PedAM
Pediatric Disease Annotations & Medicines
| large cell carcinoma | ||||
| Disease ID | 799 |
|---|---|
| Disease | large cell carcinoma |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:6) HP:0030731 | Carcinoma | 3 HP:0030357 | Small cell lung carcinoma | 2 HP:0002860 | Squamous cell carcinoma | 2 HP:0001974 | Leukocytosis | 1 HP:0030358 | Non-small cell lung carcinoma | 1 HP:0002664 | Neoplasia | 1 |
| Disease ID | 799 |
|---|---|
| Disease | large cell carcinoma |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:2) |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:2) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs121434569 | 21635547 | 1956 | EGFR | umls:C0206704 | BeFree | We analyzed 147 NSCLC tissues [70 adenocarcinomas (AD), 62 squamous cell carcinomas (SQ), 12 large cell carcinomas (LC), and three adenosquamous carcinomas] that had not been exposed to the TKI therapies, and found 12 (8.2%; 12/147) EGFR T790M mutation in eight AD (11.4%), three SQ (4.8%), and one LC (8.3%) by the PNA-clamping PCR. | 0.004267125 | 2011 | EGFR;EGFR-AS1 | 7 | 55181378 | C | T |
| rs28934578 | 19287302 | 7157 | TP53 | umls:C0206704 | BeFree | The results demonstrate that the excision of incorporated nucleoside analogs in mitochondrial fractions of H1299 cells increased in the presence of purified recombinant p53, or cytoplasmic extracts of large cell carcinoma 2 cells expressing endogenous wild-type p53 (but not specifically predepleted extracts) or cytoplasmic extracts of H1299 cells overexpressing wild-type p53, but not exonuclease-deficient mutant p53-R175H. | 0.004895885 | 2009 | TP53 | 17 | 7675088 | C | T,A |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:7) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0206704 | adenosine triphosphate | D000255 | 56-65-5 | carcinoma, large cell | MESH:D018287 | therapeutic | 20156429 | ||
| C0206704 | cyclophosphamide | D003520 | 50-18-0 | carcinoma, large cell | MESH:D018287 | therapeutic | 6301671 | ||
| C0206704 | cisplatin | D002945 | 15663-27-1 | carcinoma, large cell | MESH:D018287 | therapeutic | 20156429 | ||
| C0206704 | gemcitabine | C056507 | 103882-84-4 | carcinoma, large cell | MESH:D018287 | therapeutic | 12796036 | ||
| C0206704 | ifosfamide | D007069 | 3778-73-2 | carcinoma, large cell | MESH:D018287 | therapeutic | 206339 | ||
| C0206704 | paclitaxel | D017239 | - | carcinoma, large cell | MESH:D018287 | therapeutic | 8643967 | ||
| C0206704 | vinorelbine | C030852 | 71486-22-1 | carcinoma, large cell | MESH:D018287 | therapeutic | 12796036 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |