PedAM

Pediatric Disease Annotations & Medicines


	hyperthyroidism

Disease ID	320
Disease	hyperthyroidism
Definition	Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.
Synonym	hyperthyroid hyperthyroidism (disorder) hyperthyroidism [disease/finding] hyperthyroidism nos hyperthyroidism, nos hyperthyroids overactive thyroid
DOID	DOID:7998
UMLS	C0020550
MeSH	D006980
SNOMED-CT	SNOMEDCT_US_2016_09_01:34486009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:160) C0018213 \| graves' disease \| 21 C0018021 \| goiter \| 14 C0020676 \| hypothyroidism \| 13 C0018799 \| heart disease \| 12 C0018801 \| heart failure \| 12 C0010068 \| coronary heart disease \| 9 C0020538 \| hypertension \| 9 C0040147 \| thyroiditis \| 9 C0007115 \| thyroid ca \| 7 C0011847 \| diabetes \| 6 C0040156 \| thyrotoxicosis \| 6 C0040137 \| thyroid nodule \| 6 C0007115 \| thyroid cancer \| 5 C0029456 \| osteoporosis \| 5 C0018021 \| goitre \| 5 C0027051 \| myocardial infarction \| 4 C0018023 \| nodular goiter \| 4 C0030312 \| pancytopenia \| 4 C0027051 \| myocardial infarct \| 4 C0018802 \| congestive heart failure \| 4 C0001430 \| adenoma \| 4 C0878544 \| cardiomyopathy \| 4 C0151468 \| thyroid adenoma \| 4 C0040053 \| thrombosis \| 3 C0020676 \| hypothyroid \| 3 C0032000 \| pituitary adenoma \| 3 C0398623 \| hypercoagulable state \| 3 C0018801 \| cardiac failure \| 3 C0030443 \| periodic paralysis \| 3 C0020450 \| hyperemesis gravidarum \| 3 C0020542 \| pulmonary hypertension \| 3 C0398623 \| hypercoagulability \| 3 C0238358 \| hypokalemic periodic paralysis \| 3 C0235250 \| hyperemesis \| 3 C0022661 \| chronic kidney disease \| 2 C0004096 \| asthma \| 2 C0010278 \| craniosynostosis \| 2 C0022116 \| ischemia \| 2 C0042373 \| vascular disorder \| 2 C0497327 \| dementia \| 2 C0026848 \| muscular disorders \| 2 C0155626 \| acute myocardial infarction \| 2 C0020550 \| hyperthyroidism \| 2 C0042373 \| vascular disorders \| 2 C0342199 \| iodine deficiency \| 2 C0040137 \| thyroid nodules \| 2 C0030319 \| panic disorder \| 2 C0042870 \| vitamin d deficiency \| 2 C0001824 \| agranulocytosis \| 2 C0342208 \| multinodular goitre \| 2 C0677607 \| hashimoto thyroiditis \| 2 C0018213 \| graves disease \| 2 C0745140 \| hyperthyroid \| 2 C0026848 \| myopathy \| 2 C0040128 \| thyroid disease \| 2 C0007222 \| cardiovascular disorders \| 2 C0040127 \| thyroid storm \| 2 C0018023 \| nodular goitre \| 2 C0020437 \| hypercalcemia \| 2 C0032914 \| preeclampsia \| 2 C0023895 \| liver disease \| 2 C0011570 \| depression \| 2 C0034065 \| pulmonary embolism \| 2 C0002871 \| anemia \| 2 C0042870 \| vitamin d defic \| 2 C0033975 \| psychosis \| 2 C0549473 \| thyroid carcinoma \| 2 C0023418 \| leukemia \| 1 C0033038 \| premature ejaculation \| 1 C0000809 \| recurrent miscarriage \| 1 C0011848 \| diabetes insipidus \| 1 C0677607 \| hashimoto's disease \| 1 C0206682 \| follicular carcinoma \| 1 C0002170 \| alopecia \| 1 C1619734 \| pulmonary arterial hypertension \| 1 C0018024 \| retrosternal goitre \| 1 C0019196 \| hepatitis c \| 1 C0022661 \| end stage renal disease (esrd) \| 1 C0002395 \| alzheimer's disease \| 1 C0015397 \| eye disease \| 1 C0027145 \| myxedema \| 1 C0000809 \| recurrent miscarriages \| 1 C0018799 \| heart diseases \| 1 C0025183 \| meige's syndrome \| 1 C0010308 \| cretinism \| 1 C0019158 \| hepatitis \| 1 C0032000 \| pituitary adenomas \| 1 C0000786 \| miscarriage \| 1 C0008370 \| cholestasis \| 1 C0034372 \| quadriplegia \| 1 C0040100 \| thymoma \| 1 C0018024 \| intrathoracic goiter \| 1 C0152025 \| polyneuropathy \| 1 C0041696 \| major depressive disorder \| 1 C0004153 \| atherosclerosis \| 1 C0028754 \| obesity \| 1 C0042384 \| vasculitis \| 1 C0020456 \| hyperglycemia \| 1 C0159069 \| impaired glucose tolerance \| 1 C0002878 \| hemolytic anemia \| 1 C0022658 \| renal disease \| 1 C0042164 \| uveitis \| 1 C0009171 \| cocaine abuse \| 1 C0026896 \| myasthenia gravis \| 1 C0040150 \| acute suppurative thyroiditis \| 1 C0238463 \| papillary thyroid carcinoma \| 1 C0022354 \| cholestatic jaundice \| 1 C0042900 \| vitiligo \| 1 C0022658 \| nephropathy \| 1 C1135868 \| gestational trophoblastic neoplasia \| 1 C0272126 \| evans' syndrome \| 1 C0242520 \| chronic thyroiditis \| 1 C0031039 \| pericardial effusion \| 1 C0021053 \| immune disease \| 1 C0085681 \| hyperphosphatemia \| 1 C0013395 \| indigestion \| 1 C0013473 \| eating disorders \| 1 C0339143 \| thyroid ophthalmopathy \| 1 C0010481 \| cushing syndrome \| 1 C0022658 \| kidney disease \| 1 C0004096 \| bronchial asthma \| 1 C0006142 \| breast cancer \| 1 C0011860 \| type 2 diabetes \| 1 C0013384 \| dyskinesia \| 1 C0242231 \| coronary stenoses \| 1 C1561644 \| chronic kidney disease (ckd) \| 1 C1140680 \| malignant ovarian tumor \| 1 C1868720 \| periventricular nodular heterotopia \| 1 C0018799 \| cardiac disease \| 1 C0004245 \| atrioventricular block \| 1 C0262587 \| parathyroid adenoma \| 1 C0032002 \| pituitary disease \| 1 C0002871 \| anaemia \| 1 C0022116 \| ischaemia \| 1 C0030920 \| peptic ulcer \| 1 C0031511 \| pheochromocytoma \| 1 C0152171 \| idiopathic pulmonary hypertension \| 1 C0151740 \| increased intracranial pressure \| 1 C0342208 \| multinodular goiter \| 1 C0030499 \| parasitosis \| 1 C0020502 \| hyperparathyroidism \| 1 C0018099 \| gout \| 1 C0221002 \| primary hyperparathyroidism \| 1 C0030567 \| parkinson's disease \| 1 C0339143 \| thyroid eye disease \| 1 C0920350 \| autoimmune thyroiditis \| 1 C0259779 \| fibrous dysplasia \| 1 C0010073 \| coronary spasm \| 1 C0033687 \| proteinuria \| 1 C0013473 \| eating disorder \| 1 C0027868 \| neuromuscular disorders \| 1 C0339143 \| graves' ophthalmopathy \| 1 C0242604 \| thyroid hormone resistance \| 1 C0154143 \| toxic multinodular goitre \| 1 C0085655 \| polymyositis \| 1 C0034013 \| precocious puberty \| 1 C0005586 \| bipolar disorder \| 1 C0042721 \| viral hepatitis \| 1 C0022661 \| end stage renal disease \| 1 C0677607 \| hashimoto's thyroiditis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:9) SOD1 \| 6647 \| CTD_human SOD2 \| 6648 \| CTD_human PON1 \| 5444 \| CTD_human AQP1 \| 358 \| CTD_human TSHR \| 7253 \| CTD_human GPX1 \| 2876 \| CTD_human CAT \| 847 \| CTD_human CARTPT \| 9607 \| CTD_human GSR \| 2936 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) 4524 \| MTHFR \| infer 7421 \| VDR \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:325) 6515 \| SLC2A3 \| DISEASES 1361 \| CPB2 \| DISEASES 27102 \| EIF2AK1 \| DISEASES 9552 \| SPAG7 \| DISEASES 4320 \| MMP11 \| DISEASES 84844 \| PHF5A \| DISEASES 5020 \| OXT \| DISEASES 23439 \| ATP1B4 \| DISEASES 54 \| ACP5 \| DISEASES 7038 \| TG \| DISEASES 1666 \| DECR1 \| DISEASES 8797 \| TNFRSF10A \| DISEASES 56729 \| RETN \| DISEASES 973 \| CD79A \| DISEASES 9545 \| RAB3D \| DISEASES 6528 \| SLC5A5 \| DISEASES 5054 \| SERPINE1 \| DISEASES 4353 \| MPO \| DISEASES 5691 \| PSMB3 \| DISEASES 80157 \| CWH43 \| DISEASES 3558 \| IL2 \| DISEASES 4256 \| MGP \| DISEASES 3458 \| IFNG \| DISEASES 389434 \| IYD \| DISEASES 6908 \| TBP \| DISEASES 2690 \| GHR \| DISEASES 3565 \| IL4 \| DISEASES 338 \| APOB \| DISEASES 3488 \| IGFBP5 \| DISEASES 566 \| AZU1 \| DISEASES 4953 \| ODC1 \| DISEASES 5657 \| PRTN3 \| DISEASES 335 \| APOA1 \| DISEASES 7276 \| TTR \| DISEASES 134637 \| ADAT2 \| DISEASES 2691 \| GHRH \| DISEASES 8074 \| FGF23 \| DISEASES 57616 \| TSHZ3 \| DISEASES 2693 \| GHSR \| DISEASES 4852 \| NPY \| DISEASES 3759 \| KCNJ2 \| DISEASES 7355 \| SLC35A2 \| DISEASES 4974 \| OMG \| DISEASES 2678 \| GGT1 \| DISEASES 11135 \| CDC42EP1 \| DISEASES 482 \| ATP1B2 \| DISEASES 3630 \| INS \| DISEASES 3741 \| KCNA5 \| DISEASES 27112 \| FAM155B \| DISEASES 376497 \| SLC27A1 \| DISEASES 2056 \| EPO \| DISEASES 50617 \| ATP6V0A4 \| DISEASES 23378 \| RRP8 \| DISEASES 1401 \| CRP \| DISEASES 4922 \| NTS \| DISEASES 759 \| CA1 \| DISEASES 7252 \| TSHB \| DISEASES 2694 \| GIF \| DISEASES 79074 \| C2orf49 \| DISEASES 3569 \| IL6 \| DISEASES 29113 \| C6orf15 \| DISEASES 51163 \| DBR1 \| DISEASES 29953 \| TRHDE \| DISEASES 7450 \| VWF \| DISEASES 54947 \| LPCAT2 \| DISEASES 4591 \| TRIM37 \| DISEASES 28965 \| SLC27A6 \| DISEASES 5465 \| PPARA \| DISEASES 671 \| BPI \| DISEASES 25939 \| SAMHD1 \| DISEASES 7350 \| UCP1 \| DISEASES 3553 \| IL1B \| DISEASES 27143 \| PALD1 \| DISEASES 1991 \| ELANE \| DISEASES 56981 \| PRDM11 \| DISEASES 832 \| CAPZB \| DISEASES 84273 \| NOA1 \| DISEASES 79031 \| PDCL3 \| DISEASES 7067 \| THRA \| DISEASES 5443 \| POMC \| DISEASES 3383 \| ICAM1 \| DISEASES 1950 \| EGF \| DISEASES 5172 \| SLC26A4 \| DISEASES 5286 \| PIK3C2A \| DISEASES 3705 \| ITPK1 \| DISEASES 3480 \| IGF1R \| DISEASES 55520 \| ELAC1 \| DISEASES 3487 \| IGFBP4 \| DISEASES 126374 \| WTIP \| DISEASES 5226 \| PGD \| DISEASES 5972 \| REN \| DISEASES 23549 \| DNPEP \| DISEASES 185 \| AGTR1 \| DISEASES 3484 \| IGFBP1 \| DISEASES 6567 \| SLC16A2 \| DISEASES 84636 \| GPR174 \| DISEASES 2796 \| GNRH1 \| DISEASES 1392 \| CRH \| DISEASES 3439 \| IFNA1 \| DISEASES 3606 \| IL18 \| DISEASES 7069 \| THRSP \| DISEASES 23704 \| KCNE4 \| DISEASES 5163 \| PDK1 \| DISEASES 5741 \| PTH \| DISEASES 1420 \| CRYGC \| DISEASES 339896 \| GADL1 \| DISEASES 23250 \| ATP11A \| DISEASES 4900 \| NRGN \| DISEASES 6750 \| SST \| DISEASES 222696 \| ZSCAN23 \| DISEASES 56683 \| C21orf59 \| DISEASES 539 \| ATP5O \| DISEASES 1636 \| ACE \| DISEASES 181 \| AGRP \| DISEASES 3101 \| HK3 \| DISEASES 6755 \| SSTR5 \| DISEASES 7412 \| VCAM1 \| DISEASES 3973 \| LHCGR \| DISEASES 4880 \| NPPC \| DISEASES 213 \| ALB \| DISEASES 117156 \| SCGB3A2 \| DISEASES 9607 \| CARTPT \| DISEASES 94120 \| SYTL3 \| DISEASES 4982 \| TNFRSF11B \| DISEASES 7253 \| TSHR \| DISEASES 11067 \| C10orf10 \| DISEASES 27343 \| POLL \| DISEASES 6447 \| SCG5 \| DISEASES 3904 \| LAIR2 \| DISEASES 956 \| ENTPD3 \| DISEASES 5617 \| PRL \| DISEASES 3479 \| IGF1 \| DISEASES 7200 \| TRH \| DISEASES 1493 \| CTLA4 \| DISEASES 219409 \| GSX1 \| DISEASES 260425 \| MAGI3 \| DISEASES 84342 \| COG8 \| DISEASES 5066 \| PAM \| DISEASES 2353 \| FOS \| DISEASES 147 \| ADRA1B \| DISEASES 4632 \| MYL1 \| DISEASES 4176 \| MCM7 \| DISEASES 5122 \| PCSK1 \| DISEASES 2147 \| F2 \| DISEASES 3626 \| INHBC \| DISEASES 5340 \| PLG \| DISEASES 10008 \| KCNE3 \| DISEASES 7351 \| UCP2 \| DISEASES 3952 \| LEP \| DISEASES 55584 \| CHRNA9 \| DISEASES 2688 \| GH1 \| DISEASES 81832 \| NETO1 \| DISEASES 3737 \| KCNA2 \| DISEASES 201164 \| PLD6 \| DISEASES 22864 \| R3HDM2 \| DISEASES 7173 \| TPO \| DISEASES 132243 \| H1FOO \| DISEASES 23428 \| SLC7A8 \| DISEASES 9370 \| ADIPOQ \| DISEASES 64787 \| EPS8L2 \| DISEASES 6517 \| SLC2A4 \| DISEASES 6863 \| TAC1 \| DISEASES 4018 \| LPA \| DISEASES 4808 \| NHLH2 \| DISEASES 2274 \| FHL2 \| DISEASES 7352 \| UCP3 \| DISEASES 91012 \| CERS5 \| DISEASES 2187 \| FANCB \| DISEASES 2863 \| GPR39 \| DISEASES 3768 \| KCNJ12 \| DISEASES 114786 \| XKR4 \| DISEASES 3739 \| KCNA4 \| DISEASES 6906 \| SERPINA7 \| DISEASES 29110 \| TBK1 \| DISEASES 283869 \| NPW \| DISEASES 2831 \| NPBWR1 \| DISEASES 2520 \| GAST \| DISEASES 3772 \| KCNJ15 \| DISEASES 6401 \| SELE \| DISEASES 796 \| CALCA \| DISEASES 3751 \| KCND2 \| DISEASES 353164 \| TAS2R42 \| DISEASES 2152 \| F3 \| DISEASES 5133 \| PDCD1 \| DISEASES 51738 \| GHRL \| DISEASES 93974 \| ATPIF1 \| DISEASES 135 \| ADORA2A \| DISEASES 1103 \| CHAT \| DISEASES 3363 \| HTR7 \| DISEASES 23583 \| SMUG1 \| DISEASES 114904 \| C1QTNF6 \| DISEASES 84144 \| SYDE2 \| DISEASES 3770 \| KCNJ14 \| DISEASES 10488 \| CREB3 \| DISEASES 866 \| SERPINA6 \| DISEASES 31 \| ACACA \| DISEASES 7316 \| UBC \| DISEASES 2624 \| GATA2 \| DISEASES 100132406 \| NBPF10 \| DISEASES 3767 \| KCNJ11 \| DISEASES 51322 \| WAC \| DISEASES 286133 \| SCARA5 \| DISEASES 4624 \| MYH6 \| DISEASES 7068 \| THRB \| DISEASES 487 \| ATP2A1 \| DISEASES 6752 \| SSTR2 \| DISEASES 2764 \| GMFB \| DISEASES 10004 \| NAALADL1 \| DISEASES 1735 \| DIO3 \| DISEASES 9464 \| HAND2 \| DISEASES 57181 \| SLC39A10 \| DISEASES 26191 \| PTPN22 \| DISEASES 4151 \| MB \| DISEASES 51150 \| SDF4 \| DISEASES 2157 \| F8 \| DISEASES 80274 \| SCUBE1 \| DISEASES 23245 \| ASTN2 \| DISEASES 1733 \| DIO1 \| DISEASES 10724 \| MGEA5 \| DISEASES 779 \| CACNA1S \| DISEASES 54617 \| INO80 \| DISEASES 23038 \| WDTC1 \| DISEASES 183 \| AGT \| DISEASES 22796 \| COG2 \| DISEASES 11116 \| FGFR1OP \| DISEASES 6993 \| DYNLT1 \| DISEASES 7432 \| VIP \| DISEASES 481 \| ATP1B1 \| DISEASES 55811 \| ADCY10 \| DISEASES 336 \| APOA2 \| DISEASES 844 \| CASQ1 \| DISEASES 115352 \| FCRL3 \| DISEASES 632 \| BGLAP \| DISEASES 64077 \| LHPP \| DISEASES 117247 \| SLC16A10 \| DISEASES 262 \| AMD1 \| DISEASES 153 \| ADRB1 \| DISEASES 4803 \| NGF \| DISEASES 2832 \| NPBWR2 \| DISEASES 959 \| CD40LG \| DISEASES 2778 \| GNAS \| DISEASES 26027 \| ACOT11 \| DISEASES 3745 \| KCNB1 \| DISEASES 8022 \| LHX3 \| DISEASES 958 \| CD40 \| DISEASES 90550 \| MCU \| DISEASES 9452 \| ITM2A \| DISEASES 252995 \| FNDC5 \| DISEASES 253430 \| IPMK \| DISEASES 1043 \| CD52 \| DISEASES 23732 \| FRRS1L \| DISEASES 6257 \| RXRB \| DISEASES 2304 \| FOXE1 \| DISEASES 3055 \| HCK \| DISEASES 50943 \| FOXP3 \| DISEASES 4879 \| NPPB \| DISEASES 4878 \| NPPA \| DISEASES 6992 \| PPP1R11 \| DISEASES 3105 \| HLA-A \| DISEASES 1471 \| CST3 \| DISEASES 8718 \| TNFRSF25 \| DISEASES 57380 \| MRS2 \| DISEASES 2782 \| GNB1 \| DISEASES 1906 \| EDN1 \| DISEASES 5160 \| PDHA1 \| DISEASES 3440 \| IFNA2 \| DISEASES 3456 \| IFNB1 \| DISEASES 551 \| AVP \| DISEASES 6462 \| SHBG \| DISEASES 3486 \| IGFBP3 \| DISEASES 5618 \| PRLR \| DISEASES 6649 \| SOD3 \| DISEASES 83650 \| SLC35G5 \| DISEASES 54476 \| RNF216 \| DISEASES 6996 \| TDG \| DISEASES 6152 \| RPL24 \| DISEASES 4828 \| NMB \| DISEASES 79001 \| VKORC1 \| DISEASES 56624 \| ASAH2 \| DISEASES 816 \| CAMK2B \| DISEASES 5744 \| PTHLH \| DISEASES 144195 \| SLC2A14 \| DISEASES 55234 \| SMU1 \| DISEASES 594857 \| NPS \| DISEASES 6345 \| SRL \| DISEASES 10587 \| TXNRD2 \| DISEASES 2492 \| FSHR \| DISEASES 3098 \| HK1 \| DISEASES 728441 \| GGT2 \| DISEASES 7018 \| TF \| DISEASES 10989 \| IMMT \| DISEASES 3267 \| AGFG1 \| DISEASES 2641 \| GCG \| DISEASES 5073 \| PARN \| DISEASES 8604 \| SLC25A12 \| DISEASES 4295 \| MLN \| DISEASES 3481 \| IGF2 \| DISEASES 201456 \| FBXO15 \| DISEASES 7849 \| PAX8 \| DISEASES 6329 \| SCN4A \| DISEASES 7124 \| TNF \| DISEASES 51562 \| MBIP \| DISEASES 84290 \| CAPNS2 \| DISEASES 2145 \| EZH1 \| DISEASES 3451 \| IFNA17 \| DISEASES 6513 \| SLC2A1 \| DISEASES 4700 \| NDUFA6 \| DISEASES 2317 \| FLNB \| DISEASES 5164 \| PDK2 \| DISEASES 51428 \| DDX41 \| DISEASES 8635 \| RNASET2 \| DISEASES 4975 \| OMP \| DISEASES 930 \| CD19 \| DISEASES 100288485 \| MTRNR2L7 \| DISEASES 488 \| ATP2A2 \| DISEASES 3250 \| HPR \| DISEASES 6999 \| TDO2 \| DISEASES 4850 \| CNOT4 \| DISEASES 1734 \| DIO2 \| DISEASES 567 \| B2M \| DISEASES 5297 \| PI4KA \| DISEASES 102723508 \| KANTR \| DISEASES 348120 \| LINC01193 \| DISEASES 23642 \| SNHG1 \| DISEASES 27004 \| TCL6 \| DISEASES
Locus	(Waiting for update.)

Disease ID	320
Disease	hyperthyroidism
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:143) HP:0000853 \| Goitre \| 19 HP:0005110 \| Atrial fibrillation \| 18 HP:0000821 \| Underactive thyroid \| 13 HP:0001635 \| Congestive heart failure \| 13 HP:0100646 \| Thyroiditis \| 9 HP:0000822 \| Hypertension \| 9 HP:0000855 \| Insulin resistance \| 8 HP:0001824 \| Weight loss \| 6 HP:0000939 \| Osteoporosis \| 5 HP:0002900 \| Hypokalemia \| 4 HP:0011675 \| Arrhythmias \| 4 HP:0001638 \| Cardiomyopathy \| 4 HP:0000854 \| Thyroid adenoma \| 4 HP:0005994 \| Nodular goiter \| 4 HP:0001876 \| Low blood cell count \| 4 HP:0002092 \| Pulmonary artery hypertension \| 4 HP:0012188 \| Hyperemesis gravidarum \| 3 HP:0002893 \| Pituitary adenoma \| 3 HP:0001903 \| Anemia \| 3 HP:0003768 \| Periodic paralysis \| 3 HP:0000872 \| Hashimoto's thyroiditis \| 3 HP:0003470 \| Inability to move \| 3 HP:0000836 \| Overactive thyroid \| 3 HP:0001658 \| Myocardial infarction \| 3 HP:0030731 \| Carcinoma \| 3 HP:0001297 \| Cerebral vascular events \| 3 HP:0000952 \| Yellow skin \| 3 HP:0100724 \| Hypercoagulability \| 3 HP:0001649 \| Tachycardia \| 3 HP:0003198 \| Myopathic changes \| 2 HP:0100602 \| Pre-eclampsia \| 2 HP:0001324 \| Muscular weakness \| 2 HP:0000938 \| Decreased bone mineral density \| 2 HP:0000709 \| Psychosis \| 2 HP:0011665 \| Takotsubo cardiomyopathy \| 2 HP:0002925 \| Increased serum thyroid-stimulating hormone \| 2 HP:0001907 \| Thromboembolic disease \| 2 HP:0000820 \| Thyroid abnormality \| 2 HP:0002072 \| Chorea \| 2 HP:0002664 \| Neoplasia \| 2 HP:0002015 \| Swallowing difficulty \| 2 HP:0001363 \| Early fusion of cranial sutures \| 2 HP:0002099 \| Asthma \| 2 HP:0003072 \| Hypercalcemia \| 2 HP:0000752 \| Hyperactive behavior \| 2 HP:0100647 \| Morbus Basedow \| 2 HP:0000969 \| Dropsy \| 2 HP:0100512 \| Vitamin D deficiency \| 2 HP:0002204 \| Pulmonary embolism \| 2 HP:0012234 \| Agranulocytosis \| 2 HP:0002930 \| Resistance to thyroid hormone \| 2 HP:0002890 \| Thyroid carcinoma \| 2 HP:0001511 \| Prenatal onset growth retardation \| 2 HP:0000726 \| Dementia \| 2 HP:0100029 \| Lingual thyroid \| 2 HP:0012622 \| Chronic kidney disease \| 2 HP:0001399 \| Liver failure \| 2 HP:0003287 \| Abnormality of mitochondrial metabolism \| 2 HP:0000716 \| Depression \| 2 HP:0002046 \| Heat intolerance \| 2 HP:0004349 \| Reduced bone mineral density \| 2 HP:0004936 \| Blood clot in vein \| 2 HP:0002591 \| Voracious appetite \| 1 HP:0004308 \| Ventricular arrhythmia \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0001396 \| Cholestasis \| 1 HP:0001250 \| Seizures \| 1 HP:0002150 \| Hypercalcinuria \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0001878 \| Haemolytic anaemia \| 1 HP:0001623 \| Breech presentation at birth \| 1 HP:0002140 \| Ischemic stroke \| 1 HP:0001622 \| Premature delivery \| 1 HP:0012876 \| Premature ejaculation \| 1 HP:0004757 \| Paroxysmal atrial fibrillation \| 1 HP:0003074 \| High blood glucose \| 1 HP:0007302 \| Bipolar disorder \| 1 HP:0001578 \| Hypercortisolism \| 1 HP:0000873 \| Diabetes insipidus \| 1 HP:0001513 \| Obesity \| 1 HP:0005305 \| Cerebral vein thrombosis \| 1 HP:0006554 \| Acute hepatic failure \| 1 HP:0004398 \| Peptic ulcer \| 1 HP:0003546 \| Exercise intolerance \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0001698 \| Pericardial effusions \| 1 HP:0002157 \| Azotaemia \| 1 HP:0002797 \| Increased bone resorption \| 1 HP:0000112 \| Nephropathy \| 1 HP:0100615 \| Neoplasm of the ovary \| 1 HP:0006562 \| Viral hepatitis \| 1 HP:0002493 \| Corticospinal tract dysfunction \| 1 HP:0002905 \| Hyperphosphatemia \| 1 HP:0000078 \| Genital abnormalities \| 1 HP:0100028 \| Abnormal thryoid location \| 1 HP:0001541 \| Ascites \| 1 HP:0000093 \| Proteinuria \| 1 HP:0001045 \| Blotchy loss of skin color \| 1 HP:0011787 \| Central hypothyroidism \| 1 HP:0000738 \| Sensory hallucination \| 1 HP:0002013 \| Emesis \| 1 HP:0002445 \| Paralysis of all four limbs \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0008200 \| Primary hyperparathyroidism \| 1 HP:0002666 \| Pheochromocytoma \| 1 HP:0010741 \| Peripheral edema of lower extremity \| 1 HP:0012251 \| ST segment elevation \| 1 HP:0005987 \| Multinodular goiter \| 1 HP:0000554 \| Uveitis \| 1 HP:0001596 \| Hair loss \| 1 HP:0001259 \| Coma \| 1 HP:0001901 \| Abnormally shaped erythrocytes \| 1 HP:0100246 \| Osteoma \| 1 HP:0002287 \| Progressive alopecia \| 1 HP:0002621 \| Atherosclerosis \| 1 HP:0001337 \| Tremor \| 1 HP:0001909 \| Leukemia \| 1 HP:0003473 \| Fatigable weakness \| 1 HP:0001997 \| Gout \| 1 HP:0003201 \| Rhabdomyolysis \| 1 HP:0002516 \| Intracranial pressure elevation \| 1 HP:0003146 \| Decreased circulating cholesterol level \| 1 HP:0000967 \| Petechiae \| 1 HP:0000826 \| Precocious puberty \| 1 HP:0002895 \| Papillary thyroid carcinoma \| 1 HP:0000843 \| Hyperparathyroidism \| 1 HP:0002633 \| Vasculitis \| 1 HP:0008249 \| Large thyroid \| 1 HP:0000833 \| Glucose intolerance \| 1 HP:0002094 \| Dyspnea \| 1 HP:0001993 \| Ketoacidosis \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0002045 \| Abnormally low body temperature \| 1 HP:0001410 \| Decreased liver function \| 1 HP:0003701 \| Proximal limb muscle weakness \| 1 HP:0100660 \| Dyskinesis \| 1 HP:0100539 \| Periorbital swelling \| 1 HP:0002897 \| Parathyroid adenoma \| 1 HP:0100522 \| Thymoma \| 1 HP:0100820 \| Glomerulopathy \| 1 HP:0001254 \| Lethargy \| 1 HP:0001271 \| Polyneuropathy \| 1

Disease ID	320
Disease	hyperthyroidism
Manually Symptom	UMLS \| Name(Total Manually Symptoms:255) C2712340 \| dyspnoea C2712332 \| vomiting C2712323 \| hypoglycaemia C2712322 \| tachycardia C2711227 \| hepatic steatosis C2700526 \| erythrocytosis C2678504 \| osteoporosis C2676454 \| h syndrome C2364377 \| delirium C2364324 \| increased intracranial pressure C2364133 \| infection C2364118 \| weakness C2364108 \| stigma C2364072 \| depression C2364051 \| fatigue C2364050 \| hypothermia C2348360 \| atrial enlargement C2240374 \| eosinophilia C2219717 \| amenorrhea C2203646 \| jaundice C2186532 \| liver disease C2108109 \| sinus tachycardia C2108077 \| atrioventricular block C2048468 \| male infertility C2015956 \| throat pain C1963279 \| viral hepatitis C1963274 \| vasculitis C1963235 \| sick sinus syndrome C1963220 \| pulmonary hypertension C1963165 \| malabsorption C1963138 \| hypertension C1963135 \| hepatic necrosis C1963120 \| gynecomastia C1963091 \| diarrhea C1963064 \| anxiety C1956391 \| temporal arteritis C1868682 \| paroxysmal kinesigenic choreoathetosis C1839141 \| thyroxine-binding globulin deficiency C1704212 \| embolism C1619734 \| pulmonary arterial hypertension C1609519 \| adrenal myelolipoma C1565489 \| renal insufficiency C1555754 \| cardiovascular disease C1527330 \| pyridoxine deficiency C1522057 \| duodenitis C1456784 \| paranoid disorder C1442871 \| craniosynostosis C1442837 \| myocardial necrosis C1384672 \| hypoparathyroidism C1336753 \| thyroid lymphoma C1330961 \| acidity C1279412 \| periodic paralysis C1135191 \| systolic heart failure C1135188 \| critical illness myopathy C1059185 \| exophthalmus C1000483 \| anemia C0948266 \| latent tetany C0948008 \| ischemic stroke C0920157 \| mesenteric ischemia C0917981 \| progressive spinal muscular atrophy C0878544 \| cardiomyopathy C0851578 \| sleep disorders C0848676 \| male subfertility C0752303 \| urological manifestations C0752303 \| urological manifestation C0752196 \| ballism C0748159 \| pulmonary involvement C0743711 \| eye lesion C0741949 \| cardiovascular pathology C0740394 \| hyperuricemia C0700323 \| neuromuscular blockade C0679466 \| cognitive deficits C0678222 \| breast cancer C0600336 \| subcorneal pustular dermatosis C0600086 \| toxic goiter C0549473 \| thyroid gland carcinoma C0549473 \| thyroid carcinoma C0549473 \| thyroid cancer C0549473 \| carcinoma of the thyroid C0549473 \| cancer of the thyroid C0549124 \| arterial embolism C0542052 \| coronary insufficiency C0497327 \| dementia C0494491 \| mononeuropathy C0476270 \| cardiovascular symptoms C0428908 \| sinus node dysfunction C0427008 \| stiffness C0426768 \| o sign C0424755 \| fever C0422833 \| ent symptoms C0419203 \| osteopathy C0410198 \| proximal myopathy C0400916 \| acute hepatitis e C0398623 \| hypercoagulable state C0398623 \| hypercoagulability state C0376293 \| stigmata C0342882 \| heterozygous familial hypercholesterolemia C0342342 \| idiopathic hypoparathyroidism C0339143 \| thyroid ophthalmopathy C0338573 \| cerebral venous sinus thrombosis C0311223 \| frozen shoulder C0277928 \| venous hum C0271650 \| impaired glucose tolerance C0271650 \| glucose intolerance C0270823 \| petit mal status C0270739 \| hemichorea C0270327 \| enuresis C0268445 \| normokalemic periodic paralysis C0268283 \| disorders of steroid metabolism C0267804 \| centrilobular hepatic necrosis C0266928 \| rapidly progressive periodontitis C0264886 \| conduction disorders C0264757 \| rheumatic valvular disease C0264686 \| coronary embolism C0262587 \| parathyroid adenoma C0243050 \| cardiovascular abnormalities C0242342 \| sheehan's syndrome C0242292 \| mccune-albright syndrome C0241885 \| exercise intolerance C0238462 \| medullary thyroid carcinoma C0236663 \| alcohol withdrawal syndrome C0235527 \| right-sided heart failure C0235527 \| right heart failure C0235480 \| paroxysmal atrial fibrillation C0235430 \| ketonaemia C0235401 \| abnormal glucose tolerance C0235394 \| wasting C0235369 \| granulomatous hepatitis C0235250 \| hyperemesis C0235169 \| excitability C0234132 \| pyramidal sign C0233401 \| psychiatric symptoms C0233397 \| psychological symptoms C0232848 \| secondary enuresis C0232197 \| fibrillation C0231230 \| fatigability C0221505 \| cerebral lesions C0221002 \| primary hyperparathyroidism C0206682 \| follicular carcinoma C0206146 \| myocardial stunning C0162568 \| erythropoietic protoporphyria C0162565 \| acute intermittent porphyria C0162316 \| iron deficiency anemia C0156259 \| renal hypertrophy C0155301 \| retrobulbar neuritis C0152171 \| primary pulmonary hypertension C0152171 \| idiopathic pulmonary hypertension C0152025 \| polyneuropathy C0151945 \| cerebral venous thrombosis C0151798 \| liver necrosis C0151744 \| myocardial ischemia C0149670 \| disorders of carbohydrate metabolism C0085681 \| hyperphosphatemia C0085681 \| hyperphosphataemia C0085661 \| onycholysis C0085655 \| polymyositis C0085583 \| choreoathetosis C0043117 \| idiopathic thrombocytopenic purpura C0043117 \| autoimmune thrombocytopenic purpura C0042024 \| loss of bladder control C0041326 \| pleural tuberculosis C0040149 \| subacute thyroiditis C0040137 \| thyroid nodules C0040034 \| thrombocytopenia C0039621 \| tetany C0038478 \| struma ovarii C0038238 \| steatorrhoea C0038218 \| status asthmaticus C0038013 \| ankylosing spondylitis C0037763 \| muscle spasms C0037672 \| sleepwalking C0035579 \| rickets C0035435 \| rheumatism C0034150 \| purpura C0034063 \| pulmonary edema C0033774 \| pruritus C0033103 \| pretibial myxedema C0033038 \| premature ejaculation C0032617 \| polyuria C0032000 \| pituitary adenomas C0031117 \| peripheral neuropathy C0030552 \| muscle pareses C0030517 \| parathyroid disease C0030312 \| pancytopenia C0029458 \| postmenopausal bone loss C0029132 \| optic neuropathies C0029089 \| oculomotor paralysis C0027947 \| neutropenia C0027868 \| neuromuscular disorders C0027726 \| nephrotic syndrome C0027145 \| myxoedema C0027145 \| myxedema C0027126 \| myotonic dystrophy C0027066 \| myoclonus C0027051 \| myocardial infarction C0026896 \| myasthenia gravis C0026848 \| myopathy C0026848 \| myopathies C0026848 \| muscular disorders C0026848 \| muscular diseases C0026846 \| muscle wasting C0026650 \| movement disorders C0026267 \| mitral valve prolapse C0026266 \| mitral regurgitation C0025517 \| metabolism disorder C0025517 \| metabolic disorders C0024141 \| systemic lupus erythematosus C0023895 \| hepatic pathology C0022972 \| lambert-eaton syndrome C0022354 \| cholestatic jaundice C0020640 \| hypoprothrombinemia C0020615 \| hypoglycemia C0020505 \| hyperphagia C0020502 \| hyperparathyroidism C0020456 \| hyperglycemia C0020437 \| hypercalcemia C0020437 \| hypercalcaemia C0020217 \| molar pregnancy C0019158 \| hepatitis C0018817 \| atrial septal defect C0018802 \| congestive heart failure C0018801 \| heart failure C0018801 \| cardiac insufficiency C0018801 \| cardiac failure C0018799 \| cardiac disorders C0018794 \| heart block C0018418 \| gynaecomastia C0018213 \| graves-basedow disease C0018213 \| graves' disease C0018021 \| goitre C0018021 \| goiter C0016065 \| polyostotic fibrous dysplasia C0015300 \| exophthalmos C0012569 \| diplopia C0012242 \| digestive diseases C0011880 \| diabetic ketosis C0011860 \| diabetes C0011849 \| diabetes mellitus C0011168 \| dysphagia C0010073 \| coronary vasospasm C0010073 \| coronary artery spasm C0008497 \| choriocarcinoma C0008489 \| chorea C0008372 \| intrahepatic cholestasis C0008312 \| primary biliary cirrhosis C0007222 \| cardiovascular disorders C0007193 \| dilated cardiomyopathy C0005779 \| blood coagulation disorders C0005586 \| bipolar disorder C0004936 \| mental disorders C0004364 \| autoimmune disorder C0004245 \| av blocks C0003811 \| rhythm disorder C0002892 \| pernicious anaemia C0001403 \| addison's disease
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:75) C0018213 \| graves' disease \| 21 C0232197 \| fibrillation \| 16 C0018021 \| goiter \| 14 C0018801 \| heart failure \| 9 C0020538 \| hypertension \| 9 C0011847 \| diabetes \| 6 C0007115 \| thyroid cancer \| 5 C0018021 \| goitre \| 5 C0878544 \| cardiomyopathy \| 4 C0030312 \| pancytopenia \| 4 C0029456 \| osteoporosis \| 4 C0018802 \| congestive heart failure \| 3 C0039231 \| tachycardia \| 3 C0398623 \| hypercoagulable state \| 3 C0030443 \| periodic paralysis \| 3 C0235250 \| hyperemesis \| 3 C0020542 \| pulmonary hypertension \| 3 C0004093 \| weakness \| 3 C0011168 \| dysphagia \| 2 C0040147 \| thyroiditis \| 2 C0020217 \| molar pregnancy \| 2 C0013922 \| embolism \| 2 C0026848 \| muscular disorders \| 2 C0022346 \| jaundice \| 2 C0018801 \| cardiac failure \| 2 C0549473 \| thyroid carcinoma \| 2 C0010278 \| craniosynostosis \| 2 C0020437 \| hypercalcemia \| 2 C0026848 \| myopathy \| 2 C0023895 \| liver disease \| 2 C0009450 \| infection \| 2 C0027051 \| myocardial infarction \| 2 C0497327 \| dementia \| 2 C0011570 \| depression \| 2 C0007222 \| cardiovascular disorders \| 2 C0040137 \| thyroid nodules \| 1 C0221002 \| primary hyperparathyroidism \| 1 C0152025 \| polyneuropathy \| 1 C0085655 \| polymyositis \| 1 C0410198 \| proximal myopathy \| 1 C0020456 \| hyperglycemia \| 1 C0042963 \| vomiting \| 1 C0948008 \| ischemic stroke \| 1 C0085681 \| hyperphosphatemia \| 1 C0027126 \| myotonic dystrophy \| 1 C0426768 \| o sign \| 1 C0042721 \| viral hepatitis \| 1 C0019158 \| hepatitis \| 1 C0151740 \| increased intracranial pressure \| 1 C0020672 \| hypothermia \| 1 C0233401 \| psychiatric symptoms \| 1 C0032000 \| pituitary adenomas \| 1 C0262587 \| parathyroid adenoma \| 1 C0151945 \| cerebral venous thrombosis \| 1 C0002871 \| anemia \| 1 C0241885 \| exercise intolerance \| 1 C0270739 \| hemichorea \| 1 C1527405 \| erythrocytosis \| 1 C0004096 \| asthma \| 1 C0020502 \| hyperparathyroidism \| 1 C0206682 \| follicular carcinoma \| 1 C0339143 \| thyroid ophthalmopathy \| 1 C0026896 \| myasthenia gravis \| 1 C0027145 \| myxedema \| 1 C0235480 \| paroxysmal atrial fibrillation \| 1 C0159069 \| impaired glucose tolerance \| 1 C0042384 \| vasculitis \| 1 C0027868 \| neuromuscular disorders \| 1 C0008489 \| chorea \| 1 C0020505 \| hyperphagia \| 1 C0033038 \| premature ejaculation \| 1 C0235527 \| right heart failure \| 1 C0152171 \| idiopathic pulmonary hypertension \| 1 C0005586 \| bipolar disorder \| 1 C1619734 \| pulmonary arterial hypertension \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs121908873	18466076	7253	TSHR	umls:C0020550	BeFree	Interestingly, an additional constitutively active somatic mutation (S281N) was identified on the second parental TSHR allele of the hyperthyroid index patient.	0.152642545	2008	TSHR;LOC101928462	14	81139828	G	A,T
rs17879469	22968483	26191	PTPN22	umls:C0020550	BeFree	Evaluation of genotypes (HLA DRB103, DQA105, DQB1*02; CTLA4 49A/G, CT60 A/G; PTPN22 C/T) in relation to phenotypes (age, sex, severity (clinical, biochemical, and immunological)) of hyperthyroidism and environmental factors (smoking, stress questionnaires).	0.000271442	2012	HLA-DRB1;LOC105369230	6	32584333	C	G
rs17879469	22968483	3123	HLA-DRB1	umls:C0020550	BeFree	Evaluation of genotypes (HLA DRB103, DQA105, DQB1*02; CTLA4 49A/G, CT60 A/G; PTPN22 C/T) in relation to phenotypes (age, sex, severity (clinical, biochemical, and immunological)) of hyperthyroidism and environmental factors (smoking, stress questionnaires).	0.000271442	2012	HLA-DRB1;LOC105369230	6	32584333	C	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:11)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0020550	carbimazole	D002231	22232-54-8	hyperthyroidism	MESH:D006980	therapeutic	12549952
C0020550	glutathione	D005978	70-18-8	hyperthyroidism	MESH:D006980	marker/mechanism	19914224
C0020550	peginterferon alfa-2a	C100416	-	hyperthyroidism	MESH:D006980	marker/mechanism	18097301
C0020550	propranolol	D011433	525-66-6	hyperthyroidism	MESH:D006980	therapeutic	11193444
C0020550	propylthiouracil	D011441	51-52-5	hyperthyroidism	MESH:D006980	marker/mechanism	12621104
C0020550	propylthiouracil	D011441	51-52-5	hyperthyroidism	MESH:D006980	therapeutic	11014318
C0020550	reserpine	D012110	50-55-5	hyperthyroidism	MESH:D006980	therapeutic	4589407
C0020550	ribavirin	D012254	36791-04-5	hyperthyroidism	MESH:D006980	marker/mechanism	18097301
C0020550	rifampin	D012293	13292-46-1	hyperthyroidism	MESH:D006980	marker/mechanism	16236685
C0020550	sotalol	D013015	3930-20-9	hyperthyroidism	MESH:D006980	marker/mechanism	83509
C0020550	vitamin e	D014810	1406-18-4	hyperthyroidism	MESH:D006980	therapeutic	19914224

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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