PedAM

Pediatric Disease Annotations & Medicines


	hypersplenism

Disease ID	1219
Disease	hypersplenism
Definition	Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy.
Synonym	big spleen syndrome hypersplenia hypersplenism (disorder) hypersplenism [disease/finding] hypersplenism, nos
DOID	DOID:6376
ICD10	ICD10CM:D73.1
UMLS	C0020532
MeSH	D006971
SNOMED-CT	SNOMEDCT_US_2016_09_01:58381000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:35) C0040034 \| thrombocytopenia \| 23 C0023890 \| cirrhosis \| 12 C0023890 \| liver cirrhosis \| 8 C0020541 \| portal hypertension \| 8 C0020538 \| hypertension \| 6 C0030312 \| pancytopenia \| 5 C0023895 \| liver disease \| 3 C0023895 \| liver diseases \| 3 C0019204 \| hepatocellular carcinoma \| 3 C0002871 \| anemia \| 3 C0019158 \| hepatitis \| 3 C0023530 \| leucopenia \| 2 C0019151 \| hepatic encephalopathy \| 2 C0014867 \| esophageal varices \| 2 C0023530 \| leukopenia \| 2 C0027947 \| neutropenia \| 2 C0008311 \| cholangitis \| 1 C0155773 \| portal vein thrombosis \| 1 C0023530 \| leukocytopenia \| 1 C0024623 \| gastric cancer \| 1 C0042345 \| varices \| 1 C0019196 \| hepatitis c \| 1 C0039730 \| thalassemia \| 1 C0019163 \| hepatitis b \| 1 C0019202 \| wilson's disease \| 1 C0008325 \| cholecystitis \| 1 C0002895 \| sickle cell disease \| 1 C0014867 \| oesophageal varices \| 1 C0023290 \| visceral leishmaniasis \| 1 C0037889 \| hereditary spherocytosis \| 1 C0023281 \| leishmaniasis \| 1 C0024790 \| paroxysmal nocturnal hemoglobinuria \| 1 C0023891 \| alcoholic cirrhosis \| 1 C0005283 \| beta thalassemia \| 1 C0042721 \| viral hepatitis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) FAS \| 355 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:78) 6362 \| CCL18 \| DISEASES 6793 \| STK10 \| DISEASES 27102 \| EIF2AK1 \| DISEASES 23645 \| PPP1R15A \| DISEASES 7066 \| THPO \| DISEASES 27344 \| PCSK1N \| DISEASES 54 \| ACP5 \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 952 \| CD38 \| DISEASES 3458 \| IFNG \| DISEASES 80218 \| NAA50 \| DISEASES 2678 \| GGT1 \| DISEASES 968 \| CD68 \| DISEASES 6299 \| SALL1 \| DISEASES 84262 \| PSMG3 \| DISEASES 2056 \| EPO \| DISEASES 8431 \| NR0B2 \| DISEASES 29969 \| MDFIC \| DISEASES 3674 \| ITGA2B \| DISEASES 3249 \| HPN \| DISEASES 7301 \| TYRO3 \| DISEASES 590 \| BCHE \| DISEASES 3589 \| IL11 \| DISEASES 950 \| SCARB2 \| DISEASES 150094 \| SIK1 \| DISEASES 3756 \| KCNH1 \| DISEASES 5295 \| PIK3R1 \| DISEASES 3439 \| IFNA1 \| DISEASES 27163 \| NAAA \| DISEASES 213 \| ALB \| DISEASES 3673 \| ITGA2 \| DISEASES 133418 \| EMB \| DISEASES 646 \| BNC1 \| DISEASES 2147 \| F2 \| DISEASES 1657 \| DMXL1 \| DISEASES 6868 \| ADAM17 \| DISEASES 924 \| CD7 \| DISEASES 2629 \| GBA \| DISEASES 9475 \| ROCK2 \| DISEASES 3039 \| HBA1 \| DISEASES 5580 \| PRKCD \| DISEASES 6297 \| SALL2 \| DISEASES 3043 \| HBB \| DISEASES 2152 \| F3 \| DISEASES 5501 \| PPP1CC \| DISEASES 3988 \| LIPA \| DISEASES 6609 \| SMPD1 \| DISEASES 54345 \| SOX18 \| DISEASES 3240 \| HP \| DISEASES 84458 \| LCOR \| DISEASES 5169 \| ENPP3 \| DISEASES 4217 \| MAP3K5 \| DISEASES 5294 \| PIK3CG \| DISEASES 2157 \| F8 \| DISEASES 462 \| SERPINC1 \| DISEASES 55974 \| SLC50A1 \| DISEASES 4288 \| MKI67 \| DISEASES 7390 \| UROS \| DISEASES 914 \| CD2 \| DISEASES 959 \| CD40LG \| DISEASES 978 \| CDA \| DISEASES 79048 \| SECISBP2 \| DISEASES 50943 \| FOXP3 \| DISEASES 64344 \| HIF3A \| DISEASES 1906 \| EDN1 \| DISEASES 54790 \| TET2 \| DISEASES 3704 \| ITPA \| DISEASES 3440 \| IFNA2 \| DISEASES 2618 \| GART \| DISEASES 83650 \| SLC35G5 \| DISEASES 51466 \| EVL \| DISEASES 728441 \| GGT2 \| DISEASES 7018 \| TF \| DISEASES 23066 \| CAND2 \| DISEASES 55683 \| KANSL3 \| DISEASES 7124 \| TNF \| DISEASES 440823 \| MIAT \| DISEASES
Locus	(Waiting for update.)

Disease ID	1219
Disease	hypersplenism
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:24) HP:0001873 \| Low platelet count \| 23 HP:0001394 \| Hepatic cirrhosis \| 12 HP:0001744 \| Splenomegaly \| 11 HP:0001409 \| Portal hypertension \| 8 HP:0000822 \| Hypertension \| 6 HP:0001876 \| Low blood cell count \| 5 HP:0001903 \| Anemia \| 3 HP:0001433 \| Enlarged liver and spleen \| 3 HP:0012115 \| Liver inflammation \| 3 HP:0030731 \| Carcinoma \| 2 HP:0002480 \| Hepatic encephalopathy \| 2 HP:0001402 \| Hepatocellular carcinoma \| 2 HP:0001875 \| Neutropenia \| 2 HP:0001882 \| Decreased blood leukocyte number \| 2 HP:0001298 \| Encephalopathy \| 2 HP:0030242 \| Blood clot in portal vein \| 1 HP:0006562 \| Viral hepatitis \| 1 HP:0004818 \| Paroxysmal nocturnal hemoglobinuria \| 1 HP:0030151 \| Cholangitis \| 1 HP:0012126 \| Gastric cancer \| 1 HP:0002584 \| Intestinal hemorrhage \| 1 HP:0001082 \| Cholecystitis \| 1 HP:0002239 \| Gastrointestinal hemorrhage \| 1 HP:0002716 \| Lymph node hyperplasia \| 1

Disease ID	1219
Disease	hypersplenism
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:5) C0040034 \| thrombocytopenia \| 23 C0020541 \| portal hypertension \| 8 C0030312 \| pancytopenia \| 5 C0002871 \| anemia \| 3 C0019204 \| hepatocellular carcinoma \| 2

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:0)
(Waiting for update.)

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

Web
Analytics