PedAM

Pediatric Disease Annotations & Medicines


	hypopituitarism

Disease ID	221
Disease	hypopituitarism
Definition	Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including LH; FOLLICLE STIMULATING HORMONE; SOMATOTROPIN; and CORTICOTROPIN). This may result from surgical or radiation ablation, non-secretory PITUITARY NEOPLASMS, metastatic tumors, infarction, PITUITARY APOPLEXY, infiltrative or granulomatous processes, and other conditions.
Synonym	adenohypophyseal hyposecret adenohypophyseal hyposecretion anterior pituitary hyposecret syndrome anterior pituitary hyposecretion syndrome deficiencies pituitary deficient secretion of one or more pituitary hormones hypopituitarism (disorder) hypopituitarism [disease/finding] hypopituitarism nos hypopituitarism nos (disorder) hypopituitarism, nos hypopitutitarism hyposecret adenohypophyseal hyposecret syndrome anterior pituitary hyposecretion syndrome, anterior pituitary hyposecretion, adenohypophyseal insufficiency pituitary insufficiency, pituitary pituitary deficiency pituitary failure pituitary hypofunction pituitary insufficiency pituitary insufficiency nos pituitary insufficiency, nos
Orphanet	ORPHANET:101957
DOID	DOID:9406
ICD10	ICD10CM:E23.0
UMLS	C0020635
MeSH	D007018
SNOMED-CT	SNOMEDCT_US_2016_09_01:74728003
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:54) C0013338 \| growth hormone deficiency \| 6 C0020676 \| hypothyroidism \| 5 C0011848 \| diabetes insipidus \| 4 C0032000 \| pituitary adenoma \| 4 C0020619 \| hypogonadism \| 4 C0011847 \| diabetes \| 3 C0030312 \| pancytopenia \| 3 C0032000 \| pituitary adenomas \| 3 C0001206 \| acromegaly \| 3 C0242342 \| sheehan's syndrome \| 3 C0878544 \| cardiomyopathy \| 2 C0010276 \| craniopharyngioma \| 2 C0020598 \| hypoglycemia \| 2 C0022735 \| hypogonadotropic hypogonadism \| 2 C0020514 \| hyperprolactinemia \| 2 C0079731 \| b-cell lymphoma \| 2 C0040053 \| thrombosis \| 1 C0687720 \| central diabetes insipidus \| 1 C0948740 \| pituitary hypoplasia \| 1 C0342388 \| acth deficiency \| 1 C0271558 \| pituitary necrosis \| 1 C0376358 \| prostate cancer \| 1 C0014038 \| encephalitis \| 1 C0001430 \| adenoma \| 1 C0854486 \| functioning pituitary adenoma \| 1 C0155307 \| chiasmal syndrome \| 1 C0007115 \| thyroid cancer \| 1 C0024299 \| lymphoma \| 1 C0004903 \| beckwith-wiedemann syndrome \| 1 C0271789 \| tsh deficiency \| 1 C0020255 \| hydrocephalus \| 1 C0242342 \| sheehan syndrome \| 1 C0001403 \| addison's disease \| 1 C0242343 \| panhypopituitarism \| 1 C0029456 \| osteoporosis \| 1 C0242342 \| postpartum pituitary necrosis \| 1 C0001623 \| adrenal insufficiency \| 1 C1565489 \| renal insufficiency \| 1 C1535927 \| charge syndrome \| 1 C0342388 \| adrenocorticotropic hormone deficiency \| 1 C0040147 \| thyroiditis \| 1 C0271623 \| secondary hypogonadism \| 1 C0007115 \| thyroid ca \| 1 C0020635 \| pituitary insufficiency \| 1 C0151740 \| increased intracranial pressure \| 1 C0023448 \| lymphoblastic leukemia \| 1 C0007222 \| cardiovascular disease \| 1 C0042373 \| vascular disease \| 1 C0005940 \| bone disease \| 1 C0032002 \| pituitary disease \| 1 C1333387 \| endocrine syndrome \| 1 C0034012 \| delayed puberty \| 1 C0020617 \| hypoglycaemic coma \| 1 C0023449 \| acute lymphoblastic leukemia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:11) CYP19A1 \| 1588 \| CTD_human HESX1 \| 8820 \| GHR POU1F1 \| 5449 \| GHR PRL \| 5617 \| CTD_human CYP17A1 \| 1586 \| CTD_human GLI2 \| 2736 \| GHR PROP1 \| 5626 \| GHR SOX2 \| 6657 \| GHR LHX4 \| 89884 \| GHR OTX2 \| 5015 \| GHR LHX3 \| 8022 \| GHR
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 5626 \| PROP1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:203) 990 \| CDC6 \| DISEASES 128674 \| PROKR2 \| DISEASES 5020 \| OXT \| DISEASES 23594 \| ORC6 \| DISEASES 55512 \| SMPD3 \| DISEASES 7038 \| TG \| DISEASES 268 \| AMH \| DISEASES 166 \| AES \| DISEASES 3982 \| LIM2 \| DISEASES 6822 \| SULT2A1 \| DISEASES 5864 \| RAB3A \| DISEASES 55131 \| RBM28 \| DISEASES 9570 \| GOSR2 \| DISEASES 7126 \| TNFAIP1 \| DISEASES 2798 \| GNRHR \| DISEASES 26952 \| SMR3A \| DISEASES 51053 \| GMNN \| DISEASES 3670 \| ISL1 \| DISEASES 2690 \| GHR \| DISEASES 9421 \| HAND1 \| DISEASES 338 \| APOB \| DISEASES 9068 \| ANGPTL1 \| DISEASES 2691 \| GHRH \| DISEASES 9419 \| CRIPT \| DISEASES 2693 \| GHSR \| DISEASES 4189 \| DNAJB9 \| DISEASES 968 \| CD68 \| DISEASES 9459 \| ARHGEF6 \| DISEASES 3630 \| INS \| DISEASES 1911 \| PHC1 \| DISEASES 2488 \| FSHB \| DISEASES 1401 \| CRP \| DISEASES 25914 \| RTTN \| DISEASES 7252 \| TSHB \| DISEASES 6927 \| HNF1A \| DISEASES 6610 \| SMPD2 \| DISEASES 2016 \| EMX1 \| DISEASES 80210 \| ARMC9 \| DISEASES 10643 \| IGF2BP3 \| DISEASES 81873 \| ARPC5L \| DISEASES 10817 \| FRS3 \| DISEASES 6496 \| SIX3 \| DISEASES 3290 \| HSD11B1 \| DISEASES 79817 \| MOB3B \| DISEASES 9894 \| TELO2 \| DISEASES 6132 \| RPL8 \| DISEASES 7089 \| TLE2 \| DISEASES 6855 \| SYP \| DISEASES 10994 \| ILVBL \| DISEASES 9789 \| SPCS2 \| DISEASES 89884 \| LHX4 \| DISEASES 5000 \| ORC4 \| DISEASES 5443 \| POMC \| DISEASES 80321 \| CEP70 \| DISEASES 5307 \| PITX1 \| DISEASES 597 \| BCL2A1 \| DISEASES 10733 \| PLK4 \| DISEASES 23432 \| GPR161 \| DISEASES 5972 \| REN \| DISEASES 1393 \| CRHBP \| DISEASES 4594 \| MUT \| DISEASES 3484 \| IGFBP1 \| DISEASES 2796 \| GNRH1 \| DISEASES 1392 \| CRH \| DISEASES 4863 \| NPAT \| DISEASES 83439 \| TCF7L1 \| DISEASES 3087 \| HHEX \| DISEASES 4838 \| NODAL \| DISEASES 286053 \| NSMCE2 \| DISEASES 6750 \| SST \| DISEASES 6777 \| STAT5B \| DISEASES 60675 \| PROK2 \| DISEASES 3549 \| IHH \| DISEASES 8820 \| HESX1 \| DISEASES 25886 \| POC1A \| DISEASES 6469 \| SHH \| DISEASES 83550 \| GPR101 \| DISEASES 915 \| CD3D \| DISEASES 81620 \| CDT1 \| DISEASES 5617 \| PRL \| DISEASES 3479 \| IGF1 \| DISEASES 7200 \| TRH \| DISEASES 1493 \| CTLA4 \| DISEASES 5308 \| PITX2 \| DISEASES 147 \| ADRA1B \| DISEASES 9079 \| LDB2 \| DISEASES 9915 \| ARNT2 \| DISEASES 64852 \| TUT1 \| DISEASES 695 \| BTK \| DISEASES 7201 \| TRHR \| DISEASES 2000 \| ELF4 \| DISEASES 5626 \| PROP1 \| DISEASES 3952 \| LEP \| DISEASES 2688 \| GH1 \| DISEASES 2771 \| GNAI2 \| DISEASES 51574 \| LARP7 \| DISEASES 4234 \| METTL1 \| DISEASES 1442 \| CSH1 \| DISEASES 2692 \| GHRHR \| DISEASES 2253 \| FGF8 \| DISEASES 2274 \| FHL2 \| DISEASES 84126 \| ATRIP \| DISEASES 6657 \| SOX2 \| DISEASES 63925 \| ZNF335 \| DISEASES 10293 \| TRAIP \| DISEASES 4990 \| SIX6 \| DISEASES 10785 \| WDR4 \| DISEASES 84295 \| PHF6 \| DISEASES 3543 \| IGLL1 \| DISEASES 6906 \| SERPINA7 \| DISEASES 8971 \| H1FX \| DISEASES 84679 \| SLC9A7 \| DISEASES 83482 \| SCRT1 \| DISEASES 286410 \| ATP11C \| DISEASES 51738 \| GHRL \| DISEASES 80254 \| CEP63 \| DISEASES 4221 \| MEN1 \| DISEASES 7225 \| TRPC6 \| DISEASES 7518 \| XRCC4 \| DISEASES 5449 \| POU1F1 \| DISEASES 545 \| ATR \| DISEASES 55755 \| CDK5RAP2 \| DISEASES 5015 \| OTX2 \| DISEASES 54820 \| NDE1 \| DISEASES 57596 \| BEGAIN \| DISEASES 26503 \| SLC17A5 \| DISEASES 91687 \| CENPL \| DISEASES 26052 \| DNM3 \| DISEASES 5116 \| PCNT \| DISEASES 147409 \| DSG4 \| DISEASES 9782 \| MATR3 \| DISEASES 2736 \| GLI2 \| DISEASES 259230 \| SGMS1 \| DISEASES 23137 \| SMC5 \| DISEASES 24149 \| ZNF318 \| DISEASES 3664 \| IRF6 \| DISEASES 9095 \| TBX19 \| DISEASES 51506 \| UFC1 \| DISEASES 632 \| BGLAP \| DISEASES 23036 \| ZNF292 \| DISEASES 6566 \| SLC16A1 \| DISEASES 2316 \| FLNA \| DISEASES 2773 \| GNAI3 \| DISEASES 4791 \| NFKB2 \| DISEASES 6658 \| SOX3 \| DISEASES 959 \| CD40LG \| DISEASES 3547 \| IGSF1 \| DISEASES 27022 \| FOXD3 \| DISEASES 56889 \| TM9SF3 \| DISEASES 7737 \| RNF113A \| DISEASES 4998 \| ORC1 \| DISEASES 8022 \| LHX3 \| DISEASES 57169 \| ZNFX1 \| DISEASES 55661 \| DDX27 \| DISEASES 80712 \| ESX1 \| DISEASES 9355 \| LHX2 \| DISEASES 7088 \| TLE1 \| DISEASES 8928 \| FOXH1 \| DISEASES 123872 \| DNAAF1 \| DISEASES 190 \| NR0B1 \| DISEASES 5080 \| PAX6 \| DISEASES 10300 \| KATNB1 \| DISEASES 551 \| AVP \| DISEASES 6462 \| SHBG \| DISEASES 54875 \| CNTLN \| DISEASES 3030 \| HADHA \| DISEASES 3486 \| IGFBP3 \| DISEASES 6473 \| SHOX \| DISEASES 55835 \| CENPJ \| DISEASES 5618 \| PRLR \| DISEASES 51244 \| CCDC174 \| DISEASES 80757 \| TMEM121 \| DISEASES 1443 \| CSH2 \| DISEASES 174 \| AFP \| DISEASES 2737 \| GLI3 \| DISEASES 163223 \| ZNF676 \| DISEASES 22995 \| CEP152 \| DISEASES 9718 \| ECE2 \| DISEASES 2492 \| FSHR \| DISEASES 284403 \| WDR62 \| DISEASES 2641 \| GCG \| DISEASES 55599 \| RNPC3 \| DISEASES 3481 \| IGF2 \| DISEASES 55636 \| CHD7 \| DISEASES 8861 \| LDB1 \| DISEASES 2260 \| FGFR1 \| DISEASES 8318 \| CDC45 \| DISEASES 8439 \| NSMAF \| DISEASES 1967 \| EIF2B1 \| DISEASES 3483 \| IGFALS \| DISEASES 60559 \| SPCS3 \| DISEASES 2675 \| GFRA2 \| DISEASES 137075 \| CLDN23 \| DISEASES 100423062 \| IGLL5 \| DISEASES 9820 \| CUL7 \| DISEASES 27164 \| SALL3 \| DISEASES 246744 \| STH \| DISEASES 64426 \| SUDS3 \| DISEASES 7090 \| TLE3 \| DISEASES 284424 \| MIR7-3HG \| DISEASES 100151683 \| RNU4ATAC \| DISEASES 677833 \| SNORA54 \| DISEASES 692057 \| SNORD12 \| DISEASES
Locus	(Waiting for update.)

Disease ID	221
Disease	hypopituitarism
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:51) HP:0000824 \| Growth hormone deficiency \| 6 HP:0000821 \| Underactive thyroid \| 5 HP:0000135 \| Hypogonadism \| 4 HP:0011787 \| Central hypothyroidism \| 4 HP:0000873 \| Diabetes insipidus \| 4 HP:0002893 \| Pituitary adenoma \| 4 HP:0000845 \| Acromegalic growth \| 3 HP:0002664 \| Neoplasia \| 3 HP:0001876 \| Low blood cell count \| 3 HP:0000609 \| Optic nerve hypoplasia \| 3 HP:0001297 \| Cerebral vascular events \| 2 HP:0000870 \| Hyperprolactinemia \| 2 HP:0030062 \| Craniopharyngioma \| 2 HP:0012191 \| B-cell lymphoma \| 2 HP:0001943 \| Hypoglycemia \| 2 HP:0001638 \| Cardiomyopathy \| 2 HP:0011748 \| Adrenocorticotropic hormone deficiency \| 2 HP:0002140 \| Ischemic stroke \| 2 HP:0000938 \| Decreased bone mineral density \| 1 HP:0003510 \| Proportionate dwarfism \| 1 HP:0100842 \| Septo-optic dysplasia \| 1 HP:0000939 \| Osteoporosis \| 1 HP:0008207 \| Addison's disease \| 1 HP:0001259 \| Coma \| 1 HP:0100646 \| Thyroiditis \| 1 HP:0002516 \| Intracranial pressure elevation \| 1 HP:0011734 \| Central adrenal insufficiency \| 1 HP:0002617 \| Aneurysmal dilatation \| 1 HP:0012125 \| Prostate cancer \| 1 HP:0010627 \| Anterior pituitary hypoplasia \| 1 HP:0000871 \| Panhypopituitarism \| 1 HP:0002138 \| Subarachnoid hemorrhage \| 1 HP:0030149 \| Cardiovascular shock \| 1 HP:0012342 \| Macroprolactinoma \| 1 HP:0002383 \| Encephalitis \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0001325 \| Coma caused by low blood sugar \| 1 HP:0002902 \| Hyponatremia \| 1 HP:0002098 \| Respiratory distress \| 1 HP:0008245 \| Thyroid stimulating hormone deficiency \| 1 HP:0006721 \| Acute lymphocytic leukemia \| 1 HP:0000846 \| Hypoadrenalism \| 1 HP:0000505 \| Poor vision \| 1 HP:0000863 \| Neurohypophyseal diabetes insipidus \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0000238 \| Nonsyndromal hydrocephalus \| 1 HP:0001508 \| Weight faltering \| 1 HP:0011675 \| Arrhythmias \| 1 HP:0002665 \| Lymphoma \| 1 HP:0005103 \| Calcification of the auricular cartilage \| 1 HP:0000823 \| Pubertal delay \| 1

Disease ID	221
Disease	hypopituitarism
Manually Symptom	UMLS \| Name(Total Manually Symptoms:46) C2697310 \| sarcoidosis C2364118 \| weakness C2318511 \| nonalcoholic steatohepatitis C1963059 \| adrenal insufficiency C1695689 \| non-dipping C1555754 \| cardiovascular disease C1112443 \| male sexual dysfunction C1000483 \| anemia C0878544 \| cardiomyopathy C0856169 \| endothelial dysfunction C0851302 \| hypoglycemic shock C0700502 \| primary hypothyroidism C0600142 \| hot flashes C0549473 \| thyroid carcinoma C0497327 \| dementia C0422833 \| ent symptoms C0342527 \| androgen deficiency C0339477 \| lipemia retinalis C0271801 \| central hypothyroidism C0271561 \| growth hormone deficiency C0242339 \| dyslipidemia C0235394 \| wasting C0234428 \| disturbances of consciousness C0233401 \| psychiatric symptom C0042373 \| vascular disease C0040156 \| thyrotoxicosis C0040147 \| thyroiditis C0033975 \| psychosis C0032000 \| pituitary adenomas C0032000 \| pituitary adenoma C0030421 \| paraganglioma C0030312 \| pancytopenia C0020676 \| thyroid insufficiency C0020625 \| hyponatremia C0020550 \| hyperthyroidism C0020473 \| hyperlipidaemia C0020473 \| hyperlipemia C0018802 \| congestive heart failure C0011849 \| diabetes mellitus C0011608 \| dermatitis herpetiformis C0009241 \| cognitive disorders C0004352 \| autism C0004153 \| atherosclerosis C0004096 \| asthma C0002940 \| aneurysm C0002871 \| anaemia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:11) C0271801 \| central hypothyroidism \| 4 C0013338 \| growth hormone deficiency \| 4 C0032000 \| pituitary adenoma \| 3 C0030312 \| pancytopenia \| 3 C0856169 \| endothelial dysfunction \| 2 C0878544 \| cardiomyopathy \| 2 C0042373 \| vascular disease \| 1 C0001623 \| adrenal insufficiency \| 1 C0007115 \| thyroid cancer \| 1 C0007222 \| cardiovascular disease \| 1 C0040147 \| thyroiditis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
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All Snps(Total Genotypes:0)
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GWASdb Annotation(Total Genotypes:0)
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GWASdb Snp Trait(Total Genotypes:0)
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Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
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Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0020635	morphine	D009020	57-27-2	hypopituitarism	MESH:D007018	marker/mechanism	14631063
C0020635	progesterone	D011374	57-83-0	hypopituitarism	MESH:D007018	therapeutic	2673747

FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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