PedAM

Pediatric Disease Annotations & Medicines


	intestinal pseudo-obstruction

Disease ID	851
Disease	intestinal pseudo-obstruction
Definition	A type of ILEUS, a functional not mechanical obstruction of the INTESTINES. This syndrome is caused by a large number of disorders involving the smooth muscles (MUSCLE, SMOOTH) or the NERVOUS SYSTEM.
Synonym	chronic idiopathic intestinal pseudo-obstruction congenital short bowel syndrome congenital short bowel syndrome (disorder) csbs enteric neuropathy idiopathic intestinal pseudo-obstruction idiopathic intestinal pseudo-obstructions intestinal pseudo obstruction intestinal pseudo obstruction, idiopathic intestinal pseudo-obstruction [disease/finding] intestinal pseudo-obstruction, idiopathic intestinal pseudo-obstructions intestinal pseudo-obstructions, idiopathic intestinal pseudoobstruction intestinal pseudoobstructions intestine pseudoobstruction intestine, pseudoobstruction pseudo intestinal obstruction pseudo obstruction intestinal pseudo obstruction, intestinal pseudo-obstruction of intestine pseudo-obstruction of intestine (disorder) pseudo-obstruction, idiopathic intestinal pseudo-obstruction, intestinal pseudo-obstructions, idiopathic intestinal pseudo-obstructions, intestinal pseudointestinal obstruction syndrome pseudoobstruction, intestinal pseudoobstructions, intestinal pseudoobstructive syndrome
Orphanet	ORPHANET:2301
OMIM	OMIM:615237
DOID	DOID:3878
UMLS	C0021847
MeSH	D007418
SNOMED-CT	SNOMEDCT_US_2016_09_01:235825006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:13) C0409974 \| lupus erythematosus \| 3 C0024141 \| systemic lupus erythematosus \| 3 C0042961 \| volvulus \| 2 C0014848 \| achalasia \| 2 C0751651 \| mitochondrial disease \| 1 C0025160 \| megacolon \| 1 C0013473 \| eating disorder \| 1 C0152020 \| gastroparesis \| 1 C0751651 \| mitochondrial diseases \| 1 C0036421 \| systemic sclerosis \| 1 C0442874 \| neuropathy \| 1 C0031511 \| phaeochromocytoma \| 1 C0026691 \| kawasaki disease \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) FLNA \| 2316 \| ORPHANET;GHR CLMP \| 79827 \| CLINVAR;ORPHANET;UNIPROT
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:83) 2767 \| GNA11 \| DISEASES 28954 \| REM1 \| DISEASES 49 \| ACR \| DISEASES 2862 \| MLNR \| DISEASES 2765 \| GML \| DISEASES 59 \| ACTA2 \| DISEASES 79176 \| FBXL15 \| DISEASES 5539 \| PPY \| DISEASES 2798 \| GNRHR \| DISEASES 2026 \| ENO2 \| DISEASES 55907 \| CMAS \| DISEASES 3196 \| TLX2 \| DISEASES 2797 \| GNRH2 \| DISEASES 1890 \| TYMP \| DISEASES 1264 \| CNN1 \| DISEASES 3110 \| MNX1 \| DISEASES 6535 \| SLC6A8 \| DISEASES 6741 \| SSB \| DISEASES 2294 \| FOXF1 \| DISEASES 3249 \| HPN \| DISEASES 2769 \| GNA15 \| DISEASES 6855 \| SYP \| DISEASES 590 \| BCHE \| DISEASES 6722 \| SRF \| DISEASES 8829 \| NRP1 \| DISEASES 5428 \| POLG \| DISEASES 6876 \| TAGLN \| DISEASES 83706 \| FERMT3 \| DISEASES 7345 \| UCHL1 \| DISEASES 6750 \| SST \| DISEASES 3815 \| KIT \| DISEASES 56896 \| DPYSL5 \| DISEASES 3973 \| LHCGR \| DISEASES 129401 \| NUP35 \| DISEASES 72 \| ACTG2 \| DISEASES 213 \| ALB \| DISEASES 10653 \| SPINT2 \| DISEASES 43 \| ACHE \| DISEASES 794 \| CALB2 \| DISEASES 5644 \| PRSS1 \| DISEASES 8557 \| TCAP \| DISEASES 2744 \| GLS \| DISEASES 6331 \| SCN5A \| DISEASES 51738 \| GHRL \| DISEASES 885 \| CCK \| DISEASES 1908 \| EDN3 \| DISEASES 3363 \| HTR7 \| DISEASES 6609 \| SMPD1 \| DISEASES 1431 \| CS \| DISEASES 132884 \| EVC2 \| DISEASES 1760 \| DMPK \| DISEASES 7453 \| WARS \| DISEASES 1785 \| DNM2 \| DISEASES 5979 \| RET \| DISEASES 6525 \| SMTN \| DISEASES 1995 \| ELAVL3 \| DISEASES 4638 \| MYLK \| DISEASES 3360 \| HTR4 \| DISEASES 6663 \| SOX10 \| DISEASES 7432 \| VIP \| DISEASES 9446 \| GSTO1 \| DISEASES 2316 \| FLNA \| DISEASES 3897 \| L1CAM \| DISEASES 3195 \| TLX1 \| DISEASES 959 \| CD40LG \| DISEASES 81030 \| ZBP1 \| DISEASES 4303 \| FOXO4 \| DISEASES 229 \| ALDOB \| DISEASES 1910 \| EDNRB \| DISEASES 54840 \| APTX \| DISEASES 4629 \| MYH11 \| DISEASES 6314 \| ATXN7 \| DISEASES 3778 \| KCNMA1 \| DISEASES 4295 \| MLN \| DISEASES 93649 \| MYOCD \| DISEASES 9278 \| ZBTB22 \| DISEASES 79827 \| CLMP \| DISEASES 7019 \| TFAM \| DISEASES 136541 \| PRSS58 \| DISEASES 567 \| B2M \| DISEASES 6625 \| SNRNP70 \| DISEASES 102723508 \| KANTR \| DISEASES 4567 \| MT-TL1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	851
Disease	intestinal pseudo-obstruction
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:9) HP:0002725 \| Systemic lupus erythematosus \| 3 HP:0002251 \| Hirschsprung megacolon \| 3 HP:0002571 \| Achalasia \| 2 HP:0002580 \| Volvulus \| 2 HP:0001541 \| Ascites \| 1 HP:0002015 \| Swallowing difficulty \| 1 HP:0011947 \| Respiratory infection \| 1 HP:0000155 \| Oral ulcer \| 1 HP:0002578 \| Gastroparesis \| 1

Disease ID	851
Disease	intestinal pseudo-obstruction
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:4)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs587776964	NA	79827	CLMP	umls:C0021847	CLINVAR	NA	0.240542884	NA	CLMP;LOC101929289	11	123084670	T	-
rs587776965	NA	79827	CLMP	umls:C0021847	CLINVAR	NA	0.240542884	NA	CLMP;LOC101929289	11	123074702	C	T
rs587776966	NA	79827	CLMP	umls:C0021847	CLINVAR	NA	0.240542884	NA	CLMP;LOC101929289	11	123083100	G	A
rs587776967	NA	79827	CLMP	umls:C0021847	CLINVAR	NA	0.240542884	NA	CLMP;LOC101929289	11	123084529	A	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:3)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0021847	clozapine	D003024	5786-21-0	intestinal pseudo-obstruction	MESH:D007418	marker/mechanism	1860384
C0021847	vincristine	D014750	-	intestinal pseudo-obstruction	MESH:D007418	marker/mechanism	9434832
C0021847	vindesine	D014751	53643-48-4	intestinal pseudo-obstruction	MESH:D007418	marker/mechanism	17617780

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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