PedAM

Pediatric Disease Annotations & Medicines


	hepatocellular adenoma

Disease ID	321
Disease	hepatocellular adenoma
Definition	A benign epithelial tumor of the LIVER.
Synonym	adenoma liver adenoma of liver adenoma of liver (disorder) adenoma of liver cells adenoma of the liver cells adenoma, hepatocellular adenoma, hepatocellular, benign adenoma, liver cell adenoma, liver cell [disease/finding] adenomas hepatic adenomas liver adenomas, hepatocellular adenomas, liver cell benign hepatoma benign hepatomas hca hca - hepatocellular adenoma hepatic adenoma hepatocellular adenoma hepatocellular adenomas hepatoma, benign hepatomas, benign liver adenoma liver adenomas liver cell adenoma liver cell adenoma (morphologic abnormality) liver cell adenomas
Orphanet	ORPHANET:54272
DOID	DOID:0050868
UMLS	C0206669
MeSH	D018248
SNOMED-CT	SNOMEDCT_US_2016_09_01:424263008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:19) C0017919 \| glycogen storage disease \| 5 C0019204 \| hepatocellular carcinoma \| 3 C0017920 \| glycogen storage disease type i \| 2 C0028754 \| obesity \| 1 C0032580 \| polyposis coli \| 1 C0008313 \| sclerosing cholangitis \| 1 C0032580 \| adenomatous polyposis coli \| 1 C0011847 \| diabetes \| 1 C0032580 \| familial adenomatous polyposis coli \| 1 C0153676 \| lung metastasis \| 1 C0017920 \| type i glycogen storage disease \| 1 C0023903 \| liver neoplasms \| 1 C0566602 \| primary sclerosing cholangitis \| 1 C0023903 \| liver tumor \| 1 C0032580 \| adenomatous polyposis \| 1 C0032580 \| familial adenomatous polyposis \| 1 C0342276 \| maturity-onset diabetes of the young \| 1 C1261473 \| sarcoma \| 1 C0011860 \| maturity-onset diabetes \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) HRAS \| 3265 \| CTD_human CTNNB1 \| 1499 \| CTD_human NR1I3 \| 9970 \| CTD_human CDKN1B \| 1027 \| CTD_human A2M \| 2 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:109) 5898 \| RALA \| DISEASES 6820 \| SULT2B1 \| DISEASES 57186 \| RALGAPA2 \| DISEASES 5716 \| PSMD10 \| DISEASES 10226 \| PLIN3 \| DISEASES 3036 \| HAS1 \| DISEASES 1962 \| EHHADH \| DISEASES 7799 \| PRDM2 \| DISEASES 2806 \| GOT2 \| DISEASES 1446 \| CSN1S1 \| DISEASES 4974 \| OMG \| DISEASES 2678 \| GGT1 \| DISEASES 1571 \| CYP2E1 \| DISEASES 445 \| ASS1 \| DISEASES 9113 \| LATS1 \| DISEASES 2538 \| G6PC \| DISEASES 1401 \| CRP \| DISEASES 3845 \| KRAS \| DISEASES 6289 \| SAA2 \| DISEASES 10599 \| SLCO1B1 \| DISEASES 152831 \| KLB \| DISEASES 6927 \| HNF1A \| DISEASES 28234 \| SLCO1B3 \| DISEASES 894 \| CCND2 \| DISEASES 999 \| CDH1 \| DISEASES 1326 \| MAP3K8 \| DISEASES 8647 \| ABCB11 \| DISEASES 2817 \| GPC1 \| DISEASES 6774 \| STAT3 \| DISEASES 57561 \| ARRDC3 \| DISEASES 83729 \| INHBE \| DISEASES 8549 \| LGR5 \| DISEASES 5925 \| RB1 \| DISEASES 7157 \| TP53 \| DISEASES 5899 \| RALB \| DISEASES 2169 \| FABP2 \| DISEASES 6872 \| TAF1 \| DISEASES 5047 \| PAEP \| DISEASES 10449 \| ACAA2 \| DISEASES 8714 \| ABCC3 \| DISEASES 389 \| RHOC \| DISEASES 9133 \| CCNB2 \| DISEASES 51 \| ACOX1 \| DISEASES 6359 \| CCL15 \| DISEASES 3856 \| KRT8 \| DISEASES 178 \| AGL \| DISEASES 27306 \| HPGDS \| DISEASES 7203 \| CCT3 \| DISEASES 2168 \| FABP1 \| DISEASES 6469 \| SHH \| DISEASES 3308 \| HSPA4 \| DISEASES 7364 \| UGT2B7 \| DISEASES 9836 \| LCMT2 \| DISEASES 10067 \| SCAMP3 \| DISEASES 2752 \| GLUL \| DISEASES 7015 \| TERT \| DISEASES 3265 \| HRAS \| DISEASES 947 \| CD34 \| DISEASES 4744 \| NEFH \| DISEASES 285 \| ANGPT2 \| DISEASES 51085 \| MLXIPL \| DISEASES 1555 \| CYP2B6 \| DISEASES 3855 \| KRT7 \| DISEASES 957 \| ENTPD5 \| DISEASES 8856 \| NR1I2 \| DISEASES 1576 \| CYP3A4 \| DISEASES 23583 \| SMUG1 \| DISEASES 3572 \| IL6ST \| DISEASES 4521 \| NUDT1 \| DISEASES 1544 \| CYP1A2 \| DISEASES 1499 \| CTNNB1 \| DISEASES 1811 \| SLC26A3 \| DISEASES 83593 \| RASSF5 \| DISEASES 6720 \| SREBF1 \| DISEASES 6288 \| SAA1 \| DISEASES 11186 \| RASSF1 \| DISEASES 2996 \| GYPE \| DISEASES 1995 \| ELAVL3 \| DISEASES 1786 \| DNMT1 \| DISEASES 128239 \| IQGAP3 \| DISEASES 3880 \| KRT19 \| DISEASES 7957 \| EPM2A \| DISEASES 10767 \| HBS1L \| DISEASES 9970 \| NR1I3 \| DISEASES 90780 \| PYGO2 \| DISEASES 8661 \| EIF3A \| DISEASES 1629 \| DBT \| DISEASES 2564 \| GABRE \| DISEASES 6319 \| SCD \| DISEASES 2778 \| GNAS \| DISEASES 23304 \| UBR2 \| DISEASES 6191 \| RPS4X \| DISEASES 1192 \| CLIC1 \| DISEASES 27237 \| ARHGEF16 \| DISEASES 1543 \| CYP1A1 \| DISEASES 51280 \| GOLM1 \| DISEASES 55870 \| ASH1L \| DISEASES 2719 \| GPC3 \| DISEASES 4891 \| SLC11A2 \| DISEASES 174 \| AFP \| DISEASES 2950 \| GSTP1 \| DISEASES 728441 \| GGT2 \| DISEASES 1029 \| CDKN2A \| DISEASES 54865 \| GPATCH4 \| DISEASES 2632 \| GBE1 \| DISEASES 8801 \| SUCLG2 \| DISEASES 284 \| ANGPT1 \| DISEASES 56899 \| ANKS1B \| DISEASES 26771 \| SNORD102 \| DISEASES
Locus	(Waiting for update.)

Disease ID	321
Disease	hepatocellular adenoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:10) HP:0001402 \| Hepatocellular carcinoma \| 3 HP:0002664 \| Neoplasia \| 2 HP:0030731 \| Carcinoma \| 2 HP:0001397 \| Hepatic steatosis \| 1 HP:0002612 \| Congenital hepatic fibrosis \| 1 HP:0001513 \| Obesity \| 1 HP:0001395 \| Hepatic fibrosis \| 1 HP:0004904 \| Maturity-onset diabetes of the young \| 1 HP:0100242 \| Sarcoma \| 1 HP:0002896 \| Liver cancer \| 1

Disease ID	321
Disease	hepatocellular adenoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:2) C2248595 \| dedifferentiation C1608408 \| malignant transformation
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C1608408 \| malignant transformation \| 3

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs28934571	16799619	7157	TP53	umls:C0206669	BeFree	It includes integration of hepatitis B virus (HBV) DNA, R249S TP53 (tumor protein p53) mutation in aflatoxin B1-exposed patients, KRAS mutations related to vinyl chloride exposure, hepatocyte nuclear factor 1alpha (HNF1alpha) mutations associated to hepatocellular adenomas and adenomatosis polyposis coli (APC) germline mutations predisposing to hepatoblastomas.	0.002909916	2006	TP53	17	7674216	C	A
rs28934571	16799619	324	APC	umls:C0206669	BeFree	It includes integration of hepatitis B virus (HBV) DNA, R249S TP53 (tumor protein p53) mutation in aflatoxin B1-exposed patients, KRAS mutations related to vinyl chloride exposure, hepatocyte nuclear factor 1alpha (HNF1alpha) mutations associated to hepatocellular adenomas and adenomatosis polyposis coli (APC) germline mutations predisposing to hepatoblastomas.	0.000271442	2006	TP53	17	7674216	C	A
rs28934571	16799619	3845	KRAS	umls:C0206669	BeFree	It includes integration of hepatitis B virus (HBV) DNA, R249S TP53 (tumor protein p53) mutation in aflatoxin B1-exposed patients, KRAS mutations related to vinyl chloride exposure, hepatocyte nuclear factor 1alpha (HNF1alpha) mutations associated to hepatocellular adenomas and adenomatosis polyposis coli (APC) germline mutations predisposing to hepatoblastomas.	0.000271442	2006	TP53	17	7674216	C	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:4)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0206669	carbamazepine	D002220	298-46-4	adenoma, liver cell	MESH:D018248	marker/mechanism	10383724
C0206669	diethylstilbestrol	D004054	56-53-1	adenoma, liver cell	MESH:D018248	marker/mechanism	8443792
C0206669	phenytoin	D010672	57-41-0	adenoma, liver cell	MESH:D018248	marker/mechanism	11354469
C0206669	streptozocin	D013311	18883-66-4	adenoma, liver cell	MESH:D018248	marker/mechanism	6237805

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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