PedAM

Pediatric Disease Annotations & Medicines


	lactic acidosis

Disease ID	1053
Disease	lactic acidosis
Definition	Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE.
Synonym	acidosis lactic acidosis, lactic acidosis, lactic [disease/finding] lactacidosis lactic acidosis (disorder) lacticacidosis
DOID	DOID:3650
UMLS	C0001125
MeSH	D000140
SNOMED-CT	SNOMEDCT_US_2016_09_01:91273001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:77) C0162666 \| mitochondrial encephalomyopathy \| 15 C0026848 \| myopathy \| 10 C0024299 \| lymphoma \| 9 C0023418 \| leukemia \| 5 C0011847 \| diabetes \| 5 C0035078 \| renal failure \| 5 C0079731 \| b-cell lymphoma \| 4 C0751651 \| mitochondrial disorder \| 3 C0023449 \| acute lymphoblastic leukemia \| 3 C0002871 \| anemia \| 3 C0026764 \| multiple myeloma \| 3 C0011860 \| type 2 diabetes \| 3 C0022660 \| acute renal failure \| 3 C0023448 \| lymphoblastic leukemia \| 3 C0022658 \| renal disease \| 2 C0004096 \| asthma \| 2 C0027051 \| myocardial infarction \| 2 C0162670 \| mitochondrial myopathy \| 2 C0376545 \| hematologic malignancies \| 2 C0020456 \| hyperglycemia \| 2 C0751651 \| mitochondrial disease \| 2 C0024623 \| gastric cancer \| 2 C0027051 \| myocardial infarct \| 2 C0007102 \| colon cancer \| 2 C0038218 \| acute severe asthma \| 2 C0011860 \| type 2 diabetes mellitus \| 2 C0085669 \| acute leukemia \| 2 C0011849 \| diabetes mellitus \| 2 C0011880 \| diabetic ketoacidosis \| 2 C0024530 \| malaria \| 2 C0079744 \| diffuse large b-cell lymphoma \| 2 C0019158 \| hepatitis \| 2 C0456909 \| vision loss \| 2 C0020598 \| hypoglycemia \| 2 C0022661 \| end-stage renal disease \| 2 C0035334 \| pigmentary retinopathy \| 1 C0001973 \| alcoholism \| 1 C0004352 \| autism \| 1 C0023890 \| cirrhosis \| 1 C0025958 \| microcephaly \| 1 C0002871 \| anaemia \| 1 C0040127 \| thyroid storm \| 1 C0023448 \| lymphocytic leukemia \| 1 C0162671 \| melas syndrome \| 1 C0018801 \| cardiac failure \| 1 C0036992 \| short bowel syndrome \| 1 C0376358 \| prostate cancer \| 1 C0030305 \| pancreatitis \| 1 C0043202 \| wolff-parkinson-white syndrome \| 1 C0018802 \| congestive heart failure \| 1 C0751651 \| mitochondrial disorders \| 1 C0040188 \| tic disorders \| 1 C0019196 \| hepatitis c \| 1 C0022661 \| chronic kidney disease \| 1 C0002896 \| sideroblastic anemia \| 1 C0001418 \| adenocarcinoma \| 1 C0024305 \| non-hodgkin's lymphoma \| 1 C0751651 \| mitochondrial diseases \| 1 C1145670 \| respiratory failure \| 1 C0342727 \| 3-methylglutaconic aciduria \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0040127 \| thyroid crisis \| 1 C0278701 \| gastric adenocarcinoma \| 1 C0221773 \| hyperamylasemia \| 1 C0035309 \| retinopathy \| 1 C0022658 \| kidney disease \| 1 C0878544 \| cardiomyopathy \| 1 C0268583 \| methylmalonic aciduria \| 1 C0039841 \| thiamine deficiency \| 1 C0018801 \| heart failure \| 1 C0004134 \| ataxia \| 1 C0022116 \| ischemia \| 1 C0019829 \| hodgkin's lymphoma \| 1 C0018799 \| cardiac disease \| 1 C0019829 \| hodgkins lymphoma \| 1 C0024305 \| non-hodgkins lymphoma \| 1 C0085436 \| cryptococcal meningitis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) PLAT \| 5327 \| CTD_human PDHA1 \| 5160 \| CTD_human RRM2B \| 50484 \| CTD_human DNM1L \| 10059 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 3586 \| IL10 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:457) 11183 \| MAP4K5 \| DISEASES 1355 \| COX15 \| DISEASES 5009 \| OTC \| DISEASES 3028 \| HSD17B10 \| DISEASES 6561 \| SLC13A1 \| DISEASES 5019 \| OXCT1 \| DISEASES 359 \| AQP2 \| DISEASES 28954 \| REM1 \| DISEASES 1738 \| DLD \| DISEASES 55644 \| OSGEP \| DISEASES 2940 \| GSTA3 \| DISEASES 6576 \| SLC25A1 \| DISEASES 50 \| ACO2 \| DISEASES 2287 \| FKBP3 \| DISEASES 2954 \| GSTZ1 \| DISEASES 5106 \| PCK2 \| DISEASES 2937 \| GSS \| DISEASES 5020 \| OXT \| DISEASES 479 \| ATP12A \| DISEASES 1723 \| DHODH \| DISEASES 343 \| AQP8 \| DISEASES 366 \| AQP9 \| DISEASES 2553 \| GABPB1 \| DISEASES 1666 \| DECR1 \| DISEASES 54332 \| GDAP1 \| DISEASES 4967 \| OGDH \| DISEASES 55131 \| RBM28 \| DISEASES 4899 \| NRF1 \| DISEASES 5026 \| P2RX5 \| DISEASES 40 \| ASIC2 \| DISEASES 8050 \| PDHX \| DISEASES 5250 \| SLC25A3 \| DISEASES 4256 \| MGP \| DISEASES 2597 \| GAPDH \| DISEASES 26235 \| FBXL4 \| DISEASES 4358 \| MPV17 \| DISEASES 374291 \| NDUFS7 \| DISEASES 6549 \| SLC9A2 \| DISEASES 9167 \| COX7A2L \| DISEASES 25806 \| VAX2 \| DISEASES 525 \| ATP6V1B1 \| DISEASES 7276 \| TTR \| DISEASES 8074 \| FGF23 \| DISEASES 35 \| ACADS \| DISEASES 514 \| ATP5E \| DISEASES 84693 \| MCEE \| DISEASES 54210 \| TREM1 \| DISEASES 6945 \| MLX \| DISEASES 65266 \| WNK4 \| DISEASES 2671 \| GFER \| DISEASES 3630 \| INS \| DISEASES 259232 \| NALCN \| DISEASES 50484 \| RRM2B \| DISEASES 1890 \| TYMP \| DISEASES 2056 \| EPO \| DISEASES 9997 \| SCO2 \| DISEASES 91574 \| C12orf65 \| DISEASES 9584 \| RBM39 \| DISEASES 47 \| ACLY \| DISEASES 2538 \| G6PC \| DISEASES 50617 \| ATP6V0A4 \| DISEASES 7014 \| TERF2 \| DISEASES 1401 \| CRP \| DISEASES 4622 \| MYH4 \| DISEASES 6341 \| SCO1 \| DISEASES 4608 \| MYBPH \| DISEASES 759 \| CA1 \| DISEASES 78986 \| DUSP26 \| DISEASES 271 \| AMPD2 \| DISEASES 54407 \| SLC38A2 \| DISEASES 10993 \| SDS \| DISEASES 50640 \| PNPLA8 \| DISEASES 10574 \| CCT7 \| DISEASES 80896 \| NPL \| DISEASES 80704 \| SLC19A3 \| DISEASES 1329 \| COX5B \| DISEASES 3569 \| IL6 \| DISEASES 3795 \| KHK \| DISEASES 10128 \| LRPPRC \| DISEASES 2660 \| MSTN \| DISEASES 9194 \| SLC16A7 \| DISEASES 57570 \| TRMT5 \| DISEASES 4069 \| LYZ \| DISEASES 11019 \| LIAS \| DISEASES 54902 \| TTC19 \| DISEASES 23531 \| MMD \| DISEASES 6521 \| SLC4A1 \| DISEASES 23417 \| MLYCD \| DISEASES 6558 \| SLC12A2 \| DISEASES 57017 \| COQ9 \| DISEASES 64377 \| CHST8 \| DISEASES 495 \| ATP4A \| DISEASES 25939 \| SAMHD1 \| DISEASES 8455 \| ATRN \| DISEASES 1 \| A1BG \| DISEASES 4858 \| NOVA2 \| DISEASES 4924 \| NUCB1 \| DISEASES 3553 \| IL1B \| DISEASES 23476 \| BRD4 \| DISEASES 28960 \| DCPS \| DISEASES 5775 \| PTPN4 \| DISEASES 23095 \| KIF1B \| DISEASES 6548 \| SLC9A1 \| DISEASES 1716 \| DGUOK \| DISEASES 3938 \| LCT \| DISEASES 8452 \| CUL3 \| DISEASES 3004 \| GZMM \| DISEASES 535 \| ATP6V0A1 \| DISEASES 5443 \| POMC \| DISEASES 10891 \| PPARGC1A \| DISEASES 10723 \| SLC12A7 \| DISEASES 10016 \| PDCD6 \| DISEASES 6550 \| SLC9A3 \| DISEASES 11222 \| MRPL3 \| DISEASES 3827 \| KNG1 \| DISEASES 6742 \| SSBP1 \| DISEASES 56302 \| TRPV5 \| DISEASES 55825 \| PECR \| DISEASES 793 \| CALB1 \| DISEASES 23395 \| LARS2 \| DISEASES 4885 \| NPTX2 \| DISEASES 5172 \| SLC26A4 \| DISEASES 38 \| ACAT1 \| DISEASES 5286 \| PIK3C2A \| DISEASES 6527 \| SLC5A4 \| DISEASES 6523 \| SLC5A1 \| DISEASES 8477 \| GPR65 \| DISEASES 90527 \| DUOXA1 \| DISEASES 91947 \| ARRDC4 \| DISEASES 51458 \| RHCG \| DISEASES 5428 \| POLG \| DISEASES 7385 \| UQCRC2 \| DISEASES 4716 \| NDUFB10 \| DISEASES 55244 \| SLC47A1 \| DISEASES 49860 \| CRNN \| DISEASES 3930 \| LBR \| DISEASES 5972 \| REN \| DISEASES 4726 \| NDUFS6 \| DISEASES 167410 \| LIX1 \| DISEASES 4594 \| MUT \| DISEASES 3484 \| IGFBP1 \| DISEASES 526 \| ATP6V1B2 \| DISEASES 196743 \| PAOX \| DISEASES 133 \| ADM \| DISEASES 64849 \| SLC13A3 \| DISEASES 161835 \| FSIP1 \| DISEASES 1737 \| DLAT \| DISEASES 80224 \| NUBPL \| DISEASES 83447 \| SLC25A31 \| DISEASES 166785 \| MMAA \| DISEASES 291 \| SLC25A4 \| DISEASES 5741 \| PTH \| DISEASES 23250 \| ATP11A \| DISEASES 3773 \| KCNJ16 \| DISEASES 4645 \| MYO5B \| DISEASES 10449 \| ACAA2 \| DISEASES 760 \| CA2 \| DISEASES 9056 \| SLC7A7 \| DISEASES 9337 \| CNOT8 \| DISEASES 2040 \| STOM \| DISEASES 9073 \| CLDN8 \| DISEASES 7381 \| UQCRB \| DISEASES 6750 \| SST \| DISEASES 3242 \| HPD \| DISEASES 55687 \| TRMU \| DISEASES 1636 \| ACE \| DISEASES 6285 \| S100B \| DISEASES 80308 \| FLAD1 \| DISEASES 114757 \| CYGB \| DISEASES 6006 \| RHCE \| DISEASES 91461 \| PKDCC \| DISEASES 84661 \| DPY30 \| DISEASES 5161 \| PDHA2 \| DISEASES 389015 \| SLC9A4 \| DISEASES 9497 \| SLC4A7 \| DISEASES 131474 \| CHCHD4 \| DISEASES 213 \| ALB \| DISEASES 7349 \| UCN \| DISEASES 84340 \| GFM2 \| DISEASES 4846 \| NOS3 \| DISEASES 9311 \| ASIC3 \| DISEASES 79789 \| CLMN \| DISEASES 6901 \| TAZ \| DISEASES 6553 \| SLC9A5 \| DISEASES 6340 \| SCNN1G \| DISEASES 90678 \| LRSAM1 \| DISEASES 51117 \| COQ4 \| DISEASES 762 \| CA4 \| DISEASES 10653 \| SPINT2 \| DISEASES 124935 \| SLC43A2 \| DISEASES 51293 \| CD320 \| DISEASES 27249 \| MMADHC \| DISEASES 3479 \| IGF1 \| DISEASES 3094 \| HINT1 \| DISEASES 5066 \| PAM \| DISEASES 2353 \| FOS \| DISEASES 686 \| BTD \| DISEASES 5162 \| PDHB \| DISEASES 54498 \| SMOX \| DISEASES 54205 \| CYCS \| DISEASES 2752 \| GLUL \| DISEASES 2147 \| F2 \| DISEASES 24146 \| CLDN15 \| DISEASES 115111 \| SLC26A7 \| DISEASES 763 \| CA5A \| DISEASES 1657 \| DMXL1 \| DISEASES 285590 \| SH3PXD2B \| DISEASES 9344 \| TAOK2 \| DISEASES 8884 \| SLC5A6 \| DISEASES 9390 \| SLC22A13 \| DISEASES 26512 \| INTS6 \| DISEASES 23209 \| MLC1 \| DISEASES 23479 \| ISCU \| DISEASES 27235 \| COQ2 \| DISEASES 836 \| CASP3 \| DISEASES 54931 \| TRMT10C \| DISEASES 26249 \| KLHL3 \| DISEASES 54968 \| TMEM70 \| DISEASES 28976 \| ACAD9 \| DISEASES 3952 \| LEP \| DISEASES 22877 \| MLXIP \| DISEASES 65125 \| WNK1 \| DISEASES 3184 \| HNRNPD \| DISEASES 10102 \| TSFM \| DISEASES 10294 \| DNAJA2 \| DISEASES 4728 \| NDUFS8 \| DISEASES 60386 \| SLC25A19 \| DISEASES 63951 \| DMRTA1 \| DISEASES 2828 \| GPR4 \| DISEASES 5105 \| PCK1 \| DISEASES 197322 \| ACSF3 \| DISEASES 51067 \| YARS2 \| DISEASES 6888 \| TALDO1 \| DISEASES 23539 \| SLC16A8 \| DISEASES 10229 \| COQ7 \| DISEASES 4723 \| NDUFV1 \| DISEASES 9202 \| ZMYM4 \| DISEASES 25915 \| NDUFAF3 \| DISEASES 57010 \| CABP4 \| DISEASES 3032 \| HADHB \| DISEASES 84987 \| COX14 \| DISEASES 788 \| SLC25A20 \| DISEASES 146802 \| SLC47A2 \| DISEASES 284439 \| SLC25A42 \| DISEASES 55432 \| YOD1 \| DISEASES 4843 \| NOS2 \| DISEASES 26276 \| VPS33B \| DISEASES 6524 \| SLC5A2 \| DISEASES 9735 \| KNTC1 \| DISEASES 51218 \| GLRX5 \| DISEASES 527 \| ATP6V0C \| DISEASES 7490 \| WT1 \| DISEASES 388962 \| BOLA3 \| DISEASES 796 \| CALCA \| DISEASES 64782 \| AEN \| DISEASES 30 \| ACAA1 \| DISEASES 55256 \| ADI1 \| DISEASES 51004 \| COQ6 \| DISEASES 2152 \| F3 \| DISEASES 27445 \| PCLO \| DISEASES 11261 \| CHP1 \| DISEASES 375318 \| AQP12A \| DISEASES 10011 \| SRA1 \| DISEASES 10147 \| SUGP2 \| DISEASES 554 \| AVPR2 \| DISEASES 3141 \| HLCS \| DISEASES 395 \| ARHGAP6 \| DISEASES 6575 \| SLC20A2 \| DISEASES 4306 \| NR3C2 \| DISEASES 1431 \| CS \| DISEASES 51601 \| LIPT1 \| DISEASES 124454 \| EARS2 \| DISEASES 92399 \| MRRF \| DISEASES 27068 \| PPA2 \| DISEASES 31 \| ACACA \| DISEASES 55972 \| SLC25A40 \| DISEASES 6338 \| SCNN1B \| DISEASES 1811 \| SLC26A3 \| DISEASES 6227 \| RPS21 \| DISEASES 223 \| ALDH9A1 \| DISEASES 55750 \| AGK \| DISEASES 27347 \| STK39 \| DISEASES 57835 \| SLC4A5 \| DISEASES 84705 \| GTPBP3 \| DISEASES 56980 \| PRDM10 \| DISEASES 617 \| BCS1L \| DISEASES 6261 \| RYR1 \| DISEASES 4151 \| MB \| DISEASES 27010 \| TPK1 \| DISEASES 5697 \| PYY \| DISEASES 6337 \| SCNN1A \| DISEASES 57091 \| CASS4 \| DISEASES 1803 \| DPP4 \| DISEASES 6238 \| RRBP1 \| DISEASES 4512 \| MT-CO1 \| DISEASES 4519 \| MT-CYB \| DISEASES 2475 \| MTOR \| DISEASES 4508 \| MT-ATP6 \| DISEASES 4541 \| MT-ND6 \| DISEASES 4535 \| MT-ND1 \| DISEASES 4539 \| MT-ND4L \| DISEASES 4540 \| MT-ND5 \| DISEASES 10724 \| MGEA5 \| DISEASES 4513 \| MT-CO2 \| DISEASES 4538 \| MT-ND4 \| DISEASES 23315 \| SLC9A8 \| DISEASES 4514 \| MT-CO3 \| DISEASES 4536 \| MT-ND2 \| DISEASES 55157 \| DARS2 \| DISEASES 779 \| CACNA1S \| DISEASES 4537 \| MT-ND3 \| DISEASES 4509 \| MT-ATP8 \| DISEASES 23038 \| WDTC1 \| DISEASES 4548 \| MTR \| DISEASES 200205 \| IBA57 \| DISEASES 28514 \| DLL1 \| DISEASES 6582 \| SLC22A2 \| DISEASES 84947 \| SERAC1 \| DISEASES 7432 \| VIP \| DISEASES 55005 \| RMND1 \| DISEASES 462 \| SERPINC1 \| DISEASES 55811 \| ADCY10 \| DISEASES 57127 \| RHBG \| DISEASES 632 \| BGLAP \| DISEASES 1892 \| ECHS1 \| DISEASES 1755 \| DMBT1 \| DISEASES 1520 \| CTSS \| DISEASES 57107 \| PDSS2 \| DISEASES 29078 \| NDUFAF4 \| DISEASES 26227 \| PHGDH \| DISEASES 57038 \| RARS2 \| DISEASES 29944 \| PNMA3 \| DISEASES 55788 \| LMBRD1 \| DISEASES 4952 \| OCRL \| DISEASES 4694 \| NDUFA1 \| DISEASES 1376 \| CPT2 \| DISEASES 6834 \| SURF1 \| DISEASES 10953 \| TOMM34 \| DISEASES 51021 \| MRPS16 \| DISEASES 4702 \| NDUFA8 \| DISEASES 84890 \| ADO \| DISEASES 9968 \| MED12 \| DISEASES 84676 \| TRIM63 \| DISEASES 3155 \| HMGCL \| DISEASES 229 \| ALDOB \| DISEASES 84909 \| C9orf3 \| DISEASES 2203 \| FBP1 \| DISEASES 8789 \| FBP2 \| DISEASES 7407 \| VARS \| DISEASES 1192 \| CLIC1 \| DISEASES 3055 \| HCK \| DISEASES 11330 \| CTRC \| DISEASES 81689 \| ISCA1 \| DISEASES 1184 \| CLCN5 \| DISEASES 23590 \| PDSS1 \| DISEASES 5095 \| PCCA \| DISEASES 80324 \| PUS1 \| DISEASES 1910 \| EDNRB \| DISEASES 9356 \| SLC22A6 \| DISEASES 390992 \| HES3 \| DISEASES 8514 \| KCNAB2 \| DISEASES 8573 \| CASK \| DISEASES 8803 \| SUCLA2 \| DISEASES 285440 \| CYP4V2 \| DISEASES 2710 \| GK \| DISEASES 1906 \| EDN1 \| DISEASES 90624 \| LYRM7 \| DISEASES 5160 \| PDHA1 \| DISEASES 551 \| AVP \| DISEASES 3030 \| HADHA \| DISEASES 265 \| AMELX \| DISEASES 6557 \| SLC12A1 \| DISEASES 3486 \| IGFBP3 \| DISEASES 51109 \| RDH11 \| DISEASES 293 \| SLC25A6 \| DISEASES 26278 \| SACS \| DISEASES 238 \| ALK \| DISEASES 29844 \| TFPT \| DISEASES 90135 \| BTBD6 \| DISEASES 3758 \| KCNJ1 \| DISEASES 8802 \| SUCLG1 \| DISEASES 5091 \| PC \| DISEASES 3886 \| KRT35 \| DISEASES 782 \| CACNB1 \| DISEASES 51520 \| LARS \| DISEASES 5530 \| PPP3CA \| DISEASES 130 \| ADH6 \| DISEASES 6696 \| SPP1 \| DISEASES 5744 \| PTHLH \| DISEASES 159963 \| SLC5A12 \| DISEASES 137682 \| NDUFAF6 \| DISEASES 54704 \| PDP1 \| DISEASES 272 \| AMPD3 \| DISEASES 64223 \| MLST8 \| DISEASES 79706 \| PRKRIP1 \| DISEASES 54826 \| GIN1 \| DISEASES 25974 \| MMACHC \| DISEASES 1994 \| ELAVL1 \| DISEASES 3033 \| HADH \| DISEASES 7018 \| TF \| DISEASES 210 \| ALAD \| DISEASES 27247 \| NFU1 \| DISEASES 10989 \| IMMT \| DISEASES 2641 \| GCG \| DISEASES 8907 \| AP1M1 \| DISEASES 126328 \| NDUFA11 \| DISEASES 132158 \| GLYCTK \| DISEASES 522 \| ATP5J \| DISEASES 3112 \| HLA-DOB \| DISEASES 9058 \| SLC13A2 \| DISEASES 4719 \| NDUFS1 \| DISEASES 57282 \| SLC4A10 \| DISEASES 8671 \| SLC4A4 \| DISEASES 279 \| AMY2A \| DISEASES 7124 \| TNF \| DISEASES 441581 \| FRG2B \| DISEASES 25821 \| MTO1 \| DISEASES 6559 \| SLC12A3 \| DISEASES 340205 \| TREML1 \| DISEASES 2821 \| GPI \| DISEASES 9498 \| SLC4A8 \| DISEASES 5830 \| PEX5 \| DISEASES 34 \| ACADM \| DISEASES 3586 \| IL10 \| DISEASES 91647 \| ATPAF2 \| DISEASES 3712 \| IVD \| DISEASES 5096 \| PCCB \| DISEASES 85476 \| GFM1 \| DISEASES 7019 \| TFAM \| DISEASES 8635 \| RNASET2 \| DISEASES 503542 \| SPRN \| DISEASES 8111 \| GPR68 \| DISEASES 83695 \| RHNO1 \| DISEASES 57176 \| VARS2 \| DISEASES 3939 \| LDHA \| DISEASES 8972 \| MGAM \| DISEASES 122961 \| ISCA2 \| DISEASES 567 \| B2M \| DISEASES 9692 \| KIAA0391 \| DISEASES 100131801 \| PET100 \| DISEASES 246734 \| NPCDR1 \| DISEASES 102723508 \| KANTR \| DISEASES 378938 \| MALAT1 \| DISEASES 104502417 \| MGAT3-AS1 \| DISEASES 114614 \| MIR155HG \| DISEASES 4555 \| MT-TD \| DISEASES 4556 \| MT-TE \| DISEASES 4564 \| MT-TH \| DISEASES 4565 \| MT-TI \| DISEASES 4566 \| MT-TK \| DISEASES 4567 \| MT-TL1 \| DISEASES 4568 \| MT-TL2 \| DISEASES 4569 \| MT-TM \| DISEASES 4570 \| MT-TN \| DISEASES 4574 \| MT-TS1 \| DISEASES 4578 \| MT-TW \| DISEASES 100126781 \| SNAR-F \| DISEASES
Locus	(Waiting for update.)

Disease ID	1053
Disease	lactic acidosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:82) HP:0001298 \| Encephalopathy \| 24 HP:0006789 \| Mitochondrial encephalopathy \| 20 HP:0001941 \| acidemia \| 14 HP:0001942 \| Metabolic acidosis \| 12 HP:0003198 \| Myopathic changes \| 10 HP:0002665 \| Lymphoma \| 9 HP:0001919 \| Acute renal failure \| 6 HP:0000083 \| Renal insufficiency \| 5 HP:0001297 \| Cerebral vascular events \| 4 HP:0012191 \| B-cell lymphoma \| 4 HP:0001909 \| Leukemia \| 4 HP:0001903 \| Anemia \| 4 HP:0100806 \| Sepsis \| 3 HP:0012531 \| Pain \| 3 HP:0100033 \| Tic disorder \| 3 HP:0002401 \| Strokelike episodes \| 3 HP:0006775 \| Multiple myeloma \| 3 HP:0001399 \| Liver failure \| 3 HP:0000819 \| Diabetes mellitus \| 2 HP:0006721 \| Acute lymphocytic leukemia \| 2 HP:0006554 \| Acute hepatic failure \| 2 HP:0012126 \| Gastric cancer \| 2 HP:0012653 \| Acute severe asthma \| 2 HP:0003003 \| Colon cancer \| 2 HP:0000572 \| Visual loss \| 2 HP:0002099 \| Asthma \| 2 HP:0001953 \| Diabetic ketosis \| 2 HP:0012115 \| Liver inflammation \| 2 HP:0003737 \| Mitochondrial myopathy \| 2 HP:0001250 \| Seizures \| 2 HP:0003774 \| End-stage renal failure \| 2 HP:0002488 \| Acute leukemias \| 2 HP:0001410 \| Decreased liver function \| 2 HP:0001943 \| Hypoglycemia \| 2 HP:0012072 \| Aciduria \| 2 HP:0001658 \| Myocardial infarction \| 2 HP:0003074 \| High blood glucose \| 2 HP:0012378 \| Fatigue \| 2 HP:0001635 \| Congestive heart failure \| 2 HP:0001892 \| Bleeding diathesis \| 1 HP:0001251 \| Ataxia \| 1 HP:0003756 \| Skeletal myopathy \| 1 HP:0002354 \| Memory loss \| 1 HP:0001397 \| Hepatic steatosis \| 1 HP:0002878 \| Respiratory failure \| 1 HP:0011782 \| Thyroid crisis \| 1 HP:0001270 \| Motor retardation \| 1 HP:0002063 \| Muscle rigidity \| 1 HP:0002153 \| Elevated serum potassium levels \| 1 HP:0002045 \| Abnormally low body temperature \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0000855 \| Insulin resistance \| 1 HP:0001324 \| Muscular weakness \| 1 HP:0003535 \| 3-Methylglutaconic aciduria \| 1 HP:0001716 \| Wolff-Parkinson-White syndrome \| 1 HP:0001394 \| Hepatic cirrhosis \| 1 HP:0012622 \| Chronic kidney disease \| 1 HP:0000717 \| Autism \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0002080 \| Intention tremor \| 1 HP:0001337 \| Tremor \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0012120 \| Methymalonicaciduria \| 1 HP:0003219 \| Ethylmalonic aciduria \| 1 HP:0007371 \| Atrophy/Degeneration of the corpus callosum \| 1 HP:0004448 \| Fulminant hepatic failure \| 1 HP:0002157 \| Azotaemia \| 1 HP:0002027 \| Abdominal pain \| 1 HP:0003326 \| Muscle pain \| 1 HP:0001263 \| Developmental retardation \| 1 HP:0001924 \| Hypersideremic anemia \| 1 HP:0006846 \| Acute encephalopathy \| 1 HP:0001962 \| Palpitations \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0000252 \| Small head circumference \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0002664 \| Neoplasia \| 1 HP:0100749 \| Thoracic pain \| 1 HP:0002615 \| Low blood pressure \| 1 HP:0000488 \| Noninflammatory retina disease \| 1 HP:0000580 \| Pigmentary retinopathy \| 1 HP:0012125 \| Prostate cancer \| 1

Disease ID	1053
Disease	lactic acidosis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:9) C0085584 \| encephalopathy \| 24 C0026764 \| multiple myeloma \| 3 C0022660 \| acute renal failure \| 3 C0085669 \| acute leukemia \| 2 C0162670 \| mitochondrial myopathy \| 2 C0221773 \| hyperamylasemia \| 1 C0040127 \| thyroid storm \| 1 C0748351 \| respiratory compensation \| 1 C0746869 \| neuromuscular weakness \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:13)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0001125	acetaminophen	D000082	103-90-2	acidosis, lactic	MESH:D000140	marker/mechanism	10447915
C0001125	clozapine	D003024	5786-21-0	acidosis, lactic	MESH:D000140	marker/mechanism	9034416
C0001125	creatine	D003401	57-00-1	acidosis, lactic	MESH:D000140	marker/mechanism	20223410
C0001125	fluorouracil	D005472	51-21-8	acidosis, lactic	MESH:D000140	marker/mechanism	9020500
C0001125	indinavir	D019469	150378-17-9	acidosis, lactic	MESH:D000140	marker/mechanism	16798620
C0001125	metformin	D008687	657-24-9	acidosis, lactic	MESH:D000140	marker/mechanism	10643227
C0001125	nevirapine	D019829	129618-40-2	acidosis, lactic	MESH:D000140	marker/mechanism	17279048
C0001125	ribavirin	D012254	36791-04-5	acidosis, lactic	MESH:D000140	marker/mechanism	11214134
C0001125	ritonavir	D019438	-	acidosis, lactic	MESH:D000140	marker/mechanism	9786823
C0001125	tenofovir	D000068698	-	acidosis, lactic	MESH:D000140	marker/mechanism	16176639
C0001125	valproic acid	D014635	99-66-1	acidosis, lactic	MESH:D000140	marker/mechanism	3922731
C0001125	vancomycin	D014640	1404-90-6	acidosis, lactic	MESH:D000140	marker/mechanism	11356440
C0001125	zidovudine	D015215	30516-87-1	acidosis, lactic	MESH:D000140	marker/mechanism	10219365

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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