PedAM

Pediatric Disease Annotations & Medicines


	herpes zoster

Disease ID	720
Disease	herpes zoster
Definition	An acute infectious, usually self-limited, disease believed to represent activation of latent varicella-zoster virus (HERPESVIRUS 3, HUMAN) in those who have been rendered partially immune after a previous attack of CHICKENPOX. It involves the SENSORY GANGLIA and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area. (From Dorland, 27th ed)
Synonym	herpes zona herpes zoster (disorder) herpes zoster [disease/finding] herpes zoster disease herpes zoster infection herpes zoster infection (disorder) herpes zoster nos herpes zoster nos (disorder) herpes zoster, nos shingles zona zonas zoster
DOID	DOID:8536
UMLS	C0019360
MeSH	D006562
SNOMED-CT	SNOMEDCT_US_2016_09_01:4740000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:90) C0008049 \| varicella \| 10 C0003873 \| rheumatoid arthritis \| 8 C0003864 \| arthritis \| 6 C0015230 \| rash \| 5 C0024141 \| systemic lupus erythematosus \| 5 C0011847 \| diabetes \| 5 C0409974 \| lupus erythematosus \| 4 C0011849 \| diabetes mellitus \| 4 C0022568 \| keratitis \| 3 C0019360 \| zoster \| 3 C0027813 \| neuritis \| 3 C0024299 \| lymphoma \| 3 C0009377 \| colonic pseudo-obstruction \| 2 C0004623 \| bacterial infection \| 2 C0019829 \| hodgkin lymphoma \| 2 C0024305 \| non-hodgkin lymphoma \| 2 C0042373 \| vascular disease \| 2 C0024117 \| chronic obstructive pulmonary disease \| 2 C0014038 \| encephalitis \| 2 C0442874 \| neuropathy \| 2 C0042164 \| uveitis \| 2 C0376175 \| bell's palsy \| 2 C0029089 \| ophthalmoplegia \| 2 C0029134 \| optic neuritis \| 2 C0030920 \| peptic ulcer \| 2 C0007785 \| cerebral infarcts \| 2 C0024115 \| pulmonary disease \| 2 C0039483 \| giant cell arteritis \| 2 C1834580 \| ramsay hunt syndrome \| 2 C0007785 \| cerebral infarct \| 2 C0042769 \| virus infection \| 2 C0026764 \| myeloma \| 2 C0600260 \| obstructive pulmonary disease \| 2 C0033860 \| psoriasis \| 2 C0001339 \| acute pancreatitis \| 1 C0023487 \| promyelocytic leukemia \| 1 C0023493 \| adult t-cell leukemia/lymphoma \| 1 C0007222 \| cardiovascular disease \| 1 C0030920 \| peptic ulcer disease \| 1 C0011570 \| depression \| 1 C0007137 \| squamous carcinoma \| 1 C0015464 \| facial palsy \| 1 C0023487 \| acute promyelocytic leukemia \| 1 C0002871 \| anemia \| 1 C0022573 \| keratoconjunctivitis \| 1 C0700594 \| radiculopathy \| 1 C0007137 \| squamous carcinomas \| 1 C0085096 \| peripheral vascular disease \| 1 C0019937 \| horner syndrome \| 1 C0010346 \| crohn's disease \| 1 C0023418 \| leukaemia \| 1 C0151436 \| leukocytoclastic vasculitis \| 1 C1847523 \| abducens palsy \| 1 C0002171 \| alopecia areata \| 1 C0036508 \| seborrhoeic eczema \| 1 C0152176 \| trochlear nerve palsy \| 1 C0042384 \| vasculitis \| 1 C0023470 \| myelocytic leukemia \| 1 C0023646 \| lichen planus \| 1 C0025289 \| meningitis \| 1 C0021141 \| syndrome of inappropriate secretion of antidiuretic hormone \| 1 C0221759 \| brachial neuritis \| 1 C1261473 \| sarcoma \| 1 C0042109 \| urticarial \| 1 C0019348 \| herpes simplex \| 1 C0025202 \| melanoma \| 1 C0011633 \| dermatomyositis \| 1 C0030305 \| pancreatitis \| 1 C0553662 \| juvenile idiopathic arthritis \| 1 C0036202 \| sarcoidosis \| 1 C0004096 \| asthma \| 1 C0151311 \| cranial nerve palsy \| 1 C0015230 \| exanthema \| 1 C0008049 \| chickenpox \| 1 C0023493 \| adult t-cell leukemia \| 1 C0456909 \| blindness \| 1 C0242350 \| erectile dysfunction \| 1 C0015469 \| facial paralysis \| 1 C0026764 \| multiple myeloma \| 1 C0025297 \| viral meningitis \| 1 C0029443 \| osteomyelitis \| 1 C0152025 \| polyneuropathy \| 1 C0002170 \| alopecia \| 1 C0042373 \| vascular diseases \| 1 C0007222 \| cardiovascular diseases \| 1 C0023492 \| t-cell leukemia \| 1 C0009806 \| constipation \| 1 C0010692 \| cystitis \| 1 C0036220 \| kaposi sarcoma \| 1 C0034065 \| pulmonary embolism \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) HCP5 \| 10866 \| GWASCAT
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) 1234 \| CCR5 \| infer 3586 \| IL10 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:137) 5954 \| RCN1 \| DISEASES 84699 \| CREB3L3 \| DISEASES 83992 \| CTTNBP2 \| DISEASES 27248 \| ERLEC1 \| DISEASES 3002 \| GZMB \| DISEASES 1666 \| DECR1 \| DISEASES 973 \| CD79A \| DISEASES 9545 \| RAB3D \| DISEASES 858 \| CAV2 \| DISEASES 1440 \| CSF3 \| DISEASES 3558 \| IL2 \| DISEASES 3458 \| IFNG \| DISEASES 7903 \| ST8SIA4 \| DISEASES 51185 \| CRBN \| DISEASES 1236 \| CCR7 \| DISEASES 968 \| CD68 \| DISEASES 1401 \| CRP \| DISEASES 4608 \| MYBPH \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 2995 \| GYPC \| DISEASES 10113 \| PREB \| DISEASES 8766 \| RAB11A \| DISEASES 4591 \| TRIM37 \| DISEASES 25939 \| SAMHD1 \| DISEASES 23523 \| CABIN1 \| DISEASES 8726 \| EED \| DISEASES 7301 \| TYRO3 \| DISEASES 10578 \| GNLY \| DISEASES 5443 \| POMC \| DISEASES 22915 \| MMRN1 \| DISEASES 3371 \| TNC \| DISEASES 1390 \| CREM \| DISEASES 27074 \| LAMP3 \| DISEASES 51083 \| GAL \| DISEASES 150094 \| SIK1 \| DISEASES 3439 \| IFNA1 \| DISEASES 7345 \| UCHL1 \| DISEASES 1562 \| CYP2C18 \| DISEASES 267 \| AMFR \| DISEASES 4041 \| LRP5 \| DISEASES 2215 \| FCGR3B \| DISEASES 213 \| ALB \| DISEASES 9607 \| CARTPT \| DISEASES 81501 \| DCSTAMP \| DISEASES 4714 \| NDUFB8 \| DISEASES 717 \| C2 \| DISEASES 136647 \| MPLKIP \| DISEASES 56246 \| MRAP \| DISEASES 4815 \| NINJ2 \| DISEASES 54205 \| CYCS \| DISEASES 27087 \| B3GAT1 \| DISEASES 660 \| BMX \| DISEASES 23529 \| CLCF1 \| DISEASES 3054 \| HCFC1 \| DISEASES 947 \| CD34 \| DISEASES 641371 \| ACOT1 \| DISEASES 6773 \| STAT2 \| DISEASES 51268 \| PIPOX \| DISEASES 4684 \| NCAM1 \| DISEASES 6863 \| TAC1 \| DISEASES 923 \| CD6 \| DISEASES 83733 \| SLC25A18 \| DISEASES 200504 \| GKN2 \| DISEASES 8651 \| SOCS1 \| DISEASES 8519 \| IFITM1 \| DISEASES 3916 \| LAMP1 \| DISEASES 219699 \| UNC5B \| DISEASES 9094 \| UNC119 \| DISEASES 2042 \| EPHA3 \| DISEASES 23583 \| SMUG1 \| DISEASES 3266 \| ERAS \| DISEASES 3329 \| HSPD1 \| DISEASES 80320 \| SP6 \| DISEASES 1308 \| COL17A1 \| DISEASES 113675 \| SDSL \| DISEASES 3716 \| JAK1 \| DISEASES 467 \| ATF3 \| DISEASES 2879 \| GPX4 \| DISEASES 6334 \| SCN8A \| DISEASES 5325 \| PLAGL1 \| DISEASES 4010 \| LMX1B \| DISEASES 160364 \| CLEC12A \| DISEASES 3482 \| IGF2R \| DISEASES 5625 \| PRODH \| DISEASES 54097 \| FAM3B \| DISEASES 6693 \| SPN \| DISEASES 9851 \| KIAA0753 \| DISEASES 2214 \| FCGR3A \| DISEASES 51744 \| CD244 \| DISEASES 962 \| CD48 \| DISEASES 9447 \| AIM2 \| DISEASES 911 \| CD1C \| DISEASES 257 \| ALX3 \| DISEASES 1629 \| DBT \| DISEASES 8945 \| BTRC \| DISEASES 1806 \| DPYD \| DISEASES 959 \| CD40LG \| DISEASES 680 \| BRS3 \| DISEASES 9968 \| MED12 \| DISEASES 3376 \| IARS \| DISEASES 114769 \| CARD16 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 3105 \| HLA-A \| DISEASES 57126 \| CD177 \| DISEASES 9308 \| CD83 \| DISEASES 3440 \| IFNA2 \| DISEASES 3456 \| IFNB1 \| DISEASES 551 \| AVP \| DISEASES 11168 \| PSIP1 \| DISEASES 51109 \| RDH11 \| DISEASES 361 \| AQP4 \| DISEASES 8513 \| LIPF \| DISEASES 137872 \| ADHFE1 \| DISEASES 2628 \| GATM \| DISEASES 10379 \| IRF9 \| DISEASES 594857 \| NPS \| DISEASES 7442 \| TRPV1 \| DISEASES 146713 \| RBFOX3 \| DISEASES 7124 \| TNF \| DISEASES 7086 \| TKT \| DISEASES 139728 \| PNCK \| DISEASES 81704 \| DOCK8 \| DISEASES 196527 \| ANO6 \| DISEASES 3850 \| KRT3 \| DISEASES 6229 \| RPS24 \| DISEASES 23741 \| EID1 \| DISEASES 3347 \| HTN3 \| DISEASES 9152 \| SLC6A5 \| DISEASES 930 \| CD19 \| DISEASES 83695 \| RHNO1 \| DISEASES 488 \| ATP2A2 \| DISEASES 8615 \| USO1 \| DISEASES 567 \| B2M \| DISEASES 10866 \| HCP5 \| DISEASES 102723508 \| KANTR \| DISEASES 94161 \| SNORD46 \| DISEASES
Locus	(Waiting for update.)

Disease ID	720
Disease	herpes zoster
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:71) HP:0012531 \| Pain \| 27 HP:0001370 \| Rheumatoid arthritis \| 8 HP:0001369 \| Arthritis \| 6 HP:0002725 \| Systemic lupus erythematosus \| 5 HP:0000819 \| Diabetes mellitus \| 4 HP:0000491 \| Corneal inflammation \| 3 HP:0002721 \| Immunodeficiency \| 3 HP:0002665 \| Lymphoma \| 3 HP:0002326 \| TIA \| 2 HP:0004398 \| Peptic ulcer \| 2 HP:0003765 \| Psoriasis \| 2 HP:0012189 \| Hodgkin disease \| 2 HP:0007824 \| Total ophthalmoplegia \| 2 HP:0000554 \| Uveitis \| 2 HP:0100653 \| Optic neuritis \| 2 HP:0010628 \| Facial palsy, unilateral or bilateral \| 2 HP:0006510 \| Chronic obstructive pulmonary disease \| 2 HP:0003470 \| Inability to move \| 2 HP:0002383 \| Encephalitis \| 2 HP:0012539 \| Non-Hodgkin lymphoma \| 2 HP:0000602 \| Ophthalmoplegia \| 2 HP:0001596 \| Hair loss \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0100280 \| Morbus Crohn \| 1 HP:0001945 \| Fever \| 1 HP:0002204 \| Pulmonary embolism \| 1 HP:0002664 \| Neoplasia \| 1 HP:0000802 \| Erectile dysfunction \| 1 HP:0004836 \| Acute promyelocytic leukemia \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0001271 \| Polyneuropathy \| 1 HP:0002754 \| Bone infection \| 1 HP:0002527 \| Falls \| 1 HP:0001287 \| Meningitis \| 1 HP:0100533 \| Ocular inflammation \| 1 HP:0001096 \| Keratoconjunctivitis \| 1 HP:0012190 \| T cell lymphoma \| 1 HP:0012155 \| Reduced corneal sensation \| 1 HP:0000618 \| Blindness \| 1 HP:0001903 \| Anemia \| 1 HP:0002019 \| Dyschezia \| 1 HP:0000716 \| Depression \| 1 HP:0012451 \| Acute constipation \| 1 HP:0011349 \| Sixth nerve palsy \| 1 HP:0001649 \| Tachycardia \| 1 HP:0002633 \| Vasculitis \| 1 HP:0001735 \| Acute pancreatitis \| 1 HP:0012533 \| Allodynia \| 1 HP:0010783 \| Erythema \| 1 HP:0005681 \| Juvenile idiopathic arthritis \| 1 HP:0002277 \| Horner's syndrome \| 1 HP:0001291 \| Cranial nerve disease \| 1 HP:0002861 \| Melanoma \| 1 HP:0000016 \| Urinary retention \| 1 HP:0002094 \| Dyspnea \| 1 HP:0002099 \| Asthma \| 1 HP:0007209 \| Facial paresis \| 1 HP:0200034 \| Papule \| 1 HP:0000572 \| Visual loss \| 1 HP:0006597 \| Paralyzed diaphragm \| 1 HP:0007011 \| Superior oblique palsy \| 1 HP:0006775 \| Multiple myeloma \| 1 HP:0006824 \| Cranial nerve palsy \| 1 HP:0012089 \| Arteritis \| 1 HP:0100242 \| Sarcoma \| 1 HP:0200037 \| Skin vesicle \| 1 HP:0010562 \| Keloids \| 1 HP:0002229 \| Alopecia areata \| 1 HP:0011868 \| Sciatica \| 1 HP:0010550 \| Paraplegia \| 1 HP:0000989 \| pruritis \| 1

Disease ID	720
Disease	herpes zoster
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:27) C0030193 \| pain \| 27 C0009450 \| infection \| 12 C0027796 \| neuralgia \| 7 C0032768 \| postherpetic neuralgia \| 6 C0021311 \| infections \| 6 C0003864 \| arthritis \| 6 C0423716 \| neuropathic pain \| 5 C0015230 \| rash \| 5 C0024141 \| systemic lupus erythematosus \| 5 C0184567 \| acute pain \| 3 C0027813 \| neuritis \| 3 C0278140 \| severe pain \| 3 C0030552 \| paresis \| 3 C0009377 \| colonic pseudo-obstruction \| 2 C0033860 \| psoriasis \| 2 C0029089 \| ophthalmoplegia \| 2 C0014038 \| encephalitis \| 2 C0025289 \| meningitis \| 1 C0008049 \| chickenpox \| 1 C0341742 \| acute urinary retention \| 1 C0263358 \| erythema annulare centrifugum \| 1 C0015469 \| facial paralysis \| 1 C1834580 \| ramsay hunt syndrome \| 1 C0037284 \| skin lesions \| 1 C0037284 \| skin lesion \| 1 C0015464 \| facial palsy \| 1 C1839611 \| n syndrome \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs114864815	25297839	10866	HCP5	umls:C0019360	GWASCAT	Genetic variation in the HLA region is associated with susceptibility to herpes zoster.	0.12	2014	NA	NA	NA	NA	NA

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:2)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0019360	famciclovir	C060590	104227-87-4	herpes zoster	MESH:D006562	therapeutic	15181487
C0019360	methotrexate	D008727	1959/5/2	herpes zoster	MESH:D006562	marker/mechanism	8779788

FDA approved drug and dosage information(Total Drugs:2)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D006562	famvir	famciclovir	250MG	TABLET;ORAL	Discontinued	None	Yes	No
MESH:D006562	famvir	famciclovir	250MG	TABLET;ORAL	Discontinued	None	Yes	No

FDA labeling changes(Total Drugs:2)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D006562	12/24/2009	famvir	famciclovir	Treatment of children 1 month 12 years of age w/ herpes simplex (HSV) & 1 12 years w/ varicella zoster (VSV)	Available data are insufficient to support the use of famciclovir for the treatment of children with chickenpox or infections due to HSV The PK profile and safety were studied in 2 open-label studies: (1) a single-dose PK and safety study in infants 1 month to	Labeling	-	-	B, P	-	Novartis	09/21/2009	FALSE'
MESH:D006562	9/2/2012	famvir	famciclovir	Recurrent herpes labialis	Efficacy has not been established in pediatric patients for the treatment of recurrent herpes labialis Information on an open label PK, safety and efficacy study in children 12 to	Labeling	-	P	-	-	Novartis	-	-

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