PedAM

Pediatric Disease Annotations & Medicines


	juvenile idiopathic arthritis

Disease ID	352
Disease	juvenile idiopathic arthritis
Definition	Arthritis in children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic arthritis (JIA) refer to classification systems for chronic arthritis in children. Only one subtype of juvenile arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.
Synonym	arthritis, juvenile arthritis, juvenile [disease/finding] arthritis, juvenile chronic arthritis, juvenile idiopathic arthritis, juvenile rheumatoid arthritis, juvenile systemic chronic arthritis, juvenile idiopathic arthritis, juvenile idiopathic juvenile arthritis jca - juvenile chronic arthritis jia juvenile arthritis juvenile chronic arthritis juvenile chronic arthritis (disorder) juvenile idiopathic arthritis (disorder) juvenile oligoarthritis juvenile rheumatoid arthritis juvenile systemic arthritis oligoarthritis, juvenile rheumatoid arthritis, juvenile systemic arthritis, juvenile
Orphanet	ORPHANET:92
DOID	DOID:676
UMLS	C3495559
MeSH	D001171
SNOMED-CT	SNOMEDCT_US_2016_09_01:239796000;SNOMEDCT_US_2016_09_01:410502007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:69) C0042164 \| uveitis \| 42 C0003864 \| arthritis \| 16 C0042165 \| anterior uveitis \| 9 C0039103 \| synovitis \| 6 C0029456 \| osteoporosis \| 3 C0017601 \| glaucoma \| 2 C0221026 \| x-linked agammaglobulinemia \| 2 C0086543 \| cataract \| 2 C0010346 \| crohn's disease \| 2 C0024299 \| lymphoma \| 2 C0002726 \| amyloidosis \| 2 C0001768 \| agammaglobulinemia \| 2 C0039520 \| tenosynovitis \| 2 C0003864 \| joint inflammation \| 2 C0004153 \| atherosclerosis \| 2 C0271051 \| macular edema \| 2 C0021053 \| immune disease \| 2 C0011847 \| diabetes \| 2 C0019360 \| herpes zoster \| 1 C0014527 \| epidermolysis bullosa \| 1 C0022073 \| iridocyclitis \| 1 C0024302 \| large cell lymphoma \| 1 C0021400 \| influenza \| 1 C0039494 \| temporomandibular disorder \| 1 C0011854 \| type 1 diabetes mellitus \| 1 C0018802 \| congestive heart failure \| 1 C0023895 \| liver disease \| 1 C0002871 \| anemia \| 1 C0028754 \| obesity \| 1 C0021390 \| inflammatory bowel disease \| 1 C0022568 \| keratitis \| 1 C0023418 \| leukemia \| 1 C0031069 \| familial mediterranean fever \| 1 C0024115 \| lung disease \| 1 C0019114 \| hemosiderosis \| 1 C0339143 \| thyroid-associated ophthalmopathy \| 1 C0040147 \| thyroiditis \| 1 C0029134 \| optic neuritis \| 1 C0042769 \| virus infection \| 1 C0018213 \| graves' disease \| 1 C0004623 \| bacterial infection \| 1 C0042166 \| intermediate uveitis \| 1 C0085435 \| reactive arthritis \| 1 C0206180 \| anaplastic large cell lymphoma \| 1 C0027813 \| neuritis \| 1 C0021831 \| bowel disease \| 1 C0086543 \| cataracts \| 1 C0018801 \| heart failure \| 1 C0024440 \| cystoid macular edema \| 1 C0019360 \| zoster \| 1 C0035305 \| retinal detachment \| 1 C0005940 \| bone disease \| 1 C0020807 \| pulmonary hemosiderosis \| 1 C0011849 \| diabetes mellitus \| 1 C0011633 \| dermatomyositis \| 1 C0006444 \| bursitis \| 1 C0041296 \| tuberculosis \| 1 C0011603 \| dermatitis \| 1 C0263666 \| juvenile dermatomyositis \| 1 C0027092 \| myopia \| 1 C0026703 \| mucopolysaccharidosis \| 1 C0949690 \| spondyloarthritis \| 1 C0040149 \| subacute thyroiditis \| 1 C0011854 \| type 1 diabetes \| 1 C0003467 \| anxiety \| 1 C0002895 \| sickle cell disease \| 1 C0033860 \| psoriasis \| 1 C0003090 \| ankylosis \| 1 C0028432 \| nasal disease \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:143) HLA-DRB1 \| 3123 \| GHR PLK2 \| 10769 \| CTD_human TNF \| 7124 \| GHR IL6 \| 3569 \| GHR SH3BGRL2 \| 83699 \| CTD_human HLA-DQA1 \| 3117 \| GHR C8B \| 732 \| CTD_human FAM20A \| 54757 \| CTD_human CTLA4 \| 1493 \| CTD_human STAT3 \| 6774 \| CTD_human SMAD3 \| 4088 \| CTD_human RERE \| 473 \| CTD_human WISP3 \| 8838 \| GHR TNFAIP8 \| 25816 \| CTD_human C9orf72 \| 203228 \| CTD_human RHOBTB1 \| 9886 \| CTD_human JUN \| 3725 \| CTD_human TNFAIP3 \| 7128 \| GHR STAT4 \| 6775 \| GHR HLA-DPB1 \| 3115 \| GHR HLA-B \| 3106 \| GHR DUSP2 \| 1844 \| CTD_human DUSP1 \| 1843 \| CTD_human DUSP4 \| 1846 \| CTD_human SLC2A3 \| 6515 \| CTD_human ITGB5 \| 3693 \| CTD_human BEND2 \| 139105 \| CTD_human MSN \| 4478 \| CTD_human MEX3C \| 51320 \| CTD_human PTPN22 \| 26191 \| GHR IGF1R \| 3480 \| CTD_human HLA-DQB1 \| 3119 \| GHR TNIK \| 23043 \| CTD_human TFDP1 \| 7027 \| CTD_human NEAT1 \| 283131 \| CTD_human CMTM2 \| 146225 \| CTD_human FOXP1 \| 27086 \| CTD_human PROS1 \| 5627 \| CTD_human IL2RA \| 3559 \| GHR IL1RN \| 3557 \| CTD_human OLR1 \| 4973 \| CTD_human FOS \| 2353 \| CTD_human CTTN \| 2017 \| CTD_human TRAF1 \| 7185 \| GHR C9orf3 \| 84909 \| CTD_human PLOD2 \| 5352 \| CTD_human UBE2E1 \| 7324 \| CTD_human PCYT1B \| 9468 \| CTD_human KRAS \| 3845 \| CTD_human HIST1H2BG \| 8339 \| CTD_human CLU \| 1191 \| CTD_human FOSL2 \| 2355 \| CTD_human EGF \| 1950 \| CTD_human SLC11A1 \| 6556 \| CTD_human;GHR MAPK1 \| 5594 \| CTD_human FOSB \| 2354 \| CTD_human PGM5 \| 5239 \| CTD_human ETV6 \| 2120 \| CTD_human NR4A2 \| 4929 \| CTD_human MIF \| 4282 \| GHR TTLL5 \| 23093 \| CTD_human THBS1 \| 7057 \| CTD_human OSM \| 5008 \| CTD_human MAD1L1 \| 8379 \| CTD_human DDIT3 \| 1649 \| CTD_human RNF103 \| 7844 \| CTD_human GP1BB \| 2812 \| CTD_human NRG1 \| 3084 \| CTD_human CD8B \| 926 \| CTD_human CD83 \| 9308 \| CTD_human EGR1 \| 1958 \| CTD_human HSPA6 \| 3310 \| CTD_human STIM1 \| 6786 \| CTD_human RASGEF1B \| 153020 \| CTD_human SIK1 \| 150094 \| CTD_human TCF7L2 \| 6934 \| CTD_human CXCL1 \| 2919 \| CTD_human BTG3 \| 10950 \| CTD_human BTG1 \| 694 \| CTD_human CD14 \| 929 \| CTD_human MAP2 \| 4133 \| CTD_human ITGA2B \| 3674 \| CTD_human HLA-A \| 3105 \| GHR ETNK1 \| 55500 \| CTD_human NR4A3 \| 8013 \| CTD_human GNG11 \| 2791 \| CTD_human PER1 \| 5187 \| CTD_human TFPI \| 7035 \| CTD_human AREG \| 374 \| CTD_human KCNJ15 \| 3772 \| CTD_human MYZAP \| 100820829 \| CTD_human PLAUR \| 5329 \| CTD_human DAPK1 \| 1612 \| CTD_human ALOX12 \| 239 \| CTD_human ZFAND3 \| 60685 \| CTD_human WWOX \| 51741 \| CTD_human ELF2 \| 1998 \| CTD_human TUBB2A \| 7280 \| CTD_human ADCY7 \| 113 \| CTD_human C2orf88 \| 84281 \| CTD_human GADD45A \| 1647 \| CTD_human RBM47 \| 54502 \| CTD_human UBE3C \| 9690 \| CTD_human MS4A4A \| 51338 \| CTD_human R3HDM2 \| 22864 \| CTD_human KLF4 \| 9314 \| CTD_human CXCR4 \| 7852 \| CTD_human MIR22HG \| 84981 \| CTD_human FCGR1A \| 2209 \| CTD_human GMPR \| 2766 \| CTD_human LPP \| 4026 \| CTD_human CAMSAP1 \| 157922 \| CTD_human ACRBP \| 84519 \| CTD_human HERPUD2 \| 64224 \| CTD_human DYSF \| 8291 \| CTD_human CREM \| 1390 \| CTD_human JMJD1C \| 221037 \| CTD_human SIPA1L1 \| 26037 \| CTD_human CALD1 \| 800 \| CTD_human SLC22A16 \| 85413 \| CTD_human WASF3 \| 10810 \| CTD_human LILRA5 \| 353514 \| CTD_human NDEL1 \| 81565 \| CTD_human HBEGF \| 1839 \| CTD_human TREML1 \| 340205 \| CTD_human STAB1 \| 23166 \| CTD_human TNFAIP6 \| 7130 \| CTD_human PACSIN2 \| 11252 \| CTD_human AQP9 \| 366 \| CTD_human ANKRD9 \| 122416 \| CTD_human ACPP \| 55 \| CTD_human UHRF1BP1L \| 23074 \| CTD_human TNFRSF10C \| 8794 \| CTD_human MAML2 \| 84441 \| CTD_human AVL9 \| 23080 \| CTD_human FCHSD2 \| 9873 \| CTD_human MAFF \| 23764 \| CTD_human FAXDC2 \| 10826 \| CTD_human B4GALT5 \| 9334 \| CTD_human ZFC3H1 \| 196441 \| CTD_human MTSS1 \| 9788 \| CTD_human APOBEC3A \| 200315 \| CTD_human HIST1H2AE \| 3012 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:46) 799 \| CALCR \| infer 1392 \| CRH \| infer 1588 \| CYP19A1 \| infer 2099 \| ESR1 \| infer 3105 \| HLA-A \| infer 3117 \| HLA-DQA1 \| infer 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer 4282 \| MIF \| infer 5617 \| PRL \| infer 5696 \| PSMB8 \| infer 866 \| SERPINA6 \| infer 7124 \| TNF \| infer 7132 \| TNFRSF1A \| infer 7133 \| TNFRSF1B \| infer 7421 \| VDR \| infer 10665 \| C6orf10 \| infer 8836 \| GGH \| infer 79679 \| VTCN1 \| infer 6347 \| CCL2 \| infer 50943 \| FOXP3 \| infer 3115 \| HLA-DPB1 \| infer 3458 \| IFNG \| infer 3586 \| IL10 \| infer 3592 \| IL12A \| infer 3552 \| IL1A \| infer 3553 \| IL1B \| infer 3554 \| IL1R1 \| infer 3557 \| IL1RN \| infer 3558 \| IL2 \| infer 3565 \| IL4 \| infer 3566 \| IL4R \| infer 3569 \| IL6 \| infer 3659 \| IRF1 \| infer 5698 \| PSMB9 \| infer 6556 \| SLC11A1 \| infer 1836 \| SLC26A2 \| infer 6890 \| TAP1 \| infer 6891 \| TAP2 \| infer 6892 \| TAPBP \| infer 7040 \| TGFB1 \| infer 28606 \| TRBV6-1 \| infer 355 \| FAS \| infer 5551 \| PRF1 \| infer 26191 \| PTPN22 \| infer 780 \| DDR1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:235) 64132 \| XYLT2 \| DISEASES 90956 \| ADCK2 \| DISEASES 7132 \| TNFRSF1A \| DISEASES 3566 \| IL4R \| DISEASES 29992 \| PILRA \| DISEASES 201294 \| UNC13D \| DISEASES 4282 \| MIF \| DISEASES 3002 \| GZMB \| DISEASES 5684 \| PSMA3 \| DISEASES 7076 \| TIMP1 \| DISEASES 54 \| ACP5 \| DISEASES 6367 \| CCL22 \| DISEASES 6361 \| CCL17 \| DISEASES 4210 \| MEFV \| DISEASES 8797 \| TNFRSF10A \| DISEASES 6813 \| STXBP2 \| DISEASES 973 \| CD79A \| DISEASES 1311 \| COMP \| DISEASES 79176 \| FBXL15 \| DISEASES 6347 \| CCL2 \| DISEASES 3558 \| IL2 \| DISEASES 969 \| CD69 \| DISEASES 4598 \| MVK \| DISEASES 3458 \| IFNG \| DISEASES 3820 \| KLRB1 \| DISEASES 3003 \| GZMK \| DISEASES 3565 \| IL4 \| DISEASES 3567 \| IL5 \| DISEASES 6556 \| SLC11A1 \| DISEASES 3554 \| IL1R1 \| DISEASES 5657 \| PRTN3 \| DISEASES 6402 \| SELL \| DISEASES 471 \| ATIC \| DISEASES 7128 \| TNFAIP3 \| DISEASES 8600 \| TNFSF11 \| DISEASES 2946 \| GSTM2 \| DISEASES 3624 \| INHBA \| DISEASES 3659 \| IRF1 \| DISEASES 718 \| C3 \| DISEASES 7429 \| VIL1 \| DISEASES 2792 \| GNGT1 \| DISEASES 599 \| BCL2L2 \| DISEASES 80762 \| NDFIP1 \| DISEASES 1401 \| CRP \| DISEASES 4907 \| NT5E \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 55997 \| CFC1 \| DISEASES 55014 \| STX17 \| DISEASES 7097 \| TLR2 \| DISEASES 4069 \| LYZ \| DISEASES 54665 \| RSBN1 \| DISEASES 7188 \| TRAF5 \| DISEASES 5687 \| PSMA6 \| DISEASES 7597 \| ZBTB25 \| DISEASES 80018 \| NAA25 \| DISEASES 22850 \| ADNP2 \| DISEASES 4025 \| LPO \| DISEASES 5588 \| PRKCQ \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 55717 \| WDR11 \| DISEASES 3574 \| IL7 \| DISEASES 941 \| CD80 \| DISEASES 8807 \| IL18RAP \| DISEASES 5443 \| POMC \| DISEASES 3383 \| ICAM1 \| DISEASES 51726 \| DNAJB11 \| DISEASES 311 \| ANXA11 \| DISEASES 53616 \| ADAM22 \| DISEASES 3373 \| HYAL1 \| DISEASES 939 \| CD27 \| DISEASES 150094 \| SIK1 \| DISEASES 1404 \| HAPLN1 \| DISEASES 8795 \| TNFRSF10B \| DISEASES 6291 \| SAA4 \| DISEASES 10666 \| CD226 \| DISEASES 3606 \| IL18 \| DISEASES 283635 \| FAM177A1 \| DISEASES 130733 \| TMEM178A \| DISEASES 5741 \| PTH \| DISEASES 3087 \| HHEX \| DISEASES 2528 \| FUT6 \| DISEASES 2220 \| FCN2 \| DISEASES 1234 \| CCR5 \| DISEASES 114757 \| CYGB \| DISEASES 6352 \| CCL5 \| DISEASES 2215 \| FCGR3B \| DISEASES 11167 \| FSTL1 \| DISEASES 213 \| ALB \| DISEASES 132612 \| ADAD1 \| DISEASES 3600 \| IL15 \| DISEASES 51752 \| ERAP1 \| DISEASES 27242 \| TNFRSF21 \| DISEASES 4982 \| TNFRSF11B \| DISEASES 79778 \| MICALL2 \| DISEASES 122769 \| LRR1 \| DISEASES 79841 \| AGBL2 \| DISEASES 4314 \| MMP3 \| DISEASES 64127 \| NOD2 \| DISEASES 3479 \| IGF1 \| DISEASES 1493 \| CTLA4 \| DISEASES 10663 \| CXCR6 \| DISEASES 171558 \| PTCRA \| DISEASES 3627 \| CXCL10 \| DISEASES 3575 \| IL7R \| DISEASES 56246 \| MRAP \| DISEASES 6373 \| CXCL11 \| DISEASES 5222 \| PGA5 \| DISEASES 51172 \| NAGPA \| DISEASES 5771 \| PTPN2 \| DISEASES 3556 \| IL1RAP \| DISEASES 1776 \| DNASE1L3 \| DISEASES 4261 \| CIITA \| DISEASES 83953 \| FCAMR \| DISEASES 144811 \| LACC1 \| DISEASES 4026 \| LPP \| DISEASES 2529 \| FUT7 \| DISEASES 80381 \| CD276 \| DISEASES 4312 \| MMP1 \| DISEASES 127623 \| OR2B11 \| DISEASES 3563 \| IL3RA \| DISEASES 7050 \| TGIF1 \| DISEASES 6401 \| SELE \| DISEASES 942 \| CD86 \| DISEASES 81565 \| NDEL1 \| DISEASES 57178 \| ZMIZ1 \| DISEASES 114548 \| NLRP3 \| DISEASES 441108 \| C5orf56 \| DISEASES 3117 \| HLA-DQA1 \| DISEASES 3329 \| HSPD1 \| DISEASES 79722 \| ANKRD55 \| DISEASES 921 \| CD5 \| DISEASES 29949 \| IL19 \| DISEASES 3605 \| IL17A \| DISEASES 10019 \| SH2B3 \| DISEASES 355 \| FAS \| DISEASES 5265 \| SERPINA1 \| DISEASES 3240 \| HP \| DISEASES 3899 \| AFF3 \| DISEASES 6288 \| SAA1 \| DISEASES 1822 \| ATN1 \| DISEASES 987 \| LRBA \| DISEASES 6775 \| STAT4 \| DISEASES 6364 \| CCL20 \| DISEASES 9332 \| CD163 \| DISEASES 26191 \| PTPN22 \| DISEASES 3123 \| HLA-DRB1 \| DISEASES 170482 \| CLEC4C \| DISEASES 6772 \| STAT1 \| DISEASES 2882 \| GPX7 \| DISEASES 8838 \| WISP3 \| DISEASES 4283 \| CXCL9 \| DISEASES 3151 \| HMGN2 \| DISEASES 5693 \| PSMB5 \| DISEASES 8676 \| STX11 \| DISEASES 356 \| FASLG \| DISEASES 2214 \| FCGR3A \| DISEASES 911 \| CD1C \| DISEASES 115352 \| FCRL3 \| DISEASES 632 \| BGLAP \| DISEASES 4580 \| MTX1 \| DISEASES 6283 \| S100A12 \| DISEASES 6280 \| S100A9 \| DISEASES 79679 \| VTCN1 \| DISEASES 3654 \| IRAK1 \| DISEASES 115004 \| MB21D1 \| DISEASES 959 \| CD40LG \| DISEASES 2219 \| FCN1 \| DISEASES 1503 \| CTPS1 \| DISEASES 221476 \| PI16 \| DISEASES 2833 \| CXCR3 \| DISEASES 7185 \| TRAF1 \| DISEASES 7321 \| UBE2D1 \| DISEASES 7099 \| TLR4 \| DISEASES 3055 \| HCK \| DISEASES 7916 \| PRRC2A \| DISEASES 4795 \| NFKBIL1 \| DISEASES 50943 \| FOXP3 \| DISEASES 100507436 \| MICA \| DISEASES 7133 \| TNFRSF1B \| DISEASES 1041 \| CDSN \| DISEASES 9656 \| MDC1 \| DISEASES 4524 \| MTHFR \| DISEASES 3105 \| HLA-A \| DISEASES 6311 \| ATXN2 \| DISEASES 8718 \| TNFRSF25 \| DISEASES 57623 \| ZFAT \| DISEASES 441376 \| AARD \| DISEASES 79899 \| PRR5L \| DISEASES 4113 \| MAGEB2 \| DISEASES 3559 \| IL2RA \| DISEASES 3704 \| ITPA \| DISEASES 3486 \| IGFBP3 \| DISEASES 9047 \| SH2D2A \| DISEASES 9862 \| MED24 \| DISEASES 594855 \| CPLX3 \| DISEASES 3652 \| IPP \| DISEASES 7913 \| DEK \| DISEASES 221037 \| JMJD1C \| DISEASES 10747 \| MASP2 \| DISEASES 23274 \| CLEC16A \| DISEASES 176 \| ACAN \| DISEASES 340351 \| AGBL3 \| DISEASES 6916 \| TBXAS1 \| DISEASES 3120 \| HLA-DQB2 \| DISEASES 3447 \| IFNA13 \| DISEASES 720 \| C4A \| DISEASES 57511 \| COG6 \| DISEASES 7124 \| TNF \| DISEASES 3106 \| HLA-B \| DISEASES 10216 \| PRG4 \| DISEASES 5334 \| PLCL1 \| DISEASES 4049 \| LTA \| DISEASES 3115 \| HLA-DPB1 \| DISEASES 84897 \| TBRG1 \| DISEASES 55655 \| NLRP2 \| DISEASES 834 \| CASP1 \| DISEASES 4140 \| MARK3 \| DISEASES 3586 \| IL10 \| DISEASES 133396 \| IL31RA \| DISEASES 721 \| C4B \| DISEASES 51300 \| TIMMDC1 \| DISEASES 51428 \| DDX41 \| DISEASES 284 \| ANGPT1 \| DISEASES 11331 \| PHB2 \| DISEASES 9051 \| PSTPIP1 \| DISEASES 567 \| B2M \| DISEASES 9692 \| KIAA0391 \| DISEASES 22861 \| NLRP1 \| DISEASES 348120 \| LINC01193 \| DISEASES 79104 \| MEG8 \| DISEASES 677767 \| SCARNA7 \| DISEASES 9298 \| SNORD31 \| DISEASES 692225 \| SNORD94 \| DISEASES
Locus	(Waiting for update.)

Disease ID	352
Disease	juvenile idiopathic arthritis
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:25) HP:0002829 \| Arthralgia HP:0001373 \| Joint dislocation HP:0000988 \| Skin rash HP:0100773 \| Cartilage destruction HP:0002103 \| Abnormality of the pleura HP:0001231 \| Abnormality of the fingernails HP:0002960 \| Autoimmunity HP:0001945 \| Fever HP:0005595 \| Generalized hyperkeratosis HP:0001386 \| Joint swelling HP:0001744 \| Splenomegaly HP:0002240 \| Hepatomegaly HP:0001072 \| Thickened skin HP:0001367 \| Abnormal joint morphology HP:0001597 \| Abnormality of the nail HP:0001369 \| Arthritis HP:0000554 \| Uveitis HP:0002024 \| Malabsorption HP:0100781 \| Abnormality of the sacroiliac joint HP:0001698 \| Pericardial effusion HP:0100721 \| Mediastinal lymphadenopathy HP:0003765 \| Psoriasis HP:0001387 \| Joint stiffness HP:0001803 \| Nail pits HP:0002027 \| Abdominal pain
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:45) HP:0000554 \| Uveitis \| 42 HP:0001369 \| Arthritis \| 16 HP:0012122 \| Anterior uveitis \| 9 HP:0012531 \| Pain \| 8 HP:0100769 \| Synovitis \| 6 HP:0100686 \| Enthesitis \| 4 HP:0000939 \| Osteoporosis \| 3 HP:0002960 \| Autoimmune condition \| 3 HP:0000518 \| Cataract \| 3 HP:0001945 \| Fever \| 3 HP:0012378 \| Fatigue \| 2 HP:0000969 \| Dropsy \| 2 HP:0100280 \| Morbus Crohn \| 2 HP:0004432 \| Agammaglobulinaemia \| 2 HP:0002665 \| Lymphoma \| 2 HP:0002621 \| Atherosclerosis \| 2 HP:0040049 \| Macular edema \| 2 HP:0001909 \| Leukemia \| 1 HP:0004233 \| Advanced carpal ossification \| 1 HP:0100653 \| Optic neuritis \| 1 HP:0030833 \| Neck pain \| 1 HP:0001513 \| Obesity \| 1 HP:0012124 \| Intermediate uveitis \| 1 HP:0001635 \| Congestive heart failure \| 1 HP:0002716 \| Lymph node hyperplasia \| 1 HP:0008940 \| Generalized lymphadenopathy \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0002653 \| Bone pain \| 1 HP:0012156 \| Hemophagocytosis \| 1 HP:0000324 \| Asymmetry of face \| 1 HP:0011505 \| Cystoid macular edema \| 1 HP:0000501 \| Glaucoma \| 1 HP:0010885 \| Aseptic necrosis \| 1 HP:0001094 \| Iridocyclitis \| 1 HP:0100806 \| Sepsis \| 1 HP:0001903 \| Anemia \| 1 HP:0000491 \| Corneal inflammation \| 1 HP:0000545 \| Near sightedness \| 1 HP:0003765 \| Psoriasis \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0010889 \| Lunatomalacia \| 1 HP:0009940 \| Lower jaw shifted to one side \| 1 HP:0000739 \| Anxiety \| 1 HP:0100646 \| Thyroiditis \| 1 HP:0011034 \| Amyloid disease \| 1

Disease ID	352
Disease	juvenile idiopathic arthritis
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:13) C0042164 \| uveitis \| 42 C1096155 \| macrophage activation syndrome \| 10 C0030193 \| pain \| 8 C0008690 \| chronic anterior uveitis \| 6 C0039103 \| synovitis \| 6 C0029456 \| osteoporosis \| 3 C0003864 \| joint inflammation \| 2 C1510449 \| chronic iridocyclitis \| 1 C0022073 \| iridocyclitis \| 1 C0021308 \| infarction \| 1 C0020807 \| pulmonary hemosiderosis \| 1 C0002726 \| amyloidosis \| 1 C0162323 \| polyarthritis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:36)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1045642	22859359	6573	SLC19A1	umls:C3495559	BeFree	ABCB1 rs1045642, ABCC3 rs4793665, and SLC19A1 rs1051266 polymorphisms were associated with response to MTX in 287 patients with JIA studied longitudinally.	0.000271442	2012	ABCB1	7	87509329	A	T,G
rs1045642	22859359	6573	SLC19A1	umls:C3714757	BeFree	ABCB1 rs1045642, ABCC3 rs4793665, and SLC19A1 rs1051266 polymorphisms were associated with response to MTX in 287 patients with JIA studied longitudinally.	0.000271442	2012	ABCB1	7	87509329	A	T,G
rs104894176	23274377	5551	PRF1	umls:C3495559	BeFree	The patient's extremely high serum ferritin level (267,054 ng/mL) and the recurrent course of MAS may have been because of the coexistence of juvenile idiopathic arthritis and heterozygous perforin W374X mutation.	0.005819831	2013	PRF1	10	70598599	C	T
rs104894176	23274377	5551	PRF1	umls:C3714757	BeFree	The patient's extremely high serum ferritin level (267,054 ng/mL) and the recurrent course of MAS may have been because of the coexistence of juvenile idiopathic arthritis and heterozygous perforin W374X mutation.	0.001085767	2013	PRF1	10	70598599	C	T
rs1051266	22859359	6573	SLC19A1	umls:C3714757	BeFree	ABCB1 rs1045642, ABCC3 rs4793665, and SLC19A1 rs1051266 polymorphisms were associated with response to MTX in 287 patients with JIA studied longitudinally.	0.000271442	2012	SLC19A1	21	45537880	T	C
rs1051266	22859359	6573	SLC19A1	umls:C3495559	BeFree	ABCB1 rs1045642, ABCC3 rs4793665, and SLC19A1 rs1051266 polymorphisms were associated with response to MTX in 287 patients with JIA studied longitudinally.	0.000271442	2012	SLC19A1	21	45537880	T	C
rs12046117	19116933	79679	VTCN1	umls:C3495559	GAD	[The replicated association with markers in the VTCN1 gene defined an additional susceptibility locus for JIA and implicates a novel pathway in the pathogenesis of this chronic disease of childhood.]	0.002909916	2009	VTCN1	1	117208743	C	T
rs1464510	20647273	4026	LPP	umls:C3714757	BeFree	One SNP in the LPP gene, rs1464510, showed significant association with JIA (p(trend)=0.002, OR=1.18, 95% CI 1.06 to 1.30).	0.000271442	2010	LPP	3	188394766	C	T,A
rs1464510	20647273	4026	LPP	umls:C3495559	BeFree	One SNP in the LPP gene, rs1464510, showed significant association with JIA (p(trend)=0.002, OR=1.18, 95% CI 1.06 to 1.30).	0.122638474	2010	LPP	3	188394766	C	T,A
rs224204	18576390	4210	MEFV	umls:C3714757	BeFree	After Bonferroni correction for multiple testing, 2 genotype associations remained significant in the subgroup of patients with psoriatic JIA (MEFV SNP rs224204 [corrected P = 0.025] and NLRP3 SNP rs3806265 [corrected P = 0.04]).	0.001085767	2008	MEFV	16	3246429	G	A
rs224204	18576390	114548	NLRP3	umls:C3714757	BeFree	After Bonferroni correction for multiple testing, 2 genotype associations remained significant in the subgroup of patients with psoriatic JIA (MEFV SNP rs224204 [corrected P = 0.025] and NLRP3 SNP rs3806265 [corrected P = 0.04]).	0.001085767	2008	MEFV	16	3246429	G	A
rs224204	18576390	114548	NLRP3	umls:C3495559	BeFree	After Bonferroni correction for multiple testing, 2 genotype associations remained significant in the subgroup of patients with psoriatic JIA (MEFV SNP rs224204 [corrected P = 0.025] and NLRP3 SNP rs3806265 [corrected P = 0.04]).	0.003452799	2008	MEFV	16	3246429	G	A
rs224204	18576390	4210	MEFV	umls:C3495559	BeFree	After Bonferroni correction for multiple testing, 2 genotype associations remained significant in the subgroup of patients with psoriatic JIA (MEFV SNP rs224204 [corrected P = 0.025] and NLRP3 SNP rs3806265 [corrected P = 0.04]).	0.008458305	2008	MEFV	16	3246429	G	A
rs231775	18576317	348120	LINC01193	umls:C3495559	BeFree	Families of 531 children with JIA were genotyped for SNPs located in the promoter region (C-318T), exon 1 (A49G), and the 3'-untranslated region (CT60) of CTLA4 by polymerase chain reaction amplification and digestion.	0.000271442	2008	CTLA4	2	203867991	A	G,T
rs231775	18576317	348120	LINC01193	umls:C3714757	BeFree	Families of 531 children with JIA were genotyped for SNPs located in the promoter region (C-318T), exon 1 (A49G), and the 3'-untranslated region (CT60) of CTLA4 by polymerase chain reaction amplification and digestion.	0.000271442	2008	CTLA4	2	203867991	A	G,T
rs2395148	18576341	10665	C6orf10	umls:C3495559	GAD	[Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritis.]	0.002367032	2008	C6orf10;LOC101929163	6	32353777	G	T
rs2476601	22327470	26191	PTPN22	umls:C3714757	BeFree	The association between the functional PTPN22 1858 C/T and MIF -173 C/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis.	0.003800186	2012	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	25003765	26191	PTPN22	umls:C3714757	BeFree	A single nucleotide polymorphism of PTPN22, 1858C>T (rs2476601), disrupts an interaction motif in the protein, and is the most important non-HLA genetic risk factor for rheumatoid arthritis and the second most important for juvenile idiopathic arthritis.	0.003800186	2014	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	22327470	52	ACP1	umls:C3714757	BeFree	The aim of this study was to determine whether the protein tyrosine phosphatase nonreceptor 22 (PTPN22) 1858 C/T (rs2476601) and macrophage migration inhibitory factor (MIF) -173 C/G polymorphisms confer susceptibility to juvenile idiopathic arthritis (JIA).	0.000542884	2012	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	15934099	26191	PTPN22	umls:C3495559	GAD	[Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene.]	0.018717015	2005	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	25003765	26191	PTPN22	umls:C3495559	BeFree	A single nucleotide polymorphism of PTPN22, 1858C>T (rs2476601), disrupts an interaction motif in the protein, and is the most important non-HLA genetic risk factor for rheumatoid arthritis and the second most important for juvenile idiopathic arthritis.	0.018717015	2014	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	22327470	26191	PTPN22	umls:C3495559	BeFree	The association between the functional PTPN22 1858 C/T and MIF -173 C/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis.	0.018717015	2012	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	22327470	52	ACP1	umls:C3495559	BeFree	The aim of this study was to determine whether the protein tyrosine phosphatase nonreceptor 22 (PTPN22) 1858 C/T (rs2476601) and macrophage migration inhibitory factor (MIF) -173 C/G polymorphisms confer susceptibility to juvenile idiopathic arthritis (JIA).	0.000542884	2012	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2476601	16107870	26191	PTPN22	umls:C3495559	GAD	[Finnish case-control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis.]	0.018717015	2005	PTPN22;AP4B1-AS1	1	113834946	A	G
rs2488457	25781893	26191	PTPN22	umls:C3495559	BeFree	STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms influence the risk of developing juvenile idiopathic arthritis in Han Chinese patients.	0.018717015	2014	PTPN22;AP4B1-AS1	1	113872746	G	C,A
rs2488457	25781893	26191	PTPN22	umls:C3714757	BeFree	STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms influence the risk of developing juvenile idiopathic arthritis in Han Chinese patients.	0.003800186	2014	PTPN22;AP4B1-AS1	1	113872746	G	C,A
rs361525	24069456	7124	TNF	umls:C3714757	BeFree	Several meta-analyses and replicated association studies have implicated the minor 'A' variant within the TNF promoter single nucleotide polymorphism (SNP) rs361525 (-238A/G) as a risk allele in joint related disorders, including psoriatic and juvenile idiopathic arthritis, and osteolysis after joint arthroplasty.	0.005428837	2013	TNF	6	31575324	G	A
rs361525	24069456	7124	TNF	umls:C3495559	BeFree	Several meta-analyses and replicated association studies have implicated the minor 'A' variant within the TNF promoter single nucleotide polymorphism (SNP) rs361525 (-238A/G) as a risk allele in joint related disorders, including psoriatic and juvenile idiopathic arthritis, and osteolysis after joint arthroplasty.	0.045482816	2013	TNF	6	31575324	G	A
rs3806265	18576390	4210	MEFV	umls:C3495559	BeFree	After Bonferroni correction for multiple testing, 2 genotype associations remained significant in the subgroup of patients with psoriatic JIA (MEFV SNP rs224204 [corrected P = 0.025] and NLRP3 SNP rs3806265 [corrected P = 0.04]).	0.008458305	2008	NLRP3	1	247423034	T	C
rs3806265	18576390	4210	MEFV	umls:C3714757	BeFree	After Bonferroni correction for multiple testing, 2 genotype associations remained significant in the subgroup of patients with psoriatic JIA (MEFV SNP rs224204 [corrected P = 0.025] and NLRP3 SNP rs3806265 [corrected P = 0.04]).	0.001085767	2008	NLRP3	1	247423034	T	C
rs3806265	18576390	114548	NLRP3	umls:C3495559	BeFree	After Bonferroni correction for multiple testing, 2 genotype associations remained significant in the subgroup of patients with psoriatic JIA (MEFV SNP rs224204 [corrected P = 0.025] and NLRP3 SNP rs3806265 [corrected P = 0.04]).	0.003452799	2008	NLRP3	1	247423034	T	C
rs3806265	18576390	114548	NLRP3	umls:C3714757	BeFree	After Bonferroni correction for multiple testing, 2 genotype associations remained significant in the subgroup of patients with psoriatic JIA (MEFV SNP rs224204 [corrected P = 0.025] and NLRP3 SNP rs3806265 [corrected P = 0.04]).	0.001085767	2008	NLRP3	1	247423034	T	C
rs4793665	22859359	6573	SLC19A1	umls:C3714757	BeFree	ABCB1 rs1045642, ABCC3 rs4793665, and SLC19A1 rs1051266 polymorphisms were associated with response to MTX in 287 patients with JIA studied longitudinally.	0.000271442	2012	ABCC3	17	50634726	C	T
rs4793665	22859359	6573	SLC19A1	umls:C3495559	BeFree	ABCB1 rs1045642, ABCC3 rs4793665, and SLC19A1 rs1051266 polymorphisms were associated with response to MTX in 287 patients with JIA studied longitudinally.	0.000271442	2012	ABCC3	17	50634726	C	T
rs7574865	25781893	26191	PTPN22	umls:C3495559	BeFree	STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms influence the risk of developing juvenile idiopathic arthritis in Han Chinese patients.	0.018717015	2014	STAT4	2	191099907	T	G
rs7574865	25781893	26191	PTPN22	umls:C3714757	BeFree	STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms influence the risk of developing juvenile idiopathic arthritis in Han Chinese patients.	0.003800186	2014	STAT4	2	191099907	T	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:333)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	25197155	rs4648881	G	A	rs4648881	23603761	0.000000466	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
1	25197155	rs4648881	G	A	rs4648881	23603761	0.000084	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
1	25197155	rs4648881	G	A	rs4648881	23603761	0.000213	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
1	37605441	rs215792	T	C	rs215792	22354554	1.72E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
1	53929463	rs1108989	T	A	rs1108989	22354554	6.69E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
1	53929536	rs1288632	C	G	rs1288632	22354554	5.71E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
1	79403450	rs3811438	T	C	rs3811438	22354554	1.68E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
1	79437368	rs12029928	C	T	rs12029928	22354554	1.20E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
1	114173410	rs1230666	A	G	rs1230666	22354554	1.95E-06	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
1	114303808	rs6679677	C	A	rs6679677	22354554	1.07E-06	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
1	114303808	rs6679677	C	A	rs6679677	23603761	1.11E-18	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
1	114303808	rs6679677	C	A	rs6679677	23603761	3.19E-25	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
1	114303808	rs6679677	C	A	rs6679677	23603761	3.45E-11	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
1	114436482	rs10776775	G	A	rs10776775	22354554	2.73E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
1	115882541	rs10776801	A	G	rs10776801	22354554	4.76E-06	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
1	117751365	rs12046117	C	T	rs12046117	19116933	1.00E-06	NA	1.58	[1.29-1.94]	279 cases; 184 controls	NOPOP(463)	ALL(463)	NOPOP(463)	ALL(463)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, Non-U.S. Gov't	Validation Studies	C
1	154364140	rs11265608	G	A	rs11265608	23603761	0.0000574	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
1	154364140	rs11265608	G	A	rs11265608	23603761	0.000112	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
1	154364140	rs11265608	G	A	rs11265608	23603761	2.75E-08	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
1	154379369	rs72698115	A	C	rs72698115	23603761	1.26E-08	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
1	165107979	rs60624478	G	A	rs60624478	24709693	6.00E-06	(PhysVAS)	1.17	[0.66-1.68] unit increase	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs60624478-A	Research Support, Non-U.S. Gov't	G	NA
1	165110832	rs60950492	A	G	rs60950492	24709693	4.05E-05	(ACR-pedi)	0.87	[0.46-1.28] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs60950492-G	Research Support, Non-U.S. Gov't	A	NA
1	187055561	rs7511950	A	G	rs7511950	22354554	7.96E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	26894589	rs1009221	A	G	rs1009221	22354554	1.81E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	39911151	rs13427136	T	C	rs13427136	22354554	1.63E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	43542480	rs11690012	G	C	rs11690012	22354554	5.90E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	60886477	rs2118480	G	A	rs2118480	22354554	1.50E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	65609677	rs268132	T	C	rs268132	22354554	1.12E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	71182900	rs10210235	T	C	rs10210235	22354554	8.57E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	100813499	rs6740838	T	G	rs6740838	23603761	0.000000883	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
2	100813499	rs6740838	T	G	rs6740838	23603761	0.00000535	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
2	100834217	rs10194635	T	A	rs10194635	23603761	0.00000081	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
2	106367561	rs12987484	T	C	rs12987484	22354554	1.17E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	109571440	rs260705	G	A	rs260705	22354554	8.04E-06	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	116481940	rs13019180	T	C	rs13019180	22354554	7.54E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	116486451	rs13033400	G	A	rs13033400	22354554	7.76E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	116534922	rs1374271	A	G	rs1374271	22354554	1.15E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	146672778	rs997033	A	G	rs997033	22354554	8.60E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	150891651	rs4533492	A	G	rs4533492	22354554	1.20E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	150903121	rs330646	C	T	rs330646	22354554	8.71E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	150909115	rs108136	T	G	rs108136	22354554	1.49E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	150911159	rs330625	A	G	rs330625	22354554	3.13E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	150912703	rs330624	A	G	rs330624	22354554	1.54E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	191954047	rs10931480	G	A	rs10931480	22354554	1.88E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	191973034	rs10174238	G	A	rs10174238	23603761	0.00000239	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
2	191973034	rs10174238	G	A	rs10174238	23603761	1.28E-13	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
2	191973034	rs10174238	G	A	rs10174238	23603761	1.81E-10	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
2	233397525	rs12466358	T	G	rs12466358	22354554	1.03E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	238509759	rs11894280	G	A	rs11894280	22354554	1.81E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	238526411	rs12464145	A	C	rs12464145	22354554	1.39E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	238526498	rs12464181	A	G	rs12464181	22354554	2.57E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
2	238576444	rs4663779	G	A	rs4663779	22354554	1.90E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	12580246	rs1552484	G	C	rs1552484	22354554	1.34E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	12596844	rs2596822	T	C	rs2596822	22354554	9.26E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	12603900	rs2454422	G	A	rs2454422	22354554	6.22E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	12635706	rs1532533	G	A	rs1532533	22354554	8.55E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	33545785	rs6781484	T	C	rs6781484	22354554	1.05E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	33609330	rs8179967	T	C	rs8179967	22354554	6.04E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	33653622	rs6807542	T	G	rs6807542	22354554	9.56E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	46253650	rs79893749	C	T	rs79893749	23603761	0.000000188	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
3	46253650	rs79893749	C	T	rs79893749	23603761	0.000000939	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
3	46498865	rs11707471	T	G	rs11707471	22354554	1.73E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	101718657	rs771795	T	A	rs771795	22354554	1.45E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	101719299	rs771797	A	T	rs771797	22354554	1.79E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	101719377	rs771798	A	C	rs771798	22354554	1.25E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	101735205	rs4683863	A	G	rs4683863	22354554	1.42E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	119214549	rs3755579	T	C	rs3755579	22354554	1.40E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	119221064	rs11714843	T	A	rs11714843	23603761	0.000000364	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
3	119227247	rs4688011	G	A	rs4688011	22354554	1.00E-07	NA	1.23	[1.13-1.33]	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	rs4688011-T	Research Support, N.I.H., Extramural
3	119229486	rs4688013	G	A	rs4688013	23603761	0.00000063	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
3	119229486	rs4688013	G	A	rs4688013	23603761	0.00000706	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
3	119235977	rs4447803	C	A	rs4447803	22354554	9.54E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	119236017	rs4461452	G	T	rs4461452	22354554	9.92E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	125865766	rs2886059	C	A	rs2886059	22354554	1.23E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	127484431	rs541042	C	T	rs541042	22354554	7.98E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	143216783	rs838601	G	A	rs838601	22354554	7.23E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	184355688	rs7646910	G	A	rs7646910	22354554	1.15E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
3	184356355	rs4686705	C	T	rs4686705	22354554	1.86E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
4	64481847	rs1947549	A	G	rs1947549	22354554	1.57E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
4	66362487	rs6815080	C	T	rs6815080	22354554	1.60E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
4	80836126	rs7690697	G	C	rs7690697	22354554	1.87E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
4	80850758	rs4234847	A	C	rs4234847	22354554	2.40E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
4	82902304	rs10034564	T	A	rs10034564	22354554	1.63E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
4	123329362	rs17388568	G	A	rs17388568	22354554	1.39E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
4	123333177	rs12499753	T	C	rs12499753	22354554	6.78E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
4	123387600	rs1479924	G	A	rs1479924	23603761	0.000332	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
4	123387600	rs1479924	G	A	rs1479924	23603761	2.17E-09	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
4	123387600	rs1479924	G	A	rs1479924	23603761	6.24E-11	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
4	123391464	rs11724582	A	G	rs11724582	22354554	1.73E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
4	123396028	rs11098659	T	C	rs11098659	22354554	9.78E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
4	123510766	rs6829845	A	G	rs6829845	22354554	2.37E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
4	123530993	rs925549	C	T	rs925549	22354554	1.37E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
4	142661969	rs1602777	G	C	rs1602777	22354554	1.09E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
4	142664259	rs2322305	T	G	rs2322305	22354554	7.13E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
4	142677821	rs970509	G	A	rs970509	22354554	7.24E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
4	150477841	rs11724130	C	T	rs11724130	22354554	1.06E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
4	150557751	rs1125051	G	C	rs1125051	22354554	9.96E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
4	150617889	rs6535695	C	G	rs6535695	22354554	9.44E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
5	28270559	rs10520942	C	A	rs10520942	22354554	1.93E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
5	29283857	rs75104673	T	C	rs75104673	24709693	1.09E-05	(ESR)	16.89	[9.44-24.34] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs75104673-C	Research Support, Non-U.S. Gov't	T	NA
5	30836079	rs12652364	G	A	rs12652364	24709693	6.00E-07	(PhysVAS)	1.45	[0.88-2.02] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs12652364-A	Research Support, Non-U.S. Gov't	G	NA
5	55440730	rs71624119	G	A	rs71624119	23603761	0.0000121	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
5	55440730	rs71624119	G	A	rs71624119	23603761	4.40E-11	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
5	55440730	rs71624119	G	A	rs71624119	23603761	6.45E-08	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
5	55442249	rs10213692	T	C	rs10213692	23603761	2.73E-11	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
5	73242130	rs283595	C	T	rs283595	22354554	1.23E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
5	89951585	rs11748911	A	C	rs11748911	22354554	1.76E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
5	96235896	rs2248374	A	G	rs2248374	23603761	0.00000018	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
5	96350088	rs27290	G	A	rs27290	23603761	0.000124	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
5	96350088	rs27290	G	A	rs27290	23603761	7.50E-09	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
5	96357178	rs27293	A	G	rs27293	23603761	7.37E-09	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
5	118154368	rs1428638	T	C	rs1428638	22354554	1.63E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
5	131797547	rs6894249	A	G	rs6894249	23603761	9.73E-10	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
5	131813219	rs4705862	A	T	rs4705862	23603761	1.02E-08	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
5	131813219	rs4705862	A	T	rs4705862	23603761	4.46E-10	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
5	131835395	rs2548997	G	A	rs2548997	22354554	1.82E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
5	174515327	rs949637	C	T	rs949637	22354554	2.69E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
5	179861507	rs17080306	C	G	rs17080306	22354554	1.11E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
5	179861583	rs4700921	T	C	rs4700921	22354554	9.70E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
5	179869595	rs17629918	A	G	rs17629918	22354554	1.78E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
6	32321554	rs2395148	G	T	rs2395148	18576341	2.00E-10	NA	5.37	[3.02-9.56]	130 cases; 1,952 controls	NOPOP(2082)	ALL(2082)	NOPOP(2082)	ALL(2082)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	NA	G	C6orf10
6	32657916	rs7775055	T	C	rs7775055	23603761	2.24E-162	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
6	32657916	rs7775055	T	C	rs7775055	23603761	3.14E-174	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
6	32657916	rs7775055	T	C	rs7775055	23603761	6.64E-52	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
6	52196117	rs12191519	A	G	rs12191519	22354554	6.25E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
6	106374868	rs7772171	C	A	rs7772171	22354554	1.26E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
6	106734040	rs633724	C	T	rs633724	22354554	1.19E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
6	106819586	rs533685	C	T	rs533685	22354554	1.26E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
6	108028879	rs3862834	C	T	rs3862834	22354554	1.44E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
6	108030088	rs1621495	A	G	rs1621495	22354554	1.08E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
6	108030405	rs1624055	C	T	rs1624055	22354554	8.41E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
6	108033181	rs1728123	C	T	rs1728123	22354554	1.57E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
6	108033895	rs1629910	T	C	rs1629910	22354554	1.05E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
6	108066144	rs6922304	A	G	rs6922304	22354554	1.92E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
6	108069833	rs12664414	A	G	rs12664414	22354554	1.79E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
6	108070239	rs9320231	A	G	rs9320231	22354554	1.16E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
6	132466782	rs1321270	C	A	rs1321270	22354554	1.37E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
6	135710694	rs2614264	G	A	rs2614264	22354554	1.54E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
7	10122140	rs6463967	C	G	rs6463967	22354554	1.89E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
7	21165694	rs17143897	A	G	rs17143897	22354554	1.63E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
7	22798080	rs7808122	T	C	rs7808122	23603761	0.000000058	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
7	22798080	rs7808122	T	C	rs7808122	23603761	0.0000189	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
7	22798080	rs7808122	T	C	rs7808122	23603761	0.000142	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
7	22809490	rs6946509	T	C	rs6946509	23603761	3.36E-08	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
7	28182306	rs10280937	T	C	rs10280937	23603761	0.00000066	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
7	28182306	rs10280937	T	C	rs10280937	23603761	0.0000356	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
7	28187344	rs73300638	A	C	rs73300638	23603761	0.000000112	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
7	32625526	rs3173734	T	G	rs3173734	22354554	9.71E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
7	94039410	rs2621208	C	G	rs2621208	22354554	1.06E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
7	98125134	rs4729451	C	T	rs4729451	22354554	3.56E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
7	107721121	rs390547	G	A	rs390547	22354554	3.05E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
7	117377645	rs757278	G	T	rs757278	24709693	5.00E-07	(ParVAS)	1.32	[0.81-1.83] unit increase	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs757278-T	Research Support, Non-U.S. Gov't	T	CTTNBP2
7	117459043	rs7800668	G	C	rs7800668	24709693	6.00E-06	(ACR-pedi)	1.34	[0.75-1.93] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs7800668-C	Research Support, Non-U.S. Gov't	G	CTTNBP2
7	117528054	rs115255079	T	C	rs115255079	24709693	7.28E-05	(LJC)	2.68	[1.37-3.99] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs115255079-C	Research Support, Non-U.S. Gov't	T	NA
8	334709	rs1550950	G	A	rs1550950	22354554	1.73E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
8	335646	rs1550948	C	T	rs1550948	22354554	1.71E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
8	3116686	rs73185595	T	A	rs73185595	24709693	2.06E-05	(PhysVAS)	0.84	[0.45-1.23] unit increase	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs73185595-A	Research Support, Non-U.S. Gov't	T	CSMD1
8	4025644	rs4395908	C	G	rs4395908	24709693	1.00E-06	(CHAQ)	0.27	[0.17-0.37] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs4395908-C	Research Support, Non-U.S. Gov't	C	CSMD1
8	5644933	rs1512817	G	A	rs1512817	24709693	3.55E-05	(AJC)	1.88	[1-2.76] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs1512817-A	Research Support, Non-U.S. Gov't	C	NA
8	22650159	rs4871834	G	C	rs4871834	22354554	6.33E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
8	65387467	rs7836768	A	G	rs7836768	22354554	1.51E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
8	81451995	rs381349	G	A	rs381349	22354554	2.87E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
8	82888608	rs10113213	T	C	rs10113213	24709693	3.00E-06	(AJC)	1.99	[1.15-2.83] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs10113213-T	Research Support, Non-U.S. Gov't	T	NA
8	82894306	rs7839040	G	A	rs7839040	24709693	2.00E-06	(LJC)	1.81	[1.07-2.55] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs7839040-G	Research Support, Non-U.S. Gov't	G	NA
8	82899934	rs111629714	A	C	rs139456570	24709693	2.74E-05	(PhysVAS)	0.92	[0.49-1.35] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs139456570-C	Research Support, Non-U.S. Gov't	C	NA
8	100758980	rs1788148	T	C	rs1788148	22354554	1.86E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
8	103912514	rs678839	C	T	rs678839	22354554	1.64E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
8	129051940	rs1532560	G	A	rs1532560	22354554	1.67E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
8	129773535	rs10110365	G	A	rs144444502	24709693	6.00E-06	(LJC)	2.27	[1.29-3.25] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs144444502-A	Research Support, Non-U.S. Gov't	G	NA
8	129787976	rs10956445	T	C	rs10956445	24709693	5.00E-07	(AJC)	2.73	[1.67-3.79] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs10956445-C	Research Support, Non-U.S. Gov't	T	NA
8	132054152	rs3829210	G	A	rs3829210	24709693	2.07E-05	(ParVAS)	1.01	[0.56-1.46] unit increase	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs3829210-G	Research Support, Non-U.S. Gov't	C	NA
9	1469317	rs12002949	G	A	rs12002949	22354554	5.98E-07	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
9	16129630	rs1536689	A	G	rs1536689	22354554	1.87E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
9	35405543	rs10814234	C	G	rs10814234	22354554	1.64E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
9	82971428	rs10735544	T	C	rs10735544	22354554	1.40E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
9	82975578	rs12686543	C	T	rs12686543	22354554	2.52E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
9	82980562	rs7851576	G	A	rs7851576	22354554	1.89E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
9	82991662	rs4877557	T	C	rs4877557	22354554	1.95E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	1831994	rs11250787	C	T	rs11250787	22354554	1.93E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	1845059	rs4367871	C	T	rs4367871	22354554	7.00E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	6089841	rs7909519	T	G	rs7909519	23603761	0.000000984	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
10	6089841	rs7909519	T	G	rs7909519	23603761	0.0000341	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
10	6089841	rs7909519	T	G	rs7909519	23603761	8.00E-10	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
10	6108340	rs10795791	A	G	rs10795791	22354554	1.60E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	26566427	rs1999241	A	G	rs1999241	22354554	1.68E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	64313404	rs16917442	T	A	rs16917442	22354554	1.34E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	64896477	rs12416113	T	A	rs12416113	22354554	2.39E-07	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	64916469	rs1009984	T	G	rs1009984	22354554	2.60E-06	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	64924217	rs11817689	T	C	rs11817689	22354554	9.77E-08	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	64999012	rs7082090	A	G	rs7082090	22354554	2.20E-07	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	65001433	rs9414780	A	C	rs9414780	22354554	5.95E-07	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	65006456	rs6479891	T	C	rs6479891	22354554	2.00E-07	NA	1.19	[1.07-1.32]	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	rs6479891-T	Research Support, N.I.H., Extramural
10	65056712	rs9414788	A	G	rs9414788	22354554	2.48E-07	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	65101026	rs10761744	C	G	rs10761744	22354554	2.56E-07	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	65101071	rs10761745	G	C	rs10761745	22354554	2.23E-07	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	65143558	rs9415699	T	C	rs9415699	22354554	1.72E-07	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	65161550	rs9415705	T	G	rs9415705	22354554	1.84E-07	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	65247019	rs2893922	T	G	rs2893922	22354554	3.19E-07	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	65284603	rs10761781	T	C	rs10761781	22354554	3.95E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	65301325	rs16918575	A	G	rs16918575	22354554	1.67E-07	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	65315397	rs12411988	G	C	rs12411988	22354554	3.00E-07	NA	1.18	[1.06-1.31]	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	rs12411988-C	Research Support, N.I.H., Extramural
10	65322381	rs4746201	G	T	rs4746201	22354554	1.01E-07	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	80959973	rs10128264	T	C	rs10128264	24709693	1.00E-06	(ParVAS)	1.18	[0.71-1.65] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs10128264-C	Research Support, Non-U.S. Gov't	C	ZMIZ1
10	80960828	rs2802369	C	A	rs2802369	24709693	7.00E-06	(ESR)	9.37	[5.33-13.41] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs2802369-C	Research Support, Non-U.S. Gov't	G	ZMIZ1
10	80965109	rs942794	T	C	rs942794	24709693	1.06E-05	(ACR-pedi)	0.67	[0.38-0.96] unit increase	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs942794-T	Research Support, Non-U.S. Gov't	C	ZMIZ1
10	82946940	rs7922505	C	A	rs7922505	24709693	9.41E-05	(CHAQ)	0.24	[0.12-0.36] unit increase	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs7922505-C	Research Support, Non-U.S. Gov't	A	NA
10	90091540	rs1426619	C	T	rs1426619	22354554	5.78E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	90762376	rs7069750	G	C,T	rs7069750	23603761	0.00000694	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
10	90762376	rs7069750	G	C,T	rs7069750	23603761	0.00014	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
10	90762376	rs7069750	G	C,T	rs7069750	23603761	2.93E-08	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
10	95449259	rs10882303	G	A	rs10882303	22354554	1.08E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
10	97393475	rs11188409	C	T	rs11188409	22354554	1.42E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
11	11403077	rs4453231	C	G	rs4453231	22354554	1.72E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
11	18172814	rs10832890	T	A	rs10832890	22354554	7.52E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
11	36343693	rs7127214	C	G	rs7127214	23603761	0.000000019	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
11	36363575	rs4755450	G	A	rs4755450	23603761	0.000000335	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
11	36363575	rs4755450	G	A	rs4755450	23603761	0.0000638	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
11	36363575	rs4755450	G	A	rs4755450	23603761	0.000475	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
11	45027780	rs2863140	T	C	rs2863140	22354554	1.70E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
11	46442526	rs12283172	C	T	rs12283172	22354554	1.75E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
11	101771433	rs11225055	T	C	rs11225055	24709693	1.00E-06	(LJC)	3.49	[2.08-4.90] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs11225055-C	Research Support, Non-U.S. Gov't	T	ANGPTL5
12	3226930	rs6489438	A	G	rs6489438	22354554	1.14E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
12	6493351	rs10849448	A	G	rs10849448	23603761	4.54E-09	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
12	6495275	rs2364480	C	A	rs2364480	23603761	0.000000051	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
12	6495275	rs2364480	C	A	rs2364480	23603761	0.00000887	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
12	6495275	rs2364480	C	A	rs2364480	23603761	0.000414	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
12	25101572	rs11047723	C	G	rs11047723	22354554	1.06E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
12	46479056	rs10880908	T	C	rs10880908	22354554	1.28E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
12	92646000	rs872969	C	T	rs872969	22354554	5.10E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
12	99349828	rs4536282	G	A	rs4536282	24709693	4.35E-05	(PhysVAS)	0.97	[0.52-1.42] unit increase	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs4536282-A	Research Support, Non-U.S. Gov't	G	ANKS1B
12	101383958	rs66861122	T	G	rs66861122	24709693	5.00E-06	(ParVAS)	1.82	[1.06-2.58] unit increase	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs66861122-G	Research Support, Non-U.S. Gov't	T	ANO4
12	101842391	rs59420447	G	C	rs59420447	24709693	3.56E-05	(ACR-pedi)	0.75	[0.4-1.1] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs59420447-C	Research Support, Non-U.S. Gov't	G	NA
12	104965584	rs313315	C	A	rs313315	24709693	3.21E-05	(PhysVAS)	0.75	[0.4-1.1] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs313315-C	Research Support, Non-U.S. Gov't	T	CHST11
12	105008908	rs10507177	C	T	rs10507177	24709693	2.72E-05	(AJC)	1.88	[1.02-2.74] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs10507177-C	Research Support, Non-U.S. Gov't	T	CHST11
12	107879066	rs11113349	C	T	rs11113349	24709693	1.16E-05	(ESR)	9.66	[5.39-13.93] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs11113349-T	Research Support, Non-U.S. Gov't	C	BTBD11
12	108717929	rs11113818	C	T	rs11113818	24709693	4.00E-06	(ParVAS)	1.16	[0.67-1.65] unit increase	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs11113818-T	Research Support, Non-U.S. Gov't	T	CMKLR1
12	111884608	rs3184504	T	C	rs3184504	23603761	0.000000396	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
12	111884608	rs3184504	T	C	rs3184504	23603761	0.0000711	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
12	111884608	rs3184504	T	C	rs3184504	23603761	2.60E-09	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
12	111932800	rs7137828	C	T	rs7137828	23603761	1.61E-09	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
12	128663933	rs11059562	G	A	rs11059562	22354554	2.28E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
13	40252190	rs4941939	C	T	rs4941939	22354554	1.69E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
13	40350912	rs7993214	T	C	rs7993214	23603761	0.000000161	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
13	40350912	rs7993214	T	C	rs7993214	23603761	0.00000826	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
13	40355913	rs9532434	T	C	rs9532434	23603761	4.52E-08	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
13	43056036	rs34132030	C	T	rs34132030	23603761	0.000000177	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
13	43056036	rs34132030	C	T	rs34132030	23603761	0.0000168	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
13	43056036	rs34132030	C	T	rs34132030	23603761	0.000612	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
13	63063671	rs17061417	A	G	rs17061417	22354554	2.37E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
13	75281755	rs17063408	G	A	rs17063408	22354554	7.55E-06	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
14	21674364	rs17102539	G	A	rs17102539	22354554	6.02E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
14	25573353	rs8020810	C	G	rs8020810	22354554	1.63E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
14	69253364	rs12434551	A	T	rs12434551	23603761	1.59E-08	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
14	69253364	rs12434551	A	T	rs12434551	23603761	3.84E-08	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
14	69260588	rs3825568	C	T	rs3825568	23603761	1.24E-08	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
14	75928973	rs7359140	G	C	rs7359140	22354554	1.06E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
14	75929017	rs7359152	T	A	rs7359152	22354554	1.32E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
15	26804131	rs61996546	T	C	rs61996546	24709693	3.00E-06	(PhysVAS)	0.78	[0.47-1.09] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs61996546-C	Research Support, Non-U.S. Gov't	T	GABRB3
15	26818362	rs8030011	G	A	rs8030011	24709693	1.30E-05	(LJC)	2.48	[1.38-3.58] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs8030011-A	Research Support, Non-U.S. Gov't	G	GABRB3
15	99072905	rs12719740	G	A	rs12719740	22354554	7.00E-07	NA	1.15	[1.06-1.25]	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	rs12719740-T	Research Support, N.I.H., Extramural
15	99073306	rs8043332	A	G	rs8043332	22354554	1.30E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
16	11428643	rs66718203	C	G	rs66718203	23603761	0.000000446	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
16	11428643	rs66718203	C	G	rs66718203	23603761	0.00000487	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
16	11471414	rs11074967	C	G	rs11074967	23603761	0.00000024	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	C
16	24379983	rs11074618	C	A	rs11074618	22354554	1.03E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
16	24385538	rs9936233	G	A	rs9936233	22354554	1.35E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
16	52997498	rs9930106	A	G	rs9930106	22354554	6.77E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
16	80892483	rs2432414	C	T	rs2432414	22354554	1.64E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
17	2714251	rs4790365	A	G	rs4790365	22354554	1.17E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
17	10266970	rs12951092	T	C	rs12951092	22354554	9.42E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
17	10267204	rs12950258	C	T	rs12950258	22354554	5.93E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
17	10272636	rs11658620	A	G	rs11658620	22354554	7.80E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
17	10272891	rs11653603	G	A	rs11653603	22354554	2.12E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
17	13169858	rs10521213	G	A	rs10521213	22354554	7.23E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
17	15116760	rs230922	A	G	rs230922	22354554	2.08E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
17	15148256	rs230915	T	C	rs230915	22354554	1.19E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
17	26081029	rs9901734	C	G	rs9901734	22354554	1.23E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
17	57976658	rs2526354	T	C	rs2526354	22354554	1.01E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
18	3388779	rs9954608	A	G	rs9954608	24709693	5.69E-05	(AJC)	1.73	[0.89-2.57] unit increase	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs9954608-G	Research Support, Non-U.S. Gov't	A,G	NA
18	3394449	rs6506122	T	C	rs6506122	24709693	5.00E-06	(LJC)	1.82	[1.06-2.58] unit increase	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs6506122-C	Research Support, Non-U.S. Gov't	T	NA
18	7063532	rs11659412	G	A	rs11659412	22354554	4.46E-06	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
18	12779947	rs2542151	G	T	rs2542151	22354554	2.50E-07	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
18	12782448	rs2847293	A	T	rs2847293	23603761	0.00000112	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
18	12782448	rs2847293	A	T	rs2847293	23603761	1.44E-12	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
18	12782448	rs2847293	A	T	rs2847293	23603761	7.17E-09	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
18	12789246	rs2542160	G	C	rs2542160	22354554	1.79E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
18	12797694	rs2847297	A	G	rs2847297	22354554	3.06E-06	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
18	12821593	rs2847281	A	G	rs2847281	22354554	4.20E-06	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
18	12821903	rs16939895	G	A	rs16939895	22354554	5.52E-08	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
18	12834359	rs8087237	C	A	rs8087237	22354554	2.24E-06	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
18	12877060	rs7234029	A	G	rs7234029	22354554	1.65E-08	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
18	41903433	rs12968853	C	T	rs12968853	22354554	8.71E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
18	47195574	rs12970803	A	T	rs12970803	22354554	1.33E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
18	47277757	rs7241641	A	G	rs7241641	22354554	8.66E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
18	47278147	rs6507952	C	T	rs6507952	22354554	4.29E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
18	73811509	rs7237886	G	A	rs7237886	22354554	1.65E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
18	74218509	rs4267414	C	A	rs4267414	22354554	1.08E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
19	5212482	rs2230611	G	A	rs2230611	22354554	1.26E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
19	10463118	rs34536443	G	C	rs34536443	23603761	0.00000068	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
19	10463118	rs34536443	G	C	rs34536443	23603761	0.00000941	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
19	10463118	rs34536443	G	C	rs34536443	23603761	1.00E-10	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
19	53587370	rs10419891	A	C	rs10419891	22354554	1.07E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
19	53814574	rs7255074	C	T	rs7255074	22354554	5.31E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
20	10471619	rs622293	G	C	rs622293	22354554	1.78E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
20	10476071	rs652325	G	A	rs652325	22354554	1.62E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
20	30109829	rs6058022	G	A	rs6058022	22354554	1.18E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
20	30147145	rs6059980	C	G	rs6059980	22354554	1.74E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
20	30154237	rs11906851	G	C	rs11906851	22354554	1.24E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
20	30156378	rs6120719	T	G	rs6120719	22354554	5.28E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
20	52415107	rs6126970	C	T	rs6126970	22354554	1.12E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
20	56431237	rs35569127	G	GA	rs6025837	22354554	6.26E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
20	56431237	rs6025837	G	A	rs6025837	22354554	6.26E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
21	36677318	rs2834890	G	A	rs2834890	22354554	1.92E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
21	36712588	rs8129030	T	A	rs8129030	23603761	5.44E-09	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	A
21	36715761	rs9979383	C	T	rs9979383	23603761	0.0000477	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
21	36715761	rs9979383	C	T	rs9979383	23603761	0.000105	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
21	36715761	rs9979383	C	T	rs9979383	23603761	1.06E-08	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	T
21	41141852	rs2837193	G	A	rs2837193	22354554	1.41E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
21	41183190	rs458297	G	A	rs458297	22354554	9.62E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
21	41193094	rs462782	T	G	rs462782	22354554	6.84E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
21	41232560	rs380673	A	G	rs380673	22354554	1.91E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
22	21922904	rs2266959	G	T	rs2266959	23603761	0.000298	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
22	21922904	rs2266959	G	T	rs2266959	23603761	6.20E-09	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
22	21922904	rs2266959	G	T	rs2266959	23603761	6.93E-08	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
22	28772817	rs1534884	C	T	rs1534884	22354554	7.45E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
22	29454477	rs6005975	T	C	rs6005975	22354554	1.26E-04	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
22	35913606	rs5999854	A	G	rs5999854	22354554	2.97E-05	NA	NA	NA	814 European ancestry cases; 658 European ancestry controls; 2,400 controls	NOPOP(2400)	European(1472)	ALL(3872)	NOPOP(2400)	EUR(1472)	ALL(3872)	Arthritis (juvenile idiopathic)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	D001171	Arthritis, Juvenile	EFOID:0002609	chronic childhood arthritis	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural
22	37534034	rs2284033	G	A	rs2284033	23603761	0.000000599	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Oligoarticular juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
22	37534034	rs2284033	G	A	rs2284033	23603761	1.55E-08	NA	NA	NA	2816 European ancestry cases; 13056 European ancestry controls	European(15872)	ALL(15872)	EUR(15872)	ALL(15872)	Juvenile idiopathic arthritis (including oligoarticular and rheumatoid factor-negative polyarticular JIA)	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	NA	Research Support, N.I.H., Extramural	Research Support, Non-U.S. Gov't	G
22	37581485	rs229527	C	A	rs229527	24709693	5.96E-05	(AJC)	1.7	[0.88-2.52] unit decrease	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs229527-A	Research Support, Non-U.S. Gov't	G	C1QTNF6
22	37679487	rs10084630	C	G,T	rs10084630	24709693	9.00E-06	(ParVAS)	1.13	[0.64-1.62] unit increase	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs10084630-G	Research Support, Non-U.S. Gov't	G	CYTH4
22	37753999	rs739189	C	A	rs739189	24709693	8.23E-05	(ESR)	8.59	[4.36-12.82] unit increase	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs739189-A	Research Support, Non-U.S. Gov't	C	NA
22	40075400	rs2294369	G	A	rs2294369	24709693	9.00E-08	(AJC)	2.77	[1.77-3.77] unit increase	694 European ancestry child cases	European(694)	ALL(694)	EUR(694)	ALL(694)	Response to methotrexate in juvenile idiopathic arthritis	HPOID:0005681	Juvenile rheumatoid arthritis	DOID:676	juvenile rheumatoid arthritis	NA	NA	NA	NA	Rheumatoid arthritis	rs2294369-A	Research Support, Non-U.S. Gov't	G	CACNA1I

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:3)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C3495559	chloroquine	D002738	1954/5/7	arthritis, juvenile	MESH:D001171	therapeutic	9523387
C3495559	indomethacin	D007213	53-86-1	arthritis, juvenile	MESH:D001171	therapeutic	6125715
C3495559	methotrexate	D008727	1959/5/2	arthritis, juvenile	MESH:D001171	therapeutic	12682624

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)