PedAM

Pediatric Disease Annotations & Medicines


	herpes simplex infections

Disease ID	1055
Disease	herpes simplex infections
Definition	A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)
Synonym	diseases herpes simplex herpes infections simplex herpes simplex herpes simplex (disorder) herpes simplex (excl f85 x90 y72) herpes simplex (excluding f85 x90 y72) herpes simplex [disease/finding] herpes simplex complex herpes simplex disease herpes simplex infection herpes simplex viral infection herpes simplex virus infection herpes simplex, nos herpesvirus hominis disease hsv infection herpes simplex simplex - herpes simplex herpes
DOID	DOID:8566
UMLS	C0019348
MeSH	D006561
SNOMED-CT	SNOMEDCT_US_2016_09_01:88594005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:97) C0014038 \| encephalitis \| 8 C0022568 \| keratitis \| 6 C0025289 \| meningitis \| 6 C0042769 \| viral infection \| 5 C0010346 \| crohn's disease \| 5 C0014742 \| erythema multiforme \| 4 C0019158 \| hepatitis \| 4 C0042769 \| viral infections \| 3 C0015397 \| eye disease \| 3 C0025290 \| aseptic meningitis \| 2 C0023418 \| leukemia \| 2 C0019342 \| genital herpes \| 2 C0001175 \| acquired immunodeficiency syndrome \| 2 C0019360 \| zoster \| 2 C0042164 \| uveitis \| 2 C0032285 \| pneumonia \| 2 C0014544 \| epilepsy \| 2 C0035319 \| acute retinal necrosis \| 2 C0750114 \| vaginosis \| 2 C0011847 \| diabetes \| 1 C0028840 \| ocular hypertension \| 1 C0001339 \| acute pancreatitis \| 1 C0020538 \| hypertension \| 1 C0279637 \| anal carcinoma \| 1 C0009402 \| colorectal cancer \| 1 C0008049 \| varicella \| 1 C0156147 \| crohn's colitis \| 1 C0011603 \| dermatitis \| 1 C0024305 \| non-hodgkin lymphoma \| 1 C0242770 \| bronchiolitis obliterans organizing pneumonia \| 1 C0007113 \| rectal cancer \| 1 C0019829 \| hodgkin lymphoma \| 1 C0085166 \| bacterial vaginosis \| 1 C0032285 \| pneumoniae \| 1 C0024115 \| lung diseases \| 1 C0025202 \| malignant melanoma \| 1 C0151436 \| leukocytoclastic vasculitis \| 1 C0086543 \| cataract \| 1 C0018378 \| guillain-barre syndrome \| 1 C0030305 \| pancreatitis \| 1 C0007682 \| central nervous system disease \| 1 C0024115 \| lung disease \| 1 C1704437 \| respiratory distress syndrome \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0042165 \| anterior uveitis \| 1 C0025297 \| viral meningitis \| 1 C0007102 \| colon cancer \| 1 C0034494 \| rabies \| 1 C0271051 \| macular edema \| 1 C0409974 \| lupus erythematosus \| 1 C0020555 \| hypertrichosis \| 1 C0014236 \| endophthalmitis \| 1 C0014068 \| encephalomalacia \| 1 C0037274 \| dermatosis \| 1 C0014070 \| encephalomyelitis \| 1 C0025286 \| meningioma \| 1 C0024291 \| hemophagocytic lymphohistiocytosis \| 1 C0042384 \| vasculitis \| 1 C0024291 \| hemophagocytic syndrome \| 1 C0008526 \| choroiditis \| 1 C0037274 \| skin disease \| 1 C1096063 \| intractable epilepsy \| 1 C0030807 \| pemphigus \| 1 C0019360 \| herpes zoster \| 1 C0011226 \| hepatitis d \| 1 C0025202 \| melanoma \| 1 C0035302 \| retinal artery occlusion \| 1 C0014179 \| uterine infection \| 1 C0010043 \| corneal ulcer \| 1 C0035222 \| acute respiratory distress syndrome \| 1 C0751690 \| malignant peripheral nerve sheath tumor \| 1 C0024205 \| lymphadenitis \| 1 C0011570 \| depression \| 1 C0008312 \| primary biliary cirrhosis \| 1 C0004114 \| astrocytoma \| 1 C0024440 \| cystoid macular edema \| 1 C0334579 \| anaplastic astrocytoma \| 1 C0152113 \| acute chorea \| 1 C0016436 \| folliculitis \| 1 C0008312 \| biliary cirrhosis \| 1 C0021400 \| influenza \| 1 C0010043 \| corneal ulceration \| 1 C0027765 \| nervous system disease \| 1 C0007688 \| central retinal artery occlusion \| 1 C0015469 \| facial paralysis \| 1 C0042109 \| urticaria \| 1 C1145670 \| respiratory failure \| 1 C0038220 \| status epilepticus \| 1 C0006142 \| breast cancer \| 1 C0014868 \| esophagitis \| 1 C0022398 \| hyper-ige syndrome \| 1 C0162293 \| papillitis \| 1 C0007137 \| squamous cell carcinoma \| 1 C0006430 \| burning mouth syndrome \| 1 C0016057 \| fibrosarcoma \| 1 C0004771 \| bartonellosis \| 1 C0009447 \| common variable immunodeficiency \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 1312 \| COMT \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:290) 9957 \| HS3ST1 \| DISEASES 920 \| CD4 \| DISEASES 83992 \| CTTNBP2 \| DISEASES 30009 \| TBX21 \| DISEASES 4710 \| NDUFB4 \| DISEASES 23645 \| PPP1R15A \| DISEASES 124 \| ADH1A \| DISEASES 83933 \| HDAC10 \| DISEASES 3002 \| GZMB \| DISEASES 4792 \| NFKBIA \| DISEASES 51311 \| TLR8 \| DISEASES 2137 \| EXTL3 \| DISEASES 7038 \| TG \| DISEASES 2765 \| GML \| DISEASES 23581 \| CASP14 \| DISEASES 973 \| CD79A \| DISEASES 3982 \| LIM2 \| DISEASES 6348 \| CCL3 \| DISEASES 30851 \| TAX1BP3 \| DISEASES 10951 \| CBX1 \| DISEASES 6347 \| CCL2 \| DISEASES 5197 \| PF4V1 \| DISEASES 3558 \| IL2 \| DISEASES 81622 \| UNC93B1 \| DISEASES 969 \| CD69 \| DISEASES 3458 \| IFNG \| DISEASES 6908 \| TBP \| DISEASES 3003 \| GZMK \| DISEASES 3565 \| IL4 \| DISEASES 5948 \| RBP2 \| DISEASES 5610 \| EIF2AK2 \| DISEASES 22924 \| MAPRE3 \| DISEASES 55640 \| FLVCR2 \| DISEASES 1846 \| DUSP4 \| DISEASES 2322 \| FLT3 \| DISEASES 84329 \| HVCN1 \| DISEASES 5266 \| PI3 \| DISEASES 3024 \| HIST1H1A \| DISEASES 3659 \| IRF1 \| DISEASES 718 \| C3 \| DISEASES 7533 \| YWHAH \| DISEASES 43849 \| KLK12 \| DISEASES 348 \| APOE \| DISEASES 3727 \| JUND \| DISEASES 1401 \| CRP \| DISEASES 1965 \| EIF2S1 \| DISEASES 1823 \| DSC1 \| DISEASES 3569 \| IL6 \| DISEASES 2995 \| GYPC \| DISEASES 7097 \| TLR2 \| DISEASES 3685 \| ITGAV \| DISEASES 3843 \| IPO5 \| DISEASES 3839 \| KPNA3 \| DISEASES 83464 \| APH1B \| DISEASES 904 \| CCNT1 \| DISEASES 7528 \| YY1 \| DISEASES 27033 \| ZBTB32 \| DISEASES 23523 \| CABIN1 \| DISEASES 51586 \| MED15 \| DISEASES 2033 \| EP300 \| DISEASES 3553 \| IL1B \| DISEASES 5067 \| CNTN3 \| DISEASES 7301 \| TYRO3 \| DISEASES 3574 \| IL7 \| DISEASES 1615 \| DARS \| DISEASES 941 \| CD80 \| DISEASES 7294 \| TXK \| DISEASES 5443 \| POMC \| DISEASES 7297 \| TYK2 \| DISEASES 51809 \| GALNT7 \| DISEASES 10923 \| SUB1 \| DISEASES 3371 \| TNC \| DISEASES 793 \| CALB1 \| DISEASES 2515 \| ADAM2 \| DISEASES 2965 \| GTF2H1 \| DISEASES 3700 \| ITIH4 \| DISEASES 25793 \| FBXO7 \| DISEASES 7112 \| TMPO \| DISEASES 50511 \| SYCP3 \| DISEASES 10140 \| TOB1 \| DISEASES 7157 \| TP53 \| DISEASES 402665 \| IGLON5 \| DISEASES 10699 \| CORIN \| DISEASES 3439 \| IFNA1 \| DISEASES 2697 \| GJA1 \| DISEASES 136991 \| ASZ1 \| DISEASES 54149 \| C21orf91 \| DISEASES 1436 \| CSF1R \| DISEASES 9154 \| SLC28A1 \| DISEASES 29028 \| ATAD2 \| DISEASES 2207 \| FCER1G \| DISEASES 3460 \| IFNGR2 \| DISEASES 5152 \| PDE9A \| DISEASES 5316 \| PKNOX1 \| DISEASES 92799 \| SHKBP1 \| DISEASES 9437 \| NCR1 \| DISEASES 1234 \| CCR5 \| DISEASES 6352 \| CCL5 \| DISEASES 2215 \| FCGR3B \| DISEASES 23498 \| HAAO \| DISEASES 213 \| ALB \| DISEASES 134147 \| CMBL \| DISEASES 9607 \| CARTPT \| DISEASES 7098 \| TLR3 \| DISEASES 1437 \| CSF2 \| DISEASES 6240 \| RRM1 \| DISEASES 7083 \| TK1 \| DISEASES 116285 \| ACSM1 \| DISEASES 3960 \| LGALS4 \| DISEASES 9081 \| PRY \| DISEASES 442862 \| PRY2 \| DISEASES 1673 \| DEFB4A \| DISEASES 442866 \| PRYP4 \| DISEASES 136647 \| MPLKIP \| DISEASES 1841 \| DTYMK \| DISEASES 3596 \| IL13 \| DISEASES 3627 \| CXCL10 \| DISEASES 27087 \| B3GAT1 \| DISEASES 10855 \| HPSE \| DISEASES 3054 \| HCFC1 \| DISEASES 3661 \| IRF3 \| DISEASES 836 \| CASP3 \| DISEASES 196883 \| ADCY4 \| DISEASES 493829 \| TRIM72 \| DISEASES 10713 \| USP39 \| DISEASES 998 \| CDC42 \| DISEASES 9153 \| SLC28A2 \| DISEASES 1191 \| CLU \| DISEASES 30835 \| CD209 \| DISEASES 80381 \| CD276 \| DISEASES 414325 \| DEFB103A \| DISEASES 54802 \| TRIT1 \| DISEASES 6181 \| RPLP2 \| DISEASES 11284 \| PNKP \| DISEASES 26061 \| HACL1 \| DISEASES 2 \| A2M \| DISEASES 5179 \| PENK \| DISEASES 55894 \| DEFB103B \| DISEASES 5663 \| PSEN1 \| DISEASES 81857 \| MED25 \| DISEASES 2187 \| FANCB \| DISEASES 30845 \| EHD3 \| DISEASES 1668 \| DEFA3 \| DISEASES 706 \| TSPO \| DISEASES 83733 \| SLC25A18 \| DISEASES 10871 \| CD300C \| DISEASES 29110 \| TBK1 \| DISEASES 3009 \| HIST1H1B \| DISEASES 6007 \| RHD \| DISEASES 942 \| CD86 \| DISEASES 2689 \| GH2 \| DISEASES 23180 \| RFTN1 \| DISEASES 3840 \| KPNA4 \| DISEASES 4835 \| NQO2 \| DISEASES 7430 \| EZR \| DISEASES 391 \| RHOG \| DISEASES 3423 \| IDS \| DISEASES 85480 \| TSLP \| DISEASES 84247 \| LDOC1L \| DISEASES 259197 \| NCR3 \| DISEASES 4939 \| OAS2 \| DISEASES 442865 \| PRYP3 \| DISEASES 57556 \| SEMA6A \| DISEASES 8764 \| TNFRSF14 \| DISEASES 283420 \| CLEC9A \| DISEASES 6898 \| TAT \| DISEASES 2975 \| GTF3C1 \| DISEASES 10219 \| KLRG1 \| DISEASES 5625 \| PRODH \| DISEASES 987 \| LRBA \| DISEASES 23644 \| EDC4 \| DISEASES 5139 \| PDE3A \| DISEASES 6942 \| TCF20 \| DISEASES 6693 \| SPN \| DISEASES 6241 \| RRM2 \| DISEASES 54106 \| TLR9 \| DISEASES 6772 \| STAT1 \| DISEASES 57154 \| SMURF1 \| DISEASES 800 \| CALD1 \| DISEASES 4283 \| CXCL9 \| DISEASES 159 \| ADSS \| DISEASES 2987 \| GUK1 \| DISEASES 1378 \| CR1 \| DISEASES 1380 \| CR2 \| DISEASES 93273 \| LEMD1 \| DISEASES 1660 \| DHX9 \| DISEASES 3459 \| IFNGR1 \| DISEASES 5451 \| POU2F1 \| DISEASES 2214 \| FCGR3A \| DISEASES 154215 \| NKAIN2 \| DISEASES 2444 \| FRK \| DISEASES 2312 \| FLG \| DISEASES 4942 \| OAT \| DISEASES 8732 \| RNGTT \| DISEASES 4803 \| NGF \| DISEASES 8517 \| IKBKG \| DISEASES 51750 \| RTEL1 \| DISEASES 2959 \| GTF2B \| DISEASES 959 \| CD40LG \| DISEASES 9295 \| SRSF11 \| DISEASES 9023 \| CH25H \| DISEASES 1580 \| CYP4B1 \| DISEASES 23234 \| DNAJC9 \| DISEASES 5456 \| POU3F4 \| DISEASES 7099 \| TLR4 \| DISEASES 9968 \| MED12 \| DISEASES 1043 \| CD52 \| DISEASES 58493 \| INIP \| DISEASES 25932 \| CLIC4 \| DISEASES 10880 \| ACTL7B \| DISEASES 3127 \| HLA-DRB5 \| DISEASES 3304 \| HSPA1B \| DISEASES 23013 \| SPEN \| DISEASES 7174 \| TPP2 \| DISEASES 64078 \| SLC28A3 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 5422 \| POLA1 \| DISEASES 168400 \| DDX53 \| DISEASES 23586 \| DDX58 \| DISEASES 3440 \| IFNA2 \| DISEASES 3443 \| IFNA6 \| DISEASES 3456 \| IFNB1 \| DISEASES 5277 \| PIGA \| DISEASES 8644 \| AKR1C3 \| DISEASES 3030 \| HADHA \| DISEASES 51284 \| TLR7 \| DISEASES 1854 \| DUT \| DISEASES 3822 \| KLRC2 \| DISEASES 4155 \| MBP \| DISEASES 64979 \| MRPL36 \| DISEASES 10675 \| CSPG5 \| DISEASES 388698 \| FLG2 \| DISEASES 53635 \| PTOV1 \| DISEASES 7187 \| TRAF3 \| DISEASES 51559 \| NT5DC3 \| DISEASES 8301 \| PICALM \| DISEASES 3660 \| IRF2 \| DISEASES 2919 \| CXCL1 \| DISEASES 2737 \| GLI3 \| DISEASES 63915 \| BLOC1S5 \| DISEASES 10195 \| ALG3 \| DISEASES 346562 \| GNAT3 \| DISEASES 23028 \| KDM1A \| DISEASES 8091 \| HMGA2 \| DISEASES 1439 \| CSF2RB \| DISEASES 5970 \| RELA \| DISEASES 79153 \| GDPD3 \| DISEASES 1363 \| CPE \| DISEASES 10618 \| TGOLN2 \| DISEASES 9873 \| FCHSD2 \| DISEASES 132160 \| PPM1M \| DISEASES 27247 \| NFU1 \| DISEASES 65250 \| C5orf42 \| DISEASES 404281 \| YY2 \| DISEASES 1747 \| DLX3 \| DISEASES 51135 \| IRAK4 \| DISEASES 2086 \| ERV3-1 \| DISEASES 57448 \| BIRC6 \| DISEASES 388552 \| BLOC1S3 \| DISEASES 2664 \| GDI1 \| DISEASES 387836 \| CLEC2A \| DISEASES 7124 \| TNF \| DISEASES 3106 \| HLA-B \| DISEASES 4615 \| MYD88 \| DISEASES 3594 \| IL12RB1 \| DISEASES 3586 \| IL10 \| DISEASES 6229 \| RPS24 \| DISEASES 721 \| C4B \| DISEASES 30816 \| ERVW-1 \| DISEASES 51428 \| DDX41 \| DISEASES 83697 \| SLC4A9 \| DISEASES 222537 \| HS3ST5 \| DISEASES 56943 \| ENY2 \| DISEASES 5452 \| POU2F2 \| DISEASES 2197 \| FAU \| DISEASES 10480 \| EIF3M \| DISEASES 488 \| ATP2A2 \| DISEASES 11153 \| FICD \| DISEASES 567 \| B2M \| DISEASES 100128731 \| OST4 \| DISEASES 820 \| CAMP \| DISEASES 23186 \| RCOR1 \| DISEASES 11201 \| POLI \| DISEASES 2323 \| FLT3LG \| DISEASES 246734 \| NPCDR1 \| DISEASES 147664 \| ERVV-1 \| DISEASES 594842 \| HAS2-AS1 \| DISEASES 51214 \| IGF2-AS \| DISEASES 440900 \| LINC01191 \| DISEASES 9299 \| SNORD30 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1055
Disease	herpes simplex infections
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:68) HP:0002383 \| Encephalitis \| 8 HP:0001287 \| Meningitis \| 6 HP:0002664 \| Neoplasia \| 6 HP:0000491 \| Corneal inflammation \| 6 HP:0100280 \| Morbus Crohn \| 5 HP:0012115 \| Liver inflammation \| 4 HP:0010783 \| Erythema \| 3 HP:0030731 \| Carcinoma \| 3 HP:0001399 \| Liver failure \| 3 HP:0012531 \| Pain \| 2 HP:0001581 \| Recurrent skin infections \| 2 HP:0011450 \| CNS infection \| 2 HP:0002072 \| Chorea \| 2 HP:0004787 \| Fulminant hepatitis \| 2 HP:0006554 \| Acute hepatic failure \| 2 HP:0001909 \| Leukemia \| 2 HP:0003470 \| Inability to move \| 2 HP:0000554 \| Uveitis \| 2 HP:0000969 \| Dropsy \| 2 HP:0012532 \| Chronic pain \| 2 HP:0002090 \| Pneumonia \| 2 HP:0002721 \| Immunodeficiency \| 2 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0002119 \| Ventricular dilatation \| 1 HP:0003003 \| Colon cancer \| 1 HP:0100244 \| Fibrosarcoma \| 1 HP:0002840 \| Lymphadenitis \| 1 HP:0000282 \| Facial puffiness \| 1 HP:0002098 \| Respiratory distress \| 1 HP:0009733 \| Glioma \| 1 HP:0000989 \| pruritis \| 1 HP:0002878 \| Respiratory failure \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0002858 \| Mengiomia \| 1 HP:0000518 \| Cataract \| 1 HP:0012122 \| Anterior uveitis \| 1 HP:0001892 \| Bleeding diathesis \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0002133 \| Status epilepticus \| 1 HP:0100786 \| Excessive sleepiness \| 1 HP:0009592 \| Astrocytoma \| 1 HP:0006946 \| Recurrent meningitis \| 1 HP:0001735 \| Acute pancreatitis \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0012123 \| Posterior uveitis \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0000708 \| Behavioral problems \| 1 HP:0002861 \| Melanoma \| 1 HP:0011945 \| Cryptogenic organizing pneumonia \| 1 HP:0000822 \| Hypertension \| 1 HP:0007209 \| Facial paresis \| 1 HP:0002015 \| Swallowing difficulty \| 1 HP:0001266 \| Choreoathetosis \| 1 HP:0001945 \| Fever \| 1 HP:0000155 \| Oral ulcer \| 1 HP:0100633 \| Inflammation of the esophagus \| 1 HP:0000716 \| Depression \| 1 HP:0002613 \| Biliary cirrhosis \| 1 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0040049 \| Macular edema \| 1 HP:0012539 \| Non-Hodgkin lymphoma \| 1 HP:0040197 \| Encephalomalacia \| 1 HP:0002633 \| Vasculitis \| 1 HP:0100697 \| Neurofibrosarcoma \| 1 HP:0012804 \| Corneal ulceration \| 1 HP:0001025 \| Hives \| 1 HP:0000998 \| Hypertrichosis \| 1 HP:0011505 \| Cystoid macular edema \| 1

Disease ID	1055
Disease	herpes simplex infections
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:34) C0009450 \| infection \| 163 C0021311 \| infections \| 32 C0015403 \| ocular infection \| 9 C0014038 \| encephalitis \| 8 C0025289 \| meningitis \| 6 C0022568 \| keratitis \| 6 C0042769 \| viral infection \| 5 C0872054 \| latent infection \| 4 C0014742 \| erythema multiforme \| 4 C0729552 \| genital infection \| 4 C0085605 \| liver failure \| 3 C0015397 \| eye disease \| 3 C0729777 \| corneal infection \| 3 C0025290 \| aseptic meningitis \| 2 C0042164 \| uveitis \| 2 C0019357 \| herpetic keratitis \| 2 C0275518 \| acute infection \| 2 C0404521 \| vaginal infection \| 2 C0302809 \| fulminant hepatitis \| 2 C0032285 \| pneumonia \| 2 C0275524 \| mixed infection \| 2 C0035319 \| acute retinal necrosis \| 2 C0019342 \| genital herpes \| 2 C0275544 \| congenital infection \| 1 C0555970 \| nasal infection \| 1 C0220979 \| mollaret's meningitis \| 1 C0007684 \| central nervous system infection \| 1 C0221269 \| pseudolymphoma \| 1 C0024291 \| hemophagocytic lymphohistiocytosis \| 1 C0001339 \| acute pancreatitis \| 1 C0014868 \| esophagitis \| 1 C0022504 \| kaposi's varicelliform eruption \| 1 C0024291 \| hemophagocytic syndrome \| 1 C0042165 \| anterior uveitis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:5)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs179363878	17547716	326	AIRE	umls:C0019348	BeFree	Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations.	0.000542884	2007	AIRE	21	44286089	T	C
rs179363879	17547716	326	AIRE	umls:C0019348	BeFree	Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations.	0.000542884	2007	AIRE	21	44286092	T	C
rs1805539	21919190	2904	GRIN2B	umls:C0019348	BeFree	Significant interaction between maternal HSV-2 seropositivity and GRIN2B genetic variation in the offspring were observed for seven SNPs and two remained significant after Bonferroni correction (rs1805539, P(nominal) = 0.0001 and rs1806205, P(nominal) = 0.0008).	0.000271442	2011	GRIN2B;LOC105369668	12	13617256	G	C
rs1806205	21919190	2904	GRIN2B	umls:C0019348	BeFree	Significant interaction between maternal HSV-2 seropositivity and GRIN2B genetic variation in the offspring were observed for seven SNPs and two remained significant after Bonferroni correction (rs1805539, P(nominal) = 0.0001 and rs1806205, P(nominal) = 0.0008).	0.000271442	2011	GRIN2B	12	13566469	G	C
rs4680	16542182	1312	COMT	umls:C0019348	BeFree	Both the COMT Val158Met polymorphism and serological evidence of HSV-1 infection affect cognitive functioning in individuals with bipolar disorder.	0.002638474	2006	COMT;MIR4761	22	19963748	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:4)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0019348	amsacrine	D000677	-	herpes simplex	MESH:D006561	therapeutic	10809021
C0019348	chlorpromazine	D002746	50-53-3	herpes simplex	MESH:D006561	therapeutic	1682908
C0019348	haloperidol	D006220	52-86-8	herpes simplex	MESH:D006561	therapeutic	3371192
C0019348	temozolomide	C047246	85622-93-1	herpes simplex	MESH:D006561	marker/mechanism	17134363

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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