PedAM

Pediatric Disease Annotations & Medicines


	hypothyroidism

Disease ID	155
Disease	hypothyroidism
Definition	A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA.
Synonym	hypothyroid hypothyroidism (disorder) hypothyroidism [ambiguous] hypothyroidism [disease/finding] hypothyroidism nos hypothyroidism nos (disorder) hypothyroidism, nos hypothyroidisms low t4 thyroid activity decreased thyroid deficiency thyroid insufficiency thyroid-stimulating hormone deficiency tsh deficiency underactive thyroid unspecified acquired hypothyroidism unspecified hypothyroidism
OMIM	OMIM:275100
DOID	DOID:1459
UMLS	C0020676
MeSH	D007037
SNOMED-CT	SNOMEDCT_US_2016_09_01:40930008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:266) C0040147 \| thyroiditis \| 38 C0018021 \| goiter \| 17 C0920350 \| autoimmune thyroiditis \| 16 C0011847 \| diabetes \| 16 C0020538 \| hypertension \| 14 C0007115 \| thyroid ca \| 14 C0020550 \| hyperthyroidism \| 13 C0028754 \| obesity \| 11 C0677607 \| hashimoto's thyroiditis \| 11 C0948265 \| metabolic syndrome \| 10 C0018801 \| heart failure \| 9 C0020443 \| hypercholesterolemia \| 9 C0031039 \| pericardial effusion \| 9 C0007115 \| thyroid cancer \| 8 C0011570 \| depression \| 8 C0007177 \| cardiac tamponade \| 8 C0021359 \| infertile \| 7 C0004153 \| atherosclerosis \| 7 C0020514 \| hyperprolactinemia \| 7 C0032914 \| preeclampsia \| 6 C0039730 \| thalassemia \| 6 C0002871 \| anemia \| 6 C0026848 \| myopathy \| 5 C0025362 \| mental retardation \| 5 C0152025 \| polyneuropathy \| 5 C0033975 \| psychosis \| 5 C0042373 \| vascular disease \| 5 C0020676 \| hypothyroidism \| 5 C0000786 \| miscarriage \| 5 C0020635 \| hypopituitarism \| 5 C0549473 \| thyroid carcinoma \| 5 C0002871 \| anaemia \| 5 C0007134 \| renal cell carcinoma \| 4 C0022661 \| chronic kidney disease \| 4 C0027051 \| myocardial infarction \| 4 C0007222 \| cardiovascular disease \| 4 C0029927 \| ovarian cyst \| 4 C0018799 \| heart disease \| 4 C1565489 \| renal insufficiency \| 4 C0029927 \| ovarian cysts \| 4 C0027051 \| myocardial infarct \| 4 C0040128 \| thyroid disease \| 4 C0034013 \| precocious puberty \| 4 C0677607 \| hashimoto thyroiditis \| 4 C0497327 \| dementia \| 4 C0001623 \| adrenal insufficiency \| 4 C0011860 \| type 2 diabetes \| 4 C0023895 \| liver disease \| 4 C0849777 \| cystic ovaries \| 4 C0003864 \| arthritis \| 4 C0342199 \| iodine deficiency \| 4 C0342208 \| multinodular goiter \| 3 C0745140 \| hyperthyroid \| 3 C0409974 \| lupus erythematosus \| 3 C0018021 \| goitre \| 3 C0027726 \| nephrotic syndrome \| 3 C0018916 \| hemangioma \| 3 C0009806 \| constipation \| 3 C0677607 \| hashimoto's disease \| 3 C0007570 \| celiac disease \| 3 C0020555 \| hypertrichosis \| 3 C0021359 \| infertility \| 3 C0003873 \| rheumatoid arthritis \| 3 C0041696 \| major depressive disorder \| 3 C0018023 \| nodular goiter \| 3 C0000809 \| recurrent miscarriage \| 3 C0024141 \| systemic lupus erythematosus \| 3 C0020619 \| hypogonadism \| 3 C0010308 \| congenital goitre \| 2 C0023890 \| cirrhosis \| 2 C0155626 \| acute myocardial infarction \| 2 C0027145 \| myxedema \| 2 C0017601 \| glaucoma \| 2 C0024523 \| malabsorption \| 2 C0011849 \| diabetes mellitus \| 2 C0018099 \| gout \| 2 C0149931 \| migraine \| 2 C0022658 \| kidney disease \| 2 C0031039 \| pericardial effusions \| 2 C0018213 \| graves' disease \| 2 C0032460 \| polycystic ovary \| 2 C1145670 \| respiratory failure \| 2 C0037315 \| sleep apnea \| 2 C0040137 \| thyroid nodule \| 2 C0032002 \| pituitary disease \| 2 C0040156 \| thyrotoxicosis \| 2 C1258215 \| ileus \| 2 C0002892 \| pernicious anemia \| 2 C0271650 \| glucose intolerance \| 2 C0032460 \| multicystic ovaries \| 2 C0015930 \| fetal distress \| 2 C0010068 \| coronary heart disease \| 2 C0019158 \| hepatitis \| 2 C0149931 \| migraine headache \| 2 C0032460 \| polycystic ovary syndrome \| 2 C0242520 \| chronic thyroiditis \| 2 C0677607 \| lymphocytic thyroiditis \| 2 C0242343 \| panhypopituitarism \| 2 C0021364 \| male infertility \| 2 C0006142 \| breast cancer \| 2 C0018802 \| congestive heart failure \| 2 C0238246 \| hepatic hemangioma \| 2 C0025202 \| melanoma \| 2 C0032969 \| pregnancy in diabetic \| 1 C0022658 \| renal disease \| 1 C0040053 \| thrombosis \| 1 C0021843 \| intestinal obstruction \| 1 C0033038 \| premature ejaculation \| 1 C0026848 \| muscular disorders \| 1 C0679466 \| cognitive deficits \| 1 C0027697 \| nephritis \| 1 C0021053 \| immune disorder \| 1 C0341950 \| severe pre-eclampsia \| 1 C0026769 \| multiple sclerosis \| 1 C0042847 \| vitamin b12 defic \| 1 C0023418 \| leukemia \| 1 C0042974 \| von willebrand's disease \| 1 C0042847 \| vitamin b12 deficiency \| 1 C0003467 \| anxiety \| 1 C0085655 \| polymyositis \| 1 C0025202 \| malignant melanoma \| 1 C0022735 \| hypogonadotropic hypogonadism \| 1 C0020598 \| hypoglycemia \| 1 C0042870 \| vitamin d deficiency \| 1 C0040137 \| thyroid nodules \| 1 C0751651 \| mitochondrial disorder \| 1 C0878544 \| cardiomyopathies \| 1 C0020676 \| hypothyroid \| 1 C0029408 \| osteoarthritis \| 1 C0014544 \| epilepsy \| 1 C0022596 \| palmoplantar keratoderma \| 1 C0007222 \| cardiovascular diseases \| 1 C0040188 \| tic disorders \| 1 C0017662 \| membranoproliferative glomerulonephritis \| 1 C0042870 \| vitamin d defic \| 1 C0024115 \| lung diseases \| 1 C0019204 \| hepatocellular carcinoma \| 1 C0042373 \| vascular diseases \| 1 C0010674 \| cystic fibrosis \| 1 C0238463 \| papillary thyroid carcinoma \| 1 C1135196 \| diastolic heart failure \| 1 C0456909 \| blindness \| 1 C0026764 \| multiple myeloma \| 1 C0242292 \| mccune-albright syndrome \| 1 C0024115 \| lung disease \| 1 C0221002 \| primary hyperparathyroidism \| 1 C0027765 \| neurologic disorder \| 1 C0027868 \| neuromuscular disorders \| 1 C0743098 \| dermopathy \| 1 C0022116 \| ischemia \| 1 C0032027 \| pityriasis rubra pilaris \| 1 C0020676 \| thyroid insufficiency \| 1 C0018021 \| goiters \| 1 C0152021 \| congenital heart disease \| 1 C0339143 \| thyroid orbitopathy \| 1 C0159069 \| impaired glucose tolerance \| 1 C0030305 \| pancreatitis \| 1 C0175702 \| williams syndrome \| 1 C0030446 \| paralytic ileus \| 1 C0009782 \| connective tissue disease \| 1 C0019284 \| diaphragmatic hernia \| 1 C0007785 \| cerebral ischemia \| 1 C0042109 \| urticaria \| 1 C0340274 \| gestational hypertension \| 1 C0024143 \| lupus nephritis \| 1 C0238358 \| hypokalemic periodic paralysis \| 1 C0007177 \| pericardial tamponade \| 1 C0700501 \| congenital nystagmus \| 1 C0004936 \| mental disorders \| 1 C0028738 \| nystagmus \| 1 C0000786 \| spontaneous abortion \| 1 C0035078 \| renal failure \| 1 C0014848 \| megaoesophagus \| 1 C0007570 \| coeliac disease \| 1 C0009402 \| colorectal cancer \| 1 C0029456 \| osteoporosis \| 1 C0005745 \| ptosis \| 1 C0010308 \| congenital hypothyroidism \| 1 C0242292 \| albright syndrome \| 1 C0010308 \| cretinism \| 1 C0265246 \| townes-brocks syndrome \| 1 C0153382 \| oropharyngeal cancer \| 1 C0024523 \| intestinal malabsorption \| 1 C0040127 \| thyroid crisis \| 1 C0033953 \| sexual dysfunction \| 1 C0021053 \| immune disease \| 1 C0339143 \| graves ophthalmopathy \| 1 C0018021 \| struma \| 1 C0278678 \| metastatic renal cell carcinoma \| 1 C0022661 \| end-stage renal disease \| 1 C0162855 \| mucinosis \| 1 C0271623 \| gonadotropin deficiency \| 1 C0346326 \| optic glioma \| 1 C0026272 \| mixed connective tissue disease \| 1 C0042769 \| viral illness \| 1 C0032460 \| polycystic ovaries \| 1 C0010068 \| coronary artery disease \| 1 C0033687 \| proteinuria \| 1 C0015230 \| rash \| 1 C0019569 \| hirschsprung's disease \| 1 C0677607 \| chronic lymphocytic thyroiditis \| 1 C0022658 \| nephropathy \| 1 C0022951 \| lactose intolerance \| 1 C0238246 \| hepatic haemangioma \| 1 C0009492 \| compartment syndrome \| 1 C0520679 \| obstructive sleep apnea \| 1 C0019196 \| hepatitis c \| 1 C0017636 \| glioblastoma \| 1 C0020437 \| hypercalcaemia \| 1 C0014850 \| esophageal atresia \| 1 C0042900 \| vitiligo \| 1 C0242231 \| coronary artery stenosis \| 1 C0011334 \| caries \| 1 C0020551 \| hyperthyroxinemia \| 1 C0018916 \| hemangiomas \| 1 C0023473 \| chronic myeloid leukemia \| 1 C0026654 \| moyamoya syndrome \| 1 C0007286 \| carpal tunnel syndrome \| 1 C0034063 \| pulmonary edema \| 1 C0001622 \| hypercortisolism \| 1 C0587248 \| costello syndrome \| 1 C0018799 \| heart diseases \| 1 C0010690 \| cystinosis \| 1 C0026654 \| moyamoya \| 1 C0008495 \| chorioamnionitis \| 1 C0003864 \| inflammatory arthritis \| 1 C0024419 \| waldenstrom's macroglobulinemia \| 1 C0021053 \| immune disorders \| 1 C0005586 \| bipolar disorder \| 1 C0040150 \| acute suppurative thyroiditis \| 1 C0017658 \| glomerulonephritis \| 1 C0034013 \| sexual precocity \| 1 C0034735 \| raynaud's phenomenon \| 1 C0009402 \| colorectal carcinoma \| 1 C0206526 \| multidrug-resistant tuberculosis \| 1 C0235618 \| proliferative glomerulonephritis \| 1 C0015464 \| facial palsy \| 1 C0266463 \| lissencephaly \| 1 C0342388 \| adrenocorticotropic hormone deficiency \| 1 C0008925 \| cleft palate \| 1 C0014070 \| encephalomyelitis \| 1 C0085207 \| gestational diabetes \| 1 C0023448 \| lymphocytic leukemia \| 1 C0018799 \| cardiac disease \| 1 C0497327 \| dementias \| 1 C0023890 \| liver cirrhosis \| 1 C0011854 \| type 1 diabetes \| 1 C0007113 \| rectal carcinoma \| 1 C0026848 \| myopathies \| 1 C0024523 \| malabsorption syndrome \| 1 C0030443 \| periodic paralysis \| 1 C0001206 \| acromegaly \| 1 C1704437 \| respiratory distress syndrome \| 1 C0007113 \| rectal cancer \| 1 C0271829 \| pendred syndrome \| 1 C0022660 \| acute renal failure \| 1 C0031046 \| pericarditis \| 1 C0031347 \| pharyngeal cancer \| 1 C0852949 \| arterial disease \| 1 C0151779 \| cutaneous melanoma \| 1 C0034012 \| delayed puberty \| 1 C0017612 \| open-angle glaucoma \| 1 C0023470 \| myeloid leukemia \| 1 C0020598 \| hypoglycaemia \| 1 C0027765 \| neurologic disorders \| 1 C0271789 \| tsh deficiency \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:20) NKX2-5 \| 1482 \| UniProtKB-KW SLC5A5 \| 6528 \| UniProtKB-KW;GHR TSHR \| 7253 \| UniProtKB-KW;GHR TG \| 7038 \| UniProtKB-KW;GHR PHTF1 \| 10745 \| GWASCAT VAV3 \| 10451 \| GWASCAT DUOX2 \| 50506 \| UniProtKB-KW;GHR TSHB \| 7252 \| CTD_human;GHR PAX8 \| 7849 \| UniProtKB-KW;GHR GLIS3 \| 169792 \| UniProtKB-KW NKX2-1 \| 7080 \| UniProtKB-KW THRA \| 7067 \| UniProtKB-KW LINC01387 \| 100130480 \| GWASCAT FOXE1 \| 2304 \| UniProtKB-KW SH2B3 \| 10019 \| GWASCAT IGSF1 \| 3547 \| UniProtKB-KW TRHR \| 7201 \| CTD_human IYD \| 389434 \| UniProtKB-KW DUOXA2 \| 405753 \| UniProtKB-KW TPO \| 7173 \| UniProtKB-KW;GHR
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:30) 100130396 \| ATP5LP4 \| infer 114904 \| C1QTNF6 \| infer 1493 \| CTLA4 \| infer 1733 \| DIO1 \| infer 1734 \| DIO2 \| infer 1735 \| DIO3 \| infer 2304 \| FOXE1 \| infer 3105 \| HLA-A \| infer 3106 \| HLA-B \| infer 3119 \| HLA-DQB1 \| infer 3304 \| HSPA1B \| infer 3305 \| HSPA1L \| infer 3643 \| INSR \| infer 392371 \| KRT18P13 \| infer 4049 \| LTA \| infer 4520 \| MTF1 \| infer 394263 \| MUC21 \| infer 8622 \| PDE8B \| infer 645387 \| RPL6P27 \| infer 100271211 \| RPL7AP47 \| infer 100270827 \| RPS2P14 \| infer 26278 \| SACS \| infer 10019 \| SH2B3 \| infer 7124 \| TNF \| infer 7173 \| TPO \| infer 7252 \| TSHB \| infer 7253 \| TSHR \| infer 10451 \| VAV3 \| infer 65986 \| ZBTB10 \| infer 219578 \| ZNF804B \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:443) 6515 \| SLC2A3 \| DISEASES 2767 \| GNA11 \| DISEASES 50508 \| NOX3 \| DISEASES 1361 \| CPB2 \| DISEASES 6561 \| SLC13A1 \| DISEASES 359 \| AQP2 \| DISEASES 27102 \| EIF2AK1 \| DISEASES 1071 \| CETP \| DISEASES 57186 \| RALGAPA2 \| DISEASES 4320 \| MMP11 \| DISEASES 25776 \| CBY1 \| DISEASES 23551 \| RASD2 \| DISEASES 5816 \| PVALB \| DISEASES 5106 \| PCK2 \| DISEASES 5020 \| OXT \| DISEASES 10005 \| ACOT8 \| DISEASES 6907 \| TBL1X \| DISEASES 479 \| ATP12A \| DISEASES 54 \| ACP5 \| DISEASES 869 \| CBLN1 \| DISEASES 1512 \| CTSH \| DISEASES 55192 \| DNAJC17 \| DISEASES 7038 \| TG \| DISEASES 1666 \| DECR1 \| DISEASES 27121 \| DKK4 \| DISEASES 8797 \| TNFRSF10A \| DISEASES 4741 \| NEFM \| DISEASES 1158 \| CKM \| DISEASES 268 \| AMH \| DISEASES 56729 \| RETN \| DISEASES 973 \| CD79A \| DISEASES 1048 \| CEACAM5 \| DISEASES 6822 \| SULT2A1 \| DISEASES 9545 \| RAB3D \| DISEASES 1628 \| DBP \| DISEASES 6528 \| SLC5A5 \| DISEASES 5444 \| PON1 \| DISEASES 10135 \| NAMPT \| DISEASES 5054 \| SERPINE1 \| DISEASES 3558 \| IL2 \| DISEASES 10944 \| C11orf58 \| DISEASES 4256 \| MGP \| DISEASES 3458 \| IFNG \| DISEASES 2597 \| GAPDH \| DISEASES 56994 \| CHPT1 \| DISEASES 3945 \| LDHB \| DISEASES 389434 \| IYD \| DISEASES 3670 \| ISL1 \| DISEASES 2690 \| GHR \| DISEASES 338 \| APOB \| DISEASES 3485 \| IGFBP2 \| DISEASES 4317 \| MMP8 \| DISEASES 335 \| APOA1 \| DISEASES 7276 \| TTR \| DISEASES 2691 \| GHRH \| DISEASES 1958 \| EGR1 \| DISEASES 57616 \| TSHZ3 \| DISEASES 2322 \| FLT3 \| DISEASES 4852 \| NPY \| DISEASES 9572 \| NR1D1 \| DISEASES 7355 \| SLC35A2 \| DISEASES 2678 \| GGT1 \| DISEASES 11135 \| CDC42EP1 \| DISEASES 3630 \| INS \| DISEASES 6299 \| SALL1 \| DISEASES 3741 \| KCNA5 \| DISEASES 348 \| APOE \| DISEASES 92595 \| ZNF764 \| DISEASES 47 \| ACLY \| DISEASES 50617 \| ATP6V0A4 \| DISEASES 1160 \| CKMT2 \| DISEASES 85415 \| RHPN2 \| DISEASES 6616 \| SNAP25 \| DISEASES 1401 \| CRP \| DISEASES 759 \| CA1 \| DISEASES 10752 \| CHL1 \| DISEASES 7252 \| TSHB \| DISEASES 2694 \| GIF \| DISEASES 80896 \| NPL \| DISEASES 3569 \| IL6 \| DISEASES 2572 \| GAD2 \| DISEASES 1588 \| CYP19A1 \| DISEASES 1559 \| CYP2C9 \| DISEASES 51163 \| DBR1 \| DISEASES 29953 \| TRHDE \| DISEASES 6857 \| SYT1 \| DISEASES 7450 \| VWF \| DISEASES 8924 \| HERC2 \| DISEASES 9172 \| MYOM2 \| DISEASES 4591 \| TRIM37 \| DISEASES 26118 \| WSB1 \| DISEASES 2775 \| GNAO1 \| DISEASES 495 \| ATP4A \| DISEASES 25939 \| SAMHD1 \| DISEASES 9132 \| KCNQ4 \| DISEASES 2769 \| GNA15 \| DISEASES 7350 \| UCP1 \| DISEASES 10133 \| OPTN \| DISEASES 2033 \| EP300 \| DISEASES 3553 \| IL1B \| DISEASES 56751 \| BARHL1 \| DISEASES 51430 \| SUCO \| DISEASES 89884 \| LHX4 \| DISEASES 4036 \| LRP2 \| DISEASES 3791 \| KDR \| DISEASES 60482 \| SLC5A7 \| DISEASES 80303 \| EFHD1 \| DISEASES 79594 \| MUL1 \| DISEASES 832 \| CAPZB \| DISEASES 590 \| BCHE \| DISEASES 7840 \| ALMS1 \| DISEASES 2247 \| FGF2 \| DISEASES 7067 \| THRA \| DISEASES 23530 \| NNT \| DISEASES 5443 \| POMC \| DISEASES 10891 \| PPARGC1A \| DISEASES 8622 \| PDE8B \| DISEASES 5307 \| PITX1 \| DISEASES 793 \| CALB1 \| DISEASES 25824 \| PRDX5 \| DISEASES 5172 \| SLC26A4 \| DISEASES 5286 \| PIK3C2A \| DISEASES 6252 \| RTN1 \| DISEASES 90527 \| DUOXA1 \| DISEASES 9611 \| NCOR1 \| DISEASES 5409 \| PNMT \| DISEASES 3487 \| IGFBP4 \| DISEASES 5211 \| PFKL \| DISEASES 54858 \| PGPEP1 \| DISEASES 5972 \| REN \| DISEASES 805 \| CALM2 \| DISEASES 9381 \| OTOF \| DISEASES 23549 \| DNPEP \| DISEASES 523 \| ATP6V1A \| DISEASES 2044 \| EPHA5 \| DISEASES 3484 \| IGFBP1 \| DISEASES 6567 \| SLC16A2 \| DISEASES 2796 \| GNRH1 \| DISEASES 8795 \| TNFRSF10B \| DISEASES 6770 \| STAR \| DISEASES 1392 \| CRH \| DISEASES 3439 \| IFNA1 \| DISEASES 170589 \| GPHA2 \| DISEASES 3948 \| LDHC \| DISEASES 7069 \| THRSP \| DISEASES 5741 \| PTH \| DISEASES 814 \| CAMK4 \| DISEASES 2321 \| FLT1 \| DISEASES 2697 \| GJA1 \| DISEASES 3087 \| HHEX \| DISEASES 23250 \| ATP11A \| DISEASES 4900 \| NRGN \| DISEASES 9601 \| PDIA4 \| DISEASES 1836 \| SLC26A2 \| DISEASES 23522 \| KAT6B \| DISEASES 7547 \| ZIC3 \| DISEASES 6750 \| SST \| DISEASES 5468 \| PPARG \| DISEASES 3156 \| HMGCR \| DISEASES 26060 \| APPL1 \| DISEASES 539 \| ATP5O \| DISEASES 9992 \| KCNE2 \| DISEASES 197131 \| UBR1 \| DISEASES 1636 \| ACE \| DISEASES 808 \| CALM3 \| DISEASES 326 \| AIRE \| DISEASES 221914 \| GPC2 \| DISEASES 85451 \| UNK \| DISEASES 114984 \| FLYWCH2 \| DISEASES 23358 \| USP24 \| DISEASES 3973 \| LHCGR \| DISEASES 4760 \| NEUROD1 \| DISEASES 5798 \| PTPRN \| DISEASES 213 \| ALB \| DISEASES 8820 \| HESX1 \| DISEASES 200879 \| LIPH \| DISEASES 27242 \| TNFRSF21 \| DISEASES 6469 \| SHH \| DISEASES 4982 \| TNFRSF11B \| DISEASES 360 \| AQP3 \| DISEASES 7253 \| TSHR \| DISEASES 11067 \| C10orf10 \| DISEASES 9317 \| PTER \| DISEASES 3990 \| LIPC \| DISEASES 60686 \| C14orf93 \| DISEASES 1152 \| CKB \| DISEASES 4160 \| MC4R \| DISEASES 6447 \| SCG5 \| DISEASES 1159 \| CKMT1B \| DISEASES 762 \| CA4 \| DISEASES 1581 \| CYP7A1 \| DISEASES 27166 \| PRELID1 \| DISEASES 5617 \| PRL \| DISEASES 8460 \| TPST1 \| DISEASES 27254 \| CSDC2 \| DISEASES 3479 \| IGF1 \| DISEASES 43 \| ACHE \| DISEASES 7200 \| TRH \| DISEASES 1493 \| CTLA4 \| DISEASES 8941 \| CDK5R2 \| DISEASES 3627 \| CXCL10 \| DISEASES 2353 \| FOS \| DISEASES 686 \| BTD \| DISEASES 6373 \| CXCL11 \| DISEASES 9451 \| EIF2AK3 \| DISEASES 4176 \| MCM7 \| DISEASES 794 \| CALB2 \| DISEASES 5122 \| PCSK1 \| DISEASES 84153 \| RNASEH2C \| DISEASES 2147 \| F2 \| DISEASES 2820 \| GPD2 \| DISEASES 5340 \| PLG \| DISEASES 1808 \| DPYSL2 \| DISEASES 148979 \| GLIS1 \| DISEASES 4023 \| LPL \| DISEASES 7201 \| TRHR \| DISEASES 27165 \| GLS2 \| DISEASES 253558 \| LCLAT1 \| DISEASES 126006 \| PCP2 \| DISEASES 147323 \| STARD6 \| DISEASES 5626 \| PROP1 \| DISEASES 4744 \| NEFH \| DISEASES 3952 \| LEP \| DISEASES 2688 \| GH1 \| DISEASES 5198 \| PFAS \| DISEASES 10868 \| USP20 \| DISEASES 51228 \| GLTP \| DISEASES 3291 \| HSD11B2 \| DISEASES 201164 \| PLD6 \| DISEASES 120103 \| SLC36A4 \| DISEASES 53905 \| DUOX1 \| DISEASES 7173 \| TPO \| DISEASES 3752 \| KCND3 \| DISEASES 405753 \| DUOXA2 \| DISEASES 2692 \| GHRHR \| DISEASES 9370 \| ADIPOQ \| DISEASES 64787 \| EPS8L2 \| DISEASES 6517 \| SLC2A4 \| DISEASES 8648 \| NCOA1 \| DISEASES 6863 \| TAC1 \| DISEASES 4018 \| LPA \| DISEASES 643834 \| PGA3 \| DISEASES 2274 \| FHL2 \| DISEASES 51010 \| EXOSC3 \| DISEASES 7352 \| UCP3 \| DISEASES 2027 \| ENO3 \| DISEASES 91012 \| CERS5 \| DISEASES 1482 \| NKX2-5 \| DISEASES 114786 \| XKR4 \| DISEASES 6906 \| SERPINA7 \| DISEASES 10231 \| RCAN2 \| DISEASES 2831 \| NPBWR1 \| DISEASES 9021 \| SOCS3 \| DISEASES 3953 \| LEPR \| DISEASES 146852 \| ODF4 \| DISEASES 2520 \| GAST \| DISEASES 796 \| CALCA \| DISEASES 3751 \| KCND2 \| DISEASES 3043 \| HBB \| DISEASES 27152 \| INTU \| DISEASES 2152 \| F3 \| DISEASES 23760 \| PITPNB \| DISEASES 5133 \| PDCD1 \| DISEASES 51738 \| GHRL \| DISEASES 1103 \| CHAT \| DISEASES 1641 \| DCX \| DISEASES 554 \| AVPR2 \| DISEASES 23583 \| SMUG1 \| DISEASES 8459 \| TPST2 \| DISEASES 8805 \| TRIM24 \| DISEASES 84144 \| SYDE2 \| DISEASES 866 \| SERPINA6 \| DISEASES 5449 \| POU1F1 \| DISEASES 155 \| ADRB3 \| DISEASES 10617 \| STAMBP \| DISEASES 10019 \| SH2B3 \| DISEASES 2624 \| GATA2 \| DISEASES 100132406 \| NBPF10 \| DISEASES 3767 \| KCNJ11 \| DISEASES 7080 \| NKX2-1 \| DISEASES 116369 \| SLC26A8 \| DISEASES 5979 \| RET \| DISEASES 146059 \| CDAN1 \| DISEASES 4624 \| MYH6 \| DISEASES 7068 \| THRB \| DISEASES 170685 \| NUDT10 \| DISEASES 23237 \| ARC \| DISEASES 801 \| CALM1 \| DISEASES 487 \| ATP2A1 \| DISEASES 10390 \| CEPT1 \| DISEASES 60 \| ACTB \| DISEASES 23032 \| USP33 \| DISEASES 26136 \| TES \| DISEASES 54413 \| NLGN3 \| DISEASES 1735 \| DIO3 \| DISEASES 10873 \| ME3 \| DISEASES 26191 \| PTPN22 \| DISEASES 4151 \| MB \| DISEASES 10092 \| ARPC5 \| DISEASES 2157 \| F8 \| DISEASES 4133 \| MAP2 \| DISEASES 6721 \| SREBF2 \| DISEASES 1733 \| DIO1 \| DISEASES 54617 \| INO80 \| DISEASES 5083 \| PAX9 \| DISEASES 23038 \| WDTC1 \| DISEASES 7052 \| TGM2 \| DISEASES 22796 \| COG2 \| DISEASES 58 \| ACTA1 \| DISEASES 28514 \| DLL1 \| DISEASES 4139 \| MARK1 \| DISEASES 3664 \| IRF6 \| DISEASES 7432 \| VIP \| DISEASES 462 \| SERPINC1 \| DISEASES 356 \| FASLG \| DISEASES 336 \| APOA2 \| DISEASES 632 \| BGLAP \| DISEASES 117247 \| SLC16A10 \| DISEASES 9557 \| CHD1L \| DISEASES 3283 \| HSD3B1 \| DISEASES 6975 \| TECTB \| DISEASES 4803 \| NGF \| DISEASES 2832 \| NPBWR2 \| DISEASES 9118 \| INA \| DISEASES 2316 \| FLNA \| DISEASES 2652 \| OPN1MW \| DISEASES 2332 \| FMR1 \| DISEASES 6658 \| SOX3 \| DISEASES 959 \| CD40LG \| DISEASES 3547 \| IGSF1 \| DISEASES 2778 \| GNAS \| DISEASES 8675 \| STX16 \| DISEASES 115209 \| OMA1 \| DISEASES 5950 \| RBP4 \| DISEASES 4998 \| ORC1 \| DISEASES 112970 \| KTI12 \| DISEASES 3745 \| KCNB1 \| DISEASES 8022 \| LHX3 \| DISEASES 7422 \| VEGFA \| DISEASES 23404 \| EXOSC2 \| DISEASES 80712 \| ESX1 \| DISEASES 340543 \| TCEAL5 \| DISEASES 100 \| ADA \| DISEASES 90550 \| MCU \| DISEASES 252995 \| FNDC5 \| DISEASES 9968 \| MED12 \| DISEASES 8518 \| IKBKAP \| DISEASES 2304 \| FOXE1 \| DISEASES 8858 \| PROZ \| DISEASES 2155 \| F7 \| DISEASES 3055 \| HCK \| DISEASES 23287 \| AGTPBP1 \| DISEASES 50943 \| FOXP3 \| DISEASES 1041 \| CDSN \| DISEASES 4879 \| NPPB \| DISEASES 4878 \| NPPA \| DISEASES 3105 \| HLA-A \| DISEASES 1471 \| CST3 \| DISEASES 687 \| KLF9 \| DISEASES 8718 \| TNFRSF25 \| DISEASES 26586 \| CKAP2 \| DISEASES 643847 \| PGA4 \| DISEASES 51335 \| NGRN \| DISEASES 3440 \| IFNA2 \| DISEASES 3456 \| IFNB1 \| DISEASES 551 \| AVP \| DISEASES 6462 \| SHBG \| DISEASES 3486 \| IGFBP3 \| DISEASES 5214 \| PFKP \| DISEASES 7054 \| TH \| DISEASES 53919 \| SLCO1C1 \| DISEASES 29126 \| CD274 \| DISEASES 1497 \| CTNS \| DISEASES 169792 \| GLIS3 \| DISEASES 5618 \| PRLR \| DISEASES 51199 \| NIN \| DISEASES 83650 \| SLC35G5 \| DISEASES 4155 \| MBP \| DISEASES 7932 \| OR2H2 \| DISEASES 79400 \| NOX5 \| DISEASES 50506 \| DUOX2 \| DISEASES 11340 \| EXOSC8 \| DISEASES 3898 \| LAD1 \| DISEASES 1621 \| DBH \| DISEASES 2596 \| GAP43 \| DISEASES 6439 \| SFTPB \| DISEASES 1267 \| CNP \| DISEASES 91683 \| SYT12 \| DISEASES 6152 \| RPL24 \| DISEASES 4828 \| NMB \| DISEASES 64400 \| AKTIP \| DISEASES 174 \| AFP \| DISEASES 7920 \| ABHD16A \| DISEASES 144195 \| SLC2A14 \| DISEASES 594857 \| NPS \| DISEASES 10587 \| TXNRD2 \| DISEASES 9612 \| NCOR2 \| DISEASES 80014 \| WWC2 \| DISEASES 2492 \| FSHR \| DISEASES 3033 \| HADH \| DISEASES 728441 \| GGT2 \| DISEASES 7018 \| TF \| DISEASES 2641 \| GCG \| DISEASES 1385 \| CREB1 \| DISEASES 3481 \| IGF2 \| DISEASES 5649 \| RELN \| DISEASES 146713 \| RBFOX3 \| DISEASES 7849 \| PAX8 \| DISEASES 4908 \| NTF3 \| DISEASES 7124 \| TNF \| DISEASES 51562 \| MBIP \| DISEASES 548596 \| CKMT1A \| DISEASES 3612 \| IMPA1 \| DISEASES 3925 \| STMN1 \| DISEASES 3451 \| IFNA17 \| DISEASES 627 \| BDNF \| DISEASES 10665 \| C6orf10 \| DISEASES 85365 \| ALG2 \| DISEASES 8801 \| SUCLG2 \| DISEASES 2317 \| FLNB \| DISEASES 80012 \| PHC3 \| DISEASES 256987 \| SERINC5 \| DISEASES 51428 \| DDX41 \| DISEASES 8992 \| ATP6V0E1 \| DISEASES 90161 \| HS6ST2 \| DISEASES 503542 \| SPRN \| DISEASES 9774 \| BCLAF1 \| DISEASES 4975 \| OMP \| DISEASES 488 \| ATP2A2 \| DISEASES 3250 \| HPR \| DISEASES 23312 \| DMXL2 \| DISEASES 246744 \| STH \| DISEASES 3939 \| LDHA \| DISEASES 160728 \| SLC5A8 \| DISEASES 8972 \| MGAM \| DISEASES 1734 \| DIO2 \| DISEASES 567 \| B2M \| DISEASES 5297 \| PI4KA \| DISEASES 102723508 \| KANTR \| DISEASES 348120 \| LINC01193 \| DISEASES 26812 \| SNORD37 \| DISEASES 26807 \| SNORD43 \| DISEASES 692076 \| SNORD7 \| DISEASES
Locus	(Waiting for update.)

Disease ID	155
Disease	hypothyroidism
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:240) HP:0100646 \| Thyroiditis \| 38 HP:0000853 \| Goitre \| 20 HP:0003201 \| Rhabdomyolysis \| 16 HP:0000872 \| Hashimoto's thyroiditis \| 16 HP:0000822 \| Hypertension \| 14 HP:0000836 \| Overactive thyroid \| 13 HP:0100543 \| Cognitive deficits \| 13 HP:0000855 \| Insulin resistance \| 13 HP:0001513 \| Obesity \| 11 HP:0001903 \| Anemia \| 11 HP:0001698 \| Pericardial effusions \| 9 HP:0001635 \| Congestive heart failure \| 9 HP:0003124 \| Elevated serum cholesterol \| 9 HP:0002902 \| Hyponatremia \| 8 HP:0000716 \| Depression \| 8 HP:0002925 \| Increased serum thyroid-stimulating hormone \| 8 HP:0005990 \| Thyroid hypoplasia \| 8 HP:0000870 \| Hyperprolactinemia \| 7 HP:0030731 \| Carcinoma \| 7 HP:0001510 \| Growth deficiency \| 7 HP:0002621 \| Atherosclerosis \| 7 HP:0001249 \| Mental retardation \| 6 HP:0100602 \| Pre-eclampsia \| 6 HP:0000138 \| Ovarian cyst \| 6 HP:0000820 \| Thyroid abnormality \| 5 HP:0002901 \| Hypocalcemia \| 5 HP:0000709 \| Psychosis \| 5 HP:0040075 \| Hypopituitarism \| 5 HP:0000083 \| Renal insufficiency \| 5 HP:0001271 \| Polyneuropathy \| 5 HP:0000821 \| Underactive thyroid \| 5 HP:0002890 \| Thyroid carcinoma \| 5 HP:0003077 \| Hyperlipidemia \| 4 HP:0012622 \| Chronic kidney disease \| 4 HP:0000846 \| Hypoadrenalism \| 4 HP:0005110 \| Atrial fibrillation \| 4 HP:0001658 \| Myocardial infarction \| 4 HP:0012378 \| Fatigue \| 4 HP:0000726 \| Dementia \| 4 HP:0001297 \| Cerebral vascular events \| 4 HP:0005584 \| Renal cell carcinoma \| 4 HP:0001369 \| Arthritis \| 4 HP:0001662 \| Bradycardia \| 4 HP:0001561 \| Hydramnios \| 4 HP:0100754 \| Mania \| 4 HP:0003198 \| Myopathic changes \| 4 HP:0000826 \| Precocious puberty \| 4 HP:0002960 \| Autoimmune condition \| 3 HP:0000147 \| Sclerocystic ovaries \| 3 HP:0000958 \| Xerosis \| 3 HP:0001824 \| Weight loss \| 3 HP:0001919 \| Acute renal failure \| 3 HP:0005994 \| Nodular goiter \| 3 HP:0001028 \| Strawberry mark \| 3 HP:0002608 \| Celiac disease \| 3 HP:0000365 \| Hearing impairment \| 3 HP:0000135 \| Hypogonadism \| 3 HP:0000833 \| Glucose intolerance \| 3 HP:0002725 \| Systemic lupus erythematosus \| 3 HP:0000998 \| Hypertrichosis \| 3 HP:0008188 \| Thyroid dysplasia \| 3 HP:0001370 \| Rheumatoid arthritis \| 3 HP:0012594 \| High urine albumin levels \| 3 HP:0002019 \| Dyschezia \| 3 HP:0000100 \| Nephrosis \| 3 HP:0005987 \| Multinodular goiter \| 3 HP:0000789 \| Infertility \| 3 HP:0001397 \| Hepatic steatosis \| 3 HP:0002315 \| Headaches \| 3 HP:0012115 \| Liver inflammation \| 2 HP:0003002 \| Breast carcinoma \| 2 HP:0001943 \| Hypoglycemia \| 2 HP:0011675 \| Arrhythmias \| 2 HP:0001298 \| Encephalopathy \| 2 HP:0001541 \| Ascites \| 2 HP:0002024 \| Intestinal malabsorption \| 2 HP:0004324 \| Increased body weight \| 2 HP:0008220 \| Glucocorticoid insufficiency \| 2 HP:0000708 \| Behavioral problems \| 2 HP:0004943 \| Accelerated atherosclerosis \| 2 HP:0000501 \| Glaucoma \| 2 HP:0007479 \| Nonbullous congenital ichthyosis \| 2 HP:0002861 \| Melanoma \| 2 HP:0000738 \| Sensory hallucination \| 2 HP:0000078 \| Genital abnormalities \| 2 HP:0001263 \| Developmental retardation \| 2 HP:0000969 \| Dropsy \| 2 HP:0003251 \| Male infertility \| 2 HP:0000871 \| Panhypopituitarism \| 2 HP:0002076 \| Migraine headaches \| 2 HP:0100029 \| Lingual thyroid \| 2 HP:0002910 \| Elevated transaminases \| 2 HP:0002664 \| Neoplasia \| 2 HP:0003712 \| Hypertrophic muscles \| 2 HP:0002155 \| Increased triglycerides \| 2 HP:0002104 \| Absence of spontaneous respiration \| 2 HP:0001596 \| Hair loss \| 2 HP:0001622 \| Premature delivery \| 2 HP:0002878 \| Respiratory failure \| 2 HP:0001997 \| Gout \| 2 HP:0003470 \| Inability to move \| 2 HP:0001394 \| Hepatic cirrhosis \| 2 HP:0002354 \| Memory loss \| 2 HP:0002098 \| Respiratory distress \| 2 HP:0008245 \| Thyroid stimulating hormone deficiency \| 2 HP:0000819 \| Diabetes mellitus \| 2 HP:0200123 \| Chronic liver inflammation \| 2 HP:0002926 \| Abnormality of thyroid physiology \| 2 HP:0010535 \| Sleep apnea \| 2 HP:0000158 \| Abnormally large tongue \| 1 HP:0000966 \| Decreased sweating \| 1 HP:0001664 \| Torsade de pointes \| 1 HP:0001276 \| Hypertonia \| 1 HP:0000175 \| Palatoschisis \| 1 HP:0001250 \| Seizures \| 1 HP:0001578 \| Hypercortisolism \| 1 HP:0030149 \| Cardiovascular shock \| 1 HP:0006775 \| Multiple myeloma \| 1 HP:0001259 \| Coma \| 1 HP:0002625 \| Blood clot in a deep vein \| 1 HP:0002870 \| Obstructive sleep apnea \| 1 HP:0000093 \| Proteinuria \| 1 HP:0008222 \| Female infertility \| 1 HP:0009734 \| Optic glioma \| 1 HP:0004936 \| Blood clot in vein \| 1 HP:0002032 \| Esophageal atresia \| 1 HP:0002590 \| Paralytic ileus \| 1 HP:0008213 \| Pituitary gonadotropin deficiency \| 1 HP:0008236 \| Isosexual precocious puberty \| 1 HP:0006934 \| Congenital nystagmus \| 1 HP:0000159 \| Lip abnormality \| 1 HP:0000952 \| Yellow skin \| 1 HP:0012056 \| Cutaneous melanoma \| 1 HP:0000618 \| Blindness \| 1 HP:0100028 \| Abnormal thryoid location \| 1 HP:0001988 \| hypoglycemia, recurrent \| 1 HP:0011069 \| Extra teeth \| 1 HP:0001645 \| Sudden cardiac death \| 1 HP:0001701 \| Pericarditis \| 1 HP:0011450 \| CNS infection \| 1 HP:0008200 \| Primary hyperparathyroidism \| 1 HP:0000982 \| Palmoplantar keratoderma \| 1 HP:0000951 \| dermatopathy \| 1 HP:0100615 \| Neoplasm of the ovary \| 1 HP:0000112 \| Nephropathy \| 1 HP:0002595 \| Gastrointestinal atony \| 1 HP:0100843 \| Glioblastoma \| 1 HP:0004322 \| Stature below 3rd percentile \| 1 HP:0002202 \| Pleural effusion \| 1 HP:0002829 \| Arthralgias \| 1 HP:0002140 \| Ischemic stroke \| 1 HP:0003768 \| Periodic paralysis \| 1 HP:0005268 \| Spontaneous abortion \| 1 HP:0012324 \| Myeloid leukemia \| 1 HP:0000508 \| Drooping upper eyelid \| 1 HP:0011787 \| Central hypothyroidism \| 1 HP:0003281 \| Increased ferritin \| 1 HP:0012050 \| Anasarca \| 1 HP:0001289 \| Confusion \| 1 HP:0001518 \| Small for gestational age \| 1 HP:0011748 \| Adrenocorticotropic hormone deficiency \| 1 HP:0009800 \| gestational diabetes \| 1 HP:0030880 \| Raynaud phenomenon \| 1 HP:0100806 \| Sepsis \| 1 HP:0012505 \| Enlarged pituitary gland \| 1 HP:0003552 \| Muscle stiffness \| 1 HP:0003388 \| Easy fatigability \| 1 HP:0012588 \| Steroid-resistant nephrotic syndrome \| 1 HP:0000793 \| Membranoproliferative glomerulonephritis \| 1 HP:0000746 \| Delusions \| 1 HP:0001268 \| Mental deterioration \| 1 HP:0100502 \| Vitamin B12 deficiency \| 1 HP:0000099 \| Glomerular nephritis \| 1 HP:0007302 \| Bipolar disorder \| 1 HP:0000989 \| pruritis \| 1 HP:0000851 \| Congenital hypothyroidism \| 1 HP:0000832 \| Primary hypothyroidism \| 1 HP:0000845 \| Acromegalic growth \| 1 HP:0001045 \| Blotchy loss of skin color \| 1 HP:0000609 \| Optic nerve hypoplasia \| 1 HP:0000739 \| Anxiety \| 1 HP:0005145 \| Narrowing of coronary artery \| 1 HP:0002015 \| Swallowing difficulty \| 1 HP:0004416 \| Precocious atherosclerosis \| 1 HP:0001507 \| Abnormal growth \| 1 HP:0002067 \| Bradykinesia \| 1 HP:0010628 \| Facial palsy, unilateral or bilateral \| 1 HP:0000823 \| Pubertal delay \| 1 HP:0000858 \| Menstrual irregularity \| 1 HP:0012876 \| Premature ejaculation \| 1 HP:0001410 \| Decreased liver function \| 1 HP:0010310 \| Chylothorax \| 1 HP:0002157 \| Azotaemia \| 1 HP:0003510 \| Proportionate dwarfism \| 1 HP:0002758 \| Osteoarthritis \| 1 HP:0100033 \| Tic disorder \| 1 HP:0000924 \| Abnormality of the skeletal system \| 1 HP:0003326 \| Muscle pain \| 1 HP:0001279 \| Syncope \| 1 HP:0001025 \| Hives \| 1 HP:0000119 \| Genitourinary abnormality \| 1 HP:0008207 \| Addison's disease \| 1 HP:0004789 \| Lactose intolerance \| 1 HP:0000939 \| Osteoporosis \| 1 HP:0012448 \| Delayed myelination \| 1 HP:0001677 \| Coronary artery disease \| 1 HP:0003259 \| Increased serum creatinine \| 1 HP:0001317 \| Abnormality of the cerebellum \| 1 HP:0010864 \| Early and severe mental retardation \| 1 HP:0001324 \| Muscular weakness \| 1 HP:0002045 \| Abnormally low body temperature \| 1 HP:0011782 \| Thyroid crisis \| 1 HP:0003236 \| Elevated creatine kinase \| 1 HP:0005214 \| Bowel obstruction \| 1 HP:0001402 \| Hepatocellular carcinoma \| 1 HP:0010465 \| Precocious puberty in females \| 1 HP:0000670 \| Dental caries \| 1 HP:0100598 \| Pulmonary oedema \| 1 HP:0004421 \| Elevated systolic blood pressure \| 1 HP:0000776 \| Diaphragmatic hernia \| 1 HP:0011780 \| Thyroid hemiagenesis \| 1 HP:0100512 \| Vitamin D deficiency \| 1 HP:0007868 \| ARMD \| 1 HP:0000123 \| Nephritis \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0000639 \| Nystagmus \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0009733 \| Glioma \| 1 HP:0002637 \| Brain ischemia \| 1 HP:0012592 \| Albuminuria \| 1 HP:0002895 \| Papillary thyroid carcinoma \| 1 HP:0003072 \| Hypercalcemia \| 1 HP:0000338 \| Hypomimic face \| 1 HP:0001909 \| Leukemia \| 1 HP:0005506 \| Chronic myeloid leukemia \| 1 HP:0000831 \| Insulin-resistant diabetes mellitus \| 1 HP:0000020 \| Bladder incontinence \| 1 HP:0008247 \| Asymptomatic hyperthyroxinemia \| 1 HP:0004791 \| Esophagus ulcer \| 1 HP:0001339 \| Lissencephaly \| 1

Disease ID	155
Disease	hypothyroidism
Manually Symptom	UMLS \| Name(Total Manually Symptoms:218) C2712323 \| hypoglycaemia C2712322 \| tachycardia C2607914 \| allergic rhinitis C2364118 \| weakness C2364072 \| depression C2114320 \| premature contractions C2107732 \| heat intolerance C2096315 \| headache C2073625 \| pleural effusion C2029884 \| hearing loss C1963220 \| pulmonary hypertension C1963211 \| pericarditis C1963185 \| obesity C1963154 \| renal failure C1963138 \| hypertension C1963101 \| encephalopathy C1963091 \| diarrhea C1963087 \| constipation C1963064 \| anxiety C1962986 \| glaucoma C1956346 \| coronary artery disease C1839611 \| n syndrome C1691228 \| cystic kidney disease C1578691 \| congenital myxedema C1563743 \| adiposity C1555754 \| cardiovascular disease C1527356 \| venous stasis C1522133 \| hypercholesterolemia C1521999 \| acute myocardial infarction C1510429 \| entrapment neuropathy C1510429 \| entrapment neuropathies C1510420 \| cavities C1456784 \| paranoid psychosis C1393529 \| vascular complications C1337013 \| differentiated thyroid carcinoma C1281300 \| vascular degeneration C1269841 \| keratosis lichenoides chronica C1253937 \| pericardial effusion C1145670 \| respiratory failure C1000483 \| anemia C0878544 \| myocardiopathy C0878544 \| cardiomyopathy C0877018 \| pituitary enlargement C0856169 \| endothelial dysfunction C0796232 \| c-like syndrome C0796095 \| c syndrome C0752303 \| urological manifestations C0752303 \| urological manifestation C0752252 \| neuromuscular manifestations C0751837 \| gait ataxia C0740852 \| upper airway obstruction C0740394 \| hyperuricemia C0700323 \| muscle relaxation C0679479 \| organic psychosyndrome C0599750 \| hormone deficiency C0598608 \| hyperhomocysteinemia C0595921 \| intraocular pressure C0581883 \| deafness C0554400 \| galactorrhea C0553730 \| chondrocalcinosis C0549311 \| myositis-like syndrome C0543559 \| generalized myxedema C0520680 \| central sleep apnea C0520679 \| obstructive sleep apnea C0497327 \| dementia C0442874 \| neuropathy C0427008 \| stiffness C0426941 \| muscle pseudohypertrophy C0422833 \| ent symptoms C0405580 \| hypoadrenocorticism C0376323 \| infiltrative ophthalmopathy C0376175 \| bell's palsy C0342195 \| iodotyrosine dehalogenase deficiency C0341697 \| renal impairment C0340425 \| hypertrophic cardiomyopathy C0340291 \| silent myocardial ischemia C0339143 \| dysthyroid ophthalmopathy C0333243 \| pitting oedema C0314719 \| dry eye C0302332 \| toxicosis C0302164 \| xanthoma tuberosum C0272362 \| acquired von willebrand's disease C0272362 \| acquired von willebrand disease C0270810 \| peroneal nerve palsy C0269995 \| galactorrhoea C0267063 \| cricopharyngeal achalasia C0263992 \| exertional rhabdomyolysis C0263485 \| trichorrhexis nodosa C0260662 \| hearing disorders C0259817 \| xerosis C0238246 \| hepatic hemangioma C0235946 \| brain atrophy C0235222 \| diastolic hypertension C0234428 \| impaired consciousness C0234131 \| motor dysfunction C0233401 \| psychiatric symptoms C0231796 \| respiratory abnormalities C0231528 \| myalgia C0221207 \| cold-induced urticaria C0205700 \| asymmetric septal hypertrophy C0162538 \| iga deficiency C0162359 \| hypohidrotic ectodermal dysplasia C0156259 \| renal hypertrophy C0154271 \| carotenemia C0154162 \| riedel's thyroiditis C0152115 \| orofacial dyskinesia C0152025 \| polyneuropathy C0151744 \| myocardial ischemia C0151721 \| male hypogonadism C0149931 \| migraine C0149887 \| slipped capital femoral epiphysis C0149745 \| oral ulceration C0086132 \| depressive symptoms C0085697 \| chronic pyelonephritis C0085661 \| onycholysis C0085577 \| normocytic anaemia C0085083 \| ovarian hyperstimulation syndrome C0042900 \| vitiligo C0042870 \| vitamin d deficiency C0042847 \| deficiency of vitamin b12 C0042165 \| anterior uveitis C0040188 \| tic disorders C0039319 \| tarsal tunnel syndrome C0038454 \| stroke C0037384 \| snoring C0037315 \| sleep apnoea C0037315 \| sleep apnea C0037090 \| respiratory symptoms C0035078 \| kidney failure C0034735 \| raynaud's phenomenon C0034155 \| thrombotic thrombocytopenic purpura C0034013 \| precocious puberty C0033975 \| psychosis C0033377 \| ptosis C0033103 \| pretibial myxedema C0031117 \| peripheral neuropathy C0029896 \| ent diseases C0029896 \| ent disease C0029182 \| orbital diseases C0029166 \| oral manifestations C0028866 \| third cranial nerve paralysis C0027868 \| neuromyopathy C0027868 \| neuromuscular disorders C0027765 \| neurological disorders C0027765 \| nervous system diseases C0027726 \| nephrotic syndrome C0027145 \| myxoedema C0027145 \| myxedema C0027051 \| myocardial infarction C0027051 \| myocardial infarct C0026946 \| fungal infections C0026848 \| myopathy C0026848 \| myopathies C0026848 \| muscular disorders C0026650 \| movement disorder C0025362 \| mental retardation C0024205 \| lymphadenitis C0022972 \| lambert-eaton myasthenic syndrome C0022660 \| acute renal failure C0022596 \| palmoplantar keratoderma C0021847 \| intestinal pseudoobstruction C0021847 \| intestinal pseudo-obstruction C0021843 \| intestinal occlusion C0021359 \| infertility C0020649 \| hypotension C0020625 \| hyponatremia C0020555 \| hypertrichosis C0020550 \| hyperthyroidism C0020514 \| hyperprolactinemia C0020514 \| hyperprolactinaemia C0020502 \| hyperparathyroidism C0020476 \| hyperlipoproteinemia C0020473 \| hyperlipidemia C0020443 \| hypercholesterolaemia C0020437 \| hypercalcemia C0019087 \| hemorrhagic diathesis C0018801 \| heart failure C0018799 \| cardiac disease C0018784 \| sensorineural hearing loss C0018784 \| sensori-neural deafness C0018784 \| perceptive deafness C0018099 \| gout C0018051 \| gonadal dysgenesis C0018021 \| goitre C0018021 \| goiters C0018021 \| goiter C0016436 \| folliculitis C0016412 \| folic acid deficiency C0016412 \| folate deficiency C0014571 \| slipped epiphysis C0013338 \| pituitary dwarfism C0013336 \| dwarfism C0011860 \| diabetes C0011849 \| diabetes mellitus C0011633 \| dermatomyositis C0010308 \| cretinism C0010073 \| coronary artery spasm C0010068 \| coronary disease C0010054 \| coronary sclerosis C0010054 \| arteriosclerotic coronary artery disease C0009241 \| cognitive disorders C0008732 \| chylous ascites C0007760 \| cerebellar dysfunction C0007758 \| cerebellar ataxia C0007286 \| carpal tunnel syndrome C0007222 \| cardiovascular diseases C0007193 \| congestive cardiomyopathy C0007177 \| cardiac tamponade C0006845 \| chronic mucocutaneous candidosis C0004153 \| atherosclerosis C0003868 \| gouty arthritis C0002892 \| pernicious anaemia C0002886 \| macrocytic anaemia C0002871 \| anaemia C0002170 \| alopecia C0001726 \| affective symptoms C0000744 \| familial hypobetalipoproteinemia C0000737 \| abdominal pain
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:85) C0018021 \| goiter \| 17 C0020538 \| hypertension \| 14 C0011847 \| diabetes \| 13 C0796095 \| c syndrome \| 12 C1839611 \| n syndrome \| 12 C0020550 \| hyperthyroidism \| 12 C0028754 \| obesity \| 10 C0031039 \| pericardial effusion \| 9 C0020443 \| hypercholesterolemia \| 9 C0018801 \| heart failure \| 9 C0011570 \| depression \| 8 C0020625 \| hyponatremia \| 8 C0007177 \| cardiac tamponade \| 7 C0004153 \| atherosclerosis \| 7 C0020514 \| hyperprolactinemia \| 6 C0002871 \| anemia \| 6 C0152025 \| polyneuropathy \| 5 C0033975 \| psychosis \| 5 C0856169 \| endothelial dysfunction \| 5 C0025362 \| mental retardation \| 5 C0020473 \| hyperlipidemia \| 4 C0497327 \| dementia \| 4 C0235222 \| diastolic hypertension \| 4 C0034013 \| precocious puberty \| 4 C0086132 \| depressive symptoms \| 4 C0026848 \| myopathy \| 4 C0599750 \| hormone deficiency \| 3 C0021359 \| infertility \| 3 C0027051 \| myocardial infarct \| 3 C0004093 \| weakness \| 3 C0020555 \| hypertrichosis \| 3 C0007222 \| cardiovascular disease \| 3 C0002871 \| anaemia \| 3 C0009806 \| constipation \| 3 C0018021 \| goitre \| 3 C0027726 \| nephrotic syndrome \| 3 C0085584 \| encephalopathy \| 2 C0017601 \| glaucoma \| 2 C0037315 \| sleep apnea \| 2 C0038454 \| stroke \| 2 C0027145 \| myxedema \| 2 C0155626 \| acute myocardial infarction \| 2 C0341697 \| renal impairment \| 2 C0877018 \| pituitary enlargement \| 2 C1145670 \| respiratory failure \| 2 C0154162 \| riedel's thyroiditis \| 2 C0238246 \| hepatic hemangioma \| 2 C0376323 \| infiltrative ophthalmopathy \| 2 C0018681 \| headache \| 2 C0011849 \| diabetes mellitus \| 2 C0149931 \| migraine \| 2 C0027051 \| myocardial infarction \| 1 C0027868 \| neuromuscular disorders \| 1 C1393529 \| vascular complications \| 1 C0520679 \| obstructive sleep apnea \| 1 C0031046 \| pericarditis \| 1 C0005745 \| ptosis \| 1 C0022596 \| palmoplantar keratoderma \| 1 C0018799 \| cardiac disease \| 1 C0034735 \| raynaud's phenomenon \| 1 C0007286 \| carpal tunnel syndrome \| 1 C0026848 \| myopathies \| 1 C0032460 \| polycystic ovaries \| 1 C0040188 \| tic disorders \| 1 C0032227 \| pleural effusion \| 1 C0233401 \| psychiatric symptoms \| 1 C0022660 \| acute renal failure \| 1 C0003467 \| anxiety \| 1 C0549311 \| myositis-like syndrome \| 1 C0007222 \| cardiovascular diseases \| 1 C0020676 \| hypothyroidism \| 1 C0232197 \| fibrillation \| 1 C0026848 \| muscular disorders \| 1 C0231528 \| myalgia \| 1 C0427008 \| stiffness \| 1 C0010308 \| cretinism \| 1 C0010068 \| coronary artery disease \| 1 C0035078 \| renal failure \| 1 C0042870 \| vitamin d deficiency \| 1 C0020598 \| hypoglycaemia \| 1 C0018099 \| gout \| 1 C0020672 \| hypothermia \| 1 C0042900 \| vitiligo \| 1 C0013336 \| dwarfism \| 1 C0085577 \| normocytic anaemia \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:26)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10162002	22493691	26278	SACS	umls:C0020676	GAD	[Novel associations for hypothyroidism include known autoimmune risk loci.]	0.002367032	2012	LINC00327	13	23468371	G	A
rs10248351	22493691	219578	ZNF804B	umls:C0020676	GAD	[Novel associations for hypothyroidism include known autoimmune risk loci.]	0.002367032	2012	ZNF804B	7	88852128	T	C
rs1051920	22493691	65986	ZBTB10	umls:C0020676	GAD	[Novel associations for hypothyroidism include known autoimmune risk loci.]	0.002367032	2012	ZBTB10	8	80526185	C	T
rs111033199	21551164	5172	SLC26A4	umls:C0020676	BeFree	We describe a 46-year-old female with sensorineural deafness and hypothyroidism, who presented with severe hypokalaemic metabolic alkalosis during inter-current illnesses on two occasions, and who was found to be homozygous for a loss-of-function mutation (V138F) in SLC26A4.	0.001357209	2011	SLC26A4	7	107672245	G	T
rs113488022	18426810	673	BRAF	umls:C0020676	BeFree	Screening for activating BRAF mutations in a series of 83 PTCs identified the most common V600E mutation in 39 cases (histologically, 38 classic PTCs and 1 sclerosing variant PTC) and a complex in-frame mutation involving amino acids V600-S605 in a stage III multicentric follicular variant PTC, occurring in a 50-year-old female patient, who was affected by hypothyroidism in autoimmune thyroiditis and had a family history of PTC and autoimmune thyroiditis.	0.000542884	2008	BRAF	7	140753336	A	T,G,C
rs113488022	21512141	673	BRAF	umls:C0020676	BeFree	One month following BRAF(V600E) expression, mice displayed increased thyroid size, widespread alterations in thyroid architecture, and dramatic hypothyroidism.	0.000542884	2011	BRAF	7	140753336	A	T,G,C
rs141185224	15472167	5979	RET	umls:C0020676	BeFree	We report a new RET point mutation [R694Q (CGG-->CAG)], serendipitously found in a 23-yr-old woman with hypothyroidism due to atrophic Hashimoto's thyroiditis and primary ovarian failure, without altered calcitonin secretion.	0.000271442	2004	RET	10	43114681	G	A
rs189261858	19506388	7253	TSHR	umls:C0020676	BeFree	Thyroid hormone replacement therapy should be considered based on biological data in patients with hyperthyrotropinemia who have a homozygous R450H mutation of the TSHR gene even if they do not exhibit obvious hypothyroidism in infancy.	0.016707301	2009	TSHR;LOC101928462	14	81143407	G	A
rs2076738	9790265	7038	TG	umls:C0020676	BeFree	Missense mutation (C1263R) in the thyroglobulin gene causes congenital goiter with mild hypothyroidism by impaired intracellular transport.	0.10031199	1998	TG	8	132906843	T	C
rs225014	22548953	1734	DIO2	umls:C0020676	BeFree	A polymorphism (Thr92Ala) in the gene encoding the deiodinase 2 (D2) enzyme that converts thyroxine to triiodothyronine in the brain was later identified in about 16% of hypothyroid persons.	0.003452799	2012	DIO2	14	80203237	T	C
rs229526	22493691	114904	C1QTNF6	umls:C0020676	GAD	[Novel associations for hypothyroidism include known autoimmune risk loci.]	0.002367032	2012	C1QTNF6	22	37185382	G	T,C
rs231779	22493691	1493	CTLA4	umls:C0020676	GAD	[We also show suggestive evidence of association for hypothyroidism with a SNP in the HLA class II region (independent of the other HLA association) as well as SNPs in CAPZB, PDE8B, and CTLA4.]	0.010725648	2012	CTLA4	2	203869764	C	T
rs2517532	22493691	394263	MUC21	umls:C0020676	GAD	[Novel associations for hypothyroidism include known autoimmune risk loci.]	0.002367032	2012	NA	6	31050630	A	G
rs3025039	22439647	7422	VEGFA	umls:C0020676	BeFree	The presence of C-allele in rs833061 and the T-allele in rs3025039 polymorphism of VEGFA were associated with significantly higher risk of hypothyroidism (OR: 10.0 p = 0.041 and OR: 10.5; p = 0.015, respectively).	0.000271442	2012	VEGFA	6	43784799	C	T
rs3129720	22493691	3119	HLA-DQB1	umls:C0020676	GAD	[Novel associations for hypothyroidism include known autoimmune risk loci.]	0.005091382	2012	NA	6	32695854	T	C
rs3184504	22493691	10019	SH2B3	umls:C0020676	GAD	[Novel associations for hypothyroidism include known autoimmune risk loci.]	0.122367032	2012	SH2B3	12	111446804	T	C
rs3184504	22493691	10019	SH2B3	umls:C0020676	GWASCAT	Novel associations for hypothyroidism include known autoimmune risk loci.	0.122367032	2012	SH2B3	12	111446804	T	C
rs3748682	22493691	4520	MTF1	umls:C0020676	GAD	[Novel associations for hypothyroidism include known autoimmune risk loci.]	0.002367032	2012	MTF1	1	37814315	T	C
rs4704397	22493691	8622	PDE8B	umls:C0020676	GAD	[We also show suggestive evidence of association for hypothyroidism with a SNP in the HLA class II region (independent of the other HLA association) as well as SNPs in CAPZB, PDE8B, and CTLA4.]	0.005005506	2012	PDE8B	5	77222617	G	A
rs4804416	22493691	3643	INSR	umls:C0020676	GAD	[Novel associations for hypothyroidism include known autoimmune risk loci.]	0.002367032	2012	INSR	19	7223837	T	G
rs4915077	22493691	10451	VAV3	umls:C0020676	GAD	[VAV3 is involved in immune function, and FOXE1 and PTPN22 have previously been associated with hypothyroidism.]	0.122638474	2012	VAV3	1	107823394	T	C
rs4915077	22493691	10451	VAV3	umls:C0020676	GWASCAT	VAV3 is involved in immune function, and FOXE1 and PTPN22 have previously been associated with hypothyroidism.	0.122638474	2012	VAV3	1	107823394	T	C
rs6679677	22493691	10745	PHTF1	umls:C0020676	GWASCAT	Novel associations for hypothyroidism include known autoimmune risk loci.	0.12	2012	PHTF1	1	113761186	C	A
rs833061	22439647	7422	VEGFA	umls:C0020676	BeFree	The presence of C-allele in rs833061 and the T-allele in rs3025039 polymorphism of VEGFA were associated with significantly higher risk of hypothyroidism (OR: 10.0 p = 0.041 and OR: 10.5; p = 0.015, respectively).	0.000271442	2012	VEGFA	6	43769749	C	T
rs948426	22493691	100130480	LINC01387	umls:C0020676	GWASCAT	Novel associations for hypothyroidism include known autoimmune risk loci.	0.122367032	2012	LINC01387;LOC105371972	18	6567183	A	G
rs9901756	22493691	40	ASIC2	umls:C0020676	GAD	[Novel associations for hypothyroidism include known autoimmune risk loci.]	0.002367032	2012	ASIC2	17	34137135	A	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:304)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	19755030	rs1472565	T	C	rs1472565	22493691	6.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	CAPZB
1	19797248	rs1002365	T	C	rs1002365	22493691	9.90E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	CAPZB
1	25521090	rs12736858	C	T	rs12736858	22493691	1.20E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
1	25529362	rs11248998	C	T	rs11248998	22493691	5.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
1	26057309	rs2744768	T	G	rs2744768	22493691	9.90E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	MAN1C1
1	38272660	rs2291297	G	A	rs2291297	22493691	6.90E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	YRDC
1	38279987	rs3748682	T	C	rs3748682	22493691	9.00E-06	NA	1.19	[1.10-1.28]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs3748682-T	NA	T	MTF1
1	38289383	rs12751325	T	C	rs12751325	22493691	8.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	MTF1
1	38347417	rs12742756	A	G	rs12742756	22493691	1.50E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	INPP5B
1	38349400	rs12728438	G	A	rs12728438	22493691	6.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	INPP5B
1	108245664	rs17019729	T	C	rs17019729	22493691	4.10E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	VAV3
1	108246246	rs6583042	A	G	rs6583042	22493691	5.60E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	VAV3
1	108250282	rs4503375	A	G	rs4503375	22493691	1.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	VAV3
1	108268801	rs17019810	C	T	rs17019810	22493691	2.00E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	VAV3
1	108269953	rs17019823	A	C	rs17019823	22493691	8.00E-09	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	VAV3
1	108273631	rs6674340	A	G	rs6674340	22493691	5.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	VAV3
1	108336533	rs17020055	A	C	rs17020055	22493691	6.50E-09	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	VAV3
1	108351812	rs17020088	T	C	rs17020088	22493691	5.40E-09	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	VAV3
1	108359505	rs4915076	T	C	rs4915076	22493691	8.00E-10	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	VAV3
1	108366016	rs4915077	T	C	rs4915077	22493691	8.00E-10	NA	1.3	[1.20-1.41]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs4915077-C	NA	T	VAV3
1	114303808	rs6679677	C	A	rs6679677	22493691	3.00E-13	NA	1.36	[1.25-1.48]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs6679677-A	NA	C	NA
1	114377568	rs2476601	A	G	rs2476601	22493691	3.90E-13	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G,C	NA
1	187902981	rs655167	A	G	rs655167	22493691	7.00E-06	NA	1.26	[1.14-1.39]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs655167-A	NA	T	NA
1	227935444	rs2236359	A	G	rs2236359	22493691	3.70E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	SNAP47
1	227957591	rs10916205	C	T	rs10916205	22493691	8.20E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	SNAP47
2	23754948	rs748860	C	T	rs748860	22493691	7.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	KLHL29
2	37048522	rs974966	A	G	rs974966	22493691	2.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
2	37049563	rs888053	A	T	rs888053	22493691	6.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
2	46018533	rs11898209	A	G	rs11898209	22493691	2.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	PRKCE
2	46033719	rs4953260	C	T	rs4953260	22493691	8.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	PRKCE
2	151733201	rs960615	C	T	rs960615	22493691	3.20E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
2	178029850	rs2706123	C	T	rs2706123	22493691	6.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
2	204732714	rs231775	A	G	rs231775	22493691	9.40E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	CTLA4
2	204734487	rs231779	C	T	rs231779	22493691	7.00E-06	NA	1.13	[1.07-1.19]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs231779-T	NA	C	CTLA4
2	204738919	rs3087243	G	A	rs3087243	22493691	6.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	CTLA4
3	261442	rs459362	A	G	rs459362	22493691	7.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	CHL1
3	2229166	rs9968167	C	T	rs9968167	22493691	8.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	CNTN4
3	3091331	rs7649378	C	A	rs7649378	22493691	8.90E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	CNTN4
3	70417993	rs13314351	C	T	rs13314351	22493691	1.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
3	72880470	rs17043990	T	C	rs17043990	21981779	1.58E-06	NA	NA	NA	1,317 European ancestry cases; 5,053 European ancestry controls	European(6370)	ALL(6370)	EUR(6370)	ALL(6370)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	Research Support, N.I.H., Extramural	T	SHQ1
4	6384823	rs6851340	C	T	rs6851340	22493691	1.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	PPP2R2C
4	14978435	rs4698307	G	A	rs4698307	22493691	4.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	LOC441009
4	55478686	rs17827152	G	A	rs17827152	21981779	5.20E-06	NA	NA	NA	1,317 European ancestry cases; 5,053 European ancestry controls	European(6370)	ALL(6370)	EUR(6370)	ALL(6370)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	Research Support, N.I.H., Extramural	G	NA
4	107830261	rs450533	T	C	rs450533	22493691	1.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
4	107844092	rs419558	C	T	rs419558	22493691	8.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	DKK2
4	149574788	rs7437928	T	C	rs7437928	22493691	5.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
4	149625757	rs10008892	C	A	rs10008892	22493691	9.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
4	149633713	rs6535627	T	G	rs6535627	22493691	2.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
4	149635025	rs10519980	C	T	rs10519980	22493691	7.00E-06	NA	1.16	[1.09-1.23]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs10519980-C	NA	C	NA
4	149650033	rs17025017	G	A	rs17025017	22493691	2.70E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
4	149652478	rs11935941	A	C	rs11935941	22493691	7.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
4	149660911	rs11942028	T	C	rs11942028	22493691	4.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
4	149697086	rs6848368	A	C	rs6848368	22493691	3.20E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
4	149712041	rs10519990	A	C	rs10519990	22493691	3.20E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
5	40286862	rs7723858	A	C	rs7723858	22493691	3.50E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
5	55384909	rs9647530	C	T	rs9647530	22493691	5.70E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
5	76518442	rs4704397	G	A	rs4704397	22493691	2.00E-06	NA	1.17	[1.10-1.26]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs4704397-A	NA	A	PDE8B
5	76521868	rs1382879	T	C	rs1382879	22493691	4.40E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	PDE8B
5	76530349	rs6885099	A	G	rs6885099	22493691	3.10E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	PDE8B
5	76535811	rs2046045	T	G	rs2046045	22493691	4.70E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C,G	PDE8B
5	76541325	rs10037599	A	C	rs10037599	22493691	1.10E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	PDE8B
5	76544960	rs989758	G	A	rs989758	22493691	1.90E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	PDE8B
5	76568292	rs832790	C	A	rs832790	22493691	3.90E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	PDE8B
5	105022790	rs1480583	C	T	rs1480583	22493691	3.20E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
5	177632527	rs2961674	G	A	rs2961674	22493691	2.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	HNRNPAB
5	177636571	rs2913752	C	T	rs2913752	22493691	1.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	HNRNPAB
5	178905485	rs12109210	A	G	rs12109210	22493691	8.90E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
6	4395749	rs170949	T	C	rs170949	22493691	5.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	21863899	rs9366415	C	T	rs9366415	22493691	6.90E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	LINC00340
6	29569955	rs3025643	A	G	rs3025643	21981779	9.76E-04	NA	NA	NA	1,317 European ancestry cases; 5,053 European ancestry controls	European(6370)	ALL(6370)	EUR(6370)	ALL(6370)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	Research Support, N.I.H., Extramural	C	GABBR1
6	29829265	rs3094170	T	C	rs3094170	21981779	5.38E-04	NA	NA	NA	1,317 European ancestry cases; 5,053 European ancestry controls	European(6370)	ALL(6370)	EUR(6370)	ALL(6370)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	Research Support, N.I.H., Extramural	G,A	NA
6	29943490	rs2735076	A	G	rs2735076	21981779	3.61E-04	NA	NA	NA	1,317 European ancestry cases; 5,053 European ancestry controls	European(6370)	ALL(6370)	EUR(6370)	ALL(6370)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	Research Support, N.I.H., Extramural	NA	HCG9
6	29955199	rs5025708	G	T	rs5025708	21981779	3.95E-04	NA	NA	NA	1,317 European ancestry cases; 5,053 European ancestry controls	European(6370)	ALL(6370)	EUR(6370)	ALL(6370)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	Research Support, N.I.H., Extramural	T	NA
6	30140525	rs6905949	T	C	rs6905949	22493691	6.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	TRIM15
6	31006855	rs2844665	T	C	rs2844665	22493691	5.00E-07	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31007590	rs2517552	C	T	rs2517552	22493691	1.80E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31012996	rs3131927	T	C	rs3131927	22493691	6.10E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31017334	rs2517534	A	G	rs2517534	22493691	1.70E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
6	31018407	rs2517532	A	G	rs2517532	22493691	1.00E-08	NA	1.16	[1.10-1.22]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs2517532-G	NA	C	NA
6	31021547	rs2517527	A	G	rs2517527	22493691	9.50E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	HCG22
6	31024673	rs3764808	T	C	rs3764808	22493691	1.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
6	31025989	rs9262638	C	T	rs9262638	22493691	2.40E-07	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31026009	rs9262639	C	T	rs9262639	22493691	2.10E-07	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31026434	rs2517523	A	G	rs2517523	22493691	7.40E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31028920	rs2517516	T	C	rs2517516	22493691	8.50E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A,G	NA
6	31029918	rs2517511	A	C	rs2517511	22493691	6.90E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31030122	rs2517510	T	G	rs2517510	22493691	8.20E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31031381	rs2256436	A	G	rs2256436	22493691	9.10E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31032370	rs2517504	T	G	rs2517504	22493691	8.10E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31032937	rs2517502	C	T	rs2517502	22493691	8.00E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
6	31033509	rs2517500	C	T	rs2517500	22493691	7.30E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31036783	rs2517497	A	G	rs2517497	22493691	8.20E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31038976	rs2523891	C	T	rs2523891	22493691	9.50E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31041155	rs2523884	C	T	rs2523884	22493691	6.50E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31042306	rs2517489	G	A	rs2517489	22493691	6.80E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31042608	rs2523881	T	G	rs2523881	22493691	6.90E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
6	31043232	rs2249231	G	A	rs2249231	22493691	1.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
6	31044468	rs2905759	C	T	rs2905759	22493691	8.80E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31044802	rs2517478	G	T	rs2517478	22493691	8.30E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31044863	rs2517477	G	A	rs2517477	22493691	7.50E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31046528	rs2523843	A	G	rs2523843	22493691	7.60E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31047145	rs2523836	C	T	rs2523836	22493691	8.30E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31047471	rs2523895	A	C	rs2523895	22493691	1.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31048263	rs2106067	T	C	rs2106067	22493691	6.20E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
6	31048387	rs2249876	G	A	rs2249876	22493691	4.30E-07	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
6	31048916	rs6941772	C	G	rs6941772	22493691	1.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31050179	rs9263473	A	G	rs9263473	22493691	9.50E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31050244	rs9263474	A	C	rs9263474	22493691	9.20E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
6	31051388	rs2535318	C	T	rs2535318	22493691	1.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
6	31052098	rs2517471	C	G	rs2517471	22493691	1.20E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31052127	rs2535315	C	T	rs2535315	22493691	2.70E-07	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31052684	rs2535311	A	G	rs2535311	22493691	3.00E-07	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
6	31053257	rs2535310	A	C	rs2535310	22493691	2.70E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
6	31053867	rs2535306	A	G	rs2535306	22493691	8.80E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
6	31054687	rs2535304	T	C	rs2535304	22493691	1.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31055423	rs2535303	G	A	rs2535303	22493691	2.20E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
6	31060115	rs2517453	C	T	rs2517453	22493691	2.30E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
6	31060162	rs2517452	T	C	rs2517452	22493691	1.80E-08	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31062133	rs2535294	A	G	rs2535294	22493691	1.70E-08	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
6	31062363	rs2535293	A	G	rs2535293	22493691	3.80E-08	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31062667	rs2517448	T	C	rs2517448	22493691	4.80E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31062899	rs2535291	G	A	rs2535291	22493691	3.70E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
6	31063233	rs2535289	G	A	rs2535289	22493691	4.50E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
6	31068420	rs2535283	A	G	rs2535283	22493691	2.90E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31073903	rs7381897	A	G	rs7381897	22493691	3.50E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31074030	rs6457327	A	C	rs6457327	22493691	4.20E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31074129	rs2517484	G	A	rs2517484	22493691	5.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
6	31075375	rs1064191	T	C	rs1064191	22493691	2.20E-08	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	31077938	rs1265063	A	G	rs1265063	22493691	3.10E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31079643	rs1265054	T	C	rs1265054	22493691	3.00E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	C6orf15
6	31080859	rs2233966	A	G	rs2233966	22493691	3.50E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	C6orf15
6	31081989	rs3130977	T	C	rs3130977	22493691	4.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	C6orf15
6	31082285	rs3130553	A	G	rs3130553	22493691	7.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	C6orf15
6	31256753	rs2524044	T	G	rs2524044	22493691	7.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31258846	rs2256583	T	C	rs2256583	22493691	7.70E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	31272553	rs9264904	G	A	rs9264904	22493691	1.50E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A,G	NA
6	31326082	rs9266271	T	C	rs9266271	22493691	1.70E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	HLA-B
6	31348580	rs9266689	A	G	rs9266689	22493691	1.50E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	32151443	rs2070600	C	T	rs2070600	22493691	3.90E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	AGER
6	32368087	rs3817963	T	C	rs3817963	22493691	8.90E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	BTNL2
6	32373698	rs3806156	G	T	rs3806156	22493691	4.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	BTNL2
6	32433167	rs2395185	G	T	rs2395185	22493691	2.80E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	32453191	rs527369852	T	C	rs6916742	22493691	1.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
6	32453191	rs6916742	T	C	rs6916742	22493691	1.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
6	32569691	rs477515	G	A	rs477515	22493691	7.70E-07	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	LOC100507709
6	32570400	rs2516049	T	C	rs2516049	22493691	6.00E-07	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	LOC100507709
6	32604372	rs9272346	G	A	rs9272346	22493691	2.00E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	HLA-DQA1
6	32609427	rs9272723	T	C	rs9272723	22493691	9.10E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	HLA-DQA1
6	32612397	rs6927022	A	G	rs6927022	22493691	6.10E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
6	32625869	rs9273349	T	C	rs9273349	22493691	8.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
6	32626249	rs6928482	T	C	rs6928482	22493691	3.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
6	32627714	rs1063355	T	G	rs1063355	22493691	2.50E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	HLA-DQB1
6	32636866	rs3134996	A	T	rs3134996	22493691	8.40E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
6	32651117	rs9275141	T	G	rs9275141	22493691	4.70E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	32652581	rs3134975	T	C	rs3134975	22493691	8.80E-07	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	32663631	rs3129720	T	C	rs3129720	22493691	5.00E-07	NA	1.16	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs3129720-C	NA	C	NA
6	32667119	rs3135006	T	C	rs3135006	22493691	9.60E-07	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	32669018	rs1612904	C	A	rs1612904	22493691	7.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
6	32669767	rs2647050	T	C	rs2647050	22493691	9.10E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
6	32670255	rs2856718	C	T	rs2856718	22493691	8.50E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	32677912	rs9275563	C	T	rs9275563	22493691	2.30E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	32681631	rs9275596	C	T	rs9275596	22493691	6.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T,C	NA
6	32682308	rs3104405	C	A	rs3104405	22493691	6.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
6	32792973	rs1894411	T	C	rs1894411	22493691	9.50E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	TAP2
6	33754396	rs9394167	A	G	rs9394167	21981779	9.70E-04	NA	NA	NA	1,317 European ancestry cases; 5,053 European ancestry controls	European(6370)	ALL(6370)	EUR(6370)	ALL(6370)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	Research Support, N.I.H., Extramural	A	LEMD2
6	117857488	rs3756894	T	G	rs3756894	22493691	7.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	DCBLD1
6	166050119	rs2983514	A	G	rs2983514	22493691	9.20E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	PDE10A
6	167383972	rs429083	T	C	rs429083	22493691	1.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
6	167411008	rs400837	T	C	rs400837	22493691	1.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
6	167437988	rs2301436	C	T	rs2301436	22493691	5.30E-04	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	FGFR1OP
7	44143341	rs10271244	A	G	rs10271244	22493691	2.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
7	71815170	rs11764286	T	G	rs11764286	22493691	2.20E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	CALN1
7	88481442	rs10248351	T	C	rs10248351	22493691	7.00E-06	NA	1.84	[1.43-2.37]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs10248351-C	NA	C	ZNF804B
7	104596755	rs6961188	C	T	rs6961188	22493691	5.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
7	147977039	rs6964680	T	G	rs6964680	22493691	4.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	CNTNAP2
8	633684	rs11137016	A	G	rs11137016	22493691	9.10E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	ERICH1
8	1897174	rs17064407	A	G	rs17064407	22493691	7.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	ARHGEF10
8	8174504	rs7011400	C	T	rs7011400	22493691	7.20E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
8	8241772	rs2976956	T	C	rs2976956	22493691	9.10E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
8	8258712	rs2976929	T	C	rs2976929	22493691	6.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
8	10288480	rs10089552	T	C	rs10089552	22493691	2.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
8	10289663	rs10096610	T	C	rs10096610	22493691	4.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
8	10303387	rs7005230	C	A	rs7005230	22493691	5.70E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
8	11516373	rs4841578	A	G	rs4841578	22493691	2.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
8	81357702	rs400824	C	T	rs400824	22493691	2.10E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
8	81381871	rs7830160	C	T	rs7830160	22493691	2.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
8	81438420	rs1051920	C	T	rs1051920	22493691	4.00E-06	NA	1.14	[1.08-1.21]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs1051920-T	NA	T	NA
9	14443784	rs10491775	A	C	rs10491775	22493691	7.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
9	14470833	rs10961534	A	G	rs10961534	22493691	7.00E-06	NA	1.19	[1.11-1.29]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs10961534-G	NA	G	NA
9	23638686	rs2197402	C	T	rs2197402	22493691	1.90E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
9	99620277	rs7040493	A	G	rs7040493	22493691	4.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
9	99655358	rs1046795	C	T	rs1046795	22493691	4.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
9	100522530	rs1512261	G	T	rs1512261	22493691	2.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
9	100543880	rs1877432	G	A	rs1877432	21981779	3.90E-06	NA	NA	NA	1,317 European ancestry cases; 5,053 European ancestry controls	European(6370)	ALL(6370)	EUR(6370)	ALL(6370)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	Research Support, N.I.H., Extramural	G	NA
9	100543880	rs1877432	G	A	rs1877432	22493691	4.40E-09	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
9	100546600	rs925489	C	T	rs925489	21981779	1.58E-08	NA	NA	NA	1,317 European ancestry cases; 5,053 European ancestry controls	European(6370)	ALL(6370)	EUR(6370)	ALL(6370)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	Research Support, N.I.H., Extramural	C	NA
9	100546600	rs925489	C	T	rs925489	22493691	2.00E-19	NA	1.28	[1.22-1.35]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs925489-T	NA	C	NA
9	100549013	rs7850258	A	G	rs7850258	21981779	4.00E-09	eMERGE	1.23	[1.04-1.47]	1,317 European ancestry cases; 5,053 European ancestry controls	European(6370)	ALL(6370)	EUR(6370)	ALL(6370)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	Research Support, N.I.H., Extramural	G	NA
9	100549013	rs7850258	A	G	rs7850258	22493691	2.50E-19	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
9	100550028	rs1443438	T	C	rs1443438	22493691	5.50E-11	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
9	100556109	rs965513	A	G	rs965513	21981779	1.52E-08	NA	NA	NA	1,317 European ancestry cases; 5,053 European ancestry controls	European(6370)	ALL(6370)	EUR(6370)	ALL(6370)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	Research Support, N.I.H., Extramural	G	NA
9	100556109	rs965513	A	G	rs965513	22493691	4.30E-19	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
9	100556972	rs10759944	A	G	rs10759944	21981779	2.53E-08	NA	NA	NA	1,317 European ancestry cases; 5,053 European ancestry controls	European(6370)	ALL(6370)	EUR(6370)	ALL(6370)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	Research Support, N.I.H., Extramural	G	NA
9	100556972	rs10759944	A	G	rs10759944	22493691	5.80E-19	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
9	100574120	rs7870795	T	C	rs7870795	22493691	3.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
9	100588839	rs7848973	A	G	rs7848973	22493691	7.10E-11	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
9	100595238	rs7024345	A	G	rs7024345	22493691	1.00E-08	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
9	100608745	rs10759960	A	G	rs10759960	22493691	5.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
9	100617479	rs1443434	G	T	rs1443434	22493691	4.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	FOXE1
9	100622597	rs907580	T	C	rs907580	22493691	1.20E-08	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
9	100636398	rs925487	C	T	rs925487	22493691	4.10E-08	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
9	100639275	rs10984103	A	C	rs10984103	22493691	3.90E-08	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
9	100650096	rs7866436	G	A	rs7866436	22493691	2.40E-08	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
9	104376601	rs9792648	A	G	rs9792648	22493691	2.70E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	GRIN3A
9	104543022	rs11791821	T	C	rs11791821	22493691	7.50E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
9	108380004	rs10816284	G	A	rs10816284	22493691	4.90E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	FKTN
9	117219888	rs4979397	T	C	rs4979397	21981779	9.56E-05	NA	NA	NA	1,317 European ancestry cases; 5,053 European ancestry controls	European(6370)	ALL(6370)	EUR(6370)	ALL(6370)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	Research Support, N.I.H., Extramural	T	DFNB31
9	117220773	rs1408528	C	T	rs1408528	21981779	1.01E-04	NA	NA	NA	1,317 European ancestry cases; 5,053 European ancestry controls	European(6370)	ALL(6370)	EUR(6370)	ALL(6370)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	Research Support, N.I.H., Extramural	C	DFNB31
9	117222675	rs4979402	G	A	rs4979402	21981779	6.76E-05	NA	NA	NA	1,317 European ancestry cases; 5,053 European ancestry controls	European(6370)	ALL(6370)	EUR(6370)	ALL(6370)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	Research Support, N.I.H., Extramural	G,A	DFNB31
9	117229400	rs1535971	T	G	rs1535971	21981779	1.73E-04	NA	NA	NA	1,317 European ancestry cases; 5,053 European ancestry controls	European(6370)	ALL(6370)	EUR(6370)	ALL(6370)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	Research Support, N.I.H., Extramural	T	DFNB31
10	3162423	rs6602026	G	A	rs6602026	22493691	1.70E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	PFKP
10	6098824	rs706779	T	C	rs706779	22493691	7.20E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	IL2RA
10	6110875	rs7090530	C	A	rs7090530	22493691	5.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
10	27344697	rs4747583	T	C	rs4747583	22493691	6.50E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	ANKRD26
10	36201437	rs11010324	C	T	rs11010324	22493691	1.00E-04	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
10	48607823	rs9422352	T	C	rs9422352	22493691	5.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
10	55903108	rs7907790	C	T	rs7907790	22493691	3.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	PCDH15
10	64050288	rs3852412	C	T	rs3852412	22493691	9.90E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
10	95355617	rs7094671	G	A	rs7094671	22493691	5.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	RBP4
10	109548708	rs7908795	G	A	rs7908795	22493691	9.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
10	109549467	rs2900784	C	A	rs2900784	22493691	8.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
10	109555429	rs4344419	T	C	rs4344419	22493691	7.10E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
10	114492898	rs1885281	A	G	rs1885281	22493691	5.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	VTI1A
10	128470148	rs10901703	G	A	rs10901703	22493691	8.50E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
10	128476069	rs11599718	A	G	rs11599718	22493691	9.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
11	1944202	rs965912	A	G	rs965912	22493691	8.50E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	TNNT3
11	56905977	rs3017313	T	C	rs3017313	22493691	8.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
11	81136255	rs10501511	A	G	rs10501511	22493691	9.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
11	81142678	rs10792563	T	C	rs10792563	22493691	9.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
11	121445940	rs3781834	A	G	rs3781834	22493691	8.70E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	SORL1
11	126850849	rs1939995	G	C	rs1939995	22493691	7.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	KIRREL3
11	132872052	rs7935421	C	T	rs7935421	22493691	7.90E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	OPCML
11	133376068	rs4937788	C	T	rs4937788	22493691	8.50E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	OPCML
12	7412351	rs4883177	C	T	rs4883177	22493691	2.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
12	7435250	rs11612407	A	C	rs11612407	22493691	9.50E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
12	9876091	rs10466829	G	A	rs10466829	22493691	2.10E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	CLECL1
12	77212915	rs1477745	G	A	rs1477745	22493691	2.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	ZDHHC17
12	84705307	rs2947117	A	G	rs2947117	22493691	7.50E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
12	111884608	rs3184504	T	C	rs3184504	22493691	3.00E-12	NA	1.2	[1.14-1.27]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs3184504-T	NA	C	SH2B3
12	112007756	rs653178	C	T	rs653178	22493691	5.00E-12	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	ATXN2
12	112072424	rs11065987	A	G	rs11065987	22493691	1.70E-10	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
12	112486818	rs17696736	A	G	rs17696736	22493691	2.80E-10	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NAA25
12	112610714	rs11066188	G	A	rs11066188	22493691	4.10E-10	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	C12orf51
12	112906415	rs11066320	A	G	rs11066320	22493691	3.50E-09	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	PTPN11
13	24042510	rs10162002	G	A	rs10162002	22493691	5.00E-06	NA	1.23	[1.13-1.35]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs10162002-A	NA	A	NA
13	92063955	rs9589219	T	C	rs9589219	22493691	8.70E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	GPC5
13	103526139	rs8002276	T	C	rs8002276	22493691	9.50E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	ERCC5
13	103556061	rs9514069	A	G	rs9514069	22493691	4.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
13	110354802	rs1330544	T	C	rs1330544	22493691	7.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
13	111189856	rs9521823	A	G	rs9521823	22493691	3.70E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	RAB20
13	111190101	rs2391835	T	C	rs2391835	22493691	4.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	RAB20
13	111193959	rs9521826	A	G	rs9521826	22493691	2.10E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	RAB20
14	52380187	rs3742539	G	A	rs3742539	22493691	3.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	GNG2
14	54168117	rs964254	G	A	rs964254	22493691	9.10E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
14	54173539	rs210352	A	G	rs210352	22493691	3.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
14	59714317	rs7154112	T	C	rs7154112	22493691	8.20E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	DAAM1
14	96042876	rs2208663	T	G	rs2208663	22493691	1.20E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	LOC100506999
14	96060745	rs1951462	A	G	rs1951462	22493691	6.70E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
14	96061668	rs12895778	T	C	rs12895778	22493691	6.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
15	61569516	rs8026315	G	T	rs8026315	22493691	7.90E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
15	71754225	rs16955642	T	G	rs16955642	22493691	9.50E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	THSD4
15	71762384	rs16955676	T	G	rs16955676	22493691	3.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	THSD4
15	71771585	rs1561710	A	G	rs1561710	22493691	5.00E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	THSD4
16	11179873	rs12708716	A	G	rs12708716	22493691	9.70E-04	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	CLEC16A
17	15288433	rs8066838	A	C	rs8066838	22493691	6.90E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
17	32458849	rs9303674	C	T	rs9303674	22493691	8.00E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	ASIC2
17	32464154	rs9901756	A	C	rs9901756	22493691	7.00E-06	NA	1.21	[1.11-1.32]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs9901756-A	NA	A	ASIC2
17	46840541	rs7219021	T	G	rs7219021	22493691	6.20E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	TTLL6
17	47106878	rs9899580	T	G	rs9899580	22493691	7.50E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	IGF2BP1
17	47129121	rs11655950	G	A	rs11655950	22493691	8.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	IGF2BP1
17	57832190	rs9899611	A	G	rs9899611	22493691	5.90E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	VMP1
17	57875554	rs2645492	G	A	rs2645492	22493691	8.50E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	VMP1
18	6567182	rs948426	A	G	rs948426	22493691	1.00E-06	NA	1.14	[1.08-1.19]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs948426-A	NA	T	LOC100130480
18	6579216	rs17506582	T	C	rs17506582	22493691	8.00E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	LOC100130480
18	6581793	rs2155835	G	A	rs2155835	22493691	8.70E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	LOC100130480
18	6582104	rs1941496	G	A	rs1941496	22493691	8.70E-06	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	LOC100130480
18	6587541	rs8092631	T	C	rs8092631	22493691	2.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	LOC100130480
18	6603954	rs1941491	C	T	rs1941491	22493691	1.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C,T	NA
18	36814582	rs16971699	T	C	rs16971699	22493691	6.10E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	LOC647946
19	6391219	rs8102597	A	G	rs8102597	22493691	4.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	GTF2F1
19	7222832	rs7508679	T	C	rs7508679	22493691	4.70E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	INSR
19	7223848	rs4804416	T	G	rs4804416	22493691	5.00E-06	NA	1.13	[1.07-1.18]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs4804416-G	NA	T	INSR
19	7224431	rs7248104	G	A	rs7248104	22493691	6.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	INSR
19	30458485	rs4144518	T	C	rs4144518	22493691	7.60E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	URI1
19	30537150	rs12460600	A	G	rs12460600	22493691	3.70E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
19	30566056	rs277079	A	G	rs277079	22493691	5.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
20	934948	rs550408	T	C	rs550408	22493691	4.70E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	NA
20	14522894	rs1535213	G	A	rs1535213	22493691	9.80E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	MACROD2
20	51740178	rs1293425	A	G	rs1293425	22493691	1.20E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	T	TSHZ2
22	37581422	rs229526	G	C	rs229526	22493691	9.00E-06	NA	1.22	[1.12-1.32]	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	rs229526-C	NA	C	C1QTNF6
22	37589805	rs5756546	C	T	rs5756546	22493691	8.30E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	NA
X	4930267	rs2100181	C	A	rs2100181	22493691	4.40E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	G	NA
X	23132857	rs4520319	G	A	rs4520319	22493691	7.50E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	A	NA
X	106144529	rs7057398	T	C	rs7057398	22493691	7.20E-05	NA	NA	NA	3,736 European ancestry cases; 35,546 European ancestry controls	European(39282)	ALL(39282)	EUR(39282)	ALL(39282)	Hypothyroidism	HPOID:0000821	Hypothyroidism	DOID:1459	hypothyroidism	D007037	Hypothyroidism	EFOID:0004705	hypothyroidism	Hypothyroidism	NA	NA	C	CLDN2

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:14)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0020676	s-adenosylmethionine	D012436	29908-03-0	hypothyroidism	MESH:D007037	therapeutic	18518811
C0020676	bleomycin	D001761	11056-06-7	hypothyroidism	MESH:D007037	marker/mechanism	10526668
C0020676	carbimazole	D002231	22232-54-8	hypothyroidism	MESH:D007037	marker/mechanism	4186442
C0020676	clobazam	C012255	22316-47-8	hypothyroidism	MESH:D007037	marker/mechanism	22982618
C0020676	cyclophosphamide	D003520	50-18-0	hypothyroidism	MESH:D007037	marker/mechanism	10526668
C0020676	epirubicin	D015251	56420-45-2	hypothyroidism	MESH:D007037	marker/mechanism	10526668
C0020676	imipramine	D007099	50-49-7	hypothyroidism	MESH:D007037	marker/mechanism	7691178
C0020676	lindane	D001556	58-89-9	hypothyroidism	MESH:D007037	marker/mechanism	20061368
C0020676	peginterferon alfa-2a	C100416	-	hypothyroidism	MESH:D007037	marker/mechanism	16702862
C0020676	phenytoin	D010672	57-41-0	hypothyroidism	MESH:D007037	marker/mechanism	598297
C0020676	propylthiouracil	D011441	51-52-5	hypothyroidism	MESH:D007037	marker/mechanism	12933695
C0020676	ribavirin	D012254	36791-04-5	hypothyroidism	MESH:D007037	marker/mechanism	16702862
C0020676	streptozocin	D013311	18883-66-4	hypothyroidism	MESH:D007037	marker/mechanism	7564366
C0020676	vitamin e	D014810	1406-18-4	hypothyroidism	MESH:D007037	therapeutic	12587721

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)