PedAM

Pediatric Disease Annotations & Medicines


	leiomyoma

Disease ID	886
Disease	leiomyoma
Definition	A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.
Synonym	[m]leiomyoma nos [m]leiomyoma nos (morphologic abnormality) [m]leiomyomatous neoplasm nos [m]leiomyomatous neoplasm nos (morphologic abnormality) [m]leiomyomatous neoplasms [m]leiomyomatous neoplasms (morphologic abnormality) fibroid fibroid neoplasm fibroid tumor fibroid tumors fibroids fibroids tumor fibroids tumors fibromyoma fibromyomas leiomyofibroma leiomyofibroma (morphologic abnormality) leiomyoma [disease/finding] leiomyoma, benign leiomyoma, nos leiomyomas leiomyomatous neoplasm leiomyomatous tumor tumor fibroid tumor, fibroid tumors, fibroid
DOID	DOID:127
UMLS	C0023267
MeSH	D007889
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:41) C0042133 \| uterine leiomyoma \| 5 C0162482 \| uterine inversion \| 3 C0023267 \| leiomyomas \| 2 C0341858 \| adenomyosis \| 2 C1261473 \| sarcoma \| 2 C0087086 \| thrombi \| 1 C0259779 \| fibrous dysplasia \| 1 C0009806 \| constipation \| 1 C0023798 \| lipoma \| 1 C0014175 \| endometriosis \| 1 C0007134 \| renal cell carcinoma \| 1 C0085413 \| autosomal dominant polycystic kidney \| 1 C0206654 \| leiomyomatosis \| 1 C0346200 \| intravenous leiomyomatosis \| 1 C0003857 \| arteriovenous malformation \| 1 C0004245 \| atrioventricular block \| 1 C0023269 \| leiomyosarcoma \| 1 C0006264 \| bronchial tumor \| 1 C0021359 \| infertility \| 1 C0042133 \| uterine fibroid \| 1 C0016719 \| friedreich's ataxia \| 1 C1704327 \| bone sarcoma \| 1 C0206630 \| endometrial stromal sarcoma \| 1 C0153676 \| lung metastasis \| 1 C0037856 \| testicular torsion \| 1 C1368910 \| mature teratoma \| 1 C0022679 \| cystic kidney \| 1 C0007137 \| squamous cell carcinoma \| 1 C0085413 \| autosomal dominant polycystic kidney disease \| 1 C0016063 \| fibrous dysplasia of bone \| 1 C0025202 \| melanoma \| 1 C0032461 \| polycythaemia \| 1 C0242379 \| lung cancer \| 1 C0022593 \| keratosis \| 1 C0042133 \| uterine fibromyoma \| 1 C0032285 \| pneumonitis \| 1 C0040053 \| thrombosis \| 1 C0020437 \| hypercalcemia \| 1 C0023267 \| fibromyomas \| 1 C0007138 \| transitional cell carcinoma \| 1 C0042133 \| uterine fibroids \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:6) SMAD3 \| 4088 \| CTD_human ESR1 \| 2099 \| CTD_human TSC2 \| 7249 \| CTD_human SFRP1 \| 6422 \| CTD_human INHBA \| 3624 \| CTD_human WNT5B \| 81029 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:14) 51272 \| BET1L \| infer 339799 \| EIF3FP3 \| infer 3479 \| IGF1 \| infer 23112 \| TNRC6B \| infer 2068 \| ERCC2 \| infer 2271 \| FH \| infer 2944 \| GSTM1 \| infer 3594 \| IL12RB1 \| infer 3606 \| IL18 \| infer 3553 \| IL1B \| infer 3557 \| IL1RN \| infer 3558 \| IL2 \| infer 3565 \| IL4 \| infer 7518 \| XRCC4 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:291) 401237 \| CASC15 \| DISEASES 50508 \| NOX3 \| DISEASES 7145 \| TNS1 \| DISEASES 51015 \| ISOC1 \| DISEASES 8646 \| CHRD \| DISEASES 2099 \| ESR1 \| DISEASES 124 \| ADH1A \| DISEASES 10454 \| TAB1 \| DISEASES 50 \| ACO2 \| DISEASES 10857 \| PGRMC1 \| DISEASES 9506 \| PAGE4 \| DISEASES 4313 \| MMP2 \| DISEASES 7249 \| TSC2 \| DISEASES 59284 \| CACNG7 \| DISEASES 3912 \| LAMB1 \| DISEASES 51384 \| WNT16 \| DISEASES 5054 \| SERPINE1 \| DISEASES 4232 \| MEST \| DISEASES 1592 \| CYP26A1 \| DISEASES 6347 \| CCL2 \| DISEASES 1277 \| COL1A1 \| DISEASES 2798 \| GNRHR \| DISEASES 595 \| CCND1 \| DISEASES 2026 \| ENO2 \| DISEASES 7942 \| TFEB \| DISEASES 1839 \| HBEGF \| DISEASES 7043 \| TGFB3 \| DISEASES 2797 \| GNRH2 \| DISEASES 27335 \| EIF3K \| DISEASES 9098 \| USP6 \| DISEASES 968 \| CD68 \| DISEASES 1890 \| TYMP \| DISEASES 25796 \| PGLS \| DISEASES 2670 \| GFAP \| DISEASES 5156 \| PDGFRA \| DISEASES 10220 \| GDF11 \| DISEASES 1019 \| CDK4 \| DISEASES 3658 \| IREB2 \| DISEASES 4856 \| NOV \| DISEASES 7057 \| THBS1 \| DISEASES 1588 \| CYP19A1 \| DISEASES 2660 \| MSTN \| DISEASES 10152 \| ABI2 \| DISEASES 27190 \| IL17B \| DISEASES 4053 \| LTBP2 \| DISEASES 4092 \| SMAD7 \| DISEASES 4087 \| SMAD2 \| DISEASES 284058 \| KANSL1 \| DISEASES 8503 \| PIK3R3 \| DISEASES 7077 \| TIMP2 \| DISEASES 10075 \| HUWE1 \| DISEASES 5595 \| MAPK3 \| DISEASES 6855 \| SYP \| DISEASES 6801 \| STRN \| DISEASES 2247 \| FGF2 \| DISEASES 1788 \| DNMT3A \| DISEASES 8626 \| TP63 \| DISEASES 1462 \| VCAN \| DISEASES 1950 \| EGF \| DISEASES 1017 \| CDK2 \| DISEASES 5925 \| RB1 \| DISEASES 3480 \| IGF1R \| DISEASES 9611 \| NCOR1 \| DISEASES 7157 \| TP53 \| DISEASES 207 \| AKT1 \| DISEASES 23432 \| GPR161 \| DISEASES 5546 \| PRCC \| DISEASES 1513 \| CTSK \| DISEASES 54539 \| NDUFB11 \| DISEASES 53336 \| CPXCR1 \| DISEASES 2796 \| GNRH1 \| DISEASES 5047 \| PAEP \| DISEASES 133 \| ADM \| DISEASES 6876 \| TAGLN \| DISEASES 2697 \| GJA1 \| DISEASES 3206 \| HOXA10 \| DISEASES 221895 \| JAZF1 \| DISEASES 7345 \| UCHL1 \| DISEASES 201163 \| FLCN \| DISEASES 760 \| CA2 \| DISEASES 7411 \| VBP1 \| DISEASES 23522 \| KAT6B \| DISEASES 3815 \| KIT \| DISEASES 3837 \| KPNB1 \| DISEASES 54361 \| WNT4 \| DISEASES 112950 \| MED8 \| DISEASES 23387 \| SIK3 \| DISEASES 6271 \| S100A1 \| DISEASES 112939 \| NACC1 \| DISEASES 30818 \| KCNIP3 \| DISEASES 9076 \| CLDN1 \| DISEASES 4286 \| MITF \| DISEASES 6997 \| TDGF1 \| DISEASES 122042 \| RXFP2 \| DISEASES 7248 \| TSC1 \| DISEASES 2619 \| GAS1 \| DISEASES 3429 \| IFI27 \| DISEASES 170689 \| ADAMTS15 \| DISEASES 1381 \| CRABP1 \| DISEASES 123169 \| LEO1 \| DISEASES 5617 \| PRL \| DISEASES 3479 \| IGF1 \| DISEASES 59350 \| RXFP1 \| DISEASES 3688 \| ITGB1 \| DISEASES 1281 \| COL3A1 \| DISEASES 649 \| BMP1 \| DISEASES 6638 \| SNRPN \| DISEASES 2353 \| FOS \| DISEASES 7532 \| YWHAG \| DISEASES 23627 \| PRND \| DISEASES 8462 \| KLF11 \| DISEASES 150353 \| DNAJB7 \| DISEASES 794 \| CALB2 \| DISEASES 9940 \| DLEC1 \| DISEASES 211 \| ALAS1 \| DISEASES 947 \| CD34 \| DISEASES 836 \| CASP3 \| DISEASES 9156 \| EXO1 \| DISEASES 7030 \| TFE3 \| DISEASES 23512 \| SUZ12 \| DISEASES 4233 \| MET \| DISEASES 1960 \| EGR3 \| DISEASES 4684 \| NCAM1 \| DISEASES 83787 \| ARMC10 \| DISEASES 5315 \| PKM \| DISEASES 23428 \| SLC7A8 \| DISEASES 8648 \| NCOA1 \| DISEASES 1400 \| CRMP1 \| DISEASES 222235 \| FBXL13 \| DISEASES 3039 \| HBA1 \| DISEASES 4312 \| MMP1 \| DISEASES 5021 \| OXTR \| DISEASES 5241 \| PGR \| DISEASES 4670 \| HNRNPM \| DISEASES 5324 \| PLAG1 \| DISEASES 23347 \| SMCHD1 \| DISEASES 8738 \| CRADD \| DISEASES 3855 \| KRT7 \| DISEASES 5121 \| PCP4 \| DISEASES 3009 \| HIST1H1B \| DISEASES 5155 \| PDGFB \| DISEASES 63827 \| BCAN \| DISEASES 7490 \| WT1 \| DISEASES 1287 \| COL4A5 \| DISEASES 4088 \| SMAD3 \| DISEASES 682 \| BSG \| DISEASES 3092 \| HIP1 \| DISEASES 10957 \| PNRC1 \| DISEASES 4221 \| MEN1 \| DISEASES 677 \| ZFP36L1 \| DISEASES 57820 \| CCNB1IP1 \| DISEASES 7095 \| SEC62 \| DISEASES 3091 \| HIF1A \| DISEASES 2246 \| FGF1 \| DISEASES 23583 \| SMUG1 \| DISEASES 4076 \| CAPRIN1 \| DISEASES 6590 \| SLPI \| DISEASES 2100 \| ESR2 \| DISEASES 1499 \| CTNNB1 \| DISEASES 1842 \| ECM2 \| DISEASES 10516 \| FBLN5 \| DISEASES 92737 \| DNER \| DISEASES 3767 \| KCNJ11 \| DISEASES 2335 \| FN1 \| DISEASES 2331 \| FMOD \| DISEASES 55107 \| ANO1 \| DISEASES 5733 \| PTGER3 \| DISEASES 440738 \| MAP1LC3C \| DISEASES 60 \| ACTB \| DISEASES 4763 \| NF1 \| DISEASES 56980 \| PRDM10 \| DISEASES 7048 \| TGFBR2 \| DISEASES 4151 \| MB \| DISEASES 93034 \| NT5C1B \| DISEASES 1523 \| CUX1 \| DISEASES 3164 \| NR4A1 \| DISEASES 25942 \| SIN3A \| DISEASES 1284 \| COL4A2 \| DISEASES 4311 \| MME \| DISEASES 1312 \| COMT \| DISEASES 2475 \| MTOR \| DISEASES 114814 \| GNRHR2 \| DISEASES 800 \| CALD1 \| DISEASES 4779 \| NFE2L1 \| DISEASES 57713 \| SFMBT2 \| DISEASES 3151 \| HMGN2 \| DISEASES 1122 \| CHML \| DISEASES 23596 \| OPN3 \| DISEASES 2271 \| FH \| DISEASES 6000 \| RGS7 \| DISEASES 10370 \| CITED2 \| DISEASES 1805 \| DPT \| DISEASES 6391 \| SDHC \| DISEASES 1490 \| CTGF \| DISEASES 1382 \| CRABP2 \| DISEASES 4288 \| MKI67 \| DISEASES 6277 \| S100A6 \| DISEASES 3713 \| IVL \| DISEASES 5016 \| OVGP1 \| DISEASES 1586 \| CYP17A1 \| DISEASES 2564 \| GABRE \| DISEASES 60495 \| HPSE2 \| DISEASES 5223 \| PGAM1 \| DISEASES 1791 \| DNTT \| DISEASES 5730 \| PTGDS \| DISEASES 5728 \| PTEN \| DISEASES 7422 \| VEGFA \| DISEASES 8471 \| IRS4 \| DISEASES 1288 \| COL4A6 \| DISEASES 4318 \| MMP9 \| DISEASES 7075 \| TIE1 \| DISEASES 27328 \| PCDH11X \| DISEASES 219738 \| C10orf35 \| DISEASES 5090 \| PBX3 \| DISEASES 8668 \| EIF3I \| DISEASES 23633 \| KPNA6 \| DISEASES 54797 \| MED18 \| DISEASES 9968 \| MED12 \| DISEASES 367 \| AR \| DISEASES 5698 \| PSMB9 \| DISEASES 4686 \| NCBP1 \| DISEASES 64061 \| TSPYL2 \| DISEASES 6390 \| SDHB \| DISEASES 6392 \| SDHD \| DISEASES 1282 \| COL4A1 \| DISEASES 1460 \| CSNK2B \| DISEASES 5935 \| RBM3 \| DISEASES 687 \| KLF9 \| DISEASES 5987 \| TRIM27 \| DISEASES 1910 \| EDNRB \| DISEASES 56998 \| CTNNBIP1 \| DISEASES 4609 \| MYC \| DISEASES 55966 \| AJAP1 \| DISEASES 768 \| CA9 \| DISEASES 1906 \| EDN1 \| DISEASES 2308 \| FOXO1 \| DISEASES 6462 \| SHBG \| DISEASES 171482 \| FAM9A \| DISEASES 2315 \| MLANA \| DISEASES 192668 \| CYS1 \| DISEASES 9037 \| SEMA5A \| DISEASES 6468 \| FBXW4 \| DISEASES 238 \| ALK \| DISEASES 6710 \| SPTB \| DISEASES 2869 \| GRK5 \| DISEASES 29893 \| PSMC3IP \| DISEASES 9801 \| MRPL19 \| DISEASES 65009 \| NDRG4 \| DISEASES 79868 \| ALG13 \| DISEASES 5744 \| PTHLH \| DISEASES 1285 \| COL4A3 \| DISEASES 1286 \| COL4A4 \| DISEASES 124056 \| NOXO1 \| DISEASES 116372 \| LYPD1 \| DISEASES 29911 \| HOOK2 \| DISEASES 2047 \| EPHB1 \| DISEASES 7322 \| UBE2D2 \| DISEASES 81669 \| CCNL2 \| DISEASES 9612 \| NCOR2 \| DISEASES 8091 \| HMGA2 \| DISEASES 2199 \| FBLN2 \| DISEASES 2825 \| GPR1 \| DISEASES 3238 \| HOXD12 \| DISEASES 4052 \| LTBP1 \| DISEASES 84334 \| APOPT1 \| DISEASES 200424 \| TET3 \| DISEASES 9698 \| PUM1 \| DISEASES 3481 \| IGF2 \| DISEASES 3800 \| KIF5C \| DISEASES 1029 \| CDKN2A \| DISEASES 7849 \| PAX8 \| DISEASES 387836 \| CLEC2A \| DISEASES 3491 \| CYR61 \| DISEASES 2741 \| GLRA1 \| DISEASES 1945 \| EFNA4 \| DISEASES 1967 \| EIF2B1 \| DISEASES 6513 \| SLC2A1 \| DISEASES 5890 \| RAD51B \| DISEASES 6256 \| RXRA \| DISEASES 55998 \| NXF5 \| DISEASES 55733 \| HHAT \| DISEASES 200150 \| PLD5 \| DISEASES 3250 \| HPR \| DISEASES 3939 \| LDHA \| DISEASES 641455 \| POTEM \| DISEASES 51741 \| WWOX \| DISEASES 90632 \| LINC00473 \| DISEASES 401613 \| LINC00890 \| DISEASES 4553 \| MT-TA \| DISEASES 9383 \| TSIX \| DISEASES 7503 \| XIST \| DISEASES
Locus	(Waiting for update.)

Disease ID	886
Disease	leiomyoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:42) HP:0000131 \| Uterine leiomyoma \| 6 HP:0002664 \| Neoplasia \| 5 HP:0012531 \| Pain \| 4 HP:0100242 \| Sarcoma \| 2 HP:0000016 \| Urinary retention \| 2 HP:0000969 \| Dropsy \| 2 HP:0001541 \| Ascites \| 2 HP:0000139 \| Sagging uterus \| 1 HP:0009725 \| Bladder neoplasm \| 1 HP:0011134 \| Mild fever \| 1 HP:0012721 \| Venous malformations \| 1 HP:0100518 \| Painful or difficult urination \| 1 HP:0000074 \| Ureteropelvic junction obstruction \| 1 HP:0030127 \| Endometriosis \| 1 HP:0001978 \| Extramedullary hematopoiesis \| 1 HP:0100026 \| Arteriovenous malformation \| 1 HP:0001678 \| Atrioventricular block \| 1 HP:0000855 \| Insulin resistance \| 1 HP:0100749 \| Thoracic pain \| 1 HP:0002019 \| Dyschezia \| 1 HP:0002861 \| Melanoma \| 1 HP:0002304 \| Akinesia \| 1 HP:0002094 \| Dyspnea \| 1 HP:0012032 \| Lipoma \| 1 HP:0000789 \| Infertility \| 1 HP:0000132 \| Hypermenorrhea \| 1 HP:0006548 \| Pulmonary av malformation \| 1 HP:0100570 \| Carcinoid tumor \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0100243 \| Leiomyosarcoma \| 1 HP:0030016 \| Dyspareunia \| 1 HP:0005584 \| Renal cell carcinoma \| 1 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0200116 \| Distal ileal atresia \| 1 HP:0011102 \| Ileal atresia \| 1 HP:0000113 \| Polycystic kidney dysplasia \| 1 HP:0100615 \| Neoplasm of the ovary \| 1 HP:0006515 \| Interstitial pneumonitis \| 1 HP:0030731 \| Carcinoma \| 1 HP:0100813 \| Testicular torsion \| 1 HP:0001945 \| Fever \| 1 HP:0003072 \| Hypercalcemia \| 1

Disease ID	886
Disease	leiomyoma
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:4) C0341858 \| adenomyosis \| 2 C0019080 \| hemorrhage \| 1 C0032461 \| polycythaemia \| 1 C0040053 \| thrombosis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:12)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1048943	20559649	1543	CYP1A1	umls:C0023267	BeFree	We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC genotypes predict the susceptibility to leiomyoma in Egyptian women and they are likely to contribute in the pathogenesis of leiomyoma.	0.00827274	2011	CYP1A1	15	74720644	T	G,C,A
rs1048943	20559649	1545	CYP1B1	umls:C0023267	BeFree	We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC genotypes predict the susceptibility to leiomyoma in Egyptian women and they are likely to contribute in the pathogenesis of leiomyoma.	0.005362824	2011	CYP1A1	15	74720644	T	G,C,A
rs1048943	18763031	1543	CYP1A1	umls:C0023267	BeFree	These results suggest that the genotype of CYP1A1 Ile462Val was associated with the increased risk of uterine leiomyomas in Chinese women.	0.00827274	2008	CYP1A1	15	74720644	T	G,C,A
rs1056836	20559649	1543	CYP1A1	umls:C0023267	BeFree	We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC genotypes predict the susceptibility to leiomyoma in Egyptian women and they are likely to contribute in the pathogenesis of leiomyoma.	0.00827274	2011	CYP1B1	2	38071060	G	C
rs1056836	20559649	1545	CYP1B1	umls:C0023267	BeFree	We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC genotypes predict the susceptibility to leiomyoma in Egyptian women and they are likely to contribute in the pathogenesis of leiomyoma.	0.005362824	2011	CYP1B1	2	38071060	G	C
rs121908585	24618081	81608	FIP1L1	umls:C0023267	BeFree	Activated forms of the platelet derived growth factor receptor alpha (PDGFRα) have been described in various tumors, including FIP1L1-PDGFRα in patients with myeloproliferative diseases associated with hypereosinophilia and the PDGFRα(D842V) mutant in gastrointestinal stromal tumors and inflammatory fibroid polyps.	0.000271442	2014	PDGFRA	4	54285926	A	T
rs121908585	24618081	5156	PDGFRA	umls:C0023267	BeFree	Activated forms of the platelet derived growth factor receptor alpha (PDGFRα) have been described in various tumors, including FIP1L1-PDGFRα in patients with myeloproliferative diseases associated with hypereosinophilia and the PDGFRα(D842V) mutant in gastrointestinal stromal tumors and inflammatory fibroid polyps.	0.001085767	2014	PDGFRA	4	54285926	A	T
rs12484776	21460842	23112	TNRC6B	umls:C0023267	GAD	[A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.]	0.002638474	2011	TNRC6B	22	40256869	A	G
rs2070874	21138652	3565	IL4	umls:C0023267	BeFree	An association between polymorphisms of the IL4 gene promotor at positions -590 C/T and -33 C/T, and the risk of leiomyoma was observed.	0.000542884	2010	IL4	5	132674018	C	T
rs2172873	21460842	3479	IGF1	umls:C0023267	GAD	[A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.]	0.014254393	2011	NA	12	102731912	G	A
rs2280543	21460842	51272	BET1L	umls:C0023267	GAD	[A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.]	0.002638474	2011	BET1L	11	203788	C	T
rs7913069	21460842	79991	OBFC1	umls:C0023267	GAD	[A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.]	0.002367032	2011	LOC102724351	10	103954641	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:6)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0023267	doxazosin	D017292	74191-85-8	leiomyoma	MESH:D007889	therapeutic	16403393
C0023267	gabapentin	C040029	60142-96-3	leiomyoma	MESH:D007889	therapeutic	16403393
C0023267	goserelin	D017273	65807-02-5	leiomyoma	MESH:D007889	therapeutic	16973256
C0023267	leuprolide	D016729	53714-56-0	leiomyoma	MESH:D007889	therapeutic	10763848
C0023267	progesterone	D011374	57-83-0	leiomyoma	MESH:D007889	marker/mechanism	23427402
C0023267	tranexamic acid	D014148	1197-18-8	leiomyoma	MESH:D007889	therapeutic	15229393

FDA approved drug and dosage information(Total Drugs:8)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D007889	neurontin	gabapentin	100MG	CAPSULE;ORAL	Prescription	AB	Yes	No
MESH:D007889	neurontin	gabapentin	600MG	TABLET;ORAL	Prescription	AB	Yes	No
MESH:D007889	neurontin	gabapentin	250MG/5ML	SOLUTION;ORAL	Prescription	AA	Yes	Yes
MESH:D007889	neurontin	gabapentin	0	SOLUTION; ORAL	Prescription	None	No	No
MESH:D007889	neurontin	gabapentin	600MG	TABLET; ORAL	Prescription	None	No	No
MESH:D007889	neurontin	gabapentin	800MG	CAPSULE; ORAL	Prescription	None	No	No
MESH:D007889	neurontin	gabapentin	250MG/5ML	SOLUTION; ORAL	Prescription	None	No	No
MESH:D007889	lysteda	tranexamic acid	650MG	TABLET;ORAL	Prescription	AB	Yes	Yes

FDA labeling changes(Total Drugs:8)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D007889	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D007889	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D007889	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D007889	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D007889	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D007889	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D007889	12/10/2000	neurontin	gabapentin	Adjunctive therapy in the treatment of partial seizures	Safety and effectiveness established down to 3 years Neuropsychiatric AE's identified in 3-12 year olds Oral clearance normalized per body weight increased in children	Labeling	B	-	-	-	Parke-Davis	2/2/2000	FALSE'
MESH:D007889	08/21/2013	lysteda	tranexamic acid	Treatment of cyclic heavy menstrual bleeding	Indicated for women of reproductive age. It is not intended for use in premenarcheal girls Information on PK studyPostmarketing study	-	P	-	-	Ferring	-	FALSE'	-

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