PedAM
Pediatric Disease Annotations & Medicines
| histiocytic sarcoma | ||||
| Disease ID | 694 |
|---|---|
| Disease | histiocytic sarcoma |
| Definition | Malignant neoplasms composed of MACROPHAGES or DENDRITIC CELLS. Most histiocytic sarcomas present as localized tumor masses without a leukemic phase. Though the biological behavior of these neoplasms resemble lymphomas, their cell lineage is histiocytic not lymphoid. |
| Synonym | [m]true histiocytic lymphoma histiocytic lymphoma, true histiocytic lymphomas, true histiocytic sarcoma (clinical) histiocytic sarcoma (disorder) histiocytic sarcoma (morphologic abnormality) histiocytic sarcoma [disease/finding] histiocytic sarcomas histiocytoses, true malignant histiocytosis, true malignant lymphoma, true histiocytic lymphomas, true histiocytic malignant histiocytoses, true malignant histiocytosis, true sarcoma, histiocytic sarcoma, histiocytic, malignant sarcomas, histiocytic true histiocytic lymphoma true histiocytic lymphoma (clinical) true histiocytic lymphoma (disorder) true histiocytic lymphoma (morphologic abnormality) true histiocytic lymphoma -retired- true histiocytic lymphoma [obs] true histiocytic lymphomas true malignant histiocytoses true malignant histiocytosis |
| Orphanet | |
| ICD10 | |
| UMLS | C0334663 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:18) C0024299 | lymphomas | 2 C0023465 | acute monocytic leukemia | 1 C0040034 | thrombocytopenia | 1 C0549473 | thyroid carcinoma | 1 C0041296 | tuberculosis | 1 C0007115 | thyroid ca | 1 C0023448 | lymphoblastic leukemia | 1 C0023443 | hairy cell leukemia | 1 C0043117 | idiopathic thrombocytopenia | 1 C0334634 | mantle cell lymphoma | 1 C0024299 | malignant lymphoma | 1 C0238463 | papillary thyroid carcinoma | 1 C0023418 | leukemia | 1 C1328840 | autoimmune lymphoproliferative syndrome | 1 C0598894 | monocytic leukemia | 1 C0019204 | hepatocellular carcinoma | 1 C0023449 | acute lymphoblastic leukemia | 1 C0024299 | malignant lymphomas | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 694 |
|---|---|
| Disease | histiocytic sarcoma |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:11) HP:0002664 | Neoplasia | 5 HP:0001402 | Hepatocellular carcinoma | 1 HP:0001873 | Low platelet count | 1 HP:0001973 | Autoimmune thrombocytopenia | 1 HP:0030731 | Carcinoma | 1 HP:0002890 | Thyroid carcinoma | 1 HP:0004845 | Acute monoblastic leukemia | 1 HP:0001909 | Leukemia | 1 HP:0002895 | Papillary thyroid carcinoma | 1 HP:0006721 | Acute lymphocytic leukemia | 1 HP:0001289 | Confusion | 1 |
| Disease ID | 694 |
|---|---|
| Disease | histiocytic sarcoma |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:1) C0149678 | epstein-barr virus infection |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
All Snps(Total Genotypes:1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs113488022 | 24720374 | 673 | BRAF | umls:C0334663 | BeFree | BRAF(V600E) was not limited to LCH and was detected more frequently in histiocytic sarcoma. | 0.000271442 | 2014 | BRAF | 7 | 140753336 | A | T,G,C |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
|---|
| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
|---|
| (Waiting for update.) |
Chemical(Total Drugs:2) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C0334663 | thalidomide | D013792 | 50-35-1 | histiocytic sarcoma | MESH:D054747 | therapeutic | 17408102 | ||
| C0334663 | zidovudine | D015215 | 30516-87-1 | histiocytic sarcoma | MESH:D054747 | marker/mechanism | 10558926 | ||
FDA approved drug and dosage information(Total Drugs:6) | ||||||||
|---|---|---|---|---|---|---|---|---|
| DiseaseID | Drug_name | active_ingredients | strength | Dosage Form/Route | Marketing Status | TE code | RLD | RS |
| MESH:D054747 | retrovir | zidovudine | 100MG | CAPSULE;ORAL | Prescription | AB | Yes | Yes |
| MESH:D054747 | retrovir | zidovudine | 50MG/5ML | SYRUP;ORAL | Prescription | AA | Yes | Yes |
| MESH:D054747 | retrovir | zidovudine | 10MG/ML | INJECTABLE;INJECTION | Prescription | AP | Yes | Yes |
| MESH:D054747 | retrovir | zidovudine | 200MG | TABLET;ORAL | Discontinued | None | No | No |
| MESH:D054747 | zidovudine | zidovudine | 60MG | TABLET;ORAL | Discontinued | None | No | No |
| MESH:D054747 | zidovudine | zidovudine | 60MG | TABLET;ORAL | Discontinued | None | No | No |
FDA labeling changes(Total Drugs:6) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DiseaseID | Pediatric_Labeling_Date | Trade_Name | Generic_Name_or_Proper_Name | Indications Studied | Label Changes Summary | Product Labeling | BPCA(B) | PREA(P) | BPCA(B) and PREA(P) | Pediatric Rule (R) | Sponsor | Pediatric Exclusivity Granted Date | NNPS |
| MESH:D054747 | 6/11/2009 | retrovir | zidovudine | Treatment of HIV-1 infection in combination with other antiretroviral agents | Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg | Labeling | - | P | - | - | GlaxoSmithKline | - | TRUE' |
| MESH:D054747 | 6/11/2009 | retrovir | zidovudine | Treatment of HIV-1 infection in combination with other antiretroviral agents | Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg | Labeling | - | P | - | - | GlaxoSmithKline | - | TRUE' |
| MESH:D054747 | 6/11/2009 | retrovir | zidovudine | Treatment of HIV-1 infection in combination with other antiretroviral agents | Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg | Labeling | - | P | - | - | GlaxoSmithKline | - | TRUE' |
| MESH:D054747 | 6/11/2009 | retrovir | zidovudine | Treatment of HIV-1 infection in combination with other antiretroviral agents | Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg | Labeling | - | P | - | - | GlaxoSmithKline | - | TRUE' |
| MESH:D054747 | 09/19/2008 | retrovir syrup, capsules and tablets | zidovudine | Used in combination with 18 other antiretroviral agents for the treatment of HIV-1 infection | Dosing and administration information provided to children 6 weeks to less than 18 years of age Macrocytosis was reported in the majority of pediatric patients receiving Retrovir 180 mg/m2 every 6 hours in open-label studies New dosing regimen | Labeling | - | P | - | - | GlaxoSmithKline | - | TRUE' |
| MESH:D054747 | 6/11/2009 | retrovir | zidovudine | Treatment of HIV-1 infection in combination with other antiretroviral agents | Provided dosing recommendations for patients 4 weeks to < 6 weeks of age and weighing 4 kg to < 9 kg | Labeling | - | P | - | - | GlaxoSmithKline | - | TRUE' |