \| DISEASES 5340 \| PLG \| DISEASES 23479 \| ISCU \| DISEASES 358 \| AQP1 \| DISEASES 4018 \| LPA \| DISEASES 6181 \| RPLP2 \| DISEASES 3052 \| HCCS \| DISEASES 2242 \| FES \| DISEASES 29940 \| DSE \| DISEASES 2152 \| F3 \| DISEASES 2266 \| FGG \| DISEASES 3329 \| HSPD1 \| DISEASES 140707 \| BRI3BP \| DISEASES 25870 \| SUMF2 \| DISEASES 1431 \| CS \| DISEASES 7464 \| CORO2A \| DISEASES 1003 \| CDH5 \| DISEASES 6189 \| RPS3A \| DISEASES 3240 \| HP \| DISEASES 8852 \| AKAP4 \| DISEASES 56980 \| PRDM10 \| DISEASES 4151 \| MB \| DISEASES 7096 \| TLR1 \| DISEASES 462 \| SERPINC1 \| DISEASES 55811 \| ADCY10 \| DISEASES 2334 \| AFF2 \| DISEASES 9635 \| CLCA2 \| DISEASES 959 \| CD40LG \| DISEASES 27329 \| ANGPTL3 \| DISEASES 2021 \| ENDOG \| DISEASES 29889 \| GNL2 \| DISEASES 7099 \| TLR4 \| DISEASES 2582 \| GALE \| DISEASES 3127 \| HLA-DRB5 \| DISEASES 7709 \| ZBTB17 \| DISEASES 54363 \| HAO1 \| DISEASES 2710 \| GK \| DISEASES 3030 \| HADHA \| DISEASES 6557 \| SLC12A1 \| DISEASES 55576 \| STAB2 \| DISEASES 10018 \| BCL2L11 \| DISEASES 81502 \| HM13 \| DISEASES 1837 \| DTNA \| DISEASES 3033 \| HADH \| DISEASES 255743 \| NPNT \| DISEASES 7124 \| TNF \| DISEASES 4615 \| MYD88 \| DISEASES 3594 \| IL12RB1 \| DISEASES 3925 \| STMN1 \| DISEASES 4050 \| LTB \| DISEASES 3586 \| IL10 \| DISEASES 721 \| C4B \| DISEASES 51428 \| DDX41 \| DISEASES 643836 \| ZFP62 \| DISEASES 23221 \| RHOBTB2 \| DISEASES 149466 \| C1orf210 \| DISEASES 55733 \| HHAT \| DISEASES 8972 \| MGAM \| DISEASES 54938 \| SARS2 \| DISEASES
Locus	(Waiting for update.)

Disease ID	304
Disease	leptospirosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:31) HP:0001945 \| Fever \| 12 HP:0000083 \| Renal insufficiency \| 6 HP:0001873 \| Low platelet count \| 6 HP:0001919 \| Acute renal failure \| 5 HP:0012819 \| Myocarditis \| 5 HP:0001733 \| Pancreatic inflammation \| 3 HP:0002878 \| Respiratory failure \| 3 HP:0002105 \| Hemoptysis \| 2 HP:0006554 \| Acute hepatic failure \| 2 HP:0002098 \| Respiratory distress \| 2 HP:0012115 \| Liver inflammation \| 2 HP:0001399 \| Liver failure \| 2 HP:0002315 \| Headaches \| 2 HP:0002385 \| Paraparesis \| 2 HP:0000123 \| Nephritis \| 1 HP:0001082 \| Cholecystitis \| 1 HP:0001970 \| Interstitial nephritis \| 1 HP:0001735 \| Acute pancreatitis \| 1 HP:0005110 \| Atrial fibrillation \| 1 HP:0002155 \| Increased triglycerides \| 1 HP:0000952 \| Yellow skin \| 1 HP:0100533 \| Ocular inflammation \| 1 HP:0008341 \| Renal tubular acidosis, type I \| 1 HP:0001941 \| acidemia \| 1 HP:0000554 \| Uveitis \| 1 HP:0012418 \| Low blood oxygen level \| 1 HP:0001701 \| Pericarditis \| 1 HP:0002615 \| Low blood pressure \| 1 HP:0001947 \| Renal tubular acidosis \| 1 HP:0100520 \| Oliguria \| 1 HP:0100806 \| Sepsis \| 1

Disease ID	304
Disease	leptospirosis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:57) C2364133 \| infection C2364118 \| weakness C2203646 \| jaundice C2073625 \| pleural effusion C1963266 \| uveitis C1963211 \| pericarditis C1963198 \| pancreatitis C1963164 \| lymphopenia C1963154 \| renal failure C1839611 \| n syndrome C1565662 \| acute renal insufficiency C1565489 \| renal insufficiency C1402315 \| vascular lesions C1299910 \| keratouveitis C1145670 \| respiratory failure C1000483 \| anemia C0948600 \| organ failure C0871189 \| psychotic symptoms C0836924 \| thrombocytosis C0796095 \| c syndrome C0752303 \| urological manifestations C0748159 \| pulmonary involvement C0542035 \| erythroid hypoplasia C0341697 \| renal impairment C0275544 \| congenital infection C0267842 \| acute acalculous cholecystitis C0221773 \| hyperamylasemia C0162557 \| acute liver failure C0162293 \| papillitis C0152025 \| polyneuropathy C0151295 \| mononeuritis multiplex C0085655 \| polymyositis C0085593 \| chills C0042165 \| anterior uveitis C0040034 \| thrombocytopenia C0037090 \| respiratory symptoms C0035222 \| adult respiratory distress syndrome C0033975 \| psychosis C0031154 \| peritonitis C0030312 \| pancytopenia C0025289 \| meningitis C0022660 \| acute renal failure C0022660 \| acute kidney failure C0022658 \| renal disease C0022658 \| nephropathy C0022073 \| iridocyclitis C0020433 \| hyperbilirubinaemia C0019087 \| hemorrhagic diathesis C0019080 \| hemorrhage C0019061 \| hemolytic uremic syndrome C0015469 \| facial palsy C0015469 \| facial nerve palsy C0012739 \| disseminated intravascular coagulation C0007773 \| cerebral arteritis C0007222 \| cardiovascular disorders C0002878 \| hemolytic anemia C0001339 \| acute pancreatitis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:19) C0019080 \| hemorrhage \| 12 C0009450 \| infection \| 7 C0948600 \| organ failure \| 6 C0040034 \| thrombocytopenia \| 6 C0035078 \| renal failure \| 5 C0748159 \| pulmonary involvement \| 5 C0022660 \| acute renal failure \| 4 C1145670 \| respiratory failure \| 3 C0030305 \| pancreatitis \| 3 C0162557 \| acute liver failure \| 2 C1839611 \| n syndrome \| 1 C0031046 \| pericarditis \| 1 C0085593 \| chills \| 1 C0035222 \| adult respiratory distress syndrome \| 1 C0796095 \| c syndrome \| 1 C0042164 \| uveitis \| 1 C1565489 \| renal insufficiency \| 1 C0001339 \| acute pancreatitis \| 1 C0341697 \| renal impairment \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:4)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs5743618	25784560	7096	TLR1	umls:C0023364	BeFree	Association of Toll-like receptor 2 Arg753Gln and Toll-like receptor 1 Ile602Ser single-nucleotide polymorphisms with leptospirosis in an Argentine population.	0.000271442	2015	TLR1	4	38797027	C	A
rs5743618	25784560	7097	TLR2	umls:C0023364	BeFree	Association of Toll-like receptor 2 Arg753Gln and Toll-like receptor 1 Ile602Ser single-nucleotide polymorphisms with leptospirosis in an Argentine population.	0.000542884	2015	TLR1	4	38797027	C	A
rs5743708	25784560	7096	TLR1	umls:C0023364	BeFree	Association of Toll-like receptor 2 Arg753Gln and Toll-like receptor 1 Ile602Ser single-nucleotide polymorphisms with leptospirosis in an Argentine population.	0.000271442	2015	TLR2	4	153705165	G	A
rs5743708	25784560	7097	TLR2	umls:C0023364	BeFree	Association of Toll-like receptor 2 Arg753Gln and Toll-like receptor 1 Ile602Ser single-nucleotide polymorphisms with leptospirosis in an Argentine population.	0.000542884	2015	TLR2	4	153705165	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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