PedAM

Pediatric Disease Annotations & Medicines


	histoplasmosis

Disease ID	443
Disease	histoplasmosis
Definition	Infection resulting from inhalation or ingestion of spores of the fungus of the genus HISTOPLASMA, species H. capsulatum. It is worldwide in distribution and particularly common in the midwestern United States. (From Dorland, 27th ed)
Synonym	[x]histoplasmosis, unspecified [x]histoplasmosis, unspecified (disorder) histoplasmoses histoplasmosis (disorder) histoplasmosis [disease/finding] histoplasmosis nos histoplasmosis, nos histoplasmosis, unspecified unspecified histoplasmosis infection unspecified histoplasmosis infection (disorder) unspecified histoplasmosis nos unspecified histoplasmosis nos (disorder)
Orphanet	ORPHANET:390
DOID	DOID:1731
ICD10	ICD10CM:B39.9
UMLS	C0019655
MeSH	D006660
SNOMED-CT	SNOMEDCT_US_2016_09_01:12962009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:38) C0001175 \| acquired immunodeficiency syndrome \| 3 C0009319 \| colitis \| 2 C0006840 \| candidiasis \| 2 C0024291 \| hemophagocytic lymphohistiocytosis \| 2 C0020437 \| hypercalcemia \| 2 C0025064 \| mediastinitis \| 2 C0022398 \| job's syndrome \| 1 C0032231 \| pleuritis \| 1 C0006625 \| cachexia \| 1 C0014742 \| erythema multiforme \| 1 C0023281 \| leishmaniasis \| 1 C0023351 \| tuberculoid leprosy \| 1 C0037274 \| dermatosis \| 1 C0027947 \| neutropenia \| 1 C0027707 \| interstitial nephritis \| 1 C0027697 \| nephritis \| 1 C0023290 \| visceral leishmaniasis \| 1 C0042164 \| uveitis \| 1 C0030312 \| pancytopenia \| 1 C0033860 \| psoriasis \| 1 C0010346 \| crohn's disease \| 1 C0041296 \| tuberculosis \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0001403 \| addison's disease \| 1 C0042384 \| vasculitis \| 1 C0085253 \| adult onset still's disease \| 1 C0013370 \| amoebic colitis \| 1 C0023343 \| leprosy \| 1 C0008370 \| cholestasis \| 1 C0024291 \| hemophagocytic syndrome \| 1 C0003708 \| arachnoiditis \| 1 C0003873 \| rheumatoid arthritis \| 1 C0003864 \| arthritis \| 1 C0002874 \| aplastic anemia \| 1 C0036202 \| sarcoidosis \| 1 C0008513 \| chorioretinitis \| 1 C0003872 \| psoriatic arthritis \| 1 C0001175 \| acquired immunodeficiency syndrome (aids) \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:93) 1595 \| CYP51A1 \| DISEASES 920 \| CD4 \| DISEASES 55359 \| STYK1 \| DISEASES 10777 \| ARPP21 \| DISEASES 2191 \| FAP \| DISEASES 3053 \| SERPIND1 \| DISEASES 49 \| ACR \| DISEASES 2137 \| EXTL3 \| DISEASES 973 \| CD79A \| DISEASES 3912 \| LAMB1 \| DISEASES 55703 \| POLR3B \| DISEASES 3458 \| IFNG \| DISEASES 3565 \| IL4 \| DISEASES 27241 \| BBS9 \| DISEASES 6939 \| TCF15 \| DISEASES 10365 \| KLF2 \| DISEASES 6351 \| CCL4 \| DISEASES 27112 \| FAM155B \| DISEASES 3958 \| LGALS3 \| DISEASES 27348 \| TOR1B \| DISEASES 9172 \| MYOM2 \| DISEASES 4591 \| TRIM37 \| DISEASES 27130 \| INVS \| DISEASES 941 \| CD80 \| DISEASES 5443 \| POMC \| DISEASES 54847 \| SIDT1 \| DISEASES 8829 \| NRP1 \| DISEASES 3858 \| KRT10 \| DISEASES 523 \| ATP6V1A \| DISEASES 167410 \| LIX1 \| DISEASES 4715 \| NDUFB9 \| DISEASES 1834 \| DSPP \| DISEASES 23250 \| ATP11A \| DISEASES 26059 \| ERC2 \| DISEASES 1636 \| ACE \| DISEASES 1234 \| CCR5 \| DISEASES 151112 \| ZSWIM2 \| DISEASES 3490 \| IGFBP7 \| DISEASES 213 \| ALB \| DISEASES 1437 \| CSF2 \| DISEASES 124872 \| B4GALNT2 \| DISEASES 1632 \| ECI1 \| DISEASES 64581 \| CLEC7A \| DISEASES 2357 \| FPR1 \| DISEASES 56246 \| MRAP \| DISEASES 1241 \| LTB4R \| DISEASES 1938 \| EEF2 \| DISEASES 3291 \| HSD11B2 \| DISEASES 3183 \| HNRNPC \| DISEASES 2318 \| FLNC \| DISEASES 246329 \| STAC3 \| DISEASES 1538 \| CYLC1 \| DISEASES 25834 \| MGAT4C \| DISEASES 9094 \| UNC119 \| DISEASES 23583 \| SMUG1 \| DISEASES 3006 \| HIST1H1C \| DISEASES 3329 \| HSPD1 \| DISEASES 3198 \| HOXA1 \| DISEASES 3605 \| IL17A \| DISEASES 10516 \| FBLN5 \| DISEASES 80142 \| PTGES2 \| DISEASES 2879 \| GPX4 \| DISEASES 135250 \| RAET1E \| DISEASES 9652 \| TTC37 \| DISEASES 3459 \| IFNGR1 \| DISEASES 959 \| CD40LG \| DISEASES 51013 \| EXOSC1 \| DISEASES 6005 \| RHAG \| DISEASES 7422 \| VEGFA \| DISEASES 240 \| ALOX5 \| DISEASES 1192 \| CLIC1 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 3105 \| HLA-A \| DISEASES 285440 \| CYP4V2 \| DISEASES 1993 \| ELAVL2 \| DISEASES 56953 \| NT5M \| DISEASES 284217 \| LAMA1 \| DISEASES 3652 \| IPP \| DISEASES 80380 \| PDCD1LG2 \| DISEASES 10606 \| PAICS \| DISEASES 7018 \| TF \| DISEASES 26013 \| L3MBTL1 \| DISEASES 7124 \| TNF \| DISEASES 3106 \| HLA-B \| DISEASES 3908 \| LAMA2 \| DISEASES 3594 \| IL12RB1 \| DISEASES 4049 \| LTA \| DISEASES 54900 \| LAX1 \| DISEASES 3586 \| IL10 \| DISEASES 7019 \| TFAM \| DISEASES 51428 \| DDX41 \| DISEASES 83695 \| RHNO1 \| DISEASES 6223 \| RPS19 \| DISEASES
Locus	(Waiting for update.)

Disease ID	443
Disease	histoplasmosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:31) HP:0002721 \| Immunodeficiency \| 6 HP:0002716 \| Lymph node hyperplasia \| 3 HP:0001945 \| Fever \| 3 HP:0003072 \| Hypercalcemia \| 2 HP:0002583 \| Colitis \| 2 HP:0003765 \| Psoriasis \| 1 HP:0002584 \| Intestinal hemorrhage \| 1 HP:0000123 \| Nephritis \| 1 HP:0001396 \| Cholestasis \| 1 HP:0010783 \| Erythema \| 1 HP:0001915 \| Aplastic anemia \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0001875 \| Neutropenia \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0002633 \| Vasculitis \| 1 HP:0001369 \| Arthritis \| 1 HP:0100721 \| Mediastinal lymphadenopathy \| 1 HP:0001876 \| Low blood cell count \| 1 HP:0002239 \| Gastrointestinal hemorrhage \| 1 HP:0008207 \| Addison's disease \| 1 HP:0002102 \| Pleuritis \| 1 HP:0100280 \| Morbus Crohn \| 1 HP:0012156 \| Hemophagocytosis \| 1 HP:0001297 \| Cerebral vascular events \| 1 HP:0012424 \| Chorioretinitis \| 1 HP:0004326 \| Cachexia \| 1 HP:0002094 \| Dyspnea \| 1 HP:0000554 \| Uveitis \| 1 HP:0000105 \| Renal enlargement \| 1 HP:0001970 \| Interstitial nephritis \| 1 HP:0011944 \| Small vessel vasculitis \| 1

Disease ID	443
Disease	histoplasmosis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:31) C2364133 \| infection C2073625 \| pleural effusion C1963211 \| pericarditis C1963059 \| adrenal insufficiency C1962974 \| chylothorax C1546654 \| granuloma C0876973 \| pulmonary infection C0748168 \| pulmonary pathology C0456909 \| vision loss C0340359 \| prosthetic valve endocarditis C0334121 \| inflammatory myofibroblastic tumor C0332556 \| coin lesion C0276648 \| fungal endocarditis C0240708 \| pericardial calcification C0235369 \| granulomatous hepatitis C0221386 \| fibrosing mediastinitis C0043117 \| idiopathic thrombocytopenic purpura C0040034 \| thrombocytopenia C0038833 \| superior vena caval obstruction C0038833 \| superior vena cava syndrome C0037285 \| skin manifestations C0037284 \| skin lesions C0035243 \| respiratory infection C0032227 \| pleural effusions C0030326 \| panniculitis C0029166 \| oral manifestations C0024291 \| hemophagocytic syndrome C0019829 \| hodgkin's disease C0019825 \| hoarseness C0007286 \| carpal tunnel syndrome C0001403 \| addison's disease
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:7) C0009450 \| infection \| 8 C0037284 \| skin lesions \| 2 C0029166 \| oral manifestations \| 1 C0037285 \| skin manifestations \| 1 C0221386 \| fibrosing mediastinitis \| 1 C0024291 \| hemophagocytic syndrome \| 1 C0001403 \| addison's disease \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0019655	fluocinolone acetonide	D005446	67-73-2	histoplasmosis	MESH:D006660	marker/mechanism	15767049

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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