PedAM

Pediatric Disease Annotations & Medicines


	hepatorenal syndrome

Disease ID	313
Disease	hepatorenal syndrome
Definition	Functional KIDNEY FAILURE in patients with liver disease, usually LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL), and in the absence of intrinsic renal disease or kidney abnormality. It is characterized by intense renal vasculature constriction, reduced renal blood flow, OLIGURIA, and sodium retention.
Synonym	failure hepatorenal hepatorenal failure hepatorenal syndrome (disorder) hepatorenal syndrome [disease/finding] heyd syndrome hrf - hepatorenal failure renal failure secondary to liver disease renal failure secondary to liver disease hepatorenal syndrome syndrome hepatorenal syndrome, hepatorenal urohepatic syndrome
DOID	DOID:11823
ICD10	ICD10CM:K76.7
UMLS	C0019212
MeSH	D006530
SNOMED-CT	SNOMEDCT_US_2016_09_01:51292008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:17) C0023890 \| cirrhosis \| 22 C0023890 \| liver cirrhosis \| 8 C0019158 \| hepatitis \| 4 C0035078 \| renal failure \| 4 C0023891 \| alcoholic liver cirrhosis \| 3 C0019196 \| hepatitis c \| 2 C0023895 \| liver disease \| 2 C0040558 \| toxoplasmosis \| 1 C0020538 \| hypertension \| 1 C0020541 \| portal hypertension \| 1 C0021390 \| inflammatory bowel disease \| 1 C0034063 \| pulmonary oedema \| 1 C0002726 \| amyloidosis \| 1 C0019163 \| hepatitis b \| 1 C0019151 \| hepatic encephalopathy \| 1 C0031154 \| peritonitis \| 1 C0021831 \| bowel disease \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) HMOX1 \| 3162 \| CTD_human EDN1 \| 1906 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 1636 \| ACE \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:65) 1774 \| DNASE1L1 \| DISEASES 84957 \| RELT \| DISEASES 359 \| AQP2 \| DISEASES 3929 \| LBP \| DISEASES 51285 \| RASL12 \| DISEASES 2091 \| FBL \| DISEASES 4598 \| MVK \| DISEASES 9409 \| PEX16 \| DISEASES 847 \| CAT \| DISEASES 57187 \| THOC2 \| DISEASES 2671 \| GFER \| DISEASES 10343 \| PKDREJ \| DISEASES 8170 \| SLC14A2 \| DISEASES 23523 \| CABIN1 \| DISEASES 7299 \| TYR \| DISEASES 590 \| BCHE \| DISEASES 54888 \| NSUN2 \| DISEASES 51083 \| GAL \| DISEASES 56938 \| ARNTL2 \| DISEASES 51411 \| BIN2 \| DISEASES 5972 \| REN \| DISEASES 10280 \| SIGMAR1 \| DISEASES 3934 \| LCN2 \| DISEASES 133 \| ADM \| DISEASES 3606 \| IL18 \| DISEASES 6750 \| SST \| DISEASES 1636 \| ACE \| DISEASES 2168 \| FABP1 \| DISEASES 213 \| ALB \| DISEASES 5885 \| RAD21 \| DISEASES 552 \| AVPR1A \| DISEASES 90678 \| LRSAM1 \| DISEASES 59350 \| RXFP1 \| DISEASES 3708 \| ITPR1 \| DISEASES 2147 \| F2 \| DISEASES 133522 \| PPARGC1B \| DISEASES 1909 \| EDNRA \| DISEASES 196500 \| PIANP \| DISEASES 554 \| AVPR2 \| DISEASES 26762 \| HAVCR1 \| DISEASES 10724 \| MGEA5 \| DISEASES 6905 \| TBCE \| DISEASES 8443 \| GNPAT \| DISEASES 8504 \| PEX3 \| DISEASES 55974 \| SLC50A1 \| DISEASES 4881 \| NPR1 \| DISEASES 27022 \| FOXD3 \| DISEASES 1759 \| DNM1 \| DISEASES 3710 \| ITPR3 \| DISEASES 1471 \| CST3 \| DISEASES 1906 \| EDN1 \| DISEASES 444 \| ASPH \| DISEASES 25820 \| ARIH1 \| DISEASES 551 \| AVP \| DISEASES 7053 \| TGM3 \| DISEASES 6019 \| RLN2 \| DISEASES 124220 \| ZG16B \| DISEASES 80196 \| RNF34 \| DISEASES 2641 \| GCG \| DISEASES 10478 \| SLC25A17 \| DISEASES 1029 \| CDKN2A \| DISEASES 7124 \| TNF \| DISEASES 5830 \| PEX5 \| DISEASES 51366 \| UBR5 \| DISEASES 567 \| B2M \| DISEASES
Locus	(Waiting for update.)

Disease ID	313
Disease	hepatorenal syndrome
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:17) HP:0001394 \| Hepatic cirrhosis \| 21 HP:0001399 \| Liver failure \| 5 HP:0001541 \| Ascites \| 5 HP:0000083 \| Renal insufficiency \| 4 HP:0100626 \| Chronic hepatic failure \| 3 HP:0012115 \| Liver inflammation \| 3 HP:0001919 \| Acute renal failure \| 3 HP:0001409 \| Portal hypertension \| 1 HP:0100806 \| Sepsis \| 1 HP:0000822 \| Hypertension \| 1 HP:0002586 \| Peritonitis \| 1 HP:0001945 \| Fever \| 1 HP:0011034 \| Amyloid disease \| 1 HP:0012280 \| Hepatic amyloidosis \| 1 HP:0100598 \| Pulmonary oedema \| 1 HP:0002480 \| Hepatic encephalopathy \| 1 HP:0002902 \| Hyponatremia \| 1

Disease ID	313
Disease	hepatorenal syndrome
Manually Symptom	UMLS \| Name(Total Manually Symptoms:4) C1963154 \| renal failure C0034063 \| pulmonary edema C0031154 \| peritonitis C0022672 \| acute tubular necrosis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0035078 \| renal failure \| 4 C0031154 \| peritonitis \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:4)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0019212	amitriptyline	D000639	50-48-6	hepatorenal syndrome	MESH:D006530	marker/mechanism	11092117
C0019212	citalopram	D015283	59729-33-8	hepatorenal syndrome	MESH:D006530	marker/mechanism	15930079
C0019212	fluvoxamine	D016666	54739-18-3	hepatorenal syndrome	MESH:D006530	marker/mechanism	15930079
C0019212	propranolol	D011433	525-66-6	hepatorenal syndrome	MESH:D006530	marker/mechanism	11051385

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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