PedAM

Pediatric Disease Annotations & Medicines


	infection caused by helicobacter pylori

Disease ID	1819
Disease	infection caused by helicobacter pylori
Definition	Helicobacter pylori (H. pylori) is a type of bacteria that causes infection in the stomach. It is found in about two-thirds of the world's population. It may be spread by unclean food and water, but researchers aren't sure. It causes Peptic ulcers and can also cause stomach cancer. If you have symptoms of a peptic ulcer, your doctor will test your blood, breath or stool to see if it contains H. pylori. The best treatment is a combination of antibiotics and acid-reducing medicines. You will need to be tested after treatment to make sure the infection is gone. To help prevent an H. pylori infection, you should Wash your hands after using the bathroom and before eating Eat properly prepared food Drink water from a clean, safe source NIH: National Institute of Diabetes and Digestive and Kidney Diseases
Synonym	h infection pylori h infections pylori h pylori infection h. pylori infections helicobacter infections pylori helicobacter pylori infection helicobacter pylori infections infection caused by helicobacter pylori (disorder)
DOID	DOID:3686
UMLS	C0850666
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:117) C0017152 \| gastritis \| 43 C0024623 \| gastric cancer \| 31 C0030920 \| peptic ulcer \| 21 C0017154 \| atrophic gastritis \| 10 C0013295 \| duodenal ulcer \| 9 C0030920 \| peptic ulcers \| 7 C0242647 \| malt lymphoma \| 6 C0013295 \| duodenal ulcers \| 5 C0011847 \| diabetes \| 5 C0038358 \| gastric ulcer \| 5 C0038354 \| gastric disease \| 4 C0948265 \| metabolic syndrome \| 4 C0017168 \| esophageal reflux disease \| 4 C0001418 \| adenocarcinoma \| 4 C0002871 \| anemia \| 4 C0011849 \| diabetes mellitus \| 4 C0013289 \| duodenal diseases \| 4 C0038354 \| gastric diseases \| 4 C0017168 \| esophageal reflux \| 4 C0013289 \| duodenal disease \| 4 C0013395 \| dyspepsia \| 4 C0011860 \| type 2 diabetes \| 4 C0021831 \| bowel disease \| 3 C0038358 \| gastric ulcers \| 3 C0024299 \| lymphoma \| 3 C0030920 \| gastroduodenal ulcer \| 3 C0027051 \| myocardial infarction \| 3 C0017168 \| oesophageal reflux \| 3 C0027051 \| myocardial infarct \| 3 C0030920 \| peptic ulcer disease \| 3 C0278701 \| gastric adenocarcinoma \| 3 C0162316 \| iron deficiency anemia \| 3 C0242647 \| mucosa-associated lymphoid tissue \| 2 C0010068 \| coronary heart disease \| 2 C0023895 \| liver disease \| 2 C0017154 \| chronic atrophic gastritis \| 2 C0699791 \| gastric carcinoma \| 2 C0030920 \| peptic ulceration \| 2 C0024299 \| lymphomas \| 2 C0017168 \| gastro-oesophageal reflux disease \| 2 C0011860 \| type 2 diabetes mellitus \| 2 C0600260 \| obstructive pulmonary disease \| 2 C0023890 \| cirrhosis \| 2 C0017178 \| gastrointestinal disease \| 2 C0013295 \| duodenal ulcer disease \| 2 C0497327 \| dementia \| 2 C0024117 \| chronic obstructive pulmonary disease \| 2 C0024115 \| pulmonary disease \| 2 C0017168 \| gastro-oesophageal reflux \| 2 C0021831 \| intestinal disease \| 2 C0021831 \| intestinal diseases \| 2 C0030920 \| gastroduodenal ulcers \| 2 C0021390 \| inflammatory bowel disease \| 2 C0042373 \| vascular disease \| 2 C0017178 \| gastrointestinal diseases \| 2 C0040034 \| thrombocytopenia \| 1 C0034152 \| henoch-schonlein purpura \| 1 C0017168 \| gastro-esophageal reflux disease \| 1 C0011854 \| type 1 diabetes \| 1 C0026769 \| multiple sclerosis \| 1 C0155626 \| acute myocardial infarction \| 1 C0022661 \| end-stage renal disease \| 1 C1262481 \| eosinophilic gastroenteritis \| 1 C0017178 \| gastrointestinal disorder \| 1 C0038363 \| aphthous stomatitis \| 1 C0010068 \| coronary artery disease \| 1 C0677607 \| hashimoto's thyroiditis \| 1 C0338480 \| common migraine \| 1 C0017178 \| gastrointestinal disorders \| 1 C0152136 \| normal tension glaucoma \| 1 C0021053 \| immune disease \| 1 C0024623 \| gastric cancers \| 1 C0019158 \| hepatitis \| 1 C0042847 \| vitamin b12 deficiency \| 1 C0007222 \| cardiovascular disease \| 1 C0011881 \| diabetic nephropathy \| 1 C0235974 \| pancreatic cancer \| 1 C0030567 \| idiopathic parkinsonism \| 1 C0002871 \| anaemia \| 1 C0279628 \| esophageal adenocarcinoma \| 1 C0019196 \| hepatitis c \| 1 C0017168 \| gastro-esophageal reflux \| 1 C0162316 \| iron deficiency anaemia \| 1 C0014868 \| esophagitis \| 1 C0017160 \| gastroenteritis \| 1 C0032131 \| plasmacytoma \| 1 C0242647 \| mucosa-associated lymphoid tissue lymphoma \| 1 C0007137 \| squamous cell carcinoma \| 1 C0017168 \| gastroesophageal reflux disease \| 1 C0008325 \| cholecystitis \| 1 C0010674 \| cystic fibrosis \| 1 C0149931 \| migraine \| 1 C0162429 \| nutritional deficiency \| 1 C0042847 \| vitamin b12 defic \| 1 C0030925 \| perforated peptic ulcer \| 1 C0004153 \| atherosclerosis \| 1 C0021831 \| enteropathy \| 1 C0040053 \| thrombus \| 1 C0149931 \| migraine headache \| 1 C0007570 \| gluten-sensitive enteropathy \| 1 C0017168 \| gastroesophageal reflux \| 1 C1319315 \| colorectal adenocarcinoma \| 1 C0034150 \| purpura \| 1 C0038362 \| stomatitis \| 1 C0031090 \| periodontal disease \| 1 C0024623 \| stomach cancer \| 1 C0019151 \| hepatic encephalopathy \| 1 C0022658 \| renal disease \| 1 C0017612 \| open angle glaucoma \| 1 C0004096 \| asthma \| 1 C0149825 \| adenoid hypertrophy \| 1 C0017154 \| gastric atrophy \| 1 C0339573 \| primary open angle glaucoma \| 1 C0026636 \| oral disease \| 1 C0014869 \| reflux esophagitis \| 1 C0038354 \| gastric disorders \| 1 C0013295 \| duodenal ulceration \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:6) 1557 \| CYP2C19 \| infer 2524 \| FUT2 \| infer 2525 \| FUT3 \| infer 3117 \| HLA-DQA1 \| infer 3553 \| IL1B \| infer 5225 \| PGC \| infer
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	1819
Disease	infection caused by helicobacter pylori
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:50) HP:0005263 \| Gastritis \| 43 HP:0012126 \| Gastric cancer \| 32 HP:0004398 \| Peptic ulcer \| 21 HP:0005231 \| Chronic gastritis \| 11 HP:0002588 \| Duodenal ulcer \| 9 HP:0001903 \| Anemia \| 5 HP:0002592 \| Stomach ulcer \| 5 HP:0002020 \| Heartburn \| 4 HP:0000819 \| Diabetes mellitus \| 4 HP:0002665 \| Lymphoma \| 3 HP:0002027 \| Abdominal pain \| 3 HP:0001658 \| Myocardial infarction \| 3 HP:0001891 \| Iron-deficiency anemia \| 3 HP:0030731 \| Carcinoma \| 2 HP:0001394 \| Hepatic cirrhosis \| 2 HP:0001397 \| Hepatic steatosis \| 2 HP:0001873 \| Low platelet count \| 2 HP:0006510 \| Chronic obstructive pulmonary disease \| 2 HP:0002582 \| Chronic atrophic gastritis \| 2 HP:0001297 \| Cerebral vascular events \| 2 HP:0000726 \| Dementia \| 2 HP:0000979 \| Purpura \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0001082 \| Cholecystitis \| 1 HP:0002099 \| Asthma \| 1 HP:0002140 \| Ischemic stroke \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0002242 \| Enteropathy \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0010280 \| Stomatitis \| 1 HP:0001410 \| Decreased liver function \| 1 HP:0011473 \| Villous atrophy \| 1 HP:0002480 \| Hepatic encephalopathy \| 1 HP:0002894 \| Neoplasia of the pancreas \| 1 HP:0012108 \| Primary open angle glaucoma \| 1 HP:0000872 \| Hashimoto's thyroiditis \| 1 HP:0002621 \| Atherosclerosis \| 1 HP:0002584 \| Intestinal hemorrhage \| 1 HP:0011857 \| Plasmacytoma \| 1 HP:0012594 \| High urine albumin levels \| 1 HP:0011107 \| Recurrent aphthous stomatitis \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0001677 \| Coronary artery disease \| 1 HP:0012531 \| Pain \| 1 HP:0002076 \| Migraine headaches \| 1 HP:0100502 \| Vitamin B12 deficiency \| 1 HP:0100633 \| Inflammation of the esophagus \| 1 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0002239 \| Gastrointestinal hemorrhage \| 1

Disease ID	1819
Disease	infection caused by helicobacter pylori
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:31) C0017152 \| gastritis \| 39 C0024623 \| gastric cancer \| 31 C0030920 \| peptic ulcer \| 13 C0017154 \| atrophic gastritis \| 10 C0013295 \| duodenal ulcer \| 9 C0085695 \| chronic gastritis \| 9 C0242647 \| malt lymphoma \| 6 C0030920 \| peptic ulcers \| 4 C0038354 \| gastric diseases \| 4 C0030920 \| ulcer disease \| 3 C0024299 \| lymphoma \| 3 C0162316 \| iron deficiency anemia \| 3 C0030920 \| gastroduodenal ulcer \| 3 C0017178 \| gastrointestinal diseases \| 2 C1283271 \| lymphocytic gastritis \| 2 C0013289 \| duodenal disease \| 2 C0242647 \| mucosa-associated lymphoid tissue \| 2 C0030920 \| peptic ulcer disease \| 2 C0017152 \| gastric inflammation \| 1 C1333782 \| malt lymphoma of the stomach \| 1 C0038358 \| gastric ulcers \| 1 C0017154 \| gastric atrophy \| 1 C0013289 \| duodenal diseases \| 1 C0876993 \| ventricular thrombus \| 1 C0032131 \| plasmacytoma \| 1 C0034150 \| purpura \| 1 C0162316 \| iron deficiency \| 1 C0031090 \| periodontal disease \| 1 C0349532 \| lymphoma of the stomach \| 1 C0267373 \| intestinal bleeding \| 1 C0010068 \| coronary artery disease \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:46)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1045642	17697203	5243	ABCB1	umls:C0850666	BeFree	Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infection by triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to CYP 2C19 genotypes and 23S rRNA genotypes of H. pylori.	0.006905599	2007	ABCB1	7	87509329	A	T,G
rs1045642	18644389	5243	ABCB1	umls:C0850666	BeFree	MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastric cancer and peptic ulcer in Japanese.	0.006905599	2008	ABCB1	7	87509329	A	T,G
rs1045642	22001987	5243	ABCB1	umls:C0850666	BeFree	The isolated C3435T ABCB1 SNP is not a major factor for genetic susceptibility to peptic ulcer, but in a group of men who suffered from peptic ulcer, this polymorphism seemed to be a risk factor for H. pylori infection development.	0.006905599	2011	ABCB1	7	87509329	A	T,G
rs10759932	24929142	7099	TLR4	umls:C0850666	BeFree	TLR4 rs10759932 decreased the risk of H. pylori infection (OR: 0.59, 95% CI: 0.41-0.86).	0.002985861	2014	TLR4	9	117702866	T	C
rs10983755	25084512	7099	TLR4	umls:C0850666	BeFree	Effect of the -2081G/A polymorphism of the TLR4 gene and its interaction with Helicobacter pylori infection on the risk of gastric cancer in Chinese individuals.	0.002985861	2015	TLR4	9	117702392	G	A
rs1136410	18716896	142	PARP1	umls:C0850666	BeFree	PARP-1 762Ala/Ala could be a risk factor for gastric cancer in Han Chinese population; PARP-1 762Val/Ala polymorphism and Cag(+) H. pylori infection jointly contribute to higher risk for gastric cancer.	0.000814326	2009	PARP1	1	226367601	A	G
rs1143623	21649724	5743	PTGS2	umls:C0850666	BeFree	In the Chinese subgroup, nominally significant associations were shown between (i) EBBR2+1963G (rs1801200) and H. pylori infection (per-allele OR: 0.48, 95% CI 0.23, 0.98, P = 0.04), (ii) PTGS2-1195G (rs689466) and an increased risk of GC on adjusting for H. pylori status (OR: 1.53, 95% CI 0.99, 2.37, P = 0.05), and (iii) IL1B-1473C (rs1143623) and a decreased risk of GC (OR: 0.64, 95% CI 0.41, 0.99, P = 0.05).	0.004885954	2011	IL1B	2	112838252	C	G
rs1143623	21649724	3553	IL1B	umls:C0850666	BeFree	In the Chinese subgroup, nominally significant associations were shown between (i) EBBR2+1963G (rs1801200) and H. pylori infection (per-allele OR: 0.48, 95% CI 0.23, 0.98, P = 0.04), (ii) PTGS2-1195G (rs689466) and an increased risk of GC on adjusting for H. pylori status (OR: 1.53, 95% CI 0.99, 2.37, P = 0.05), and (iii) IL1B-1473C (rs1143623) and a decreased risk of GC (OR: 0.64, 95% CI 0.41, 0.99, P = 0.05).	0.027426899	2011	IL1B	2	112838252	C	G
rs148704956	26151690	149233	IL23R	umls:C0850666	BeFree	We evaluated the relationship between IL-17A G197A, IL-17F A7488G and IL23R+2199 A/C polymorphisms with IL-6, IL-17, IL-21, IL-23 and TGF-β1 mRNAs expression in regard to H. pylori infection with chronic gastritis.	0.000271442	2015	IL17A	6	52187772	A	G
rs148704956	26151690	50616	IL22	umls:C0850666	BeFree	We evaluated the relationship between IL-17A G197A, IL-17F A7488G and IL23R+2199 A/C polymorphisms with IL-6, IL-17, IL-21, IL-23 and TGF-β1 mRNAs expression in regard to H. pylori infection with chronic gastritis.	0.000271442	2015	IL17A	6	52187772	A	G
rs148704956	26151690	51561	IL23A	umls:C0850666	BeFree	We evaluated the relationship between IL-17A G197A, IL-17F A7488G and IL23R+2199 A/C polymorphisms with IL-6, IL-17, IL-21, IL-23 and TGF-β1 mRNAs expression in regard to H. pylori infection with chronic gastritis.	0.000542884	2015	IL17A	6	52187772	A	G
rs148704956	26151690	7040	TGFB1	umls:C0850666	BeFree	We evaluated the relationship between IL-17A G197A, IL-17F A7488G and IL23R+2199 A/C polymorphisms with IL-6, IL-17, IL-21, IL-23 and TGF-β1 mRNAs expression in regard to H. pylori infection with chronic gastritis.	0.000814326	2015	IL17A	6	52187772	A	G
rs148704956	26151690	3605	IL17A	umls:C0850666	BeFree	We evaluated the relationship between IL-17A G197A, IL-17F A7488G and IL23R+2199 A/C polymorphisms with IL-6, IL-17, IL-21, IL-23 and TGF-β1 mRNAs expression in regard to H. pylori infection with chronic gastritis.	0.001085767	2015	IL17A	6	52187772	A	G
rs148704956	26151690	59067	IL21	umls:C0850666	BeFree	We evaluated the relationship between IL-17A G197A, IL-17F A7488G and IL23R+2199 A/C polymorphisms with IL-6, IL-17, IL-21, IL-23 and TGF-β1 mRNAs expression in regard to H. pylori infection with chronic gastritis.	0.000271442	2015	IL17A	6	52187772	A	G
rs148704956	26151690	27189	IL17C	umls:C0850666	BeFree	We evaluated the relationship between IL-17A G197A, IL-17F A7488G and IL23R+2199 A/C polymorphisms with IL-6, IL-17, IL-21, IL-23 and TGF-β1 mRNAs expression in regard to H. pylori infection with chronic gastritis.	0.000271442	2015	IL17A	6	52187772	A	G
rs1800925	21649724	3596	IL13	umls:C0850666	BeFree	Borderline significant associations were seen between IL2-330G (rs2069762) (OR 1.45, 95% CI 0.95, 2.15, P = 0.06) and IL13-1111T (rs1800925) (OR 0.65, 95% CI 0.42, 1.01, P = 0.06) and H. pylori infection.	0.000271442	2011	IL13;LOC101927761	5	132657117	C	T
rs1800925	21649724	3558	IL2	umls:C0850666	BeFree	Borderline significant associations were seen between IL2-330G (rs2069762) (OR 1.45, 95% CI 0.95, 2.15, P = 0.06) and IL13-1111T (rs1800925) (OR 0.65, 95% CI 0.42, 1.01, P = 0.06) and H. pylori infection.	0.001085767	2011	IL13;LOC101927761	5	132657117	C	T
rs1801200	21649724	3553	IL1B	umls:C0850666	BeFree	In the Chinese subgroup, nominally significant associations were shown between (i) EBBR2+1963G (rs1801200) and H. pylori infection (per-allele OR: 0.48, 95% CI 0.23, 0.98, P = 0.04), (ii) PTGS2-1195G (rs689466) and an increased risk of GC on adjusting for H. pylori status (OR: 1.53, 95% CI 0.99, 2.37, P = 0.05), and (iii) IL1B-1473C (rs1143623) and a decreased risk of GC (OR: 0.64, 95% CI 0.41, 0.99, P = 0.05).	0.027426899	2011	NA	NA	NA	NA	NA
rs1801200	21649724	5743	PTGS2	umls:C0850666	BeFree	In the Chinese subgroup, nominally significant associations were shown between (i) EBBR2+1963G (rs1801200) and H. pylori infection (per-allele OR: 0.48, 95% CI 0.23, 0.98, P = 0.04), (ii) PTGS2-1195G (rs689466) and an increased risk of GC on adjusting for H. pylori status (OR: 1.53, 95% CI 0.99, 2.37, P = 0.05), and (iii) IL1B-1473C (rs1143623) and a decreased risk of GC (OR: 0.64, 95% CI 0.41, 0.99, P = 0.05).	0.004885954	2011	NA	NA	NA	NA	NA
rs1801282	20568969	5468	PPARG	umls:C0850666	BeFree	Association between peroxisome proliferator-activated receptor-γ gene polymorphism (Pro12Ala) and Helicobacter pylori infection in gastric carcinogenesis.	0.001357209	2010	PPARG	3	12351626	C	G
rs1801282	18372284	5468	PPARG	umls:C0850666	BeFree	The study suggests that Pro12Ala PPARgamma polymorphism is associated with gastric adenocarcinoma and PUD, and is a potential marker for genetic susceptibility to these two diseases in the presence of H. pylori infection.	0.001357209	2008	PPARG	3	12351626	C	G
rs1801282	25824760	5468	PPARG	umls:C0850666	BeFree	Nevertheless, prospectively designed cohort studies are needed to further investigate gene-gene and gene-environment interactions to confirm the combined effects of PPARγ Pro12Ala polymorphisms and H. pylori infection on gastric cancer risk.	0.001357209	2016	PPARG	3	12351626	C	G
rs1805192	25824760	5468	PPARG	umls:C0850666	BeFree	Nevertheless, prospectively designed cohort studies are needed to further investigate gene-gene and gene-environment interactions to confirm the combined effects of PPARγ Pro12Ala polymorphisms and H. pylori infection on gastric cancer risk.	0.001357209	2016	PPARG	3	12379739	C	G
rs1805192	20568969	5468	PPARG	umls:C0850666	BeFree	Association between peroxisome proliferator-activated receptor-γ gene polymorphism (Pro12Ala) and Helicobacter pylori infection in gastric carcinogenesis.	0.001357209	2010	PPARG	3	12379739	C	G
rs1805192	18372284	5468	PPARG	umls:C0850666	BeFree	The study suggests that Pro12Ala PPARgamma polymorphism is associated with gastric adenocarcinoma and PUD, and is a potential marker for genetic susceptibility to these two diseases in the presence of H. pylori infection.	0.001357209	2008	PPARG	3	12379739	C	G
rs2069762	21649724	3558	IL2	umls:C0850666	BeFree	Borderline significant associations were seen between IL2-330G (rs2069762) (OR 1.45, 95% CI 0.95, 2.15, P = 0.06) and IL13-1111T (rs1800925) (OR 0.65, 95% CI 0.42, 1.01, P = 0.06) and H. pylori infection.	0.001085767	2011	IL2	4	122456825	A	C
rs2069762	21649724	3596	IL13	umls:C0850666	BeFree	Borderline significant associations were seen between IL2-330G (rs2069762) (OR 1.45, 95% CI 0.95, 2.15, P = 0.06) and IL13-1111T (rs1800925) (OR 0.65, 95% CI 0.42, 1.01, P = 0.06) and H. pylori infection.	0.000271442	2011	IL2	4	122456825	A	C
rs2075820	19882212	10392	NOD1	umls:C0850666	BeFree	The significance of E266K polymorphism in the NOD1 gene on Helicobacter pylori infection: an effective force on pathogenesis?	0.001357209	2010	NOD1	7	30452621	C	T
rs2294008	25721731	8000	PSCA	umls:C0850666	BeFree	Two recent genome-wide association studies in Asians have reported the association between the PSCA (prostate stem cell antigen) rs2294008C>T gene polymorphism and two Helicobacter pylori infection-related diseases such as gastric cancer (GC) and duodenal ulcer (DU).	0.000814326	2015	PSCA	8	142680513	C	T
rs2297518	20565800	4843	NOS2	umls:C0850666	BeFree	The aim of this study was to evaluate the association of NOS2 polymorphisms Ser608Leu (rs2297518) in exon 16, -954G/C and -1173C/T, both in the promoter region, with gastric cancer and chronic gastritis and the association of cancer with risk factors such as smoking, alcohol intake and H. pylori infection.	0.000814326	2010	NOS2	17	27769571	G	A
rs28362491	22614238	4790	NFKB1	umls:C0850666	BeFree	We investigated the influence of NFKB1 polymorphisms, -94 ins/del (rs28362491) and -449 C>G (rs72696119), on the aberrant gene methylation under H. pylori infection.	0.000814326	2012	NFKB1;LOC105377621	4	102500998	ATTG	-
rs3805246	20602450	2549	GAB1	umls:C0850666	BeFree	We could not confirm a major association between Gab1 SNP (rs3805246) and the predisposition to H. pylori infection and CAG in this study population from Germany.	0.000542884	2010	GAB1	4	143382955	G	A
rs4646903	23686565	1543	CYP1A1	umls:C0850666	BeFree	We studied the role of CYP2E1, CYP1A2 (rs762551), and CYP1A1 (rs4646903) polymorphisms in association with H. pylori infection in gastric carcinogenesis.	0.002638474	2013	CYP1A1	15	74719300	A	T,G
rs4833095	25687912	7096	TLR1	umls:C0850666	BeFree	A decreased risk of H. pylori infection was observed in subjects with TLR1 rs4833095 CT genotype [adjusted odds ratio (OR)=0.80; 95% confidence interval (CI): 0.66-0.96] or T allele (OR=0.82; 95%CI: 0.69-0.99).	0.000542884	2015	TLR1	4	38798089	T	C
rs4986790	22468087	7099	TLR4	umls:C0850666	BeFree	To investigate toll-like receptor 2 (TLR2) -196 to -174 del, and TLR4 (+896A/G rs4986790 and +1196C/T rs4986791) polymorphisms at risk of chronic gastritis and gastric cancer in a Brazilian population and association of gastric lesions with risk factors such as smoking, alcohol intake and Helicobacter pylori infection.	0.002985861	2012	TLR4	9	117713024	A	G
rs4986790	22468087	7097	TLR2	umls:C0850666	BeFree	To investigate toll-like receptor 2 (TLR2) -196 to -174 del, and TLR4 (+896A/G rs4986790 and +1196C/T rs4986791) polymorphisms at risk of chronic gastritis and gastric cancer in a Brazilian population and association of gastric lesions with risk factors such as smoking, alcohol intake and Helicobacter pylori infection.	0.001628651	2012	TLR4	9	117713024	A	G
rs4986791	22468087	7097	TLR2	umls:C0850666	BeFree	To investigate toll-like receptor 2 (TLR2) -196 to -174 del, and TLR4 (+896A/G rs4986790 and +1196C/T rs4986791) polymorphisms at risk of chronic gastritis and gastric cancer in a Brazilian population and association of gastric lesions with risk factors such as smoking, alcohol intake and Helicobacter pylori infection.	0.001628651	2012	TLR4	9	117713324	C	T
rs4986791	22468087	7099	TLR4	umls:C0850666	BeFree	To investigate toll-like receptor 2 (TLR2) -196 to -174 del, and TLR4 (+896A/G rs4986790 and +1196C/T rs4986791) polymorphisms at risk of chronic gastritis and gastric cancer in a Brazilian population and association of gastric lesions with risk factors such as smoking, alcohol intake and Helicobacter pylori infection.	0.002985861	2012	TLR4	9	117713324	C	T
rs5744174	21994405	7097	TLR2	umls:C0850666	BeFree	These findings suggest that TLR2 c. -196 to -174 ins > del, TLR5 rs5744174 and interaction between rs5744174 and H. pylori infection were associated with the development of GC.	0.001628651	2011	TLR5	1	223111186	A	G
rs5744174	21994405	7100	TLR5	umls:C0850666	BeFree	These findings suggest that TLR2 c. -196 to -174 ins > del, TLR5 rs5744174 and interaction between rs5744174 and H. pylori infection were associated with the development of GC.	0.000542884	2011	TLR5	1	223111186	A	G
rs6672420	19728008	864	RUNX3	umls:C0850666	BeFree	Our study results revealed that the RUNX3 intronic T/A polymorphism (rs760805) might modulate the risk of gastric atrophy among H. pylori seropositive subjects, and the RUNX3 T/A polymorphism at exon 1 (rs6672420) had little influence on the risks of H. pylori infection, gastric atrophy or gastric cancer in Japanese people.	0.002985861	2009	RUNX3;LOC105376878	1	24964519	A	T
rs689466	21649724	3553	IL1B	umls:C0850666	BeFree	In the Chinese subgroup, nominally significant associations were shown between (i) EBBR2+1963G (rs1801200) and H. pylori infection (per-allele OR: 0.48, 95% CI 0.23, 0.98, P = 0.04), (ii) PTGS2-1195G (rs689466) and an increased risk of GC on adjusting for H. pylori status (OR: 1.53, 95% CI 0.99, 2.37, P = 0.05), and (iii) IL1B-1473C (rs1143623) and a decreased risk of GC (OR: 0.64, 95% CI 0.41, 0.99, P = 0.05).	0.027426899	2011	PTGS2;PACERR	1	186681619	T	C
rs689466	21649724	5743	PTGS2	umls:C0850666	BeFree	In the Chinese subgroup, nominally significant associations were shown between (i) EBBR2+1963G (rs1801200) and H. pylori infection (per-allele OR: 0.48, 95% CI 0.23, 0.98, P = 0.04), (ii) PTGS2-1195G (rs689466) and an increased risk of GC on adjusting for H. pylori status (OR: 1.53, 95% CI 0.99, 2.37, P = 0.05), and (iii) IL1B-1473C (rs1143623) and a decreased risk of GC (OR: 0.64, 95% CI 0.41, 0.99, P = 0.05).	0.004885954	2011	PTGS2;PACERR	1	186681619	T	C
rs72696119	22614238	4790	NFKB1	umls:C0850666	BeFree	We investigated the influence of NFKB1 polymorphisms, -94 ins/del (rs28362491) and -449 C>G (rs72696119), on the aberrant gene methylation under H. pylori infection.	0.000814326	2012	NFKB1;LOC105377621	4	102501347	C	G
rs760805	19728008	864	RUNX3	umls:C0850666	BeFree	Our study results revealed that the RUNX3 intronic T/A polymorphism (rs760805) might modulate the risk of gastric atrophy among H. pylori seropositive subjects, and the RUNX3 T/A polymorphism at exon 1 (rs6672420) had little influence on the risks of H. pylori infection, gastric atrophy or gastric cancer in Japanese people.	0.002985861	2009	RUNX3	1	24925432	A	T
rs762551	23686565	1543	CYP1A1	umls:C0850666	BeFree	We studied the role of CYP2E1, CYP1A2 (rs762551), and CYP1A1 (rs4646903) polymorphisms in association with H. pylori infection in gastric carcinogenesis.	0.002638474	2013	CYP1A2	15	74749576	C	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:62)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	161484210	rs368433	T	C	rs368433	23652523	2.00E-08	NA	1.37	[1.23-1.54]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
1	161485259	rs17400517	G	T	rs17400517	23652523	4.95E-08	NA	1.37	[1.23-1.54]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
1	161492175	rs9427401	C	G	rs9427401	23652523	4.57E-08	NA	1.37	[1.23-1.54]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38710398	rs11728133	T	C	rs11728133	23652523	1.10E-08	NA	1.23	[1.15-1.33]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38711684	rs13132956	C	T	rs13132956	23652523	2.69E-09	NA	1.3	[1.19-1.41]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38724249	rs1005938	A	G	rs1005938	23652523	2.69E-11	NA	1.3	[1.19-1.39]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38724573	rs7660102	C	A	rs7660102	23652523	8.07E-11	NA	1.3	[1.20-1.41]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38724593	rs13135770	G	A	rs13135770	23652523	9.58E-11	NA	1.3	[1.20-1.41]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38724886	rs12510962	G	A	rs12510962	23652523	1.00E-10	NA	1.3	[1.20-1.41]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38724945	rs13137984	C	A	rs13137984	23652523	6.98E-09	NA	NA	NA	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38724945	rs13137984	C	A	rs13137984	23652523	7.00E-09	NA	1.22	[1.14-1.30]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38726766	rs4832786	C	G	rs4832786	23652523	3.93E-09	NA	1.22	[1.14-1.30]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38728076	rs7658334	A	G	rs7658334	23652523	2.70E-09	NA	1.22	[1.15-1.32]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38728104	rs7663292	T	C	rs7663292	23652523	2.88E-09	NA	1.22	[1.15-1.32]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38732962	rs10026553	A	G	rs10026553	23652523	8.19E-12	NA	1.28	[1.19-1.37]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38736550	rs2890620	T	C	rs2890620	23652523	4.65E-11	NA	1.27	[1.19-1.37]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38744489	rs4072590	A	T	rs4072590	23652523	5.12E-11	NA	1.27	[1.18-1.37]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38750185	rs9761637	A	G	rs9761637	23652523	5.46E-12	NA	1.28	[1.19-1.37]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38751694	rs4540058	G	A	rs4540058	23652523	1.35E-11	NA	1.28	[1.19-1.39]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38764112	rs10024216	G	A	rs10024216	23652523	4.01E-08	NA	1.2	[1.12-1.28]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38765720	rs10008492	C	T	rs10008492	23652523	2.06E-08	NA	1.2	[1.14-1.30]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38774785	rs10776482	A	G	rs10776482	23652523	1.57E-10	NA	1.3	[1.20-1.41]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38774889	rs4129009	T	A,C,G	rs4129009	23652523	3.17E-12	NA	1.37	[1.25-1.49]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38775040	rs10776483	A	G	rs10776483	23652523	1.46E-10	NA	1.3	[1.20-1.41]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38776180	rs11096956	C	A	rs11096956	23652523	1.56E-10	NA	1.3	[1.20-1.41]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38777471	rs4274855	C	T	rs4274855	23652523	3.05E-12	NA	1.37	[1.25-1.49]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38778203	rs11466645	A	T	rs11466645	23652523	3.05E-12	NA	1.37	[1.25-1.49]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38778903	rs11466640	G	A	rs11466640	23652523	2.54E-12	NA	1.37	[1.25-1.49]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38780471	rs11466617	T	C	rs11466617	23652523	3.05E-12	NA	1.37	[1.25-1.49]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38782221	rs7653908	G	C	rs7653908	23652523	3.60E-15	NA	1.39	[1.28-1.52]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38782420	rs7658893	G	A	rs7658893	23652523	9.86E-14	NA	1.35	[1.25-1.45]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38783848	rs11725309	T	C	rs11725309	23652523	2.35E-13	NA	1.39	[1.27-1.52]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38784724	rs10004195	T	A	rs10004195	23652523	1.00E-18	NA	1.43	[1.32-1.54]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38784724	rs113143765	T	TA	rs10004195	23652523	1.00E-18	NA	1.43	[1.32-1.54]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38787216	rs12233670	C	T	rs12233670	23652523	2.89E-18	NA	1.43	[1.32-1.54]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38792524	rs4543123	A	G	rs4543123	23652523	1.75E-18	NA	1.43	[1.32-1.54]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38799710	rs4833095	T	C	rs4833095	23652523	1.43E-18	NA	1.43	[1.32-1.54]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38801285	rs5743604	A	G	rs5743604	23652523	2.22E-18	NA	1.43	[1.32-1.54]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38802528	rs5743596	G	A	rs5743596	23652523	2.43E-11	NA	1.37	[1.25-1.49]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38802644	rs5743595	A	G	rs5743595	23652523	7.69E-13	NA	1.37	[1.27-1.49]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38803063	rs5743592	A	G	rs5743592	23652523	1.59E-13	NA	1.39	[1.28-1.52]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38805489	rs5743571	C	T	rs5743571	23652523	6.07E-13	NA	1.37	[1.27-1.49]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38805983	rs5743565	T	C	rs5743565	23652523	5.51E-13	NA	1.37	[1.27-1.52]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38806019	rs5743563	A	G	rs5743563	23652523	5.13E-13	NA	1.37	[1.27-1.49]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38806096	rs5743562	T	C	rs5743562	23652523	7.27E-12	NA	1.37	[1.25-1.49]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38806827	rs5743557	G	A	rs5743557	23652523	4.30E-13	NA	1.39	[1.27-1.52]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38810769	rs11722813	C	T	rs11722813	23652523	1.44E-08	NA	1.56	[1.33-1.82]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38811551	rs2101521	G	A	rs2101521	23652523	1.08E-15	NA	1.41	[1.30-1.54]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38812876	rs17616434	T	C	rs17616434	23652523	6.51E-18	NA	1.41	[1.32-1.54]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38815502	rs4833103	A	C	rs4833103	23652523	1.09E-10	NA	1.23	[1.16-1.32]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38816338	rs6815814	A	C	rs6815814	23652523	6.95E-18	NA	1.41	[1.30-1.52]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38832727	rs5743794	C	T	rs5743794	23652523	3.63E-12	NA	1.35	[1.23-1.47]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38845198	rs7673348	G	A	rs7673348	23652523	6.49E-13	NA	1.35	[1.23-1.45]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38846979	rs7687447	C	G	rs7687447	23652523	5.08E-13	NA	1.35	[1.23-1.47]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38859339	rs2174284	C	T	rs2174284	23652523	9.44E-12	NA	1.35	[1.23-1.47]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38862121	rs3860069	A	C	rs3860069	23652523	1.02E-12	NA	1.35	[1.25-1.47]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38867427	rs17582830	A	G	rs17582830	23652523	3.37E-11	NA	1.33	[1.22-1.45]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38886420	rs17582893	G	A	rs17582893	23652523	5.01E-11	NA	1.33	[1.22-1.45]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38891173	rs1873195	C	T	rs1873195	23652523	2.35E-11	NA	1.33	[1.22-1.45]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38892649	rs17582921	T	C	rs17582921	23652523	2.39E-11	NA	1.33	[1.22-1.45]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38893843	rs6851685	G	T	rs6851685	23652523	3.80E-15	NA	1.37	[1.27-1.47]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247
4	38894380	rs6835514	A	G	rs6835514	23652523	1.08E-15	NA	1.37	[1.27-1.49]	2,623 European ancestry high titer cases; 7,862 European ancestry low or no titer controls	European(10485)	ALL(10485)	EUR(10485)	ALL(10485)	Helicobacter pylori serologic status	HPOID:0005202	Helicobacter pylori infection	DOID:3686	DOID:4036	DOID:5663	DOID:7979	Helicobacter pylori infectious disease	Helicobacter pylori gastritis	helicobacter pylori-related carcinoma	helicobacter pylori-related gastric adenocarcinoma	NA	NA	EFOID:0005247

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
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