PedAM

Pediatric Disease Annotations & Medicines


	hepatopulmonary syndrome

Disease ID	1319
Disease	hepatopulmonary syndrome
Definition	A syndrome characterized by the clinical triad of advanced chronic liver disease, pulmonary vascular dilatations, and reduced arterial oxygenation (HYPOXEMIA) in the absence of intrinsic cardiopulmonary disease. This syndrome is common in the patients with LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL).
Synonym	hepato pulmonary syndrome hepato-pulmonary syndrome hepato-pulmonary syndromes hepatopulmonary syndrome (disorder) hepatopulmonary syndrome [disease/finding] hepatopulmonary syndromes syndrome, hepato-pulmonary syndrome, hepatopulmonary syndromes, hepato-pulmonary syndromes, hepatopulmonary
DOID	DOID:900
ICD10	ICD10CM:K76.81
UMLS	C0600452
MeSH	D020065
SNOMED-CT	SNOMEDCT_US_2016_09_01:371067004
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:15) C0023890 \| cirrhosis \| 5 C0035229 \| respiratory insufficiency \| 3 C0023895 \| liver disease \| 3 C0023890 \| liver cirrhosis \| 3 C0282193 \| iron overload \| 1 C0856761 \| budd-chiari syndrome \| 1 C0020541 \| portal hypertension \| 1 C0024115 \| lung disease \| 1 C0005411 \| biliary atresia \| 1 C0018799 \| heart disease \| 1 C0020598 \| hypoglycemia \| 1 C0008312 \| biliary cirrhosis \| 1 C0206062 \| interstitial lung disease \| 1 C0009447 \| common variable immunodeficiency \| 1 C0023290 \| visceral leishmaniasis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) 6347 \| CCL2 \| infer 4846 \| NOS3 \| infer 5328 \| PLAU \| infer 5270 \| SERPINE2 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:59) 6376 \| CX3CL1 \| DISEASES 3385 \| ICAM3 \| DISEASES 3162 \| HMOX1 \| DISEASES 4350 \| MPG \| DISEASES 3163 \| HMOX2 \| DISEASES 5829 \| PXN \| DISEASES 1610 \| DAO \| DISEASES 11034 \| DSTN \| DISEASES 968 \| CD68 \| DISEASES 8431 \| NR0B2 \| DISEASES 301 \| ANXA1 \| DISEASES 7450 \| VWF \| DISEASES 6521 \| SLC4A1 \| DISEASES 1 \| A1BG \| DISEASES 3791 \| KDR \| DISEASES 6722 \| SRF \| DISEASES 51608 \| GET4 \| DISEASES 207 \| AKT1 \| DISEASES 2702 \| GJA5 \| DISEASES 167410 \| LIX1 \| DISEASES 196743 \| PAOX \| DISEASES 6750 \| SST \| DISEASES 213 \| ALB \| DISEASES 168667 \| BMPER \| DISEASES 4846 \| NOS3 \| DISEASES 27249 \| MMADHC \| DISEASES 54498 \| SMOX \| DISEASES 2147 \| F2 \| DISEASES 358 \| AQP1 \| DISEASES 2629 \| GBA \| DISEASES 1909 \| EDNRA \| DISEASES 9377 \| COX5A \| DISEASES 6888 \| TALDO1 \| DISEASES 3309 \| HSPA5 \| DISEASES 4843 \| NOS2 \| DISEASES 859 \| CAV3 \| DISEASES 2701 \| GJA4 \| DISEASES 302 \| ANXA2 \| DISEASES 1785 \| DNM2 \| DISEASES 1524 \| CX3CR1 \| DISEASES 26580 \| BSCL2 \| DISEASES 57154 \| SMURF1 \| DISEASES 7432 \| VIP \| DISEASES 7422 \| VEGFA \| DISEASES 7075 \| TIE1 \| DISEASES 5292 \| PIM1 \| DISEASES 84890 \| ADO \| DISEASES 659 \| BMPR2 \| DISEASES 1910 \| EDNRB \| DISEASES 650 \| BMP2 \| DISEASES 1906 \| EDN1 \| DISEASES 4629 \| MYH11 \| DISEASES 388552 \| BLOC1S3 \| DISEASES 7124 \| TNF \| DISEASES 93649 \| MYOCD \| DISEASES 100506742 \| CASP12 \| DISEASES 441864 \| TARM1 \| DISEASES 4090 \| SMAD5 \| DISEASES 9971 \| NR1H4 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1319
Disease	hepatopulmonary syndrome
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:14) HP:0012418 \| Low blood oxygen level \| 6 HP:0001394 \| Hepatic cirrhosis \| 5 HP:0002093 \| progressive respiratory failure \| 3 HP:0001519 \| Dolichostenomelia \| 1 HP:0001943 \| Hypoglycemia \| 1 HP:0002639 \| Budd-Chiari syndrome \| 1 HP:0006530 \| Interstitial lung disease \| 1 HP:0001217 \| Digital clubbing \| 1 HP:0002613 \| Biliary cirrhosis \| 1 HP:0001667 \| Right ventricular hypertrophy \| 1 HP:0005912 \| Biliary duct atresia \| 1 HP:0000961 \| Cyanosis \| 1 HP:0001714 \| Ventricular hypertrophy \| 1 HP:0001409 \| Portal hypertension \| 1

Disease ID	1319
Disease	hepatopulmonary syndrome
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0600452	methadone	D008691	76-99-3	hepatopulmonary syndrome	MESH:D020065	marker/mechanism	20583080

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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