PedAM
Pediatric Disease Annotations & Medicines
| leiomyosarcoma | ||||
| Disease ID | 136 |
|---|---|
| Disease | leiomyosarcoma |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:26) HP:0002664 | Neoplasia | 14 HP:0100242 | Sarcoma | 3 HP:0030731 | Carcinoma | 2 HP:0002860 | Squamous cell carcinoma | 2 HP:0100721 | Mediastinal lymphadenopathy | 1 HP:0002027 | Abdominal pain | 1 HP:0012118 | Cancer of the larynx | 1 HP:0100723 | Gastrointestinal stroma tumor | 1 HP:0001289 | Confusion | 1 HP:0009733 | Glioma | 1 HP:0001733 | Pancreatic inflammation | 1 HP:0002015 | Swallowing difficulty | 1 HP:0001945 | Fever | 1 HP:0002584 | Intestinal hemorrhage | 1 HP:0001635 | Congestive heart failure | 1 HP:0002665 | Lymphoma | 1 HP:0100279 | Ulcerative colitis | 1 HP:0001824 | Weight loss | 1 HP:0002239 | Gastrointestinal hemorrhage | 1 HP:0012189 | Hodgkin disease | 1 HP:0012531 | Pain | 1 HP:0200058 | Angiosarcoma | 1 HP:0001974 | Leukocytosis | 1 HP:0000131 | Uterine leiomyoma | 1 HP:0009725 | Bladder neoplasm | 1 HP:0009919 | Retinoblastoma | 1 |
| Disease ID | 136 |
|---|---|
| Disease | leiomyosarcoma |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:21) C1142158 | hepatic vein occlusion C0555278 | cerebral metastasis C0494165 | liver metastasis C0494165 | liver metastases C0494165 | hepatic metastasis C0346989 | peritoneal metastases C0346976 | pancreatic metastasis C0302592 | carcinoma of the cervix C0302148 | thrombus C0153690 | bone metastasis C0153690 | bone metastases C0153687 | cutaneous metastasis C0153676 | pulmonary metastasis C0153676 | pulmonary metastases C0149871 | deep venous thrombosis C0040053 | thrombosis C0030552 | paresis C0023885 | liver abscesses C0023370 | leriche syndrome C0020295 | hydronephrosis C0011168 | dysphagia |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:4) C0494165 | liver metastasis | 4 C0153676 | pulmonary metastases | 2 C0011168 | dysphagia | 1 C0494165 | hepatic metastasis | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:4) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs13181 | 16646069 | 2073 | ERCC5 | umls:C0023269 | BeFree | DNA from 93 patients with synovial sarcomas, myxoid liposarcomas, dermatofibrosarcomas protuberans (DFSP), malignant fibrous histiocytomas and leiomyosarcomas were genotyped for both XPD Lys751Gln and XPG Asp1104His polymorphisms. | 0.000271442 | 2006 | ERCC2;KLC3 | 19 | 45351661 | T | A,G |
| rs13181 | 16646069 | 2068 | ERCC2 | umls:C0023269 | BeFree | DNA from 93 patients with synovial sarcomas, myxoid liposarcomas, dermatofibrosarcomas protuberans (DFSP), malignant fibrous histiocytomas and leiomyosarcomas were genotyped for both XPD Lys751Gln and XPG Asp1104His polymorphisms. | 0.000271442 | 2006 | ERCC2;KLC3 | 19 | 45351661 | T | A,G |
| rs17655 | 16646069 | 2073 | ERCC5 | umls:C0023269 | BeFree | DNA from 93 patients with synovial sarcomas, myxoid liposarcomas, dermatofibrosarcomas protuberans (DFSP), malignant fibrous histiocytomas and leiomyosarcomas were genotyped for both XPD Lys751Gln and XPG Asp1104His polymorphisms. | 0.000271442 | 2006 | ERCC5;BIVM-ERCC5 | 13 | 102875652 | G | C |
| rs17655 | 16646069 | 2068 | ERCC2 | umls:C0023269 | BeFree | DNA from 93 patients with synovial sarcomas, myxoid liposarcomas, dermatofibrosarcomas protuberans (DFSP), malignant fibrous histiocytomas and leiomyosarcomas were genotyped for both XPD Lys751Gln and XPG Asp1104His polymorphisms. | 0.000271442 | 2006 | ERCC5;BIVM-ERCC5 | 13 | 102875652 | G | C |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:1) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0002625 | Deep venous thrombosis | MP:0001855 | atrial thrombosis; | |
Mapped by homologous gene(Total Items:1) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0000126 | Hydronephrosis | MP:0010465 | aberrant origin of the right subclavian artery;HP:0002015 | Dysphagia |
Chemical(Total Drugs:8) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0023269 | cyclophosphamide | D003520 | 50-18-0 | leiomyosarcoma | MESH:D007890 | marker/mechanism | 11487082 | ||
| C0023269 | cisplatin | D002945 | 15663-27-1 | leiomyosarcoma | MESH:D007890 | therapeutic | 15878560 | ||
| C0023269 | ifosfamide | D007069 | 3778-73-2 | leiomyosarcoma | MESH:D007890 | therapeutic | 15878560 | ||
| C0023269 | mesna | D015080 | 19767-45-4 | leiomyosarcoma | MESH:D007890 | therapeutic | 15878560 | ||
| C0023269 | paclitaxel | D017239 | - | leiomyosarcoma | MESH:D007890 | therapeutic | 9774950 | ||
| C0023269 | vincristine | D014750 | - | leiomyosarcoma | MESH:D007890 | marker/mechanism | 12748258 | ||
| C0023269 | vincristine | D014750 | - | leiomyosarcoma | MESH:D007890 | therapeutic | 1421432 | ||
| C0023269 | vindesine | D014751 | 53643-48-4 | leiomyosarcoma | MESH:D007890 | therapeutic | 7438126 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
|---|---|
| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
|---|---|
| (Waiting for update.) | |