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Pediatric Disease Annotations & Medicines



   lateral sclerosis
  

Disease ID 1406
Disease lateral sclerosis
Synonym
lateral scleroses
lateral scleroses, primary
lateral sclerosis, primary
prim lateral sclerosis
primary lateral scleroses
primary lateral sclerosis
primary lateral sclerosis (disorder)
scleroses, lateral
scleroses, primary lateral
sclerosis, lateral
sclerosis, primary lateral
sclerosis, primary, lateral
Orphanet
DOID
UMLS
C0154682
SNOMED-CT
Comorbidity
UMLS | Disease | Sentences' Count(Total Sentences:55)
C0497327  |  dementia  |  25
C0338451  |  frontotemporal dementia  |  16
C1145670  |  respiratory failure  |  8
C0085084  |  motor neuron disease  |  4
C0003635  |  apraxia  |  3
C0152025  |  polyneuropathy  |  3
C0011570  |  depression  |  3
C0270922  |  demyelinating polyneuropathy  |  3
C0011847  |  diabetes  |  2
C0035229  |  respiratory insufficiency  |  2
C0035258  |  restless legs syndrome  |  2
C0003467  |  anxiety  |  2
C0032285  |  pneumonia  |  2
C0035258  |  restless legs  |  2
C1136085  |  monoclonal gammopathy  |  2
C0026848  |  myopathy  |  1
C0027765  |  neurological disorders  |  1
C0007113  |  rectal cancer  |  1
C0037317  |  sleep disturbance  |  1
C0024419  |  macroglobulinemia  |  1
C0086543  |  cataract  |  1
C0018784  |  sensorineural deafness  |  1
C0271650  |  glucose intolerance  |  1
C0027765  |  neurological disorder  |  1
C0011127  |  pressure ulcers  |  1
C0018995  |  hemochromatosis  |  1
C0270922  |  demyelinating neuropathy  |  1
C0031347  |  pharyngeal cancer  |  1
C0037317  |  sleep disturbances  |  1
C0155550  |  neural deafness  |  1
C0017601  |  glaucoma  |  1
C1848954  |  generalized dystonia  |  1
C0271270  |  oculomotor apraxia  |  1
C0032290  |  aspiration pneumonia  |  1
C0022521  |  kartagener syndrome  |  1
C0153398  |  hypopharyngeal cancer  |  1
C0024115  |  lung disease  |  1
C0026896  |  myasthenia gravis  |  1
C0004943  |  behcet's disease  |  1
C0024419  |  waldenstrom macroglobulinemia  |  1
C0028754  |  obesity  |  1
C0024117  |  chronic obstructive lung disease  |  1
C0011849  |  diabetes mellitus  |  1
C0009402  |  colorectal cancer  |  1
C0007570  |  celiac disease  |  1
C0030805  |  bullous pemphigoid  |  1
C0004245  |  atrioventricular block  |  1
C0020459  |  hyperinsulinemia  |  1
C0679466  |  cognitive deficits  |  1
C0162429  |  malnutrition  |  1
C0026846  |  muscle atrophy  |  1
C0042075  |  urological disorders  |  1
C0159069  |  impaired glucose tolerance  |  1
C0600260  |  obstructive lung disease  |  1
C0032633  |  pompholyx  |  1
Curated Gene
Entrez_id | Symbol | Resource(Total Genes:1)
SPG7  |  6687  |  ORPHANET
Inferring Gene(Waiting for update.)
Text Mined Gene
Entrez_id | Symbol | Score | Resource(Total Genes:73)
6343  |  SCT  |  DISEASES
10857  |  PGRMC1  |  DISEASES
2936  |  GSR  |  DISEASES
9896  |  FIG4  |  DISEASES
5341  |  PLEK  |  DISEASES
23435  |  TARDBP  |  DISEASES
2521  |  FUS  |  DISEASES
2660  |  MSTN  |  DISEASES
4001  |  LMNB1  |  DISEASES
4854  |  NOTCH3  |  DISEASES
492  |  ATP2B3  |  DISEASES
57679  |  ALS2  |  DISEASES
2891  |  GRIA2  |  DISEASES
793  |  CALB1  |  DISEASES
3073  |  HEXA  |  DISEASES
6687  |  SPG7  |  DISEASES
6647  |  SOD1  |  DISEASES
5868  |  RAB5A  |  DISEASES
11160  |  ERLIN2  |  DISEASES
10280  |  SIGMAR1  |  DISEASES
23657  |  SLC7A11  |  DISEASES
925  |  CD8A  |  DISEASES
351  |  APP  |  DISEASES
152185  |  SPICE1  |  DISEASES
2819  |  GPD1  |  DISEASES
3708  |  ITPR1  |  DISEASES
8411  |  EEA1  |  DISEASES
53905  |  DUOX1  |  DISEASES
6683  |  SPAST  |  DISEASES
5663  |  PSEN1  |  DISEASES
6667  |  SP1  |  DISEASES
3842  |  TNPO1  |  DISEASES
283  |  ANG  |  DISEASES
5357  |  PLS1  |  DISEASES
6622  |  SNCA  |  DISEASES
93  |  ACVR2B  |  DISEASES
4137  |  MAPT  |  DISEASES
23394  |  ADNP  |  DISEASES
124454  |  EARS2  |  DISEASES
29978  |  UBQLN2  |  DISEASES
1785  |  DNM2  |  DISEASES
7415  |  VCP  |  DISEASES
2547  |  XRCC6  |  DISEASES
9361  |  LONP1  |  DISEASES
1639  |  DCTN1  |  DISEASES
4332  |  MNDA  |  DISEASES
26227  |  PHGDH  |  DISEASES
1268  |  CNR1  |  DISEASES
959  |  CD40LG  |  DISEASES
7417  |  VDAC2  |  DISEASES
1104  |  RCC1  |  DISEASES
3710  |  ITPR3  |  DISEASES
4593  |  MUSK  |  DISEASES
1471  |  CST3  |  DISEASES
2395  |  FXN  |  DISEASES
6311  |  ATXN2  |  DISEASES
203228  |  C9orf72  |  DISEASES
9751  |  SNPH  |  DISEASES
22908  |  SACM1L  |  DISEASES
7520  |  XRCC5  |  DISEASES
54664  |  TMEM106B  |  DISEASES
10747  |  MASP2  |  DISEASES
2130  |  EWSR1  |  DISEASES
54900  |  LAX1  |  DISEASES
116  |  ADCYAP1  |  DISEASES
9217  |  VAPB  |  DISEASES
1020  |  CDK5  |  DISEASES
6949  |  TCOF1  |  DISEASES
10687  |  PNMA2  |  DISEASES
4168  |  MCF2  |  DISEASES
4359  |  MPZ  |  DISEASES
3939  |  LDHA  |  DISEASES
8792  |  TNFRSF11A  |  DISEASES
Locus(Waiting for update.)
Disease ID 1406
Disease lateral sclerosis
Integrated Phenotype(Waiting for update.)
Text Mined Phenotype
HPO | Name | Sentences' Count(Total Phenotypes:68)
HP:0000726  |  Dementia  |  25
HP:0002145  |  Frontotemporal dementia  |  16
HP:0100543  |  Cognitive deficits  |  9
HP:0002878  |  Respiratory failure  |  8
HP:0002180  |  Neurodegeneration  |  7
HP:0002307  |  Sialorrhea  |  4
HP:0000716  |  Depression  |  3
HP:0002380  |  Muscle twitch  |  3
HP:0002015  |  Swallowing difficulty  |  3
HP:0012444  |  Brain wasting  |  3
HP:0002093  |  progressive respiratory failure  |  3
HP:0001271  |  Polyneuropathy  |  3
HP:0002186  |  Apraxia  |  3
HP:0045014  |  Hypolipidemia  |  2
HP:0000739  |  Anxiety  |  2
HP:0100315  |  Lewy bodies  |  2
HP:0003202  |  Neurogenic muscle atrophy, especially in the lower limbs  |  2
HP:0012452  |  Restless legs  |  2
HP:0001300  |  Parkinsonism  |  2
HP:0001605  |  Vocal cord paralysis  |  2
HP:0002090  |  Pneumonia  |  2
HP:0012820  |  Bilateral vocal cord paralysis  |  2
HP:0000833  |  Glucose intolerance  |  2
HP:0002366  |  Lower motor neuron disease  |  2
HP:0002835  |  Aspiration  |  2
HP:0012399  |  Bedsore  |  1
HP:0001678  |  Atrioventricular block  |  1
HP:0000819  |  Diabetes mellitus  |  1
HP:0004602  |  Fusion of cervical vertebrae c2-3  |  1
HP:0012531  |  Pain  |  1
HP:0006536  |  Obstructive lung disease  |  1
HP:0002446  |  Astrocytosis  |  1
HP:0005508  |  Waldenstrom macroglobulinemia  |  1
HP:0011951  |  Aspiration pneumonia  |  1
HP:0004395  |  Malnutrition  |  1
HP:0003473  |  Fatigable weakness  |  1
HP:0003198  |  Myopathic changes  |  1
HP:0002333  |  Progressive degeneration of movement  |  1
HP:0003690  |  Limb weakness  |  1
HP:0001513  |  Obesity  |  1
HP:0001278  |  Orthostatic hypotension  |  1
HP:0002344  |  Progressive neurologic deterioration  |  1
HP:0011098  |  Verbal dyspraxia  |  1
HP:0000708  |  Behavioral problems  |  1
HP:0001324  |  Muscular weakness  |  1
HP:0003287  |  Abnormality of mitochondrial metabolism  |  1
HP:0002608  |  Celiac disease  |  1
HP:0012735  |  Coughing  |  1
HP:0030637  |  Cone dysfunction  |  1
HP:0002493  |  Corticospinal tract dysfunction  |  1
HP:0002360  |  Sleep disturbance  |  1
HP:0000407  |  sensorineural hearing loss  |  1
HP:0002529  |  Neuronal loss in central nervous system  |  1
HP:0000518  |  Cataract  |  1
HP:0001260  |  Dysarthric speech  |  1
HP:0000842  |  Elevated insulin level  |  1
HP:0003401  |  Paresthesia  |  1
HP:0003394  |  Muscle cramps  |  1
HP:0000365  |  Hearing impairment  |  1
HP:0011675  |  Arrhythmias  |  1
HP:0002185  |  Paired helical filaments  |  1
HP:0007325  |  Generalized dystonia  |  1
HP:0002615  |  Low blood pressure  |  1
HP:0003470  |  Inability to move  |  1
HP:0000501  |  Glaucoma  |  1
HP:0000657  |  Oculomotor apraxia  |  1
HP:0001907  |  Thromboembolic disease  |  1
HP:0001257  |  Spasticity  |  1
Disease ID 1406
Disease lateral sclerosis
Manually Symptom(Waiting for update.)
Text Mined Symptom(Waiting for update.)
Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)
All Snps(Total Genotypes:0)
(Waiting for update.)
GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)
GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)
Mapped by lexical matching(Total Items:0)
(Waiting for update.)
Mapped by homologous gene(Total Items:0)
(Waiting for update.)
Chemical(Total Drugs:0)
(Waiting for update.)
FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)
FDA labeling changes(Total Drugs:0)
(Waiting for update.)