PedAM

Pediatric Disease Annotations & Medicines


	hypertensive encephalopathy

Disease ID	1297
Disease	hypertensive encephalopathy
Definition	Brain dysfunction or damage resulting from sustained MALIGNANT HYPERTENSION. When BLOOD PRESSURE exceeds the limits of cerebral autoregulation, cerebral blood flow is impaired (BRAIN ISCHEMIA). Clinical manifestations include HEADACHE; NAUSEA; VOMITING; SEIZURES; altered mental status (in some cases progressing to COMA); PAPILLEDEMA; and RETINAL HEMORRHAGE.
Synonym	enceph hypertensive encephalopathy hypertensive encephalopathy, hypertensive hypertens encephalopathy hypertensive enceph hypertensive encephalopathy (disorder) hypertensive encephalopathy [disease/finding]
DOID	DOID:9427
ICD10	ICD10CM:I67.4
UMLS	C0151620
MeSH	D020343
SNOMED-CT	SNOMEDCT_US_2016_09_01:50490005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:19) C0497327 \| dementia \| 2 C0020538 \| hypertension \| 2 C0520679 \| obstructive sleep apnoea syndrome \| 1 C0221043 \| liddle's syndrome \| 1 C0014544 \| epilepsy \| 1 C0033687 \| proteinuria \| 1 C0030353 \| papilledema \| 1 C0035078 \| renal failure \| 1 C0341950 \| severe pre-eclampsia \| 1 C0037315 \| sleep apnoea \| 1 C0022661 \| chronic renal failure \| 1 C0037315 \| sleep apnoea syndrome \| 1 C0038220 \| status epilepticus \| 1 C0022658 \| renal disease \| 1 C0013537 \| eclampsia \| 1 C0743039 \| progressive dementia \| 1 C0520679 \| obstructive sleep apnoea \| 1 C0270612 \| leukoencephalopathy \| 1 C0020540 \| malignant hypertension \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:33) 6376 \| CX3CL1 \| DISEASES 10005 \| ACOT8 \| DISEASES 55907 \| CMAS \| DISEASES 8195 \| MKKS \| DISEASES 2056 \| EPO \| DISEASES 2670 \| GFAP \| DISEASES 3357 \| HTR2B \| DISEASES 1588 \| CYP19A1 \| DISEASES 5443 \| POMC \| DISEASES 5972 \| REN \| DISEASES 133 \| ADM \| DISEASES 1636 \| ACE \| DISEASES 213 \| ALB \| DISEASES 6866 \| TAC3 \| DISEASES 375611 \| SLC26A5 \| DISEASES 4968 \| OGG1 \| DISEASES 64764 \| CREB3L2 \| DISEASES 1641 \| DCX \| DISEASES 4306 \| NR3C2 \| DISEASES 1809 \| DPYSL3 \| DISEASES 100506658 \| OCLN \| DISEASES 1524 \| CX3CR1 \| DISEASES 3164 \| NR4A1 \| DISEASES 6446 \| SGK1 \| DISEASES 4923 \| NTSR1 \| DISEASES 427 \| ASAH1 \| DISEASES 7436 \| VLDLR \| DISEASES 361 \| AQP4 \| DISEASES 7122 \| CLDN5 \| DISEASES 3550 \| IK \| DISEASES 627 \| BDNF \| DISEASES 6207 \| RPS13 \| DISEASES 102723508 \| KANTR \| DISEASES
Locus	(Waiting for update.)

Disease ID	1297
Disease	hypertensive encephalopathy
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:21) HP:0001250 \| Seizures \| 3 HP:0001298 \| Encephalopathy \| 3 HP:0002315 \| Headaches \| 2 HP:0000822 \| Hypertension \| 2 HP:0000969 \| Dropsy \| 2 HP:0000726 \| Dementia \| 2 HP:0002133 \| Status epilepticus \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0002170 \| Intracranial hemorrhage \| 1 HP:0002352 \| Leukoencephalopathy \| 1 HP:0001289 \| Confusion \| 1 HP:0001085 \| Papilledema \| 1 HP:0002104 \| Absence of spontaneous respiration \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0002157 \| Azotaemia \| 1 HP:0000093 \| Proteinuria \| 1 HP:0002664 \| Neoplasia \| 1 HP:0010535 \| Sleep apnea \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0001254 \| Lethargy \| 1 HP:0100601 \| Eclampsia \| 1

Disease ID	1297
Disease	hypertensive encephalopathy
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0036572 \| seizures \| 3 C0497327 \| dementia \| 2

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:4)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0151620	caffeine	D002110	1958/8/2	hypertensive encephalopathy	MESH:D020343	marker/mechanism	16956868
C0151620	carbamazepine	D002220	298-46-4	hypertensive encephalopathy	MESH:D020343	therapeutic	11836887
C0151620	labetalol	D007741	36894-69-6	hypertensive encephalopathy	MESH:D020343	therapeutic	115540
C0151620	phenytoin	D010672	57-41-0	hypertensive encephalopathy	MESH:D020343	therapeutic	11836887

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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