PedAM

Pediatric Disease Annotations & Medicines


	infective endocarditis

Disease ID	784
Disease	infective endocarditis
Definition	Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.
Synonym	bact endocarditides bact endocarditis bacterial endocarditides bacterial endocarditis bacterial endocarditis (disorder) bacterial endocarditis (disorder) [ambiguous] bacterial endocarditis, nos bacterial infection of the heart valve be - bacterial endocarditis endocarditides bact endocarditides, bacterial endocarditis bact endocarditis, bacterial endocarditis, bacterial [disease/finding] endocarditis, infective nos
DOID	DOID:762 DOID:0060000
UMLS	C0014121
MeSH	D004697
SNOMED-CT	SNOMEDCT_US_2016_09_01:301183007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:96) C0018799 \| heart disease \| 16 C0152021 \| congenital heart disease \| 11 C0037998 \| splenic infarction \| 6 C0018801 \| heart failure \| 6 C0026266 \| mitral regurgitation \| 5 C0017658 \| glomerulonephritis \| 5 C0018818 \| ventricular septal defect \| 5 C0026267 \| mitral valve prolapse \| 5 C0003504 \| aortic regurgitation \| 4 C0022658 \| renal disease \| 4 C0035439 \| rheumatic heart disease \| 4 C0035078 \| renal failure \| 3 C0018799 \| cardiac disease \| 3 C0034065 \| pulmonary embolism \| 3 C0027051 \| myocardial infarct \| 2 C0007785 \| cerebral infarct \| 2 C0022660 \| acute renal failure \| 2 C0007785 \| cerebral infarction \| 2 C0014118 \| endocarditis \| 2 C0042384 \| vasculitis \| 2 C0007194 \| hypertrophic obstructive cardiomyopathy \| 2 C0040053 \| thrombus \| 2 C0011847 \| diabetes \| 2 C0031046 \| pericarditis \| 2 C0007194 \| obstructive cardiomyopathy \| 2 C0272412 \| splenic abscess \| 2 C0027051 \| myocardial infarction \| 2 C0155626 \| acute myocardial infarction \| 2 C0007102 \| colon cancer \| 2 C0018802 \| congestive heart failure \| 2 C0028790 \| cerebral artery occlusion \| 1 C0019196 \| hepatitis c \| 1 C0003537 \| aphasia \| 1 C0035302 \| retinal artery occlusion \| 1 C0162871 \| abdominal aortic aneurysm \| 1 C0004245 \| av block \| 1 C0085669 \| acute leukemia \| 1 C0028326 \| noonan syndrome \| 1 C0013069 \| double outlet right ventricle \| 1 C0009324 \| ulcerative colitis \| 1 C0022661 \| end-stage renal disease \| 1 C0020538 \| hypertension \| 1 C0038644 \| sudden infant death \| 1 C0043117 \| idiopathic thrombocytopenic purpura \| 1 C0018816 \| septal defects \| 1 C0042164 \| uveitis \| 1 C0155747 \| splenic artery aneurysm \| 1 C0007766 \| cranial aneurysm \| 1 C0034150 \| purpura \| 1 C0151436 \| leukocytoclastic vasculitis \| 1 C0042373 \| vascular diseases \| 1 C0034088 \| pulmonary regurgitation \| 1 C0264776 \| tricuspid valve disease \| 1 C0007222 \| cardiovascular disease \| 1 C0007766 \| intracranial aneurysm \| 1 C0042373 \| vascular disease \| 1 C0155626 \| acute mi \| 1 C0007688 \| central retinal artery occlusion \| 1 C0023890 \| liver cirrhosis \| 1 C0015230 \| rash \| 1 C0026266 \| mitral incompetence \| 1 C0027947 \| neutropenia \| 1 C0009319 \| colitis \| 1 C0018799 \| heart diseases \| 1 C0007222 \| cardiovascular diseases \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0267841 \| acalculous cholecystitis \| 1 C0007766 \| intracranial aneurysms \| 1 C0018799 \| cardiac diseases \| 1 C0007642 \| cellulitis \| 1 C0018818 \| ventricular septal defects \| 1 C0043092 \| wegener granulomatosis \| 1 C0004245 \| atrioventricular block \| 1 C0018824 \| valvular heart disease \| 1 C0409974 \| lupus erythematosus \| 1 C0023530 \| leucopenia \| 1 C1565489 \| renal insufficiency \| 1 C0031099 \| periodontitis \| 1 C0011849 \| diabetes mellitus \| 1 C0034089 \| pulmonary valve stenosis \| 1 C0025289 \| meningitis \| 1 C1258215 \| ileus \| 1 C0003486 \| aortic aneurysm \| 1 C0221239 \| rapidly progressive glomerulonephritis \| 1 C0023976 \| long qt syndrome \| 1 C0032285 \| pneumonia \| 1 C0917996 \| cerebral aneurysm \| 1 C0037998 \| spleen infarct \| 1 C0003504 \| aortic insufficiency \| 1 C0029443 \| osteomyelitis \| 1 C0003509 \| aortitis \| 1 C0034152 \| henoch-schonlein purpura \| 1 C0011633 \| dermatomyositis \| 1 C0022116 \| ischaemia \| 1 C0031039 \| pericardial effusion \| 1 C0040961 \| tricuspid regurgitation \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:146) 10942 \| PRSS21 \| DISEASES 350 \| APOH \| DISEASES 5411 \| PNN \| DISEASES 3929 \| LBP \| DISEASES 366 \| AQP9 \| DISEASES 2091 \| FBL \| DISEASES 973 \| CD79A \| DISEASES 26330 \| GAPDHS \| DISEASES 5054 \| SERPINE1 \| DISEASES 4353 \| MPO \| DISEASES 708 \| C1QBP \| DISEASES 6347 \| CCL2 \| DISEASES 7448 \| VTN \| DISEASES 2597 \| GAPDH \| DISEASES 9896 \| FIG4 \| DISEASES 5657 \| PRTN3 \| DISEASES 2023 \| ENO1 \| DISEASES 2745 \| GLRX \| DISEASES 5552 \| SRGN \| DISEASES 1088 \| CEACAM8 \| DISEASES 8192 \| CLPP \| DISEASES 22879 \| MON1B \| DISEASES 7263 \| TST \| DISEASES 27112 \| FAM155B \| DISEASES 10343 \| PKDREJ \| DISEASES 2161 \| F12 \| DISEASES 1401 \| CRP \| DISEASES 3569 \| IL6 \| DISEASES 7097 \| TLR2 \| DISEASES 26160 \| IFT172 \| DISEASES 7450 \| VWF \| DISEASES 8099 \| CDK2AP1 \| DISEASES 3690 \| ITGB3 \| DISEASES 3674 \| ITGA2B \| DISEASES 8030 \| CCDC6 \| DISEASES 3553 \| IL1B \| DISEASES 6403 \| SELP \| DISEASES 7301 \| TYRO3 \| DISEASES 3383 \| ICAM1 \| DISEASES 8034 \| SLC25A16 \| DISEASES 5286 \| PIK3C2A \| DISEASES 2212 \| FCGR2A \| DISEASES 6282 \| S100A11 \| DISEASES 10637 \| LEFTY1 \| DISEASES 6567 \| SLC16A2 \| DISEASES 23196 \| FAM120A \| DISEASES 6749 \| SSRP1 \| DISEASES 26040 \| SETBP1 \| DISEASES 252969 \| NEIL2 \| DISEASES 136991 \| ASZ1 \| DISEASES 5018 \| OXA1L \| DISEASES 29028 \| ATAD2 \| DISEASES 909 \| CD1A \| DISEASES 3889 \| KRT83 \| DISEASES 10158 \| PDZK1IP1 \| DISEASES 7412 \| VCAM1 \| DISEASES 6051 \| RNPEP \| DISEASES 213 \| ALB \| DISEASES 5473 \| PPBP \| DISEASES 79158 \| GNPTAB \| DISEASES 717 \| C2 \| DISEASES 6447 \| SCG5 \| DISEASES 4589 \| MUC7 \| DISEASES 57124 \| CD248 \| DISEASES 2147 \| F2 \| DISEASES 5340 \| PLG \| DISEASES 9024 \| BRSK2 \| DISEASES 5198 \| PFAS \| DISEASES 10294 \| DNAJA2 \| DISEASES 11238 \| CA5B \| DISEASES 5551 \| PRF1 \| DISEASES 8685 \| MARCO \| DISEASES 58492 \| ZNF77 \| DISEASES 339122 \| RAB43 \| DISEASES 137814 \| NKX2-6 \| DISEASES 3996 \| LLGL1 \| DISEASES 78987 \| CRELD1 \| DISEASES 1435 \| CSF1 \| DISEASES 2811 \| GP1BA \| DISEASES 57649 \| PHF12 \| DISEASES 55256 \| ADI1 \| DISEASES 2152 \| F3 \| DISEASES 10732 \| TCFL5 \| DISEASES 23583 \| SMUG1 \| DISEASES 3266 \| ERAS \| DISEASES 3329 \| HSPD1 \| DISEASES 7137 \| TNNI3 \| DISEASES 25870 \| SUMF2 \| DISEASES 6146 \| RPL22 \| DISEASES 954 \| ENTPD2 \| DISEASES 57591 \| MKL1 \| DISEASES 871 \| SERPINH1 \| DISEASES 6539 \| SLC6A12 \| DISEASES 2993 \| GYPA \| DISEASES 51660 \| MPC1 \| DISEASES 5475 \| PPEF1 \| DISEASES 23038 \| WDTC1 \| DISEASES 28514 \| DLL1 \| DISEASES 7044 \| LEFTY2 \| DISEASES 462 \| SERPINC1 \| DISEASES 5824 \| PEX19 \| DISEASES 913 \| CD1E \| DISEASES 1755 \| DMBT1 \| DISEASES 4534 \| MTM1 \| DISEASES 959 \| CD40LG \| DISEASES 729238 \| SFTPA2 \| DISEASES 57158 \| JPH2 \| DISEASES 27286 \| SRPX2 \| DISEASES 9935 \| MAFB \| DISEASES 80312 \| TET1 \| DISEASES 7099 \| TLR4 \| DISEASES 11330 \| CTRC \| DISEASES 7917 \| BAG6 \| DISEASES 394263 \| MUC21 \| DISEASES 4879 \| NPPB \| DISEASES 8928 \| FOXH1 \| DISEASES 285440 \| CYP4V2 \| DISEASES 9308 \| CD83 \| DISEASES 10274 \| STAG1 \| DISEASES 9467 \| SH3BP5 \| DISEASES 6164 \| RPL34 \| DISEASES 5530 \| PPP3CA \| DISEASES 4145 \| MATK \| DISEASES 3122 \| HLA-DRA \| DISEASES 8887 \| TAX1BP1 \| DISEASES 1781 \| DYNC1I2 \| DISEASES 4703 \| NEB \| DISEASES 81502 \| HM13 \| DISEASES 5537 \| PPP6C \| DISEASES 23210 \| JMJD6 \| DISEASES 5783 \| PTPN13 \| DISEASES 7124 \| TNF \| DISEASES 3106 \| HLA-B \| DISEASES 84148 \| KAT8 \| DISEASES 23098 \| SARM1 \| DISEASES 23218 \| NBEAL2 \| DISEASES 51071 \| DERA \| DISEASES 389072 \| PLEKHM3 \| DISEASES 135656 \| DPCR1 \| DISEASES 3712 \| IVD \| DISEASES 8801 \| SUCLG2 \| DISEASES 2994 \| GYPB \| DISEASES 7296 \| TXNRD1 \| DISEASES 3250 \| HPR \| DISEASES 246744 \| STH \| DISEASES 103752588 \| PACERR \| DISEASES
Locus	(Waiting for update.)

Disease ID	784
Disease	infective endocarditis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:85) HP:0002617 \| Aneurysmal dilatation \| 25 HP:0001297 \| Cerebral vascular events \| 10 HP:0000099 \| Glomerular nephritis \| 5 HP:0001634 \| Mitral valve prolapse \| 5 HP:0001653 \| Mitral valve insufficiency \| 5 HP:0001635 \| Congestive heart failure \| 5 HP:0001659 \| Aortic insufficiency \| 5 HP:0001629 \| Ventricular septal defects \| 4 HP:0002140 \| Ischemic stroke \| 4 HP:0002204 \| Pulmonary embolism \| 3 HP:0000083 \| Renal insufficiency \| 3 HP:0001945 \| Fever \| 2 HP:0001919 \| Acute renal failure \| 2 HP:0001631 \| Atria septal defect \| 2 HP:0001342 \| Intracerebral hemorrhage \| 2 HP:0002633 \| Vasculitis \| 2 HP:0001647 \| Bicuspid aortic valve \| 2 HP:0030049 \| Brain abscess \| 2 HP:0001701 \| Pericarditis \| 2 HP:0003003 \| Colon cancer \| 2 HP:0002170 \| Intracranial hemorrhage \| 2 HP:0100584 \| Endocarditis \| 2 HP:0100859 \| Superior mesenteric artery aneurysm \| 1 HP:0001642 \| Pulmonic stenosis \| 1 HP:0000979 \| Purpura \| 1 HP:0001719 \| Double-outlet right ventricle \| 1 HP:0012531 \| Pain \| 1 HP:0001678 \| Atrioventricular block \| 1 HP:0000988 \| Exanthem \| 1 HP:0002488 \| Acute leukemias \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0001694 \| Right-to-left shunt \| 1 HP:0001671 \| Abnormality of the cardiac septa \| 1 HP:0002027 \| Abdominal pain \| 1 HP:0001636 \| Tetrology of fallot \| 1 HP:0011645 \| Aneurysm of the aortic sinus \| 1 HP:0001369 \| Arthritis \| 1 HP:0001658 \| Myocardial infarction \| 1 HP:0006827 \| Degeneration of the spinal cord \| 1 HP:0000554 \| Uveitis \| 1 HP:0002829 \| Arthralgias \| 1 HP:0011944 \| Small vessel vasculitis \| 1 HP:0100806 \| Sepsis \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0007813 \| Nongranulomatous uveitis \| 1 HP:0005180 \| Tricuspid insufficiency \| 1 HP:0001657 \| Prolonged QT interval \| 1 HP:0012393 \| Allergy \| 1 HP:0004953 \| Abdominal aortic aneurysm \| 1 HP:0001050 \| Plethora \| 1 HP:0100571 \| Cardiac diverticulum \| 1 HP:0030148 \| Heart murmur \| 1 HP:0100858 \| Celiac artery aneurysm \| 1 HP:0002090 \| Pneumonia \| 1 HP:0000822 \| Hypertension \| 1 HP:0002583 \| Colitis \| 1 HP:0000704 \| Pyorrhea \| 1 HP:0011934 \| Mesenteric artery aneurysm \| 1 HP:0003613 \| Antiphospholipid antibodies \| 1 HP:0001695 \| Cardiac arrest \| 1 HP:0004942 \| Aortic aneurysm \| 1 HP:0001698 \| Pericardial effusions \| 1 HP:0001680 \| Coarctation of aorta \| 1 HP:0001269 \| Hemiparesis \| 1 HP:0100523 \| Hepatic abscess \| 1 HP:0004944 \| Cerebral artery aneurysm \| 1 HP:0001287 \| Meningitis \| 1 HP:0002754 \| Bone infection \| 1 HP:0001875 \| Neutropenia \| 1 HP:0100658 \| Bacterial infection of skin \| 1 HP:0006698 \| Ventricular aneurysm \| 1 HP:0001627 \| Congenital heart defects \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0011672 \| Cardiac myxoma \| 1 HP:0100279 \| Ulcerative colitis \| 1 HP:0004947 \| Arteriovenous fistula \| 1 HP:0012251 \| ST segment elevation \| 1 HP:0011877 \| Increased mean platelet volume \| 1 HP:0030149 \| Cardiovascular shock \| 1 HP:0002595 \| Gastrointestinal atony \| 1 HP:0003095 \| Septic arthritis \| 1 HP:0001518 \| Small for gestational age \| 1 HP:0002381 \| Aphasia \| 1 HP:0001643 \| Persistent ductus arteriosus \| 1 HP:0002955 \| Granulomatosis \| 1

Disease ID	784
Disease	infective endocarditis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:86) C2707258 \| infections C2598155 \| pain C2364133 \| infection C2072946 \| aortic aneurysm C2004489 \| regurgitation C1963211 \| pericarditis C1963077 \| bone pain C1705714 \| warts C1704212 \| embolism C1621824 \| incomplete atrioventricular block C1550639 \| fistula C1546533 \| abscess C1521999 \| acute myocardial infarction C1455718 \| ventriculitis C1393529 \| vascular complications C1298807 \| acute mitral regurgitation C1282231 \| endogenous endophthalmitis C0948089 \| acute coronary syndrome C0917996 \| cerebral aneurysms C0917996 \| cerebral aneurysm C0865570 \| mitral obstruction C0752303 \| urological manifestations C0752303 \| urological manifestation C0751005 \| intracranial mycotic aneurysm C0577799 \| tricuspid valve vegetation C0549124 \| arterial embolism C0424755 \| fever C0419203 \| osteopathy C0403416 \| crescentic glomerulonephritis C0393851 \| critical illness polyneuropathy C0376293 \| stigmata C0341697 \| renal impairment C0272412 \| splenic abscess C0267842 \| acute acalculous cholecystitis C0264978 \| embolic infarction C0264974 \| superior mesenteric artery aneurysm C0264714 \| acute heart failure C0264693 \| acute coronary insufficiency C0264686 \| coronary embolism C0262469 \| embolic stroke C0240608 \| osler's nodes C0231243 \| early complication C0221239 \| rapidly progressive glomerulonephritis C0151814 \| coronary artery occlusion C0085808 \| mycotic aneurysms C0085808 \| mycotic aneurysm C0042373 \| vascular disease C0040961 \| tricuspid regurgitation C0040961 \| tricuspid incompetence C0039128 \| syphilis C0038454 \| stroke C0038454 \| cerebrovascular accidents C0038454 \| cerebral stroke C0037998 \| splenic infarction C0035085 \| renal infarction C0027697 \| nephritis C0027051 \| myocardial infarction C0026269 \| mitral stenosis C0026267 \| mitral valve prolapse C0026267 \| mitral leaflet prolapse C0026266 \| mitral valve insufficiency C0026266 \| mitral regurgitation C0026266 \| mitral insufficiency C0025289 \| meningitis C0024110 \| lung abscesses C0023885 \| liver abscess C0022658 \| renal diseases C0019080 \| hemorrhage C0018989 \| hemiparesis C0018802 \| congestive heart failure C0018801 \| heart failure C0018799 \| heart disease C0018799 \| cardiac disease C0017658 \| glomerulonephritis C0012628 \| discrete subaortic stenosis C0010051 \| coronary artery aneurysm C0007780 \| cerebral emboli C0007766 \| intracranial aneurysms C0007766 \| intracranial aneurysm C0006105 \| brain abscess C0004610 \| bacteremia C0003504 \| aortic valve regurgitation C0003504 \| aortic regurgitation C0003504 \| aortic incompetence C0002940 \| aneurysms C0002940 \| aneurysm
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:44) C0002940 \| aneurysm \| 19 C0000833 \| abscess \| 15 C0018799 \| heart disease \| 15 C0013922 \| embolism \| 14 C0004610 \| bacteremia \| 13 C0232605 \| regurgitation \| 10 C0038454 \| stroke \| 10 C1393529 \| vascular complications \| 7 C0085808 \| mycotic aneurysm \| 7 C0009450 \| infection \| 6 C0002940 \| aneurysms \| 6 C0017658 \| glomerulonephritis \| 5 C0016169 \| fistula \| 5 C0018801 \| heart failure \| 5 C0026267 \| mitral valve prolapse \| 4 C0021311 \| infections \| 4 C0019080 \| hemorrhage \| 4 C0026266 \| mitral regurgitation \| 4 C0003504 \| aortic regurgitation \| 4 C0021308 \| infarction \| 3 C0018799 \| cardiac disease \| 3 C0037998 \| splenic infarction \| 3 C0007780 \| cerebral emboli \| 3 C0948089 \| acute coronary syndrome \| 2 C0272412 \| splenic abscess \| 2 C0015967 \| fever \| 2 C0006105 \| brain abscess \| 2 C0549124 \| arterial embolism \| 1 C0018989 \| hemiparesis \| 1 C0262469 \| embolic stroke \| 1 C0007766 \| intracranial aneurysms \| 1 C0264974 \| superior mesenteric artery aneurysm \| 1 C0085808 \| mycotic aneurysms \| 1 C0025289 \| meningitis \| 1 C0155626 \| acute myocardial infarction \| 1 C0003486 \| aortic aneurysm \| 1 C0018802 \| congestive heart failure \| 1 C0023885 \| liver abscess \| 1 C0040961 \| tricuspid regurgitation \| 1 C0343192 \| microscopic polyangiitis \| 1 C0031046 \| pericarditis \| 1 C0221239 \| rapidly progressive glomerulonephritis \| 1 C0027051 \| myocardial infarction \| 1 C0030193 \| pain \| 1

Manually Genotype(Total Text Mining Genotypes:0)
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All Snps(Total Genotypes:0)
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GWASdb Annotation(Total Genotypes:0)
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GWASdb Snp Trait(Total Genotypes:0)
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Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:17)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0014121	amikacin	D000583	37517-28-5	endocarditis, bacterial	MESH:D004697	therapeutic	10223137
C0014121	ampicillin	D000667	69-53-4	endocarditis, bacterial	MESH:D004697	therapeutic	11713166
C0014121	carbenicillin	D002228	4697-36-3	endocarditis, bacterial	MESH:D004697	therapeutic	6965443
C0014121	cefmetazole	D015311	56796-20-4	endocarditis, bacterial	MESH:D004697	therapeutic	2810754
C0014121	cefotaxime	D002439	63527-52-6	endocarditis, bacterial	MESH:D004697	therapeutic	8807045
C0014121	ceftazidime	D002442	78439-06-2	endocarditis, bacterial	MESH:D004697	therapeutic	8150772
C0014121	chloramphenicol	D002701	56-75-7	endocarditis, bacterial	MESH:D004697	therapeutic	12015709
C0014121	ciprofloxacin	D002939	85721-33-1	endocarditis, bacterial	MESH:D004697	therapeutic	2327776
C0014121	daptomycin	D017576	103060-53-3	endocarditis, bacterial	MESH:D004697	therapeutic	12709345
C0014121	doxycycline	D004318	564-25-0	endocarditis, bacterial	MESH:D004697	therapeutic	9868693
C0014121	linezolid	D000069349	-	endocarditis, bacterial	MESH:D004697	therapeutic	11158767
C0014121	moxifloxacin	C104727	-	endocarditis, bacterial	MESH:D004697	therapeutic	11600359
C0014121	nafcillin	D009254	147-52-4	endocarditis, bacterial	MESH:D004697	therapeutic	11706922
C0014121	ofloxacin	D015242	82419-36-1	endocarditis, bacterial	MESH:D004697	therapeutic	8807045
C0014121	pefloxacin	D015366	70458-92-3	endocarditis, bacterial	MESH:D004697	therapeutic	3166360
C0014121	rifampin	D012293	13292-46-1	endocarditis, bacterial	MESH:D004697	therapeutic	11706922
C0014121	vancomycin	D014640	1404-90-6	endocarditis, bacterial	MESH:D004697	therapeutic	10806967

FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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