PedAM

Pediatric Disease Annotations & Medicines


	hyperaldosteronism

Disease ID	442
Disease	hyperaldosteronism
Definition	A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.
Synonym	aldosteronism aldosteronism (disorder) aldosteronism nos aldosteronism, nos elevated plasma aldosterone hyperaldosteronism [disease/finding] hyperaldosteronism nos hyperaldosteronism nos (disorder) hyperaldosteronism, nos hyperaldosteronism, unspecified increased aldosterone increased aldosterone production mineralocorticoid excess
DOID	DOID:446
ICD10	ICD10CM:E26.9
UMLS	C0020428
MeSH	D006929
SNOMED-CT	SNOMEDCT_US_2016_09_01:88213004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:26) C0020538 \| hypertension \| 13 C0001430 \| adenoma \| 3 C0020502 \| hyperparathyroidism \| 2 C1621895 \| adrenal hyperplasia \| 2 C1384514 \| primary aldosteronism \| 2 C0018801 \| heart failure \| 2 C0334684 \| renal adenoma \| 1 C0001815 \| myeloid metaplasia \| 1 C0001622 \| hypercortisolism \| 1 C0027819 \| neuroblastoma \| 1 C0011847 \| diabetes \| 1 C0037315 \| sleep apnea \| 1 C0031036 \| polyarteritis nodosa \| 1 C0206667 \| adrenocortical adenoma \| 1 C0025286 \| meningioma \| 1 C0030443 \| periodic paralysis \| 1 C0221002 \| primary hyperparathyroidism \| 1 C0022658 \| kidney disease \| 1 C0022661 \| chronic kidney disease \| 1 C0027709 \| nephrocalcinosis \| 1 C0033804 \| pseudohermaphroditism \| 1 C0010481 \| cushing syndrome \| 1 C0011991 \| diarrhea \| 1 C0206667 \| adrenal adenoma \| 1 C0085580 \| essential hypertension \| 1 C0155616 \| secondary hypertension \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) ATP1A1 \| 476 \| CTD_human CACNA1D \| 776 \| CTD_human CYP11B2 \| 1585 \| CTD_human CYP11B1 \| 1584 \| CTD_human ATP2B3 \| 492 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:111) 1407 \| CRY1 \| DISEASES 2798 \| GNRHR \| DISEASES 2908 \| NR3C1 \| DISEASES 8074 \| FGF23 \| DISEASES 65266 \| WNK4 \| DISEASES 29802 \| VPREB3 \| DISEASES 53947 \| A4GALT \| DISEASES 3630 \| INS \| DISEASES 50617 \| ATP6V0A4 \| DISEASES 3958 \| LGALS3 \| DISEASES 10542 \| LAMTOR5 \| DISEASES 10060 \| ABCC9 \| DISEASES 5597 \| MAPK6 \| DISEASES 54962 \| TIPIN \| DISEASES 9252 \| RPS6KA5 \| DISEASES 6558 \| SLC12A2 \| DISEASES 23476 \| BRD4 \| DISEASES 492 \| ATP2B3 \| DISEASES 1716 \| DGUOK \| DISEASES 5443 \| POMC \| DISEASES 118 \| ADD1 \| DISEASES 8622 \| PDE8B \| DISEASES 6550 \| SLC9A3 \| DISEASES 3827 \| KNG1 \| DISEASES 9746 \| CLSTN3 \| DISEASES 1583 \| CYP11A1 \| DISEASES 79798 \| ARMC5 \| DISEASES 5972 \| REN \| DISEASES 805 \| CALM2 \| DISEASES 185 \| AGTR1 \| DISEASES 3779 \| KCNMB1 \| DISEASES 2768 \| GNA12 \| DISEASES 57786 \| RBAK \| DISEASES 6770 \| STAR \| DISEASES 1392 \| CRH \| DISEASES 5741 \| PTH \| DISEASES 23250 \| ATP11A \| DISEASES 50940 \| PDE11A \| DISEASES 9073 \| CLDN8 \| DISEASES 776 \| CACNA1D \| DISEASES 22808 \| MRAS \| DISEASES 1636 \| ACE \| DISEASES 808 \| CALM3 \| DISEASES 1584 \| CYP11B1 \| DISEASES 162417 \| NAGS \| DISEASES 3973 \| LHCGR \| DISEASES 476 \| ATP1A1 \| DISEASES 213 \| ALB \| DISEASES 552 \| AVPR1A \| DISEASES 6340 \| SCNN1G \| DISEASES 55872 \| PBK \| DISEASES 5617 \| PRL \| DISEASES 51305 \| KCNK9 \| DISEASES 255738 \| PCSK9 \| DISEASES 10736 \| SIX2 \| DISEASES 3777 \| KCNK3 \| DISEASES 7369 \| UMOD \| DISEASES 7201 \| TRHR \| DISEASES 10008 \| KCNE3 \| DISEASES 65125 \| WNK1 \| DISEASES 3291 \| HSD11B2 \| DISEASES 8630 \| HSD17B6 \| DISEASES 54822 \| TRPM7 \| DISEASES 1555 \| CYP2B6 \| DISEASES 55553 \| SOX6 \| DISEASES 1585 \| CYP11B2 \| DISEASES 9622 \| KLK4 \| DISEASES 5121 \| PCP4 \| DISEASES 4158 \| MC2R \| DISEASES 8912 \| CACNA1H \| DISEASES 153571 \| C5orf38 \| DISEASES 93974 \| ATPIF1 \| DISEASES 4221 \| MEN1 \| DISEASES 3753 \| KCNE1 \| DISEASES 3762 \| KCNJ5 \| DISEASES 4306 \| NR3C2 \| DISEASES 54681 \| P4HTM \| DISEASES 4929 \| NR4A2 \| DISEASES 6338 \| SCNN1B \| DISEASES 1811 \| SLC26A3 \| DISEASES 200734 \| SPRED2 \| DISEASES 801 \| CALM1 \| DISEASES 5573 \| PRKAR1A \| DISEASES 6337 \| SCNN1A \| DISEASES 5575 \| PRKAR1B \| DISEASES 3164 \| NR4A1 \| DISEASES 3360 \| HTR4 \| DISEASES 183 \| AGT \| DISEASES 6446 \| SGK1 \| DISEASES 480 \| ATP1A4 \| DISEASES 3283 \| HSD3B1 \| DISEASES 3284 \| HSD3B2 \| DISEASES 1586 \| CYP17A1 \| DISEASES 7809 \| BSND \| DISEASES 774 \| CACNA1B \| DISEASES 2516 \| NR5A1 \| DISEASES 249 \| ALPL \| DISEASES 1188 \| CLCNKB \| DISEASES 4878 \| NPPA \| DISEASES 9365 \| KL \| DISEASES 551 \| AVP \| DISEASES 6557 \| SLC12A1 \| DISEASES 50834 \| TAS2R1 \| DISEASES 3758 \| KCNJ1 \| DISEASES 3778 \| KCNMA1 \| DISEASES 6559 \| SLC12A3 \| DISEASES 1408 \| CRY2 \| DISEASES 408 \| ARRB1 \| DISEASES 8972 \| MGAM \| DISEASES 2232 \| FDXR \| DISEASES 285943 \| HOXA-AS2 \| DISEASES
Locus	(Waiting for update.)

Disease ID	442
Disease	hyperaldosteronism
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:31) HP:0000822 \| Hypertension \| 13 HP:0200114 \| Metabolic alkalosis \| 4 HP:0001948 \| Alkalosis \| 4 HP:0002900 \| Hypokalemia \| 4 HP:0002615 \| Low blood pressure \| 3 HP:0001960 \| Hypokalemic metabolic alkalosis \| 2 HP:0003470 \| Inability to move \| 2 HP:0008221 \| Enlarged adrenal glands \| 2 HP:0000843 \| Hyperparathyroidism \| 2 HP:0001578 \| Hypercortisolism \| 2 HP:0001635 \| Congestive heart failure \| 2 HP:0000848 \| Hyperreninemia \| 2 HP:0011675 \| Arrhythmias \| 1 HP:0002014 \| Diarrhea \| 1 HP:0001685 \| Myocardial fibrosis \| 1 HP:0003768 \| Periodic paralysis \| 1 HP:0002385 \| Paraparesis \| 1 HP:0003006 \| Neuroblastoma \| 1 HP:0002104 \| Absence of spontaneous respiration \| 1 HP:0012622 \| Chronic kidney disease \| 1 HP:0002917 \| Low blood magnesium levels \| 1 HP:0002858 \| Mengiomia \| 1 HP:0004308 \| Ventricular arrhythmia \| 1 HP:0002150 \| Hypercalcinuria \| 1 HP:0008256 \| Adrenocortical adenomas \| 1 HP:0100570 \| Carcinoid tumor \| 1 HP:0000037 \| Male pseudohermaphroditism \| 1 HP:0012408 \| Medullary nephrocalcinosis \| 1 HP:0008200 \| Primary hyperparathyroidism \| 1 HP:0010535 \| Sleep apnea \| 1 HP:0000121 \| Nephrocalcinosis \| 1

Disease ID	442
Disease	hyperaldosteronism
Manually Symptom	UMLS \| Name(Total Manually Symptoms:15) C2364118 \| weakness C1963138 \| hypertension C1609519 \| adrenal myelolipoma C1555754 \| cardiovascular disease C1279412 \| periodic paralysis syndrome C0334684 \| renal adenoma C0232197 \| fibrillation C0220983 \| metabolic alkalosis C0206635 \| myelolipoma C0162565 \| acute intermittent porphyria C0033806 \| pseudohypoparathyroidism C0020538 \| vascular hypertension C0020488 \| sodium retention C0010481 \| hypercortisolism C0003125 \| anorexia nervosa
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:6) C0020538 \| hypertension \| 13 C0220983 \| metabolic alkalosis \| 4 C0001622 \| hypercortisolism \| 1 C0020488 \| sodium retention \| 1 C0206635 \| myelolipoma \| 1 C0334684 \| renal adenoma \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:6)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0020428	bendroflumethiazide	D001539	73-48-3	hyperaldosteronism	MESH:D006929	therapeutic	20009770
C0020428	capreomycin	D002207	11003-38-6	hyperaldosteronism	MESH:D006929	marker/mechanism	5489186
C0020428	chlorthalidone	D002752	77-36-1	hyperaldosteronism	MESH:D006929	marker/mechanism	1103606
C0020428	spironolactone	D013148	1952/1/7	hyperaldosteronism	MESH:D006929	marker/mechanism	1103606
C0020428	spironolactone	D013148	1952/1/7	hyperaldosteronism	MESH:D006929	therapeutic	19224505
C0020428	streptozocin	D013311	18883-66-4	hyperaldosteronism	MESH:D006929	marker/mechanism	2819817

FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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