PedAM

Pediatric Disease Annotations & Medicines


	keratitis

Disease ID	319
Disease	keratitis
Definition	Inflammation of the cornea.
Synonym	corneal inflammation corneal keratitis inflammation corneal keratitides keratitis (disorder) keratitis [disease/finding] keratitis nos keratitis nos (disorder) keratitis, nos unspecified keratitis
DOID	DOID:4677
ICD10	ICD10CM:H16.9
UMLS	C0022568
MeSH	D007634
SNOMED-CT	SNOMEDCT_US_2016_09_01:5888003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:83) C0456909 \| blindness \| 14 C0010043 \| corneal ulcer \| 12 C0014236 \| endophthalmitis \| 8 C0042164 \| uveitis \| 6 C0003873 \| rheumatoid arthritis \| 6 C0152226 \| lagophthalmos \| 5 C0010043 \| corneal ulceration \| 5 C0042165 \| anterior uveitis \| 4 C0026946 \| fungal infection \| 4 C0007137 \| squamous cell carcinoma \| 4 C0456909 \| vision loss \| 4 C0019348 \| herpes simplex \| 4 C0019360 \| zoster \| 3 C0314719 \| dry eye \| 3 C0085109 \| corneal neovascularization \| 3 C0019360 \| herpes zoster \| 3 C0026946 \| fungal infections \| 3 C0043092 \| wegener's granulomatosis \| 3 C0006840 \| candidiasis \| 2 C0153131 \| syphilitic interstitial keratitis \| 2 C0022081 \| iritis \| 2 C0019364 \| herpes zoster ophthalmicus \| 2 C0004623 \| bacterial infection \| 2 C0010036 \| corneal dystrophy \| 2 C0086543 \| cataract \| 2 C0022573 \| keratoconjunctivitis \| 2 C0042769 \| viral infection \| 2 C0010037 \| corneal edema \| 1 C0019364 \| zoster ophthalmicus \| 1 C0010346 \| crohn disease \| 1 C0001175 \| acquired immune deficiency \| 1 C0022575 \| keratoconjunctivitis sicca \| 1 C0004943 \| behcet's disease \| 1 C0026764 \| multiple myeloma \| 1 C0001175 \| acquired immune deficiency syndrome (aids) \| 1 C0022073 \| iridocyclitis \| 1 C0042373 \| vascular disease \| 1 C0031350 \| pharyngitis \| 1 C0042373 \| vascular diseases \| 1 C0038325 \| stevens-johnson syndrome \| 1 C0042384 \| vasculitis \| 1 C0085109 \| corneal vascularization \| 1 C0004623 \| bacterial infections \| 1 C0276758 \| fusarium infection \| 1 C0034212 \| pyoderma \| 1 C0035854 \| rosacea \| 1 C0020490 \| hyperopia \| 1 C0040188 \| tic disorders \| 1 C0497327 \| dementia \| 1 C0271270 \| cogan syndrome \| 1 C0343068 \| familial cold autoinflammatory syndrome \| 1 C0026946 \| mycoses \| 1 C0037274 \| dermatosis \| 1 C1527336 \| sjogren's syndrome \| 1 C1510471 \| hypovitaminosis \| 1 C0018179 \| granular corneal dystrophy \| 1 C0268483 \| tyrosinemia \| 1 C0085652 \| pyoderma gangrenosum \| 1 C0010346 \| crohn's disease \| 1 C0021831 \| intestinal disease \| 1 C0553662 \| juvenile idiopathic arthritis \| 1 C0009763 \| conjunctivitis \| 1 C0027947 \| neutropenia \| 1 C0553662 \| juvenile rheumatoid arthritis \| 1 C0024440 \| cystoid macular edema \| 1 C0701807 \| acute anterior uveitis \| 1 C0003864 \| arthritis \| 1 C0021390 \| inflammatory bowel disease \| 1 C0021053 \| immune disease \| 1 C0271051 \| macular edema \| 1 C0043092 \| wegener granulomatosis \| 1 C0235270 \| keratopathy \| 1 C0010034 \| corneal disease \| 1 C0085435 \| reactive arthritis \| 1 C0009806 \| constipation \| 1 C0013592 \| ectropion \| 1 C0155111 \| bullous keratopathy \| 1 C0001175 \| acquired immune deficiency syndrome \| 1 C0262428 \| collagen vascular disease \| 1 C0021831 \| bowel disease \| 1 C0036689 \| streptococcal pharyngitis \| 1 C0017178 \| gastrointestinal disease \| 1 C0017601 \| glaucoma \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) TLR2 \| 7097 \| CTD_human GJB2 \| 2706 \| CTD_human CXCL8 \| 3576 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:320) 6542 \| SLC7A2 \| DISEASES 8993 \| PGLYRP1 \| DISEASES 1634 \| DCN \| DISEASES 9423 \| NTN1 \| DISEASES 27248 \| ERLEC1 \| DISEASES 8550 \| MAPKAPK5 \| DISEASES 1947 \| EFNB1 \| DISEASES 27252 \| KLHL20 \| DISEASES 1943 \| EFNA2 \| DISEASES 4616 \| GADD45B \| DISEASES 4282 \| MIF \| DISEASES 158 \| ADSL \| DISEASES 7076 \| TIMP1 \| DISEASES 4313 \| MMP2 \| DISEASES 8767 \| RIPK2 \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 3082 \| HGF \| DISEASES 10392 \| NOD1 \| DISEASES 6348 \| CCL3 \| DISEASES 4353 \| MPO \| DISEASES 6347 \| CCL2 \| DISEASES 3558 \| IL2 \| DISEASES 81622 \| UNC93B1 \| DISEASES 969 \| CD69 \| DISEASES 3458 \| IFNG \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 3554 \| IL1R1 \| DISEASES 25806 \| VAX2 \| DISEASES 4317 \| MMP8 \| DISEASES 9429 \| ABCG2 \| DISEASES 10804 \| GJB6 \| DISEASES 1271 \| CNTFR \| DISEASES 84329 \| HVCN1 \| DISEASES 54210 \| TREM1 \| DISEASES 55831 \| EMC3 \| DISEASES 1948 \| EFNB2 \| DISEASES 8744 \| TNFSF9 \| DISEASES 718 \| C3 \| DISEASES 5199 \| CFP \| DISEASES 391013 \| PLA2G2C \| DISEASES 968 \| CD68 \| DISEASES 6351 \| CCL4 \| DISEASES 11046 \| SLC35D2 \| DISEASES 3866 \| KRT15 \| DISEASES 5176 \| SERPINF1 \| DISEASES 10894 \| LYVE1 \| DISEASES 55226 \| NAT10 \| DISEASES 90070 \| LACRT \| DISEASES 80326 \| WNT10A \| DISEASES 3569 \| IL6 \| DISEASES 80774 \| LIMD2 \| DISEASES 7097 \| TLR2 \| DISEASES 4322 \| MMP13 \| DISEASES 7057 \| THBS1 \| DISEASES 5330 \| PLCB2 \| DISEASES 4069 \| LYZ \| DISEASES 5629 \| PROX1 \| DISEASES 55813 \| UTP6 \| DISEASES 4756 \| NEO1 \| DISEASES 8482 \| SEMA7A \| DISEASES 2324 \| FLT4 \| DISEASES 4969 \| OGN \| DISEASES 898 \| CCNE1 \| DISEASES 7077 \| TIMP2 \| DISEASES 10156 \| RASA4 \| DISEASES 5595 \| MAPK3 \| DISEASES 10133 \| OPTN \| DISEASES 3682 \| ITGAE \| DISEASES 1265 \| CNN2 \| DISEASES 7290 \| HIRA \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 3977 \| LIFR \| DISEASES 3933 \| LCN1 \| DISEASES 3791 \| KDR \| DISEASES 51191 \| HERC5 \| DISEASES 2247 \| FGF2 \| DISEASES 80725 \| SRCIN1 \| DISEASES 8626 \| TP63 \| DISEASES 3383 \| ICAM1 \| DISEASES 1950 \| EGF \| DISEASES 9061 \| PAPSS1 \| DISEASES 1998 \| ELF2 \| DISEASES 25793 \| FBXO7 \| DISEASES 4060 \| LUM \| DISEASES 11081 \| KERA \| DISEASES 6252 \| RTN1 \| DISEASES 122953 \| JDP2 \| DISEASES 2252 \| FGF7 \| DISEASES 3687 \| ITGAX \| DISEASES 207 \| AKT1 \| DISEASES 10699 \| CORIN \| DISEASES 10769 \| PLK2 \| DISEASES 90523 \| MLIP \| DISEASES 2041 \| EPHA1 \| DISEASES 3439 \| IFNA1 \| DISEASES 6291 \| SAA4 \| DISEASES 4319 \| MMP10 \| DISEASES 7424 \| VEGFC \| DISEASES 3606 \| IL18 \| DISEASES 5281 \| PIGF \| DISEASES 6695 \| SPOCK1 \| DISEASES 2321 \| FLT1 \| DISEASES 2697 \| GJA1 \| DISEASES 89780 \| WNT3A \| DISEASES 23643 \| LY96 \| DISEASES 9510 \| ADAMTS1 \| DISEASES 9337 \| CNOT8 \| DISEASES 9246 \| UBE2L6 \| DISEASES 4643 \| MYO1E \| DISEASES 114771 \| PGLYRP3 \| DISEASES 1409 \| CRYAA \| DISEASES 5822 \| PWP2 \| DISEASES 326 \| AIRE \| DISEASES 6271 \| S100A1 \| DISEASES 729230 \| CCR2 \| DISEASES 1234 \| CCR5 \| DISEASES 375033 \| PEAR1 \| DISEASES 6352 \| CCL5 \| DISEASES 10630 \| PDPN \| DISEASES 7412 \| VCAM1 \| DISEASES 10461 \| MERTK \| DISEASES 213 \| ALB \| DISEASES 1230 \| CCR1 \| DISEASES 55764 \| IFT122 \| DISEASES 308 \| ANXA5 \| DISEASES 7098 \| TLR3 \| DISEASES 1437 \| CSF2 \| DISEASES 116842 \| LEAP2 \| DISEASES 1672 \| DEFB1 \| DISEASES 84889 \| SLC7A3 \| DISEASES 84659 \| RNASE7 \| DISEASES 5896 \| RAG1 \| DISEASES 4314 \| MMP3 \| DISEASES 124872 \| B4GALNT2 \| DISEASES 55872 \| PBK \| DISEASES 81603 \| TRIM8 \| DISEASES 6356 \| CCL11 \| DISEASES 64581 \| CLEC7A \| DISEASES 3308 \| HSPA4 \| DISEASES 55699 \| IARS2 \| DISEASES 6869 \| TACR1 \| DISEASES 1673 \| DEFB4A \| DISEASES 3667 \| IRS1 \| DISEASES 54538 \| ROBO4 \| DISEASES 3627 \| CXCL10 \| DISEASES 1469 \| CST1 \| DISEASES 56246 \| MRAP \| DISEASES 54498 \| SMOX \| DISEASES 4323 \| MMP14 \| DISEASES 5340 \| PLG \| DISEASES 29925 \| GMPPB \| DISEASES 4973 \| OLR1 \| DISEASES 947 \| CD34 \| DISEASES 8884 \| SLC5A6 \| DISEASES 2001 \| ELF5 \| DISEASES 836 \| CASP3 \| DISEASES 7423 \| VEGFB \| DISEASES 1474 \| CST6 \| DISEASES 112 \| ADCY6 \| DISEASES 1240 \| CMKLR1 \| DISEASES 5431 \| POLR2B \| DISEASES 285 \| ANGPT2 \| DISEASES 3291 \| HSD11B2 \| DISEASES 3579 \| CXCR2 \| DISEASES 23765 \| IL17RA \| DISEASES 414325 \| DEFB103A \| DISEASES 6863 \| TAC1 \| DISEASES 9806 \| SPOCK2 \| DISEASES 56975 \| FAM20C \| DISEASES 3039 \| HBA1 \| DISEASES 4312 \| MMP1 \| DISEASES 55894 \| DEFB103B \| DISEASES 29946 \| SERTAD3 \| DISEASES 81857 \| MED25 \| DISEASES 2318 \| FLNC \| DISEASES 4843 \| NOS2 \| DISEASES 286753 \| TUSC5 \| DISEASES 6401 \| SELE \| DISEASES 90249 \| UNC5A \| DISEASES 7318 \| UBA7 \| DISEASES 59307 \| SIGIRR \| DISEASES 219699 \| UNC5B \| DISEASES 283 \| ANG \| DISEASES 114548 \| NLRP3 \| DISEASES 200162 \| SPAG17 \| DISEASES 3932 \| LCK \| DISEASES 3983 \| ABLIM1 \| DISEASES 3329 \| HSPD1 \| DISEASES 7100 \| TLR5 \| DISEASES 2709 \| GJB5 \| DISEASES 59277 \| NTN4 \| DISEASES 5275 \| SERPINB13 \| DISEASES 6590 \| SLPI \| DISEASES 3146 \| HMGB1 \| DISEASES 388228 \| SBK1 \| DISEASES 3605 \| IL17A \| DISEASES 1499 \| CTNNB1 \| DISEASES 56704 \| JPH1 \| DISEASES 6284 \| S100A13 \| DISEASES 127534 \| GJB4 \| DISEASES 114770 \| PGLYRP2 \| DISEASES 1413 \| CRYBA4 \| DISEASES 2331 \| FMOD \| DISEASES 80781 \| COL18A1 \| DISEASES 8764 \| TNFRSF14 \| DISEASES 170622 \| COMMD6 \| DISEASES 5265 \| SERPINA1 \| DISEASES 6898 \| TAT \| DISEASES 23646 \| PLD3 \| DISEASES 6714 \| SRC \| DISEASES 1524 \| CX3CR1 \| DISEASES 6364 \| CCL20 \| DISEASES 57115 \| PGLYRP4 \| DISEASES 1999 \| ELF3 \| DISEASES 4641 \| MYO1C \| DISEASES 5599 \| MAPK8 \| DISEASES 8828 \| NRP2 \| DISEASES 54106 \| TLR9 \| DISEASES 4283 \| CXCL9 \| DISEASES 7096 \| TLR1 \| DISEASES 3880 \| KRT19 \| DISEASES 7058 \| THBS2 \| DISEASES 7432 \| VIP \| DISEASES 5788 \| PTPRC \| DISEASES 1660 \| DHX9 \| DISEASES 51534 \| VTA1 \| DISEASES 356 \| FASLG \| DISEASES 1805 \| DPT \| DISEASES 6375 \| XCL1 \| DISEASES 26002 \| MOXD1 \| DISEASES 6283 \| S100A12 \| DISEASES 202 \| AIM1 \| DISEASES 11023 \| VAX1 \| DISEASES 8732 \| RNGTT \| DISEASES 4803 \| NGF \| DISEASES 2316 \| FLNA \| DISEASES 2258 \| FGF13 \| DISEASES 959 \| CD40LG \| DISEASES 1791 \| DNTT \| DISEASES 79576 \| NKAP \| DISEASES 8813 \| DPM1 \| DISEASES 1580 \| CYP4B1 \| DISEASES 7422 \| VEGFA \| DISEASES 4318 \| MMP9 \| DISEASES 5328 \| PLAU \| DISEASES 23234 \| DNAJC9 \| DISEASES 57158 \| JPH2 \| DISEASES 2707 \| GJB3 \| DISEASES 23452 \| ANGPTL2 \| DISEASES 2833 \| CXCR3 \| DISEASES 7099 \| TLR4 \| DISEASES 9966 \| TNFSF15 \| DISEASES 3339 \| HSPG2 \| DISEASES 6850 \| SYK \| DISEASES 50943 \| FOXP3 \| DISEASES 3105 \| HLA-A \| DISEASES 10218 \| ANGPTL7 \| DISEASES 5080 \| PAX6 \| DISEASES 6303 \| SAT1 \| DISEASES 51360 \| MBTPS2 \| DISEASES 3559 \| IL2RA \| DISEASES 7010 \| TEK \| DISEASES 3440 \| IFNA2 \| DISEASES 3456 \| IFNB1 \| DISEASES 7114 \| TMSB4X \| DISEASES 2706 \| GJB2 \| DISEASES 9244 \| CRLF1 \| DISEASES 9560 \| CCL4L2 \| DISEASES 4145 \| MATK \| DISEASES 3965 \| LGALS9 \| DISEASES 2919 \| CXCL1 \| DISEASES 6387 \| CXCL12 \| DISEASES 2737 \| GLI3 \| DISEASES 3652 \| IPP \| DISEASES 7325 \| UBE2E2 \| DISEASES 2047 \| EPHB1 \| DISEASES 594857 \| NPS \| DISEASES 81035 \| COLEC12 \| DISEASES 8091 \| HMGA2 \| DISEASES 137970 \| UNC5D \| DISEASES 9873 \| FCHSD2 \| DISEASES 7852 \| CXCR4 \| DISEASES 55657 \| ZNF692 \| DISEASES 2664 \| GDI1 \| DISEASES 3447 \| IFNA13 \| DISEASES 3550 \| IK \| DISEASES 7124 \| TNF \| DISEASES 5795 \| PTPRJ \| DISEASES 4615 \| MYD88 \| DISEASES 9278 \| ZBTB22 \| DISEASES 388372 \| CCL4L1 \| DISEASES 139728 \| PNCK \| DISEASES 81704 \| DOCK8 \| DISEASES 3586 \| IL10 \| DISEASES 3850 \| KRT3 \| DISEASES 7045 \| TGFBI \| DISEASES 23429 \| RYBP \| DISEASES 23065 \| EMC1 \| DISEASES 5542 \| PRB1 \| DISEASES 9353 \| SLIT2 \| DISEASES 100289462 \| DEFB4B \| DISEASES 2920 \| CXCL2 \| DISEASES 284 \| ANGPT1 \| DISEASES 6586 \| SLIT3 \| DISEASES 4586 \| MUC5AC \| DISEASES 1232 \| CCR3 \| DISEASES 3684 \| ITGAM \| DISEASES 1961 \| EGR4 \| DISEASES 3851 \| KRT4 \| DISEASES 7786 \| MAP3K12 \| DISEASES 5228 \| PGF \| DISEASES 27229 \| TUBGCP4 \| DISEASES 820 \| CAMP \| DISEASES 11201 \| POLI \| DISEASES 104355217 \| ERICD \| DISEASES 196475 \| RMST \| DISEASES 677833 \| SNORA54 \| DISEASES
Locus	(Waiting for update.)

Disease ID	319
Disease	keratitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:55) HP:0000618 \| Blindness \| 14 HP:0012804 \| Corneal ulceration \| 12 HP:0001370 \| Rheumatoid arthritis \| 6 HP:0000572 \| Visual loss \| 5 HP:0000554 \| Uveitis \| 5 HP:0100583 \| Corneal perforation \| 5 HP:0100699 \| Scarring \| 5 HP:0011496 \| Corneal vascularization \| 4 HP:0012122 \| Anterior uveitis \| 4 HP:0007957 \| Corneal clouding \| 4 HP:0002860 \| Squamous cell carcinoma \| 4 HP:0012531 \| Pain \| 4 HP:0000559 \| Corneal scarring \| 3 HP:0000613 \| Extreme light sensitivity \| 2 HP:0005681 \| Juvenile idiopathic arthritis \| 2 HP:0001096 \| Keratoconjunctivitis \| 2 HP:0030731 \| Carcinoma \| 2 HP:0002955 \| Granulomatosis \| 2 HP:0001131 \| Corneal dystrophy \| 2 HP:0001101 \| Iritis \| 2 HP:0000518 \| Cataract \| 2 HP:0012155 \| Reduced corneal sensation \| 1 HP:0012375 \| Chemosis \| 1 HP:0006775 \| Multiple myeloma \| 1 HP:0000726 \| Dementia \| 1 HP:0000656 \| Ectropion \| 1 HP:0001094 \| Iridocyclitis \| 1 HP:0007663 \| Central visual loss \| 1 HP:0001945 \| Fever \| 1 HP:0000509 \| Conjunctivitis \| 1 HP:0001097 \| Keratoconjunctivitis sicca \| 1 HP:0000969 \| Dropsy \| 1 HP:0000505 \| Poor vision \| 1 HP:0000568 \| Abnormally small globe of eye \| 1 HP:0003764 \| Naevus \| 1 HP:0011487 \| Increased corneal thickness \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0100033 \| Tic disorder \| 1 HP:0000999 \| Pyoderma \| 1 HP:0040049 \| Macular edema \| 1 HP:0002321 \| Vertigo \| 1 HP:0002633 \| Vasculitis \| 1 HP:0000540 \| Hypermetropia \| 1 HP:0003474 \| Sensory impairment \| 1 HP:0001059 \| Pterygium \| 1 HP:0007802 \| Granular corneal dystrophy \| 1 HP:0004905 \| Vitamin A deficiency \| 1 HP:0003231 \| Increased tyrosine in blood \| 1 HP:0002019 \| Dyschezia \| 1 HP:0001369 \| Arthritis \| 1 HP:0011505 \| Cystoid macular edema \| 1 HP:0000360 \| Ringing in the ears \| 1 HP:0001824 \| Weight loss \| 1 HP:0001875 \| Neutropenia \| 1 HP:0100280 \| Morbus Crohn \| 1

Disease ID	319
Disease	keratitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:4) C0870082 \| hyperkeratosis C0042769 \| viral infections C0022596 \| palmoplantar keratosis C0010034 \| corneal disease
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0010034 \| corneal disease \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs28931594	23924173	2706	GJB2	umls:C0022568	BeFree	Heterozygous p.Asp50Asn mutation in the GJB2 gene in two Cameroonian patients with keratitis-ichthyosis-deafness (KID) syndrome.	0.124885954	2013	GJB2	13	20189434	C	T,A
rs72561723	18024254	2706	GJB2	umls:C0022568	BeFree	A familial case of Keratitis-Ichthyosis-Deafness (KID) syndrome with the GJB2 mutation G45E.	0.124885954	2008	GJB2	13	20189448	C	T
rs72561723	23756814	2706	GJB2	umls:C0022568	BeFree	Substitution of glycine at the position 45 of Cx26 to glutamic acid (p.G45E mutation) causes the Keratitis-ichthyosis-deafness (KID) syndrome.	0.124885954	2013	GJB2	13	20189448	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:5)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0022568	chloroquine	D002738	1954/5/7	keratitis	MESH:D007634	marker/mechanism	5297866
C0022568	fluorouracil	D005472	51-21-8	keratitis	MESH:D007634	marker/mechanism	12918558
C0022568	indomethacin	D007213	53-86-1	keratitis	MESH:D007634	marker/mechanism	24598350
C0022568	liposomal amphotericin b	C068538	-	keratitis	MESH:D007634	therapeutic	19320385
C0022568	timolol	D013999	26839-75-8	keratitis	MESH:D007634	marker/mechanism	6125102

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

Web
Analytics