Home Contact Sitemap

PedAM

Pediatric Disease Annotations & Medicines



   interstitial nephritis
  

Disease ID 1049
Disease interstitial nephritis
Definition
Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.
Synonym
disease tubulointerstitial
in - interstitial nephritis
interstitial nephritides
interstitial nephritis (disorder)
interstitial nephritis (qualifier value)
interstitial nephritis, nos
nephritides, interstitial
nephritis interstitial
nephritis, interstitial
nephritis, interstitial [disease/finding]
tubulointerstitial disease
tubulointerstitial nephritis
tubulointerstitial nephropathy
DOID
UMLS
C0027707
MeSH
SNOMED-CT
Comorbidity
UMLS | Disease | Sentences' Count(Total Sentences:83)
C0035078  |  renal failure  |  25
C0022660  |  acute renal failure  |  12
C0027697  |  nephritis  |  12
C0042164  |  uveitis  |  10
C0017658  |  glomerulonephritis  |  9
C0022658  |  renal disease  |  6
C0022658  |  nephropathy  |  5
C0022661  |  end-stage renal disease  |  5
C0042769  |  virus infection  |  4
C0033687  |  proteinuria  |  4
C0235618  |  proliferative glomerulonephritis  |  4
C0017665  |  membranous nephropathy  |  4
C0221238  |  mesangial proliferative glomerulonephritis  |  3
C0022661  |  chronic renal failure  |  3
C0009324  |  ulcerative colitis  |  3
C0178664  |  glomerulosclerosis  |  3
C0022658  |  kidney disease  |  3
C0015624  |  fanconi syndrome  |  3
C0017668  |  focal segmental glomerulosclerosis  |  3
C0036202  |  sarcoidosis  |  3
C1565489  |  renal insufficiency  |  3
C0034150  |  purpura  |  2
C0042384  |  vasculitis  |  2
C0023364  |  leptospirosis  |  2
C0017661  |  iga nephropathy  |  2
C1527336  |  sjogren's syndrome  |  2
C1565662  |  acute renal insufficiency  |  2
C0022672  |  acute tubular necrosis  |  2
C0026764  |  myeloma  |  2
C0024299  |  malignant lymphoma  |  1
C0024143  |  lupus nephritis  |  1
C0011848  |  diabetes insipidus  |  1
C0015230  |  rash  |  1
C0023434  |  chronic lymphocytic leukemia  |  1
C0020295  |  hydronephrosis  |  1
C0024291  |  hemophagocytic syndrome  |  1
C0042769  |  viral infection  |  1
C0022661  |  chronic kidney disease  |  1
C0021400  |  influenza  |  1
C0004943  |  behcet's disease  |  1
C0262587  |  parathyroid adenoma  |  1
C0031036  |  polyarteritis nodosa  |  1
C0026764  |  multiple myeloma  |  1
C0021053  |  immune disorder  |  1
C0022658  |  kidney diseases  |  1
C0008312  |  primary biliary cirrhosis  |  1
C0032285  |  pneumonia  |  1
C0034186  |  pyelonephritis  |  1
C0034152  |  henoch-schonlein purpura  |  1
C0023890  |  cirrhosis  |  1
C0006840  |  candida infection  |  1
C0008312  |  biliary cirrhosis  |  1
C0017160  |  gastroenteritis  |  1
C0017152  |  gastritis  |  1
C0013182  |  drug hypersensitivity  |  1
C0010346  |  crohn's disease  |  1
C0036202  |  sarcoid  |  1
C0024115  |  pulmonary disease  |  1
C0028326  |  noonan syndrome  |  1
C0178664  |  glomerular sclerosis  |  1
C1328840  |  autoimmune lymphoproliferative syndrome  |  1
C0023418  |  leukaemia  |  1
C0151468  |  thyroid adenoma  |  1
C0023448  |  lymphocytic leukemia  |  1
C0036349  |  paranoid schizophrenia  |  1
C0155765  |  microangiopathy  |  1
C0038013  |  ankylosing spondylitis  |  1
C0038012  |  spondylitis  |  1
C0018202  |  granulomatous vasculitis  |  1
C0021053  |  immune disorders  |  1
C0023434  |  chronic lymphocytic leukaemia  |  1
C0001339  |  acute pancreatitis  |  1
C0023448  |  lymphocytic leukaemia  |  1
C0001430  |  adenoma  |  1
C0024299  |  lymphoma  |  1
C0403414  |  acute poststreptococcal glomerulonephritis  |  1
C0007138  |  urothelial carcinoma  |  1
C0162283  |  nephrogenic diabetes insipidus  |  1
C0019655  |  histoplasmosis  |  1
C0030305  |  pancreatitis  |  1
C0011847  |  diabetes  |  1
C0036114  |  salmonellosis  |  1
C0009319  |  colitis  |  1
Curated Gene
Entrez_id | Symbol | Resource(Total Genes:10)
CRP  |  1401  |  CTD_human
CCL2  |  6347  |  CTD_human
ALB  |  213  |  CTD_human
THBS1  |  7057  |  CTD_human
NGF  |  4803  |  CTD_human
CCL7  |  6354  |  CTD_human
DCN  |  1634  |  CTD_human
CYP2C9  |  1559  |  CTD_human
CYP2D6  |  1565  |  CTD_human
CCL1  |  6346  |  CTD_human
Inferring Gene
Entrez_id | Symbol | Resource(Total Genes:1)
1557  |  CYP2C19  |  infer
Text Mined Gene
Entrez_id | Symbol | Score | Resource(Total Genes:170)
359  |  AQP2  |  DISEASES
4627  |  MYH9  |  DISEASES
3002  |  GZMB  |  DISEASES
113278  |  SLC52A3  |  DISEASES
51654  |  CDK5RAP1  |  DISEASES
479  |  ATP12A  |  DISEASES
51285  |  RASL12  |  DISEASES
1666  |  DECR1  |  DISEASES
29124  |  LGALS13  |  DISEASES
7040  |  TGFB1  |  DISEASES
973  |  CD79A  |  DISEASES
2639  |  GCDH  |  DISEASES
4353  |  MPO  |  DISEASES
6347  |  CCL2  |  DISEASES
3558  |  IL2  |  DISEASES
3458  |  IFNG  |  DISEASES
2822  |  GPLD1  |  DISEASES
8724  |  SNX3  |  DISEASES
3003  |  GZMK  |  DISEASES
7903  |  ST8SIA4  |  DISEASES
5657  |  PRTN3  |  DISEASES
55831  |  EMC3  |  DISEASES
10047  |  CST8  |  DISEASES
826  |  CAPNS1  |  DISEASES
7103  |  TSPAN8  |  DISEASES
2952  |  GSTT1  |  DISEASES
968  |  CD68  |  DISEASES
3998  |  LMAN1  |  DISEASES
548593  |  SLX1A  |  DISEASES
3270  |  HRC  |  DISEASES
10343  |  PKDREJ  |  DISEASES
55902  |  ACSS2  |  DISEASES
50617  |  ATP6V0A4  |  DISEASES
6382  |  SDC1  |  DISEASES
6737  |  TRIM21  |  DISEASES
1401  |  CRP  |  DISEASES
4064  |  CD180  |  DISEASES
2799  |  GNS  |  DISEASES
27283  |  TINAG  |  DISEASES
9360  |  PPIG  |  DISEASES
4069  |  LYZ  |  DISEASES
23495  |  TNFRSF13B  |  DISEASES
5939  |  RBMS2  |  DISEASES
23531  |  MMD  |  DISEASES
27130  |  INVS  |  DISEASES
495  |  ATP4A  |  DISEASES
23523  |  CABIN1  |  DISEASES
7299  |  TYR  |  DISEASES
4162  |  MCAM  |  DISEASES
941  |  CD80  |  DISEASES
10463  |  SLC30A9  |  DISEASES
25759  |  SHC2  |  DISEASES
10686  |  CLDN16  |  DISEASES
3383  |  ICAM1  |  DISEASES
11222  |  MRPL3  |  DISEASES
9061  |  PAPSS1  |  DISEASES
5286  |  PIK3C2A  |  DISEASES
939  |  CD27  |  DISEASES
7157  |  TP53  |  DISEASES
57530  |  CGN  |  DISEASES
5972  |  REN  |  DISEASES
134864  |  TAAR1  |  DISEASES
57689  |  LRRC4C  |  DISEASES
114571  |  SLC22A9  |  DISEASES
5741  |  PTH  |  DISEASES
55079  |  FEZF2  |  DISEASES
925  |  CD8A  |  DISEASES
10563  |  CXCL13  |  DISEASES
1636  |  ACE  |  DISEASES
326  |  AIRE  |  DISEASES
1234  |  CCR5  |  DISEASES
6352  |  CCL5  |  DISEASES
1990  |  CELA1  |  DISEASES
84464  |  SLX4  |  DISEASES
7412  |  VCAM1  |  DISEASES
84661  |  DPY30  |  DISEASES
27306  |  HPGDS  |  DISEASES
248  |  ALPI  |  DISEASES
8320  |  EOMES  |  DISEASES
79885  |  HDAC11  |  DISEASES
152185  |  SPICE1  |  DISEASES
213  |  ALB  |  DISEASES
134288  |  TMEM174  |  DISEASES
203286  |  ANKS6  |  DISEASES
7373  |  COL14A1  |  DISEASES
90678  |  LRSAM1  |  DISEASES
55867  |  SLC22A11  |  DISEASES
1493  |  CTLA4  |  DISEASES
171558  |  PTCRA  |  DISEASES
7369  |  UMOD  |  DISEASES
157570  |  ESCO2  |  DISEASES
54207  |  KCNK10  |  DISEASES
2944  |  GSTM1  |  DISEASES
4327  |  MMP19  |  DISEASES
23765  |  IL17RA  |  DISEASES
6888  |  TALDO1  |  DISEASES
6817  |  SULT1A1  |  DISEASES
10194  |  TSHZ1  |  DISEASES
6524  |  SLC5A2  |  DISEASES
79008  |  SLX1B  |  DISEASES
942  |  CD86  |  DISEASES
5587  |  PRKD1  |  DISEASES
338567  |  KCNK18  |  DISEASES
2938  |  GSTA1  |  DISEASES
9376  |  SLC22A8  |  DISEASES
1576  |  CYP3A4  |  DISEASES
6622  |  SNCA  |  DISEASES
6799  |  SULT1A2  |  DISEASES
1429  |  CRYZ  |  DISEASES
23480  |  SEC61G  |  DISEASES
1528  |  CYB5A  |  DISEASES
1544  |  CYP1A2  |  DISEASES
10219  |  KLRG1  |  DISEASES
23556  |  PIGN  |  DISEASES
7867  |  MAPKAPK3  |  DISEASES
56980  |  PRDM10  |  DISEASES
8645  |  KCNK5  |  DISEASES
4151  |  MB  |  DISEASES
1565  |  CYP2D6  |  DISEASES
9361  |  LONP1  |  DISEASES
22909  |  FAN1  |  DISEASES
10724  |  MGEA5  |  DISEASES
9937  |  DCLRE1A  |  DISEASES
183  |  AGT  |  DISEASES
1378  |  CR1  |  DISEASES
1380  |  CR2  |  DISEASES
5743  |  PTGS2  |  DISEASES
7101  |  NR2E1  |  DISEASES
57107  |  PDSS2  |  DISEASES
537  |  ATP6AP1  |  DISEASES
2564  |  GABRE  |  DISEASES
9635  |  CLCA2  |  DISEASES
959  |  CD40LG  |  DISEASES
1557  |  CYP2C19  |  DISEASES
2833  |  CXCR3  |  DISEASES
1896  |  EDA  |  DISEASES
3339  |  HSPG2  |  DISEASES
23590  |  PDSS1  |  DISEASES
1041  |  CDSN  |  DISEASES
7454  |  WAS  |  DISEASES
1471  |  CST3  |  DISEASES
3274  |  HRH2  |  DISEASES
261734  |  NPHP4  |  DISEASES
353  |  APRT  |  DISEASES
7498  |  XDH  |  DISEASES
1543  |  CYP1A1  |  DISEASES
551  |  AVP  |  DISEASES
5272  |  SERPINB9  |  DISEASES
55576  |  STAB2  |  DISEASES
126206  |  NLRP5  |  DISEASES
2875  |  GPT  |  DISEASES
6696  |  SPP1  |  DISEASES
4668  |  NAGA  |  DISEASES
8576  |  STK16  |  DISEASES
10379  |  IRF9  |  DISEASES
28996  |  HIPK2  |  DISEASES
7018  |  TF  |  DISEASES
644150  |  WIPF3  |  DISEASES
3776  |  KCNK2  |  DISEASES
1029  |  CDKN2A  |  DISEASES
7124  |  TNF  |  DISEASES
834  |  CASP1  |  DISEASES
389549  |  FEZF1  |  DISEASES
3850  |  KRT3  |  DISEASES
259289  |  TAS2R43  |  DISEASES
1232  |  CCR3  |  DISEASES
8972  |  MGAM  |  DISEASES
5228  |  PGF  |  DISEASES
567  |  B2M  |  DISEASES
26806  |  SNORD44  |  DISEASES
Locus(Waiting for update.)
Disease ID 1049
Disease interstitial nephritis
Integrated Phenotype(Waiting for update.)
Text Mined Phenotype
HPO | Name | Sentences' Count(Total Phenotypes:47)
HP:0000083  |  Renal insufficiency  |  28
HP:0001919  |  Acute renal failure  |  25
HP:0000123  |  Nephritis  |  13
HP:0000554  |  Uveitis  |  10
HP:0000099  |  Glomerular nephritis  |  9
HP:0003774  |  End-stage renal failure  |  8
HP:0000093  |  Proteinuria  |  4
HP:0004729  |  Acute tubulointerstitial nephritis  |  4
HP:0012578  |  Membranous glomerulonephritis  |  4
HP:0000112  |  Nephropathy  |  4
HP:0000790  |  Hematuria  |  3
HP:0000096  |  Glomerulosclerosis  |  3
HP:0000097  |  focal glomerulosclerosis  |  3
HP:0100279  |  Ulcerative colitis  |  3
HP:0002633  |  Vasculitis  |  2
HP:0004743  |  Chronic tubulointerstitial nephritis  |  2
HP:0008682  |  Renal tubular necrosis  |  2
HP:0012597  |  Heavy proteinuria  |  2
HP:0000979  |  Purpura  |  2
HP:0002665  |  Lymphoma  |  1
HP:0012622  |  Chronic kidney disease  |  1
HP:0012574  |  Mesangial hypercellularity  |  1
HP:0012579  |  Minimal change glomerulonephritis  |  1
HP:0001970  |  Interstitial nephritis  |  1
HP:0000107  |  Renal cyst  |  1
HP:0002090  |  Pneumonia  |  1
HP:0000071  |  Narrowing of the ureter  |  1
HP:0003159  |  Hyperoxaluria  |  1
HP:0000873  |  Diabetes insipidus  |  1
HP:0002902  |  Hyponatremia  |  1
HP:0001394  |  Hepatic cirrhosis  |  1
HP:0005550  |  Chronic lymphatic leukemia  |  1
HP:0000126  |  Hydronephrosis  |  1
HP:0002613  |  Biliary cirrhosis  |  1
HP:0000092  |  Tubular atrophy  |  1
HP:0000854  |  Thyroid adenoma  |  1
HP:0030762  |  Mesangiolysis  |  1
HP:0002583  |  Colitis  |  1
HP:0005263  |  Gastritis  |  1
HP:0006775  |  Multiple myeloma  |  1
HP:0009806  |  Nephrogenic diabetes insipidus  |  1
HP:0002897  |  Parathyroid adenoma  |  1
HP:0002960  |  Autoimmune condition  |  1
HP:0012330  |  Pyelonephritis  |  1
HP:0006530  |  Interstitial lung disease  |  1
HP:0000969  |  Dropsy  |  1
HP:0100280  |  Morbus Crohn  |  1
Disease ID 1049
Disease interstitial nephritis
Manually Symptom(Waiting for update.)
Text Mined Symptom
UMLS | Name | Sentences' Count(Total Symptoms:6)
C0035078  |  renal failure  |  25
C0022660  |  acute renal failure  |  12
C0022658  |  nephropathy  |  4
C0022661  |  chronic renal failure  |  3
C0022672  |  acute tubular necrosis  |  2
C0149678  |  epstein-barr virus infection  |  1
Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)
All Snps(Total Genotypes:0)
(Waiting for update.)
GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)
GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)
Mapped by lexical matching(Total Items:0)
(Waiting for update.)
Mapped by homologous gene(Total Items:0)
(Waiting for update.)
Chemical(Total Drugs:65)
CUI ChemicalName ChemicalID CasRN DiseaseName DiseaseID DirectEvidence PubMedIDs
C0027707acetaminophenD000082103-90-2nephritis, interstitialMESH:D009395marker/mechanism12832150
C0027707allopurinolD000493315-30-0nephritis, interstitialMESH:D009395marker/mechanism3822042
C0027707amlodipineD01731188150-42-9nephritis, interstitialMESH:D009395marker/mechanism10344374
C0027707amphetamineD000661300-62-9nephritis, interstitialMESH:D009395marker/mechanism6701599
C0027707ampicillinD00066769-53-4nephritis, interstitialMESH:D009395marker/mechanism1128370
C0027707azithromycinD01796383905-01-5nephritis, interstitialMESH:D009395marker/mechanism15602202
C0027707bendroflumethiazideD00153973-48-3nephritis, interstitialMESH:D009395marker/mechanism6604293
C0027707caffeineD0021101958/8/2nephritis, interstitialMESH:D009395marker/mechanism10803761
C0027707carbamazepineD002220298-46-4nephritis, interstitialMESH:D009395marker/mechanism11346062
C0027707carbenicillinD0022284697-36-3nephritis, interstitialMESH:D009395marker/mechanism622610
C0027707carbimazoleD00223122232-54-8nephritis, interstitialMESH:D009395marker/mechanism12543903
C0027707carmustineD002330154-93-8nephritis, interstitialMESH:D009395marker/mechanism7272960
C0027707cefdinirC056814-nephritis, interstitialMESH:D009395marker/mechanism11300142
C0027707cefotaximeD00243963527-52-6nephritis, interstitialMESH:D009395marker/mechanism10803769
C0027707ceftazidimeD00244278439-06-2nephritis, interstitialMESH:D009395marker/mechanism9033764
C0027707celecoxibD000068579-nephritis, interstitialMESH:D009395marker/mechanism12046048
C0027707cidofovirC059262113852-37-2nephritis, interstitialMESH:D009395marker/mechanism10589927
C0027707cimetidineD00292751481-61-9nephritis, interstitialMESH:D009395marker/mechanism10074607
C0027707ciprofloxacinD00293985721-33-1nephritis, interstitialMESH:D009395marker/mechanism10575299
C0027707clozapineD0030245786-21-0nephritis, interstitialMESH:D009395marker/mechanism10513719
C0027707creatineD00340157-00-1nephritis, interstitialMESH:D009395marker/mechanism10075534
C0027707cyclosporineD01657259865-13-3nephritis, interstitialMESH:D009395therapeutic16114793
C0027707cisplatinD00294515663-27-1nephritis, interstitialMESH:D009395marker/mechanism15464296
C0027707diclofenacD00400815307-86-5nephritis, interstitialMESH:D009395marker/mechanism10444806
C0027707dicloxacillinD0040093116-76-5nephritis, interstitialMESH:D009395marker/mechanism622610
C0027707fenoprofenD00527931879-05-7nephritis, interstitialMESH:D009395marker/mechanism503131
C0027707folic acidD00549259-30-3nephritis, interstitialMESH:D009395marker/mechanism15013062
C0027707foscarnetD0172454428-95-9nephritis, interstitialMESH:D009395marker/mechanism2560634
C0027707griseofulvinD006118126-07-8nephritis, interstitialMESH:D009395marker/mechanism2237566
C0027707hydroxyureaD006918127-07-1nephritis, interstitialMESH:D009395marker/mechanism9221195
C0027707ifosfamideD0070693778-73-2nephritis, interstitialMESH:D009395marker/mechanism10968388
C0027707indinavirD019469150378-17-9nephritis, interstitialMESH:D009395marker/mechanism10739809
C0027707indomethacinD00721353-86-1nephritis, interstitialMESH:D009395marker/mechanism10534532
C0027707lansoprazoleD064747-nephritis, interstitialMESH:D009395marker/mechanism15004262
C0027707linezolidD000069349-nephritis, interstitialMESH:D009395marker/mechanism18044266
C0027707loratadineD01733679794-75-5nephritis, interstitialMESH:D009395marker/mechanism14558336
C0027707moxifloxacinC104727-nephritis, interstitialMESH:D009395marker/mechanism20731847
C0027707nabumetoneC03560542924-53-8nephritis, interstitialMESH:D009395marker/mechanism8570441
C0027707nafcillinD009254147-52-4nephritis, interstitialMESH:D009395marker/mechanism17653125
C0027707ofloxacinD01524282419-36-1nephritis, interstitialMESH:D009395marker/mechanism11076114
C0027707omeprazoleD00985373590-58-6nephritis, interstitialMESH:D009395marker/mechanism10222687
C0027707pamidronateC01924840391-99-9nephritis, interstitialMESH:D009395marker/mechanism12637657
C0027707pantoprazoleC064276102625-70-7nephritis, interstitialMESH:D009395marker/mechanism15372423
C0027707phenindioneD0106301983/12/5nephritis, interstitialMESH:D009395marker/mechanism139882
C0027707phentermineD010645122-09-8nephritis, interstitialMESH:D009395marker/mechanism9799071
C0027707phenylpropanolamineD01066514838-15-4nephritis, interstitialMESH:D009395marker/mechanism7109141
C0027707phenytoinD01067257-41-0nephritis, interstitialMESH:D009395marker/mechanism1614700
C0027707piperacillinD01087861477-96-1nephritis, interstitialMESH:D009395marker/mechanism11793135
C0027707piroxicamD01089436322-90-4nephritis, interstitialMESH:D009395marker/mechanism3993703
C0027707propranololD011433525-66-6nephritis, interstitialMESH:D009395marker/mechanism6948214
C0027707propylthiouracilD01144151-52-5nephritis, interstitialMESH:D009395marker/mechanism10344375
C0027707propylthiouracilD01144151-52-5nephritis, interstitialMESH:D009395therapeutic16354242
C0027707quinineD011803130-95-0nephritis, interstitialMESH:D009395marker/mechanism8048427
C0027707rifampinD01229313292-46-1nephritis, interstitialMESH:D009395marker/mechanism10213665
C0027707rofecoxibC116926-nephritis, interstitialMESH:D009395marker/mechanism12613001
C0027707streptozocinD01331118883-66-4nephritis, interstitialMESH:D009395marker/mechanism186169
C0027707sulindacD01346738194-50-2nephritis, interstitialMESH:D009395marker/mechanism3208459
C0027707tacrolimusD016559109581-93-3nephritis, interstitialMESH:D009395marker/mechanism14620542
C0027707ticlopidineD01398855142-85-3nephritis, interstitialMESH:D009395marker/mechanism7771492
C0027707tolmetinD01404626171-23-3nephritis, interstitialMESH:D009395marker/mechanism3738663
C0027707tretinoinD014212302-79-4nephritis, interstitialMESH:D009395marker/mechanism11604554
C0027707triamtereneD014223396-01-0nephritis, interstitialMESH:D009395marker/mechanism6119586
C0027707valproic acidD01463599-66-1nephritis, interstitialMESH:D009395marker/mechanism11891102
C0027707vancomycinD0146401404-90-6nephritis, interstitialMESH:D009395marker/mechanism11601669
C0027707adenineD00022573-24-5nephritis, interstitialMESH:D009395marker/mechanism24107419
FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)
FDA labeling changes(Total Drugs:0)
(Waiting for update.)