PedAM

Pediatric Disease Annotations & Medicines


	hypercalcemia

Disease ID	274
Disease	hypercalcemia
Definition	Abnormally high level of calcium in the blood.
Synonym	calcium blood increased high blood calcium levels hypercalcaemia hypercalcaemia syndrome hypercalcemia (disorder) hypercalcemia [disease/finding] hypercalcemia syndrome hypercalcemias hypercalcinemia increased calcium in blood raised serum calcium level raised serum calcium level (finding)
DOID	DOID:12678
ICD10	ICD10CM:E83.52
UMLS	C0020437
MeSH	D006934
SNOMED-CT	SNOMEDCT_US_2016_09_01:166702002;SNOMEDCT_US_2016_09_01:66931009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:160) C0020502 \| hyperparathyroidism \| 44 C0035078 \| renal failure \| 21 C0221002 \| primary hyperparathyroidism \| 19 C0030305 \| pancreatitis \| 19 C0026764 \| myeloma \| 11 C0001339 \| acute pancreatitis \| 10 C0036202 \| sarcoidosis \| 10 C0026764 \| multiple myeloma \| 10 C1565489 \| renal insufficiency \| 9 C0022660 \| acute renal failure \| 8 C0029456 \| osteoporosis \| 5 C0027709 \| nephrocalcinosis \| 5 C0001418 \| adenocarcinoma \| 4 C0687150 \| parathyroid carcinoma \| 4 C0023418 \| leukemia \| 4 C0007115 \| thyroid ca \| 4 C0549473 \| thyroid carcinoma \| 4 C0242379 \| lung cancer \| 4 C0022661 \| chronic kidney disease \| 3 C0006142 \| breast cancer \| 3 C0022658 \| kidney disease \| 3 C0007137 \| squamous cell carcinoma \| 3 C0024299 \| lymphoma \| 3 C0022658 \| renal disease \| 3 C0001206 \| acromegaly \| 3 C0346185 \| ovarian dysgerminoma \| 3 C0024299 \| lymphomas \| 3 C0036202 \| sarcoid \| 2 C0042133 \| uterine fibroid \| 2 C0392525 \| nephrolithiasis \| 2 C0023434 \| chronic lymphocytic leukemia \| 2 C0020626 \| hypoparathyroidism \| 2 C1140680 \| ovarian ca \| 2 C0023448 \| lymphocytic leukemia \| 2 C0001623 \| adrenal insufficiency \| 2 C0011848 \| diabetes insipidus \| 2 C0035078 \| kidney failure \| 2 C0175702 \| williams syndrome \| 2 C0019204 \| hepatocellular carcinoma \| 2 C0162283 \| nephrogenic diabetes insipidus \| 2 C0149521 \| recurrent pancreatitis \| 2 C0151468 \| thyroid adenoma \| 2 C0013377 \| dysgerminoma \| 2 C0027059 \| myocarditis \| 2 C0262587 \| parathyroid adenomas \| 2 C0020503 \| secondary hyperparathyroidism \| 2 C0041296 \| tuberculosis \| 2 C1561644 \| chronic kidney disease (ckd) \| 2 C0022661 \| chronic renal failure \| 2 C0262587 \| parathyroid adenoma \| 2 C0040156 \| thyrotoxicosis \| 2 C0079731 \| b-cell lymphoma \| 2 C1140680 \| ovarian cancer \| 2 C0206754 \| neuroendocrine tumor \| 2 C0019655 \| histoplasmosis \| 2 C0011847 \| diabetes \| 2 C0002448 \| ameloblastoma \| 2 C0011880 \| diabetic ketoacidosis \| 1 C0019829 \| hodgkin's lymphoma \| 1 C0026948 \| mycosis fungoides \| 1 C0029401 \| paget's disease of bone \| 1 C0022661 \| chronic renal disease \| 1 C0006663 \| calcinosis \| 1 C1140680 \| ovarian cancers \| 1 C0040147 \| thyroiditis \| 1 C0403447 \| chronic renal insufficiency \| 1 C0079731 \| b-cell non-hodgkin's lymphoma \| 1 C0276688 \| pulmonary cryptococcosis \| 1 C0007134 \| renal cell carcinoma \| 1 C0023449 \| acute lymphoblastic leukaemia \| 1 C0024305 \| non-hodgkin's lymphoma \| 1 C0040028 \| essential thrombocythemia \| 1 C0003864 \| arthritis \| 1 C0007138 \| urothelial carcinoma \| 1 C0279702 \| clear cell renal carcinoma \| 1 C0001126 \| renal tubular acidosis \| 1 C0012624 \| spondylodiscitis \| 1 C0001815 \| myelofibrosis \| 1 C0025267 \| multiple endocrine neoplasia type 1 \| 1 C0017920 \| glycogen storage disease type i \| 1 C0020550 \| hyperthyroidism \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0020630 \| hypophosphatasia \| 1 C0042133 \| uterine leiomyoma \| 1 C0018213 \| graves' disease \| 1 C0006160 \| brenner tumor \| 1 C0162299 \| thyroid cyst \| 1 C0022661 \| chronic kidney failure \| 1 C0023903 \| liver tumor \| 1 C0040128 \| thyroid disease \| 1 C0079731 \| b cell lymphoma \| 1 C0684249 \| carcinoma of the lung \| 1 C0024419 \| waldenstrom's macroglobulinaemia \| 1 C0494165 \| liver metastasis \| 1 C0020538 \| hypertension \| 1 C0023267 \| leiomyoma \| 1 C0036631 \| seminoma \| 1 C1412036 \| squamous cell carcinoma of the anus \| 1 C0030517 \| parathyroid disease \| 1 C0699893 \| non-melanoma skin cancer \| 1 C1442839 \| hypervitaminosis d \| 1 C0003873 \| rheumatoid arthritis \| 1 C0040128 \| thyroid disorders \| 1 C0175702 \| williams-beuren syndrome \| 1 C0007114 \| skin cancer \| 1 C0699791 \| gastric carcinoma \| 1 C0032461 \| polycythemia \| 1 C0027662 \| multiple endocrine neoplasia \| 1 C0027022 \| myeloproliferative disorders \| 1 C1335749 \| renal pelvis carcinoma \| 1 C0010481 \| cushing's syndrome \| 1 C0035086 \| renal osteodystrophy \| 1 C0206698 \| cholangiocarcinoma \| 1 C0206754 \| neuroendocrine tumors \| 1 C0036631 \| seminomas \| 1 C0023467 \| acute myeloid leukemia \| 1 C0027022 \| myeloproliferative disorder \| 1 C0018206 \| granulosa cell tumor \| 1 C0235974 \| pancreatic carcinoma \| 1 C0005586 \| bipolar disorder \| 1 C0007847 \| cervical cancer \| 1 C0025202 \| melanoma \| 1 C0079744 \| diffuse large b-cell lymphoma \| 1 C0023470 \| myeloid leukemia \| 1 C0376545 \| hematological malignancies \| 1 C0836924 \| thrombocythemia \| 1 C0023448 \| lymphoblastic leukemia \| 1 C0023418 \| leukaemia \| 1 C0022661 \| end-stage kidney disease \| 1 C0023267 \| fibroids \| 1 C0031511 \| phaeochromocytoma \| 1 C0020676 \| hypothyroidism \| 1 C0042133 \| uterine fibroids \| 1 C0011882 \| diabetic neuropathy \| 1 C0085681 \| hyperphosphatemia \| 1 C0017919 \| glycogen storage disease \| 1 C0006112 \| metabolic encephalopathy \| 1 C0034063 \| pulmonary edema \| 1 C0026946 \| mycosis \| 1 C0149925 \| small cell carcinoma of the lung \| 1 C0027121 \| myositis \| 1 C0376545 \| hematological malignancy \| 1 C0014859 \| esophageal cancer \| 1 C0005940 \| bone disease \| 1 C0302592 \| cervical ca \| 1 C0007134 \| renal carcinoma \| 1 C0001430 \| adenoma \| 1 C0041327 \| pulmonary tb \| 1 C0279637 \| carcinoma of the anus \| 1 C0220659 \| acrodysostosis \| 1 C0024523 \| intestinal malabsorption \| 1 C0001403 \| addison's disease \| 1 C0040128 \| thyroid diseases \| 1 C0175695 \| sotos syndrome \| 1 C0155626 \| acute mi \| 1 C0030517 \| parathyroid disorders \| 1 C1565662 \| acute renal insufficiency \| 1 C0022661 \| end-stage renal disease \| 1 C0040127 \| thyroid storm \| 1 C0032463 \| polycythemia vera \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:12) TNF \| 7124 \| CTD_human IL6 \| 3569 \| CTD_human CYP27B1 \| 1594 \| CTD_human TNFRSF11B \| 4982 \| CTD_human CALCA \| 796 \| CTD_human KL \| 9365 \| CTD_human PTH \| 5741 \| CTD_human CASR \| 846 \| CTD_human TNFSF11 \| 8600 \| CTD_human PTHLH \| 5744 \| CTD_human SLC34A1 \| 6569 \| CTD_human CALCR \| 799 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:196) 5982 \| RFC2 \| DISEASES 2767 \| GNA11 \| DISEASES 6343 \| SCT \| DISEASES 771 \| CA12 \| DISEASES 359 \| AQP2 \| DISEASES 2099 \| ESR1 \| DISEASES 57026 \| PDXP \| DISEASES 1113 \| CHGA \| DISEASES 1591 \| CYP24A1 \| DISEASES 479 \| ATP12A \| DISEASES 54 \| ACP5 \| DISEASES 7038 \| TG \| DISEASES 973 \| CD79A \| DISEASES 9275 \| BCL7B \| DISEASES 6348 \| CCL3 \| DISEASES 1440 \| CSF3 \| DISEASES 5539 \| PPY \| DISEASES 952 \| CD38 \| DISEASES 3558 \| IL2 \| DISEASES 595 \| CCND1 \| DISEASES 51296 \| SLC15A3 \| DISEASES 1594 \| CYP27B1 \| DISEASES 1027 \| CDKN1B \| DISEASES 4256 \| MGP \| DISEASES 2026 \| ENO2 \| DISEASES 2691 \| GHRH \| DISEASES 8074 \| FGF23 \| DISEASES 5507 \| PPP1R3C \| DISEASES 8600 \| TNFSF11 \| DISEASES 65266 \| WNK4 \| DISEASES 3976 \| LIF \| DISEASES 9084 \| VCY \| DISEASES 353513 \| VCY1B \| DISEASES 3630 \| INS \| DISEASES 2006 \| ELN \| DISEASES 8468 \| FKBP6 \| DISEASES 2056 \| EPO \| DISEASES 50617 \| ATP6V0A4 \| DISEASES 8431 \| NR0B2 \| DISEASES 1401 \| CRP \| DISEASES 759 \| CA1 \| DISEASES 2012 \| EMP1 \| DISEASES 1593 \| CYP27A1 \| DISEASES 3569 \| IL6 \| DISEASES 55729 \| ATF7IP \| DISEASES 59341 \| TRPV4 \| DISEASES 9172 \| MYOM2 \| DISEASES 2201 \| FBN2 \| DISEASES 495 \| ATP4A \| DISEASES 8455 \| ATRN \| DISEASES 6929 \| TCF3 \| DISEASES 6855 \| SYP \| DISEASES 4858 \| NOVA2 \| DISEASES 1175 \| AP2S1 \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 23476 \| BRD4 \| DISEASES 56927 \| GPR108 \| DISEASES 6476 \| SI \| DISEASES 5443 \| POMC \| DISEASES 10686 \| CLDN16 \| DISEASES 6550 \| SLC9A3 \| DISEASES 8614 \| STC2 \| DISEASES 1950 \| EGF \| DISEASES 56302 \| TRPV5 \| DISEASES 793 \| CALB1 \| DISEASES 7458 \| EIF4H \| DISEASES 5286 \| PIK3C2A \| DISEASES 284086 \| NEK8 \| DISEASES 113091 \| PTH2 \| DISEASES 54874 \| FNBP1L \| DISEASES 5972 \| REN \| DISEASES 1392 \| CRH \| DISEASES 5741 \| PTH \| DISEASES 25836 \| NIPBL \| DISEASES 9453 \| GGPS1 \| DISEASES 5018 \| OXA1L \| DISEASES 6750 \| SST \| DISEASES 6781 \| STC1 \| DISEASES 1636 \| ACE \| DISEASES 219931 \| TPCN2 \| DISEASES 248 \| ALPI \| DISEASES 23380 \| SRGAP2 \| DISEASES 3549 \| IHH \| DISEASES 79885 \| HDAC11 \| DISEASES 213 \| ALB \| DISEASES 6690 \| SPINK1 \| DISEASES 1437 \| CSF2 \| DISEASES 4982 \| TNFRSF11B \| DISEASES 65268 \| WNK2 \| DISEASES 9318 \| COPS2 \| DISEASES 197257 \| LDHD \| DISEASES 5617 \| PRL \| DISEASES 3479 \| IGF1 \| DISEASES 7200 \| TRH \| DISEASES 10736 \| SIX2 \| DISEASES 26608 \| TBL2 \| DISEASES 51068 \| NMD3 \| DISEASES 79660 \| PPP1R3B \| DISEASES 27072 \| VPS41 \| DISEASES 763 \| CA5A \| DISEASES 3265 \| HRAS \| DISEASES 392 \| ARHGAP1 \| DISEASES 836 \| CASP3 \| DISEASES 924 \| CD7 \| DISEASES 65125 \| WNK1 \| DISEASES 354 \| KLK3 \| DISEASES 377677 \| CA13 \| DISEASES 9322 \| TRIP10 \| DISEASES 6569 \| SLC34A1 \| DISEASES 5745 \| PTH1R \| DISEASES 2969 \| GTF2I \| DISEASES 22820 \| COPG1 \| DISEASES 51780 \| KDM3B \| DISEASES 1435 \| CSF1 \| DISEASES 4772 \| NFATC1 \| DISEASES 9735 \| KNTC1 \| DISEASES 2520 \| GAST \| DISEASES 796 \| CALCA \| DISEASES 220323 \| OAF \| DISEASES 91582 \| RPS19BP1 \| DISEASES 342184 \| FMN1 \| DISEASES 120227 \| CYP2R1 \| DISEASES 3984 \| LIMK1 \| DISEASES 4221 \| MEN1 \| DISEASES 92140 \| MTDH \| DISEASES 23583 \| SMUG1 \| DISEASES 23562 \| CLDN14 \| DISEASES 6166 \| RPL36AL \| DISEASES 6050 \| RNH1 \| DISEASES 57522 \| SRGAP1 \| DISEASES 5979 \| RET \| DISEASES 10656 \| KHDRBS3 \| DISEASES 2224 \| FDPS \| DISEASES 6597 \| SMARCA4 \| DISEASES 344892 \| RTP2 \| DISEASES 4477 \| MSMB \| DISEASES 55503 \| TRPV6 \| DISEASES 799 \| CALCR \| DISEASES 387129 \| NPSR1 \| DISEASES 142680 \| SLC34A3 \| DISEASES 7432 \| VIP \| DISEASES 79577 \| CDC73 \| DISEASES 55811 \| ADCY10 \| DISEASES 6708 \| SPTA1 \| DISEASES 632 \| BGLAP \| DISEASES 393 \| ARHGAP4 \| DISEASES 139135 \| PASD1 \| DISEASES 959 \| CD40LG \| DISEASES 9124 \| PDLIM1 \| DISEASES 57720 \| GPR107 \| DISEASES 10471 \| PFDN6 \| DISEASES 249 \| ALPL \| DISEASES 63940 \| GPSM3 \| DISEASES 2159 \| F10 \| DISEASES 81689 \| ISCA1 \| DISEASES 5251 \| PHEX \| DISEASES 9247 \| GCM2 \| DISEASES 79625 \| NDNF \| DISEASES 9365 \| KL \| DISEASES 795 \| S100G \| DISEASES 551 \| AVP \| DISEASES 11117 \| EMILIN1 \| DISEASES 833 \| CARS \| DISEASES 9901 \| SRGAP3 \| DISEASES 250 \| ALPP \| DISEASES 2113 \| ETS1 \| DISEASES 2591 \| GALNT3 \| DISEASES 51313 \| FAM198B \| DISEASES 5530 \| PPP3CA \| DISEASES 6696 \| SPP1 \| DISEASES 83698 \| CALN1 \| DISEASES 174 \| AFP \| DISEASES 5744 \| PTHLH \| DISEASES 3382 \| ICA1 \| DISEASES 4214 \| MAP3K1 \| DISEASES 10636 \| RGS14 \| DISEASES 9873 \| FCHSD2 \| DISEASES 2641 \| GCG \| DISEASES 115548 \| FCHO2 \| DISEASES 197 \| AHSG \| DISEASES 7124 \| TNF \| DISEASES 89848 \| FCHSD1 \| DISEASES 4049 \| LTA \| DISEASES 54475 \| NLE1 \| DISEASES 23048 \| FNBP1 \| DISEASES 846 \| CASR \| DISEASES 2638 \| GC \| DISEASES 7421 \| VDR \| DISEASES 8972 \| MGAM \| DISEASES 567 \| B2M \| DISEASES 64772 \| ENGASE \| DISEASES 11201 \| POLI \| DISEASES 8792 \| TNFRSF11A \| DISEASES 8153 \| RND2 \| DISEASES 103164619 \| PCAT2 \| DISEASES
Locus	(Waiting for update.)

Disease ID	274
Disease	hypercalcemia
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:111) HP:0000843 \| Hyperparathyroidism \| 44 HP:0000083 \| Renal insufficiency \| 27 HP:0001733 \| Pancreatic inflammation \| 19 HP:0008200 \| Primary hyperparathyroidism \| 19 HP:0002664 \| Neoplasia \| 14 HP:0001919 \| Acute renal failure \| 13 HP:0030731 \| Carcinoma \| 12 HP:0001735 \| Acute pancreatitis \| 10 HP:0006775 \| Multiple myeloma \| 10 HP:0002150 \| Hypercalcinuria \| 6 HP:0000939 \| Osteoporosis \| 5 HP:0002797 \| Increased bone resorption \| 5 HP:0001944 \| Dehydration \| 4 HP:0001909 \| Leukemia \| 4 HP:0006780 \| Parathyroid Cancer \| 4 HP:0000121 \| Nephrocalcinosis \| 4 HP:0002039 \| Anorexia \| 4 HP:0002890 \| Thyroid carcinoma \| 4 HP:0002860 \| Squamous cell carcinoma \| 3 HP:0012622 \| Chronic kidney disease \| 3 HP:0003774 \| End-stage renal failure \| 3 HP:0012191 \| B-cell lymphoma \| 3 HP:0012531 \| Pain \| 3 HP:0000787 \| Renal calculi \| 3 HP:0000845 \| Acromegalic growth \| 3 HP:0000131 \| Uterine leiomyoma \| 3 HP:0002665 \| Lymphoma \| 3 HP:0000829 \| Hypoparathyroidism \| 3 HP:0003002 \| Breast carcinoma \| 3 HP:0003201 \| Rhabdomyolysis \| 2 HP:0005550 \| Chronic lymphatic leukemia \| 2 HP:0000854 \| Thyroid adenoma \| 2 HP:0100723 \| Gastrointestinal stroma tumor \| 2 HP:0008207 \| Addison's disease \| 2 HP:0002901 \| Hypocalcemia \| 2 HP:0003127 \| Low urine calcium levels \| 2 HP:0002897 \| Parathyroid adenoma \| 2 HP:0000873 \| Diabetes insipidus \| 2 HP:0200114 \| Metabolic alkalosis \| 2 HP:0012819 \| Myocarditis \| 2 HP:0002900 \| Hypokalemia \| 2 HP:0002902 \| Hyponatremia \| 2 HP:0100621 \| Dysgerminoma \| 2 HP:0000846 \| Hypoadrenalism \| 2 HP:0100027 \| Recurring pancreatitis \| 2 HP:0001948 \| Alkalosis \| 2 HP:0009806 \| Nephrogenic diabetes insipidus \| 2 HP:0005584 \| Renal cell carcinoma \| 2 HP:0000867 \| Secondary hyperparathyroidism \| 2 HP:0001942 \| Metabolic acidosis \| 2 HP:0002653 \| Bone pain \| 2 HP:0001402 \| Hepatocellular carcinoma \| 2 HP:0100615 \| Neoplasm of the ovary \| 1 HP:0000969 \| Dropsy \| 1 HP:0004934 \| Vascular calcification \| 1 HP:0100033 \| Tic disorder \| 1 HP:0001824 \| Weight loss \| 1 HP:0002176 \| Spinal cord compression \| 1 HP:0030404 \| Glucagonoma \| 1 HP:0001960 \| Hypokalemic metabolic alkalosis \| 1 HP:0000820 \| Thyroid abnormality \| 1 HP:0002905 \| Hyperphosphatemia \| 1 HP:0000836 \| Overactive thyroid \| 1 HP:0003761 \| Calcinosis \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0008341 \| Renal tubular acidosis, type I \| 1 HP:0002148 \| Hypophosphataemia \| 1 HP:0001974 \| Leukocytosis \| 1 HP:0001298 \| Encephalopathy \| 1 HP:0100598 \| Pulmonary oedema \| 1 HP:0100614 \| Muscle inflammation \| 1 HP:0000110 \| Renal dysplasia \| 1 HP:0007302 \| Bipolar disorder \| 1 HP:0004808 \| Acute myelogenous leukemia \| 1 HP:0002018 \| Nausea \| 1 HP:0005547 \| Myeloproliferative disorder \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0001541 \| Ascites \| 1 HP:0001947 \| Renal tubular acidosis \| 1 HP:0011974 \| Myelofibrosis \| 1 HP:0100013 \| Tumours of the breast \| 1 HP:0011675 \| Arrhythmias \| 1 HP:0004326 \| Cachexia \| 1 HP:0003081 \| Increased urinary potassium \| 1 HP:0012324 \| Myeloid leukemia \| 1 HP:0002024 \| Intestinal malabsorption \| 1 HP:0100568 \| Endocrine neoplasia \| 1 HP:0000822 \| Hypertension \| 1 HP:0001369 \| Arthritis \| 1 HP:0001941 \| acidemia \| 1 HP:0100520 \| Oliguria \| 1 HP:0002013 \| Emesis \| 1 HP:0001901 \| Abnormally shaped erythrocytes \| 1 HP:0002896 \| Liver cancer \| 1 HP:0001347 \| Hyperreflexia \| 1 HP:0000737 \| Irritability \| 1 HP:0006532 \| Pneumonia, recurrent episodes \| 1 HP:0001953 \| Diabetic ketosis \| 1 HP:0011665 \| Takotsubo cardiomyopathy \| 1 HP:0012190 \| T cell lymphoma \| 1 HP:0012378 \| Fatigue \| 1 HP:0000821 \| Underactive thyroid \| 1 HP:0002835 \| Aspiration \| 1 HP:0003259 \| Increased serum creatinine \| 1 HP:0002861 \| Melanoma \| 1 HP:0100646 \| Thyroiditis \| 1 HP:0002315 \| Headaches \| 1 HP:0030153 \| Cholangiocarcinoma \| 1 HP:0000103 \| Polyuria \| 1 HP:0010702 \| Hypergammaglobulinaemia \| 1

Disease ID	274
Disease	hypercalcemia
Manually Symptom	UMLS \| Name(Total Manually Symptoms:105) C2700565 \| pancreatic cancer C2697417 \| pheochromocytoma C2697310 \| sarcoidosis C2632116 \| stenosis C2364051 \| fatigue C1963198 \| pancreatitis C1963154 \| renal failure C1963138 \| hypertension C1963091 \| diarrhea C1962972 \| proteinuria C1704380 \| distal renal tubular acidosis C1565489 \| renal insufficiency C1378703 \| renal carcinoma C1370419 \| granulosa cell tumor of the ovary C1336745 \| thymic lymphoma C1335749 \| carcinoma of the renal pelvis C1333100 \| squamous cell carcinoma of the colon C1328479 \| malignant islet cell tumor C1328402 \| metastatic glioma C1140680 \| ovarian cancer C1112474 \| esophageal small cell carcinoma C1090821 \| sepsis C0919267 \| ovarian tumors C0919267 \| ovarian tumor C0919267 \| ovarian neoplasm C0877055 \| acute generalized exanthematous pustulosis C0752303 \| urological manifestations C0745136 \| hypertensive emergency C0740451 \| granulomatous disease C0699885 \| bladder carcinoma C0684249 \| lung carcinoma C0684249 \| lung cancer C0679309 \| somatic manifestation C0678222 \| carcinoma of the breast C0678222 \| breast cancer C0677886 \| carcinoma of the ovary C0553723 \| cutaneous squamous cell carcinoma C0549473 \| carcinoma of the thyroid C0519067 \| renal sarcoidosis C0426576 \| gastrointestinal symptoms C0346185 \| dysgerminoma of the ovary C0278828 \| metastatic bladder cancer C0276667 \| disseminated coccidioidomycosis C0270458 \| psychotic depression C0267941 \| acute necrotizing pancreatitis C0264523 \| pulmonary calcification C0238410 \| transitional cell carcinoma of the renal pelvis C0238409 \| squamous cell carcinoma of the renal pelvis C0235974 \| carcinoma of the pancreas C0235031 \| neurologic symptoms C0234428 \| consciousness disturbance C0220983 \| metabolic alkalosis C0206754 \| neuroendocrine tumors C0206686 \| adrenal cortical carcinoma C0206681 \| clear cell carcinoma C0162299 \| thyroid cyst C0155120 \| band keratopathy C0153690 \| bone metastasis C0153690 \| bone metastases C0149925 \| small cell lung cancer C0085681 \| hyperphosphatemia C0085602 \| polydipsia C0085082 \| fungemia C0085074 \| granuloma annulare C0079772 \| t cell lymphoma C0036631 \| seminoma C0036572 \| seizures C0035222 \| acute respiratory distress syndrome C0032617 \| polyuria C0032463 \| polycythemia vera C0031511 \| phaeochromocytoma C0030521 \| parathyroid neoplasms C0030472 \| paraneoplastic syndromes C0030472 \| paraneoplastic syndrome C0030297 \| pancreatic neoplasms C0030297 \| pancreatic neoplasm C0027708 \| nephroblastoma C0026946 \| fungal infection C0026764 \| multiple myeloma C0026141 \| milk-alkali syndrome C0024305 \| non-hodgkin's lymphoma C0024302 \| reticulosarcoma C0024299 \| malignant lymphoma C0023601 \| leydig cell tumor C0023494 \| chronic t-cell leukemia C0023493 \| adult t-cell leukemia-lymphoma C0023493 \| adult t cell leukemia C0023484 \| plasma cell leukemia C0023462 \| acute megakaryoblastic leukemia C0022665 \| renal tumors C0022661 \| chronic renal failure C0022660 \| acute renal failure C0020550 \| hyperthyroidism C0020503 \| secondary hyperparathyroidism C0020502 \| hyperparathyroidism C0018854 \| gamma heavy-chain disease C0018021 \| thyroid enlargement C0013377 \| dysgerminoma C0013336 \| dwarfism C0008309 \| cholangioma C0007137 \| squamous cell carcinoma C0007121 \| carcinoma of the bronchus C0006705 \| disorders of calcium metabolism C0001418 \| adenocarcinoma C0001339 \| acute pancreatitis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:37) C0020502 \| hyperparathyroidism \| 39 C0030305 \| pancreatitis \| 17 C0035078 \| renal failure \| 13 C0001339 \| acute pancreatitis \| 10 C0026764 \| multiple myeloma \| 7 C1565489 \| renal insufficiency \| 7 C0036202 \| sarcoidosis \| 6 C0022660 \| acute renal failure \| 6 C0221002 \| primary hyperparathyroidism \| 4 C0153690 \| bone metastases \| 4 C0740451 \| granulomatous disease \| 3 C0242379 \| lung cancer \| 3 C0006142 \| breast cancer \| 3 C0001418 \| adenocarcinoma \| 3 C0026141 \| milk-alkali syndrome \| 2 C0020503 \| secondary hyperparathyroidism \| 2 C1140680 \| ovarian cancer \| 2 C0022661 \| chronic renal failure \| 2 C0007137 \| squamous cell carcinoma \| 2 C0220983 \| metabolic alkalosis \| 2 C0013377 \| dysgerminoma \| 2 C0020538 \| hypertension \| 1 C0020550 \| hyperthyroidism \| 1 C0085681 \| hyperphosphatemia \| 1 C0426576 \| gastrointestinal symptoms \| 1 C0036631 \| seminoma \| 1 C0001126 \| distal renal tubular acidosis \| 1 C0032617 \| polyuria \| 1 C0030472 \| paraneoplastic syndrome \| 1 C0032463 \| polycythemia vera \| 1 C0024305 \| non-hodgkin's lymphoma \| 1 C0276667 \| disseminated coccidioidomycosis \| 1 C0162299 \| thyroid cyst \| 1 C0919267 \| ovarian tumors \| 1 C0206754 \| neuroendocrine tumors \| 1 C0267941 \| acute necrotizing pancreatitis \| 1 C0007134 \| renal carcinoma \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1042636	22166946	846	CASR	umls:C0020437	BeFree	Calcium-sensing receptor polymorphism rs1042636 (Arg990Gly) affects the response to the calcimimetic cinacalcet, used to treat hypercalcemia in secondary hyperparathyroidism (sHPT) or parathyroid carcinoma.	0.177628636	2012	CASR	3	122284922	A	G
rs1801725	19694204	846	CASR	umls:C0020437	BeFree	We report an infant with transient neonatal hypercalcemia who was found to be homozygous for a polymorphism at A986S of the CaSR.	0.177628636	2009	CASR	3	122284910	G	T
rs201858689	24854525	846	CASR	umls:C0020437	BeFree	The NSHPT associated with biallelic Gly768Val mutations of the CASR in two siblings with severe hypercalcemia and hyperparathyroidism and their clinically and biochemically normal heterozygous parents was transmitted as an autosomal recessive disorder in this family.	0.177628636	2014	CASR	3	122284257	G	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:25)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0020437	bendroflumethiazide	D001539	73-48-3	hypercalcemia	MESH:D006934	marker/mechanism	17344567
C0020437	bortezomib	D000069286	-	hypercalcemia	MESH:D006934	therapeutic	18089816
C0020437	chloroquine	D002738	1954/5/7	hypercalcemia	MESH:D006934	therapeutic	10638776
C0020437	chlorthalidone	D002752	77-36-1	hypercalcemia	MESH:D006934	marker/mechanism	4406789
C0020437	diethylstilbestrol	D004054	56-53-1	hypercalcemia	MESH:D006934	marker/mechanism	4739237
C0020437	calcitriol	D002117	32222-06-3	hypercalcemia	MESH:D006934	marker/mechanism	10027919
C0020437	calcitriol	D002117	32222-06-3	hypercalcemia	MESH:D006934	therapeutic	6687780
C0020437	fluconazole	D015725	86386-73-4	hypercalcemia	MESH:D006934	marker/mechanism	9767873
C0020437	foscarnet	D017245	4428-95-9	hypercalcemia	MESH:D006934	marker/mechanism	9223751
C0020437	ganciclovir	D015774	82410-32-0	hypercalcemia	MESH:D006934	marker/mechanism	9894745
C0020437	indomethacin	D007213	53-86-1	hypercalcemia	MESH:D006934	therapeutic	1152883
C0020437	metolazone	D008788	17560-51-9	hypercalcemia	MESH:D006934	marker/mechanism	1928234
C0020437	octreotide	D015282	83150-76-9	hypercalcemia	MESH:D006934	therapeutic	17625444
C0020437	omeprazole	D009853	73590-58-6	hypercalcemia	MESH:D006934	marker/mechanism	10978407
C0020437	pamidronate	C019248	40391-99-9	hypercalcemia	MESH:D006934	marker/mechanism	12013365
C0020437	pamidronate	C019248	40391-99-9	hypercalcemia	MESH:D006934	therapeutic	10490077
C0020437	propranolol	D011433	525-66-6	hypercalcemia	MESH:D006934	therapeutic	3013062
C0020437	rifampin	D012293	13292-46-1	hypercalcemia	MESH:D006934	marker/mechanism	3663501
C0020437	terfenadine	D016593	50679-08-8	hypercalcemia	MESH:D006934	marker/mechanism	15872215
C0020437	theophylline	D013806	58-55-9	hypercalcemia	MESH:D006934	therapeutic	17578191
C0020437	tretinoin	D014212	302-79-4	hypercalcemia	MESH:D006934	marker/mechanism	11737750
C0020437	vitamin a	D014801	11103-57-4	hypercalcemia	MESH:D006934	marker/mechanism	11225264
C0020437	cholecalciferol	D002762	67-97-0	hypercalcemia	MESH:D006934	marker/mechanism	10490077
C0020437	voriconazole	D065819	-	hypercalcemia	MESH:D006934	marker/mechanism	16263588
C0020437	zoledronic acid	C088658	-	hypercalcemia	MESH:D006934	therapeutic	15160319

FDA approved drug and dosage information(Total Drugs:9)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D006934	calcijex	calcitriol	0.001MG/ML Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	INJECTABLE;INJECTION	Discontinued	None	Yes	No
MESH:D006934	calcijex	calcitriol	0.001MG/ML Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	INJECTABLE;INJECTION	Discontinued	None	Yes	No
MESH:D006934	prilosec	omeprazole	20MG Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	CAPSULE, DELAYED REL PELLETS;ORAL	Discontinued	None	Yes	No
MESH:D006934	prilosec	omeprazole	20MG Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	CAPSULE, DELAYED REL PELLETS;ORAL	Discontinued	None	Yes	No
MESH:D006934	omeprazole	omeprazole	20MG	TABLET, DELAYED RELEASE;ORAL	Over-the-counter	None	Yes	Yes
MESH:D006934	omeprazole	omeprazole	20MG	TABLET, DELAYED RELEASE;ORAL	Over-the-counter	None	Yes	Yes
MESH:D006934	zometa	zoledronic acid	EQ 4MG BASE/VIAL Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons	INJECTABLE;IV (INFUSION)	Discontinued	None	Yes	No
MESH:D006934	zometa	zoledronic acid	EQ 4MG BASE/VIAL	INJECTABLE; IV (INFUSION)	Prescription	None	No	No
MESH:D006934	velcade	bortezomib	3.5MG/VIAL	INJECTABLE;INTRAVENOUS, SUBCUTANEOUS	Prescription	None	Yes	Yes

FDA labeling changes(Total Drugs:9)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D006934	11/16/2001	calcijex	calcitriol	Management of hypocalcemia in patients undergoing chronic renal dialysis	The safety and effectiveness of calcitriol was examined in a double-blind placebo-controlled trial of 35 pediatric patients (13-18 years of age) with end-stage renal disease and on dialysis. The primary efficacy endpoint favored the calcitriol-treated versus the placebo-treated patients Transient hypercalcemia was seen in 1 of 16 calcitriol-treated patients; 6 of 16 (38%) calcitriol-treated patients and 2 of 19 (11%) placebo-treated patients had Ca x P >75	Labeling	B	-	-	-	Abbott	02/16/2001	FALSE'
MESH:D006934	11/16/2001	calcijex	calcitriol	Management of hypocalcemia in patients undergoing chronic renal dialysis	The safety and effectiveness of calcitriol was examined in a double-blind placebo-controlled trial of 35 pediatric patients (13-18 years of age) with end-stage renal disease and on dialysis. The primary efficacy endpoint favored the calcitriol-treated versus the placebo-treated patients Transient hypercalcemia was seen in 1 of 16 calcitriol-treated patients; 6 of 16 (38%) calcitriol-treated patients and 2 of 19 (11%) placebo-treated patients had Ca x P >75	Labeling	B	-	-	-	Abbott	02/16/2001	FALSE'
MESH:D006934	12/7/2002	prilosec	omeprazole	Gastroesophageal reflux and erosive esophagitis	Safety and effectiveness established in pediatric patients 2-16 years of age Information on dose, PK parameters, exposure/response and AE profile	Labeling	B	-	-	-	AstraZeneca	-	FALSE'
MESH:D006934	03/20/2008	prilosec	omeprazole	Maintenance healing of erosive esophagitis	Efficacy was extrapolated from adults and older children to 1 to 2 year olds and supported with an open-label trial Unique adverse reactions in pediatric patients included increased respiratory system adverse events and fever. Safety and effectiveness in children less than 1 year of age have not been established Dosing and administration information provided for patients 1 year and older weighing at least 5 kg. New dosage form	Labeling	-	-	B, P	-	AstraZeneca	1/5/2001	FALSE'
MESH:D006934	12/7/2002	prilosec	omeprazole	Gastroesophageal reflux and erosive esophagitis	Safety and effectiveness established in pediatric patients 2-16 years of age Information on dose, PK parameters, exposure/response and AE profile	Labeling	B	-	-	-	AstraZeneca	-	FALSE'
MESH:D006934	03/20/2008	prilosec	omeprazole	Maintenance healing of erosive esophagitis	Efficacy was extrapolated from adults and older children to 1 to 2 year olds and supported with an open-label trial Unique adverse reactions in pediatric patients included increased respiratory system adverse events and fever. Safety and effectiveness in children less than 1 year of age have not been established Dosing and administration information provided for patients 1 year and older weighing at least 5 kg. New dosage form	Labeling	-	-	B, P	-	AstraZeneca	1/5/2001	FALSE'
MESH:D006934	03/20/2008	zometa	zoledronic acid	Severe osteogenesis imperfecta	Zoledronic acid is not indicated for use in children Safety and effectiveness was studied in 152 pediatric patients with severe osteogenesis imperfecta aged 1 - 17 years. At one year, increases in BMD were observed in the zoledronic acid treatment group but the changes did not necessarily correlate with the risk for fracture or the incidence or severity of chronic bone pain Information on PK, clinical study, and AE profile	Labeling	B	-	-	-	Novartis	12/21/2007	FALSE'
MESH:D006934	03/20/2008	zometa	zoledronic acid	Severe osteogenesis imperfecta	Zoledronic acid is not indicated for use in children Safety and effectiveness was studied in 152 pediatric patients with severe osteogenesis imperfecta aged 1 - 17 years. At one year, increases in BMD were observed in the zoledronic acid treatment group but the changes did not necessarily correlate with the risk for fracture or the incidence or severity of chronic bone pain Information on PK, clinical study, and AE profile	Labeling	B	-	-	-	Novartis	12/21/2007	FALSE'
MESH:D006934	09/14/2015	velcade	bortezomib	Relapsed Acute Lymphoblastic Leukemia (ALL) and Lymphoblastic Lymphoma (LL)	Effectiveness in pediatric patients with relapsed pre-B ALL has not been established. The activity and safety of Velcade in combination with intensive reinduction chemotherapy was evaluated in pediatric and young adult patients with lymphoid malignancies. There were 140 patients with ALL or LL enrolled and evaluated for safety. No new safety concerns were observed	Labeling	B	-	-	-	Millennium Pharmaceuticals, Inc.	-	FALSE