PedAM

Pediatric Disease Annotations & Medicines


	histiocytosis

Disease ID	915
Disease	histiocytosis
Definition	General term for the abnormal appearance of histiocytes in the blood. Based on the pathological features of the cells involved rather than on clinical findings, the histiocytic diseases are subdivided into three groups: HISTIOCYTOSIS, LANGERHANS CELL; HISTIOCYTOSIS, NON-LANGERHANS-CELL; and HISTIOCYTIC DISORDERS, MALIGNANT.
Synonym	histiocytic infiltrate histiocytic infiltrate (morphologic abnormality) histiocytic infiltrate, nos histiocytic reaction histiocytic reaction, nos histiocytic syndrome histiocytoses histiocytosis (morphologic abnormality) histiocytosis [disease/finding] histiocytosis, nos histiocytosis, unspecified histiocytosis, unspecified (disorder) reticuloendothelial cell infiltrate reticuloendothelial cell infiltrate, nos reticulohistiocytosis reticulohistiocytosis, nos
DOID	DOID:3405
UMLS	C0019618
MeSH	D015614
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:59) C0011847 \| diabetes \| 5 C0024299 \| lymphoma \| 5 C0011848 \| diabetes insipidus \| 4 C0003873 \| rheumatoid arthritis \| 3 C0079748 \| lymphoblastic lymphoma \| 2 C0032285 \| pneumonia \| 2 C0242647 \| mucosa-associated lymphoid tissue \| 2 C0598894 \| monocytic leukemia \| 2 C0687720 \| central diabetes insipidus \| 2 C0007115 \| thyroid ca \| 2 C0549473 \| thyroid carcinoma \| 2 C0020542 \| pulmonary hypertension \| 2 C0238463 \| papillary thyroid carcinoma \| 2 C0684249 \| carcinoma of the lung \| 1 C0008370 \| cholestasis \| 1 C0023467 \| acute myeloid leukemia \| 1 C0015624 \| fanconi syndrome \| 1 C0019829 \| hodgkin's lymphoma \| 1 C0007134 \| renal cell carcinoma \| 1 C0152013 \| adenocarcinoma of the lung \| 1 C0175703 \| tar syndrome \| 1 C0024214 \| lymphangiectasia \| 1 C0024314 \| lymphoproliferative disorder \| 1 C0242647 \| marginal zone b-cell lymphoma \| 1 C0023895 \| liver disease \| 1 C0023470 \| myeloid leukemia \| 1 C0242647 \| mucosa-associated lymphoid tissue lymphoma \| 1 C0011854 \| insulin dependent diabetes mellitus \| 1 C0011854 \| insulin dependent diabetes \| 1 C0029408 \| osteoarthritis \| 1 C0079731 \| b-cell lymphoma \| 1 C0085669 \| acute leukemia \| 1 C0020305 \| hydrops fetalis \| 1 C0024314 \| lymphoproliferative disorders \| 1 C0023449 \| acute lymphoblastic leukemia \| 1 C0032226 \| pleural disease \| 1 C0024291 \| hemophagocytic lymphohistiocytosis \| 1 C0011615 \| atopic dermatitis \| 1 C0023467 \| acute myeloid leukaemia \| 1 C0019621 \| langerhans cell histiocytosis \| 1 C0020538 \| hypertension \| 1 C0948303 \| peritoneal carcinoma \| 1 C0002726 \| amyloidosis \| 1 C0032131 \| plasmacytoma \| 1 C0007137 \| squamous cell carcinoma \| 1 C0078981 \| arachnoid cyst \| 1 C0032326 \| pneumothorax \| 1 C0024115 \| lung disorders \| 1 C0085669 \| acute leukemias \| 1 C0021933 \| intussusception \| 1 C1136085 \| monoclonal gammopathy \| 1 C0029443 \| osteomyelitis \| 1 C0023470 \| myeloid leukaemia \| 1 C0878675 \| erdheim-chester disease \| 1 C1261473 \| sarcoma \| 1 C0029182 \| orbital disease \| 1 C0004030 \| aspergillosis \| 1 C1527336 \| sjogren's syndrome \| 1 C0001418 \| adenocarcinoma \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) NPC2 \| 10577 \| UniProtKB-KW;GHR SMPD1 \| 6609 \| UniProtKB-KW;GHR NPC1 \| 4864 \| UniProtKB-KW;GHR BRAF \| 673 \| GHR SLC29A3 \| 55315 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:223) 4074 \| M6PR \| DISEASES 6362 \| CCL18 \| DISEASES 3385 \| ICAM3 \| DISEASES 4680 \| CEACAM6 \| DISEASES 201294 \| UNC13D \| DISEASES 50487 \| PLA2G3 \| DISEASES 410 \| ARSA \| DISEASES 54 \| ACP5 \| DISEASES 23659 \| PLA2G15 \| DISEASES 10404 \| CPQ \| DISEASES 6813 \| STXBP2 \| DISEASES 973 \| CD79A \| DISEASES 7431 \| VIM \| DISEASES 952 \| CD38 \| DISEASES 3558 \| IL2 \| DISEASES 9733 \| SART3 \| DISEASES 3458 \| IFNG \| DISEASES 2026 \| ENO2 \| DISEASES 5564 \| PRKAB1 \| DISEASES 7942 \| TFEB \| DISEASES 3565 \| IL4 \| DISEASES 1509 \| CTSD \| DISEASES 335 \| APOA1 \| DISEASES 9525 \| VPS4B \| DISEASES 8600 \| TNFSF11 \| DISEASES 718 \| C3 \| DISEASES 1236 \| CCR7 \| DISEASES 968 \| CD68 \| DISEASES 348 \| APOE \| DISEASES 2670 \| GFAP \| DISEASES 5565 \| PRKAB2 \| DISEASES 6382 \| SDC1 \| DISEASES 27183 \| VPS4A \| DISEASES 1401 \| CRP \| DISEASES 23640 \| HSPBP1 \| DISEASES 9398 \| CD101 \| DISEASES 5156 \| PDGFRA \| DISEASES 90070 \| LACRT \| DISEASES 6610 \| SMPD2 \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 3685 \| ITGAV \| DISEASES 4069 \| LYZ \| DISEASES 999 \| CDH1 \| DISEASES 6505 \| SLC1A1 \| DISEASES 5862 \| RAB2A \| DISEASES 5264 \| PHYH \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 79968 \| WDR76 \| DISEASES 5007 \| OSBP \| DISEASES 943 \| TNFRSF8 \| DISEASES 5290 \| PIK3CA \| DISEASES 3931 \| LCAT \| DISEASES 60482 \| SLC5A7 \| DISEASES 941 \| CD80 \| DISEASES 5443 \| POMC \| DISEASES 3383 \| ICAM1 \| DISEASES 950 \| SCARB2 \| DISEASES 7879 \| RAB7A \| DISEASES 29999 \| FSCN3 \| DISEASES 3189 \| HNRNPH3 \| DISEASES 51411 \| BIN2 \| DISEASES 3073 \| HEXA \| DISEASES 3687 \| ITGAX \| DISEASES 4864 \| NPC1 \| DISEASES 7157 \| TP53 \| DISEASES 63976 \| PRDM16 \| DISEASES 285362 \| SUMF1 \| DISEASES 6769 \| STAC \| DISEASES 85417 \| CCNB3 \| DISEASES 23196 \| FAM120A \| DISEASES 7070 \| THY1 \| DISEASES 7345 \| UCHL1 \| DISEASES 23643 \| LY96 \| DISEASES 5018 \| OXA1L \| DISEASES 1436 \| CSF1R \| DISEASES 3156 \| HMGCR \| DISEASES 3815 \| KIT \| DISEASES 673 \| BRAF \| DISEASES 909 \| CD1A \| DISEASES 29881 \| NPC1L1 \| DISEASES 50848 \| F11R \| DISEASES 6285 \| S100B \| DISEASES 6271 \| S100A1 \| DISEASES 2215 \| FCGR3B \| DISEASES 134429 \| STARD4 \| DISEASES 3562 \| IL3 \| DISEASES 1437 \| CSF2 \| DISEASES 84889 \| SLC7A3 \| DISEASES 5267 \| SERPINA4 \| DISEASES 290 \| ANPEP \| DISEASES 5604 \| MAP2K1 \| DISEASES 340024 \| SLC6A19 \| DISEASES 84342 \| COG8 \| DISEASES 2548 \| GAA \| DISEASES 2720 \| GLB1 \| DISEASES 153572 \| IRX2 \| DISEASES 9451 \| EIF2AK3 \| DISEASES 3265 \| HRAS \| DISEASES 947 \| CD34 \| DISEASES 7368 \| UGT8 \| DISEASES 924 \| CD7 \| DISEASES 23166 \| STAB1 \| DISEASES 2629 \| GBA \| DISEASES 30835 \| CD209 \| DISEASES 4684 \| NCAM1 \| DISEASES 3321 \| IGSF3 \| DISEASES 4018 \| LPA \| DISEASES 3039 \| HBA1 \| DISEASES 1435 \| CSF1 \| DISEASES 284359 \| IZUMO1 \| DISEASES 3563 \| IL3RA \| DISEASES 5155 \| PDGFB \| DISEASES 942 \| CD86 \| DISEASES 10227 \| MFSD10 \| DISEASES 256933 \| NPB \| DISEASES 3916 \| LAMP1 \| DISEASES 3988 \| LIPA \| DISEASES 23583 \| SMUG1 \| DISEASES 857 \| CAV1 \| DISEASES 3805 \| KIR2DL4 \| DISEASES 4602 \| MYB \| DISEASES 6609 \| SMPD1 \| DISEASES 5781 \| PTPN11 \| DISEASES 2583 \| B4GALNT1 \| DISEASES 1508 \| CTSB \| DISEASES 921 \| CD5 \| DISEASES 57515 \| SERINC1 \| DISEASES 9514 \| GAL3ST1 \| DISEASES 3605 \| IL17A \| DISEASES 53827 \| FXYD5 \| DISEASES 26762 \| HAVCR1 \| DISEASES 347 \| APOD \| DISEASES 57556 \| SEMA6A \| DISEASES 355 \| FAS \| DISEASES 26503 \| SLC17A5 \| DISEASES 5265 \| SERPINA1 \| DISEASES 3683 \| ITGAL \| DISEASES 2760 \| GM2A \| DISEASES 1510 \| CTSE \| DISEASES 4763 \| NF1 \| DISEASES 404552 \| SCGB1D4 \| DISEASES 2526 \| FUT4 \| DISEASES 6364 \| CCL20 \| DISEASES 51454 \| GULP1 \| DISEASES 9332 \| CD163 \| DISEASES 6832 \| SUPV3L1 \| DISEASES 93034 \| NT5C1B \| DISEASES 7037 \| TFRC \| DISEASES 6693 \| SPN \| DISEASES 4311 \| MME \| DISEASES 10210 \| TOPORS \| DISEASES 6721 \| SREBF2 \| DISEASES 1378 \| CR1 \| DISEASES 1380 \| CR2 \| DISEASES 1118 \| CHIT1 \| DISEASES 5788 \| PTPRC \| DISEASES 5321 \| PLA2G4A \| DISEASES 8676 \| STX11 \| DISEASES 2214 \| FCGR3A \| DISEASES 910 \| CD1B \| DISEASES 911 \| CD1C \| DISEASES 10924 \| SMPDL3A \| DISEASES 6280 \| S100A9 \| DISEASES 4942 \| OAT \| DISEASES 1520 \| CTSS \| DISEASES 914 \| CD2 \| DISEASES 965 \| CD58 \| DISEASES 4893 \| NRAS \| DISEASES 5309 \| PITX3 \| DISEASES 89885 \| FATE1 \| DISEASES 959 \| CD40LG \| DISEASES 5236 \| PGM1 \| DISEASES 4068 \| SH2D1A \| DISEASES 56623 \| INPP5E \| DISEASES 27069 \| GHITM \| DISEASES 5476 \| CTSA \| DISEASES 55315 \| SLC29A3 \| DISEASES 2934 \| GSN \| DISEASES 2268 \| FGR \| DISEASES 7357 \| UGCG \| DISEASES 367 \| AR \| DISEASES 19 \| ABCA1 \| DISEASES 50943 \| FOXP3 \| DISEASES 369 \| ARAF \| DISEASES 54880 \| BCOR \| DISEASES 9308 \| CD83 \| DISEASES 3559 \| IL2RA \| DISEASES 2665 \| GDI2 \| DISEASES 551 \| AVP \| DISEASES 414 \| ARSD \| DISEASES 427 \| ASAH1 \| DISEASES 6624 \| FSCN1 \| DISEASES 10522 \| DEAF1 \| DISEASES 238 \| ALK \| DISEASES 3681 \| ITGAD \| DISEASES 12 \| SERPINA3 \| DISEASES 5660 \| PSAP \| DISEASES 6696 \| SPP1 \| DISEASES 5609 \| MAP2K7 \| DISEASES 50489 \| CD207 \| DISEASES 9842 \| PLEKHM1 \| DISEASES 197 \| AHSG \| DISEASES 5538 \| PPT1 \| DISEASES 7124 \| TNF \| DISEASES 7072 \| TIA1 \| DISEASES 5229 \| PGGT1B \| DISEASES 7812 \| CSDE1 \| DISEASES 3586 \| IL10 \| DISEASES 57670 \| KIAA1549 \| DISEASES 338376 \| IFNE \| DISEASES 9367 \| RAB9A \| DISEASES 84000 \| TMPRSS13 \| DISEASES 727897 \| MUC5B \| DISEASES 441864 \| TARM1 \| DISEASES 3684 \| ITGAM \| DISEASES 10577 \| NPC2 \| DISEASES 100288687 \| DUX4 \| DISEASES 653545 \| DUX4L5 \| DISEASES 348120 \| LINC01193 \| DISEASES 79104 \| MEG8 \| DISEASES 4555 \| MT-TD \| DISEASES
Locus	(Waiting for update.)

Disease ID	915
Disease	histiocytosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:44) HP:0002716 \| Lymph node hyperplasia \| 110 HP:0002665 \| Lymphoma \| 5 HP:0000873 \| Diabetes insipidus \| 4 HP:0001370 \| Rheumatoid arthritis \| 3 HP:0002664 \| Neoplasia \| 3 HP:0002895 \| Papillary thyroid carcinoma \| 2 HP:0002890 \| Thyroid carcinoma \| 2 HP:0000863 \| Neurohypophyseal diabetes insipidus \| 2 HP:0002092 \| Pulmonary artery hypertension \| 2 HP:0002090 \| Pneumonia \| 2 HP:0012325 \| Chronic myelomonocytic leukemia \| 2 HP:0001789 \| Hydrops fetalis \| 1 HP:0100242 \| Sarcoma \| 1 HP:0001047 \| Atopic dermatitis \| 1 HP:0012191 \| B-cell lymphoma \| 1 HP:0002576 \| Intussusception \| 1 HP:0000969 \| Dropsy \| 1 HP:0002593 \| Intestinal lymphangiectasia \| 1 HP:0001396 \| Cholestasis \| 1 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0004808 \| Acute myelogenous leukemia \| 1 HP:0002835 \| Aspiration \| 1 HP:0005523 \| Lymphoproliferative disorder \| 1 HP:0002318 \| Cervical myelopathy \| 1 HP:0040189 \| Desquamation \| 1 HP:0100702 \| Arachnoid cyst \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0001397 \| Hepatic steatosis \| 1 HP:0000078 \| Genital abnormalities \| 1 HP:0011034 \| Amyloid disease \| 1 HP:0030731 \| Carcinoma \| 1 HP:0002758 \| Osteoarthritis \| 1 HP:0006721 \| Acute lymphocytic leukemia \| 1 HP:0005584 \| Renal cell carcinoma \| 1 HP:0011857 \| Plasmacytoma \| 1 HP:0002107 \| Collapsed lung \| 1 HP:0002754 \| Bone infection \| 1 HP:0002488 \| Acute leukemias \| 1 HP:0012156 \| Hemophagocytosis \| 1 HP:0012324 \| Myeloid leukemia \| 1 HP:0001410 \| Decreased liver function \| 1 HP:0001994 \| 'de toni-fanconi-debre' syndrome \| 1 HP:0100825 \| Inflammation of the lips \| 1 HP:0000822 \| Hypertension \| 1

Disease ID	915
Disease	histiocytosis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:3) C2363896 \| hypothalamic diabetes insipidus C2186532 \| liver disease C0376293 \| stigmata
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0023895 \| liver disease \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
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GWASdb Annotation(Total Genotypes:0)
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GWASdb Snp Trait(Total Genotypes:0)
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Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
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Chemical(Total Drugs:0)
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FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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