PedAM

Pediatric Disease Annotations & Medicines


	intrahepatic cholestasis

Disease ID	465
Disease	intrahepatic cholestasis
Definition	Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).
Synonym	bile duct obstruction, intrahepatic biliary stases, intrahepatic biliary stasis, intrahepatic cholestases, intrahepatic cholestasis intrahepatic cholestasis, intrahepatic cholestasis, intrahepatic [disease/finding] intrahepatic biliary stases intrahepatic biliary stasis intrahepatic cholestases intrahepatic cholestasis (finding)
DOID	DOID:1852
UMLS	C0008372
MeSH	D002780
SNOMED-CT	SNOMEDCT_US_2016_09_01:4637005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:16) C0019343 \| pemphigoid gestationis \| 4 C0019158 \| hepatitis \| 3 C0023890 \| cirrhosis \| 3 C0030805 \| pemphigoid \| 3 C0019196 \| hepatitis c \| 2 C0042109 \| urticarial \| 2 C0023890 \| liver cirrhosis \| 2 C0023895 \| liver diseases \| 1 C0002895 \| sickle cell disease \| 1 C0042769 \| virus infection \| 1 C0019196 \| hepatitis c infection \| 1 C0010674 \| cystic fibrosis \| 1 C0019163 \| hepatitis b \| 1 C0032285 \| pneumoniae \| 1 C0023895 \| liver disease \| 1 C0037274 \| dermatoses \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:14) MAF \| 4094 \| CTD_human ATP8B1 \| 5205 \| CTD_human;UniProtKB-KW ABCB11 \| 8647 \| CTD_human;UniProtKB-KW;GHR AMACR \| 23600 \| UniProtKB-KW TJP2 \| 9414 \| CTD_human;UniProtKB-KW SLC25A13 \| 10165 \| UniProtKB-KW NR1H4 \| 9971 \| UniProtKB-KW CYP7B1 \| 9420 \| UniProtKB-KW ABCB4 \| 5244 \| UniProtKB-KW;GHR HSD3B7 \| 80270 \| UniProtKB-KW AP1S1 \| 1174 \| CTD_human MAFG \| 4097 \| CTD_human EGR1 \| 1958 \| CTD_human AKR1D1 \| 6718 \| UniProtKB-KW
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) 8647 \| ABCB11 \| infer 1586 \| CYP17A1 \| infer 1576 \| CYP3A4 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:140) 1080 \| CFTR \| DISEASES 84957 \| RELT \| DISEASES 2099 \| ESR1 \| DISEASES 6554 \| SLC10A1 \| DISEASES 28231 \| SLCO4A1 \| DISEASES 5020 \| OXT \| DISEASES 55512 \| SMPD3 \| DISEASES 343 \| AQP8 \| DISEASES 6822 \| SULT2A1 \| DISEASES 2584 \| GALK1 \| DISEASES 2729 \| GCLC \| DISEASES 55754 \| TMEM30A \| DISEASES 338 \| APOB \| DISEASES 4358 \| MPV17 \| DISEASES 9429 \| ABCG2 \| DISEASES 6555 \| SLC10A2 \| DISEASES 51081 \| MRPS7 \| DISEASES 2678 \| GGT1 \| DISEASES 348 \| APOE \| DISEASES 445 \| ASS1 \| DISEASES 8431 \| NR0B2 \| DISEASES 182 \| JAG1 \| DISEASES 6341 \| SCO1 \| DISEASES 10599 \| SLCO1B1 \| DISEASES 1593 \| CYP27A1 \| DISEASES 3569 \| IL6 \| DISEASES 570 \| BAAT \| DISEASES 5168 \| ENPP2 \| DISEASES 64240 \| ABCG5 \| DISEASES 28234 \| SLCO1B3 \| DISEASES 10162 \| LPCAT3 \| DISEASES 10961 \| ERP29 \| DISEASES 54947 \| LPCAT2 \| DISEASES 6521 \| SLC4A1 \| DISEASES 23417 \| MLYCD \| DISEASES 27443 \| CECR2 \| DISEASES 5465 \| PPARA \| DISEASES 5338 \| PLD2 \| DISEASES 10998 \| SLC27A5 \| DISEASES 8647 \| ABCB11 \| DISEASES 2162 \| F13A1 \| DISEASES 5244 \| ABCB4 \| DISEASES 5243 \| ABCB1 \| DISEASES 64241 \| ABCG8 \| DISEASES 167410 \| LIX1 \| DISEASES 51302 \| CYP39A1 \| DISEASES 10398 \| MYL9 \| DISEASES 7082 \| TJP1 \| DISEASES 79888 \| LPCAT1 \| DISEASES 5205 \| ATP8B1 \| DISEASES 79895 \| ATP8B4 \| DISEASES 4645 \| MYO5B \| DISEASES 8714 \| ABCC3 \| DISEASES 9965 \| FGF19 \| DISEASES 213 \| ALB \| DISEASES 7349 \| UCN \| DISEASES 27242 \| TNFRSF21 \| DISEASES 80270 \| HSD3B7 \| DISEASES 10935 \| PRDX3 \| DISEASES 3990 \| LIPC \| DISEASES 2819 \| GPD1 \| DISEASES 55957 \| LIN37 \| DISEASES 1581 \| CYP7A1 \| DISEASES 54578 \| UGT1A6 \| DISEASES 54658 \| UGT1A1 \| DISEASES 7363 \| UGT2B4 \| DISEASES 6579 \| SLCO1A2 \| DISEASES 2147 \| F2 \| DISEASES 9420 \| CYP7B1 \| DISEASES 358 \| AQP1 \| DISEASES 148229 \| ATP8B3 \| DISEASES 3170 \| FOXA2 \| DISEASES 1442 \| CSH1 \| DISEASES 10170 \| DHRS9 \| DISEASES 1582 \| CYP8B1 \| DISEASES 4018 \| LPA \| DISEASES 51733 \| UPB1 \| DISEASES 10498 \| CARM1 \| DISEASES 26276 \| VPS33B \| DISEASES 8905 \| AP1S2 \| DISEASES 286410 \| ATP11C \| DISEASES 10057 \| ABCC5 \| DISEASES 123264 \| SLC51B \| DISEASES 8856 \| NR1I2 \| DISEASES 1174 \| AP1S1 \| DISEASES 1576 \| CYP3A4 \| DISEASES 7430 \| EZR \| DISEASES 63894 \| VIPAS39 \| DISEASES 1395 \| CRHR2 \| DISEASES 5174 \| PDZK1 \| DISEASES 2100 \| ESR2 \| DISEASES 285193 \| DUSP28 \| DISEASES 54716 \| SLC6A20 \| DISEASES 161291 \| TMEM30B \| DISEASES 5265 \| SERPINA1 \| DISEASES 2555 \| GABRA2 \| DISEASES 51592 \| TRIM33 \| DISEASES 4638 \| MYLK \| DISEASES 3135 \| HLA-G \| DISEASES 4539 \| MT-ND4L \| DISEASES 22977 \| AKR7A3 \| DISEASES 9970 \| NR1I3 \| DISEASES 57198 \| ATP8B2 \| DISEASES 6785 \| ELOVL4 \| DISEASES 2730 \| GCLM \| DISEASES 1244 \| ABCC2 \| DISEASES 959 \| CD40LG \| DISEASES 10864 \| SLC22A7 \| DISEASES 3155 \| HMGCL \| DISEASES 6048 \| RNF5 \| DISEASES 10257 \| ABCC4 \| DISEASES 3096 \| HIVEP1 \| DISEASES 3801 \| KIFC3 \| DISEASES 3030 \| HADHA \| DISEASES 3709 \| ITPR2 \| DISEASES 53919 \| SLCO1C1 \| DISEASES 51761 \| ATP8A2 \| DISEASES 10396 \| ATP8A1 \| DISEASES 348801 \| LNP1 \| DISEASES 1443 \| CSH2 \| DISEASES 2172 \| FABP6 \| DISEASES 8513 \| LIPF \| DISEASES 174 \| AFP \| DISEASES 728441 \| GGT2 \| DISEASES 8604 \| SLC25A12 \| DISEASES 9698 \| PUM1 \| DISEASES 3113 \| HLA-DPA1 \| DISEASES 388552 \| BLOC1S3 \| DISEASES 7124 \| TNF \| DISEASES 10165 \| SLC25A13 \| DISEASES 147372 \| CCBE1 \| DISEASES 6256 \| RXRA \| DISEASES 2939 \| GSTA2 \| DISEASES 81792 \| ADAMTS12 \| DISEASES 151306 \| GPBAR1 \| DISEASES 51312 \| SLC25A37 \| DISEASES 9414 \| TJP2 \| DISEASES 9971 \| NR1H4 \| DISEASES 11245 \| GPR176 \| DISEASES 57000 \| GSN-AS1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	465
Disease	intrahepatic cholestasis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:15) HP:0000952 \| Yellow skin \| 5 HP:0001399 \| Liver failure \| 3 HP:0001394 \| Hepatic cirrhosis \| 3 HP:0000989 \| pruritis \| 3 HP:0012115 \| Liver inflammation \| 3 HP:0200034 \| Papule \| 2 HP:0011854 \| Hemoperitoneum \| 1 HP:0002904 \| High blood bilirubin levels \| 1 HP:0003256 \| Coagulopathy \| 1 HP:0011675 \| Arrhythmias \| 1 HP:0001548 \| Overgrowth \| 1 HP:0001510 \| Growth deficiency \| 1 HP:0006554 \| Acute hepatic failure \| 1 HP:0200119 \| Acute liver inflammation \| 1 HP:0030149 \| Cardiovascular shock \| 1

Disease ID	465
Disease	intrahepatic cholestasis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:12) C2203646 \| jaundice C1963165 \| malabsorption C1839611 \| n syndrome C0853882 \| reticuloendothelial dysfunction C0745091 \| hypereosinophilia C0343065 \| dermographism C0239946 \| hepatic fibrosis C0038325 \| stevens-johnson syndrome C0033774 \| pruritus C0027613 \| neonatal hepatitis C0019158 \| hepatitis C0005779 \| blood coagulation disorders
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:3) C0022346 \| jaundice \| 5 C0019158 \| hepatitis \| 3 C0033774 \| pruritus \| 2

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:40)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0008372	azithromycin	D017963	83905-01-5	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	12395890
C0008372	bosentan	C086232	147536-97-8	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	23956101
C0008372	busulfan	D002066	55-98-1	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	2797253
C0008372	carbamazepine	D002220	298-46-4	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	7925147
C0008372	carmustine	D002330	154-93-8	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	2044907
C0008372	celecoxib	D000068579	-	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	11177350
C0008372	cetirizine	D017332	83881-51-0	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	11034010
C0008372	chlorpromazine	D002746	50-53-3	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	1088626
C0008372	chlorzoxazone	D002753	95-25-0	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	10322565
C0008372	cinnarizine	D002936	298-57-7	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	23956101
C0008372	cyclosporine	D016572	59865-13-3	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	23956101
C0008372	dapsone	D003622	80-08-0	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	8698924
C0008372	disopyramide	D004206	3737/9/5	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	71640
C0008372	enalapril	D004656	75847-73-3	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	14642633
C0008372	enoxacin	D015365	74011-58-8	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	1506651
C0008372	fluoxetine	D005473	54910-89-3	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	8931446
C0008372	flutamide	D005485	13311-84-7	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	2719431
C0008372	fosinopril	D017328	98048-97-6	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	11293449
C0008372	glimepiride	C057619	-	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	23956101
C0008372	griseofulvin	D006118	126-07-8	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	131731
C0008372	haloperidol	D006220	52-86-8	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	7095372
C0008372	indomethacin	D007213	53-86-1	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	1084454
C0008372	lovastatin	D008148	75330-75-5	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	7867482
C0008372	metformin	D008687	657-24-9	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	11467664
C0008372	nafcillin	D009254	147-52-4	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	8565754
C0008372	nevirapine	D019829	129618-40-2	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	16389032
C0008372	ofloxacin	D015242	82419-36-1	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	1506646
C0008372	omeprazole	D009853	73590-58-6	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	17266883
C0008372	oxytetracycline	D010118	79-57-2	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	15963097
C0008372	piroxicam	D010894	36322-90-4	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	1955140
C0008372	propylthiouracil	D011441	51-52-5	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	12645809
C0008372	pyrazinamide	D011718	98-96-4	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	27255380
C0008372	rifampin	D012293	13292-46-1	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	496138
C0008372	rifampin	D012293	13292-46-1	cholestasis, intrahepatic	MESH:D002780	therapeutic	9732934
C0008372	ticlopidine	D013988	55142-85-3	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	18004066
C0008372	trimethoprim	D014295	738-70-5	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	2753538
C0008372	troglitazone	C057693	97322-87-7	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	10685776
C0008372	valproic acid	D014635	99-66-1	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	8099687
C0008372	vitamin a	D014801	11103-57-4	cholestasis, intrahepatic	MESH:D002780	marker/mechanism	17924304
C0008372	zinc acetate	D019345	5970-45-6	cholestasis, intrahepatic	MESH:D002780	therapeutic	23423674

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)