PedAM

Pediatric Disease Annotations & Medicines


	interstitial cystitis

Disease ID	150
Disease	interstitial cystitis
Definition	A condition with recurring discomfort or pain in the URINARY BLADDER and the surrounding pelvic region without an identifiable disease. Severity of pain in interstitial cystitis varies greatly and often is accompanied by increased urination frequency and urgency.
Synonym	cystitides, interstitial cystitis interstitial cystitis ulcerative cystitis, interstitial cystitis, interstitial [disease/finding] ic - interstitial cystitis interstitial cystitides interstitial cystitis (ic) painful bladder syndrome (pbs) ulcerative cystitis ulcerative cystitis (disorder)
Orphanet	ORPHANET:37202
DOID	DOID:13949
UMLS	C0282488
MeSH	D018856
SNOMED-CT	SNOMEDCT_US_2016_09_01:111409009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:12) C1527336 \| sjogren's syndrome \| 3 C0011570 \| depression \| 2 C0033953 \| sexual dysfunction \| 2 C0003469 \| anxiety disorder \| 1 C0005684 \| bladder cancer \| 1 C0014175 \| endometriosis \| 1 C0014869 \| reflux esophagitis \| 1 C0019204 \| hepatocarcinoma \| 1 C0042580 \| vesicoureteral reflux \| 1 C0003467 \| anxiety \| 1 C0014868 \| esophagitis \| 1 C0010692 \| cystitis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) CXCL10 \| 3627 \| CTD_human CXCL9 \| 4283 \| CTD_human CXCL11 \| 6373 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) 146 \| ADRA1D \| infer 154 \| ADRB2 \| infer 155 \| ADRB3 \| infer 3565 \| IL4 \| infer 3566 \| IL4R \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:166) 972 \| CD74 \| DISEASES 1634 \| DCN \| DISEASES 55644 \| OSGEP \| DISEASES 4282 \| MIF \| DISEASES 9567 \| GTPBP1 \| DISEASES 7380 \| UPK3A \| DISEASES 5173 \| PDYN \| DISEASES 27344 \| PCSK1N \| DISEASES 11045 \| UPK1A \| DISEASES 4353 \| MPO \| DISEASES 5023 \| P2RX1 \| DISEASES 6347 \| CCL2 \| DISEASES 3558 \| IL2 \| DISEASES 4254 \| KITLG \| DISEASES 41 \| ASIC1 \| DISEASES 3458 \| IFNG \| DISEASES 1839 \| HBEGF \| DISEASES 3565 \| IL4 \| DISEASES 8161 \| COIL \| DISEASES 84329 \| HVCN1 \| DISEASES 4502 \| MT2A \| DISEASES 391013 \| PLA2G2C \| DISEASES 7429 \| VIL1 \| DISEASES 1215 \| CMA1 \| DISEASES 1890 \| TYMP \| DISEASES 3958 \| LGALS3 \| DISEASES 6382 \| SDC1 \| DISEASES 23135 \| KDM6B \| DISEASES 2949 \| GSTM5 \| DISEASES 59340 \| HRH4 \| DISEASES 29969 \| MDFIC \| DISEASES 3569 \| IL6 \| DISEASES 5004 \| ORM1 \| DISEASES 9360 \| PPIG \| DISEASES 59341 \| TRPV4 \| DISEASES 999 \| CDH1 \| DISEASES 51201 \| ZDHHC2 \| DISEASES 8989 \| TRPA1 \| DISEASES 22858 \| ICK \| DISEASES 5024 \| P2RX3 \| DISEASES 3553 \| IL1B \| DISEASES 7379 \| UPK2 \| DISEASES 1386 \| ATF2 \| DISEASES 7348 \| UPK1B \| DISEASES 8626 \| TP63 \| DISEASES 3383 \| ICAM1 \| DISEASES 3827 \| KNG1 \| DISEASES 3371 \| TNC \| DISEASES 1950 \| EGF \| DISEASES 286 \| ANK1 \| DISEASES 6601 \| SMARCC2 \| DISEASES 57332 \| CBX8 \| DISEASES 57530 \| CGN \| DISEASES 1392 \| CRH \| DISEASES 6876 \| TAGLN \| DISEASES 7082 \| TJP1 \| DISEASES 2697 \| GJA1 \| DISEASES 3672 \| ITGA1 \| DISEASES 55540 \| IL17RB \| DISEASES 4489 \| MT1A \| DISEASES 729230 \| CCR2 \| DISEASES 5731 \| PTGER1 \| DISEASES 6352 \| CCL5 \| DISEASES 213 \| ALB \| DISEASES 7349 \| UCN \| DISEASES 6228 \| RPS23 \| DISEASES 2150 \| F2RL1 \| DISEASES 4846 \| NOS3 \| DISEASES 7480 \| WNT10B \| DISEASES 4589 \| MUC7 \| DISEASES 6037 \| RNASE3 \| DISEASES 6869 \| TACR1 \| DISEASES 5028 \| P2RY1 \| DISEASES 4330 \| MN1 \| DISEASES 154 \| ADRB2 \| DISEASES 3627 \| CXCL10 \| DISEASES 2353 \| FOS \| DISEASES 7369 \| UMOD \| DISEASES 646 \| BNC1 \| DISEASES 4493 \| MT1E \| DISEASES 30008 \| EFEMP2 \| DISEASES 8793 \| TNFRSF10D \| DISEASES 5029 \| P2RY2 \| DISEASES 3728 \| JUP \| DISEASES 4482 \| MSRA \| DISEASES 57101 \| ANO2 \| DISEASES 1384 \| CRAT \| DISEASES 1960 \| EGR3 \| DISEASES 6863 \| TAC1 \| DISEASES 5032 \| P2RY11 \| DISEASES 5179 \| PENK \| DISEASES 9622 \| KLK4 \| DISEASES 3052 \| HCCS \| DISEASES 633 \| BGN \| DISEASES 11260 \| XPOT \| DISEASES 3739 \| KCNA4 \| DISEASES 10572 \| SIVA1 \| DISEASES 4496 \| MT1H \| DISEASES 10052 \| GJC1 \| DISEASES 4494 \| MT1F \| DISEASES 4490 \| MT1B \| DISEASES 115362 \| GBP5 \| DISEASES 1395 \| CRHR2 \| DISEASES 51393 \| TRPV2 \| DISEASES 2138 \| EYA1 \| DISEASES 22953 \| P2RX2 \| DISEASES 6318 \| SERPINB4 \| DISEASES 11276 \| SYNRG \| DISEASES 954 \| ENTPD2 \| DISEASES 253827 \| MSRB3 \| DISEASES 100506658 \| OCLN \| DISEASES 60 \| ACTB \| DISEASES 8021 \| NUP214 \| DISEASES 3635 \| INPP5D \| DISEASES 4283 \| CXCL9 \| DISEASES 83881 \| MIXL1 \| DISEASES 3664 \| IRF6 \| DISEASES 9580 \| SOX13 \| DISEASES 5743 \| PTGS2 \| DISEASES 2205 \| FCER1A \| DISEASES 6706 \| SPRR2G \| DISEASES 4803 \| NGF \| DISEASES 63910 \| SLC17A9 \| DISEASES 2634 \| GBP2 \| DISEASES 2633 \| GBP1 \| DISEASES 5737 \| PTGFR \| DISEASES 55227 \| LRRC1 \| DISEASES 1757 \| SARDH \| DISEASES 8569 \| MKNK1 \| DISEASES 7422 \| VEGFA \| DISEASES 27035 \| NOX1 \| DISEASES 6865 \| TACR2 \| DISEASES 2833 \| CXCR3 \| DISEASES 7099 \| TLR4 \| DISEASES 2268 \| FGR \| DISEASES 8325 \| FZD8 \| DISEASES 84557 \| MAP1LC3A \| DISEASES 22921 \| MSRB2 \| DISEASES 3274 \| HRH2 \| DISEASES 10970 \| CKAP4 \| DISEASES 6354 \| CCL7 \| DISEASES 4038 \| LRP4 \| DISEASES 146 \| ADRA1D \| DISEASES 3853 \| KRT6A \| DISEASES 114131 \| UCN3 \| DISEASES 11168 \| PSIP1 \| DISEASES 90865 \| IL33 \| DISEASES 654364 \| NME1-NME2 \| DISEASES 4501 \| MT1X \| DISEASES 3269 \| HRH1 \| DISEASES 594857 \| NPS \| DISEASES 1394 \| CRHR1 \| DISEASES 7442 \| TRPV1 \| DISEASES 4685 \| NCAM2 \| DISEASES 9048 \| ARTN \| DISEASES 4495 \| MT1G \| DISEASES 2935 \| GSPT1 \| DISEASES 7124 \| TNF \| DISEASES 3109 \| HLA-DMB \| DISEASES 116 \| ADCYAP1 \| DISEASES 627 \| BDNF \| DISEASES 8649 \| LAMTOR3 \| DISEASES 9152 \| SLC6A5 \| DISEASES 8740 \| TNFSF14 \| DISEASES 6625 \| SNRNP70 \| DISEASES 102723508 \| KANTR \| DISEASES
Locus	(Waiting for update.)

Disease ID	150
Disease	interstitial cystitis
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:13) HP:0000078 \| Abnormality of the genital system HP:0100577 \| Urinary bladder inflammation HP:0000140 \| Abnormality of the menstrual cycle HP:0012531 \| Pain HP:0000014 \| Abnormality of the bladder HP:0000012 \| Urinary urgency HP:0000795 \| Abnormality of the urethra HP:0030016 \| Dyspareunia HP:0100515 \| Pollakisuria HP:0000009 \| Functional abnormality of the bladder HP:0000142 \| Abnormality of the vagina HP:0000058 \| Abnormality of the labia HP:0000017 \| Nocturia
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:17) HP:0012531 \| Pain \| 13 HP:0012532 \| Chronic pain \| 2 HP:0000716 \| Depression \| 2 HP:0010992 \| Stress urinary incontinence \| 1 HP:0008711 \| Benign prostatic hypertrophy \| 1 HP:0002140 \| Ischemic stroke \| 1 HP:0000076 \| Vesicoureteric reflux \| 1 HP:0000020 \| Bladder incontinence \| 1 HP:0002500 \| Leukoaraiosis \| 1 HP:0100607 \| Painful menstruation \| 1 HP:0100633 \| Inflammation of the esophagus \| 1 HP:0009725 \| Bladder neoplasm \| 1 HP:0030127 \| Endometriosis \| 1 HP:0001297 \| Cerebral vascular events \| 1 HP:0000739 \| Anxiety \| 1 HP:0100785 \| Insomnia \| 1 HP:0000017 \| Nocturia \| 1

Disease ID	150
Disease	interstitial cystitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:19) C2598155 \| pain C1963176 \| bladder pain C1720830 \| painful bladder syndrome C1611280 \| allergy C1384606 \| dyspareunia C1112443 \| male sexual dysfunction C0850758 \| pelvic pain C0750103 \| vaginalis C0741548 \| bladder symptoms C0700361 \| distress C0545047 \| nephrogenic adenoma C0497552 \| nervous system abnormalities C0404484 \| chronic pelvic pain C0334664 \| mastocytosis C0268854 \| contracted bladder C0178879 \| obstructive uropathy C0028734 \| nocturia C0019080 \| hemorrhage C0005687 \| bladder distention
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:6) C0030193 \| pain \| 13 C0232849 \| bladder pain \| 4 C0028734 \| nocturia \| 1 C1720830 \| painful bladder syndrome \| 1 C0030794 \| pelvic pain \| 1 C0404484 \| chronic pelvic pain \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1042713	16971769	154	ADRB2	umls:C0282488	BeFree	We examined the relationship between the Arg16Gly polymorphism of beta2-adrenoceptor (ADRB2) and the efficacy of tricyclic antidepressant therapy in patients with interstitial cystitis (IC).	0.005276948	2006	ADRB2	5	148826877	G	A
rs4994	12442007	155	ADRB3	umls:C0282488	BeFree	We analyzed 5 gene polymorphisms (G404781T, Arg16Gly, Trp64Arg, C589T and Ile50Val) per gene (ADRA1d, ADRB2, ADRB3, IL-4 and IL-4 receptor, respectively) and their relationship to interstitial cystitis.	0.002638474	2002	ADRB3	8	37966280	A	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:4)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0282488	cidofovir	C059262	113852-37-2	cystitis, interstitial	MESH:D018856	therapeutic	19292661
C0282488	cyclophosphamide	D003520	50-18-0	cystitis, interstitial	MESH:D018856	marker/mechanism	12909197
C0282488	hydroxyzine	D006919	68-88-2	cystitis, interstitial	MESH:D018856	therapeutic	9839659
C0282488	indomethacin	D007213	53-86-1	cystitis, interstitial	MESH:D018856	marker/mechanism	12559315

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

Web
Analytics