PedAM

Pediatric Disease Annotations & Medicines


	henoch-schoenlein purpura

Disease ID	642
Disease	henoch-schoenlein purpura
Definition	A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). Clinical symptoms include URTICARIA; ERYTHEMA; ARTHRITIS; GASTROINTESTINAL HEMORRHAGE; and renal involvement. Most cases are seen in children after acute upper respiratory infections.
Synonym	acute vascular purpura allergic purpura allergic purpura (disorder) allergic purpura nos allergic purpura nos (disorder) anaphylactoid purpura autoimmune purpura autoimmune purpura (disorder) autoimmune purpura (disorder) [ambiguous] henoch purpura henoch schoenlein purpura henoch scholein purpura henoch schonlein henoch schonlein purpura henoch schonlein purpuras henoch schonlein syndrome henoch shonlein purpura henoch's purpura henoch-sch?nlein purpura henoch-sch?nlein purpura (disorder) henoch-sch@nlein purpura henoch-schoenlein purpura (hsp) henoch-schoenlein vasculitis henoch-scholein purpura henoch-schonlein henoch-schonlein all. purpura henoch-schonlein purpura henoch-schonlein purpura (disorder) henoch-schonlein purpuras henoch-schÃ¶nlein purpura henoch-schÃ¶nlein purpura (disorder) hsp - henoch-schonlein purpura purpura allergic purpura, allergic purpura, anaphylactoid purpura, autoimmune purpura, henoch purpura, henoch schonlein purpura, henoch-schoenlein purpura, henoch-schonlein purpura, schoenlein henoch purpura, schoenlein-henoch purpura, schoenlein-henoch [disease/finding] purpura, schonlein henoch purpura, schonlein-henoch purpura: [allergic] or [henoch-schonlein allergy] purpura: [allergic] or [henoch-schonlein allergy] (disorder) purpuras, henoch schonlein purpuras, henoch-schonlein purpuras, schonlein-henoch schoenlein henoch purpura schoenlein-henoch purpura schonlein purpura, henoch schonlein purpuras, henoch schonlein-henoch purpura schonlein-henoch purpuras spring fever
DOID	DOID:11123
ICD10	ICD10CM:D69.0
UMLS	C0034152
MeSH	D011695
SNOMED-CT	SNOMEDCT_US_2016_09_01:191306005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:62) C0042384 \| vasculitis \| 6 C0027697 \| nephritis \| 4 C0003864 \| arthritis \| 3 C0026934 \| mycoplasma \| 3 C0021933 \| intussusception \| 3 C0032285 \| pneumoniae \| 3 C0032302 \| mycoplasma pneumonia \| 3 C0030305 \| pancreatitis \| 2 C0014118 \| endocarditis \| 2 C0009324 \| ulcerative colitis \| 2 C0085278 \| antiphospholipid syndrome \| 2 C0003873 \| rheumatoid arthritis \| 2 C0001339 \| acute pancreatitis \| 2 C0033687 \| proteinuria \| 2 C0034150 \| purpura \| 2 C0017658 \| glomerulonephritis \| 2 C0019158 \| hepatitis \| 1 C0027707 \| interstitial nephritis \| 1 C0031069 \| familial mediterranean fever \| 1 C0024110 \| lung abscess \| 1 C0014121 \| bacterial endocarditis \| 1 C0014534 \| epididymitis \| 1 C0376545 \| hematological malignancies \| 1 C0021831 \| enteropathy \| 1 C0149925 \| small cell lung cancer \| 1 C0002438 \| amebiasis \| 1 C0042769 \| viral infection \| 1 C0001418 \| adenocarcinoma \| 1 C0007570 \| celiac disease \| 1 C0037199 \| sinusitis \| 1 C0041349 \| tubulointerstitial nephritis \| 1 C0033680 \| protein-losing enteropathy \| 1 C0442874 \| neuropathy \| 1 C0242379 \| lung cancer \| 1 C0010072 \| coronary thrombosis \| 1 C0152013 \| lung adenocarcinoma \| 1 C0155320 \| cortical blindness \| 1 C0024440 \| cystoid macular oedema \| 1 C0020538 \| hypertension \| 1 C0017178 \| gastrointestinal disorders \| 1 C0015530 \| factor xiii deficiency \| 1 C0270612 \| leukoencephalopathy \| 1 C0026691 \| kawasaki disease \| 1 C0456909 \| blindness \| 1 C0027726 \| nephrotic syndrome \| 1 C0271051 \| macular oedema \| 1 C0017178 \| gastrointestinal disorder \| 1 C0040053 \| thrombosis \| 1 C0018378 \| guillain-barre syndrome \| 1 C0013370 \| intestinal amebiasis \| 1 C0151436 \| leukocytoclastic vasculitis \| 1 C0009319 \| colitis \| 1 C0031154 \| peritonitis \| 1 C0042769 \| virus infection \| 1 C0038013 \| ankylosing spondylitis \| 1 C0003460 \| anuria \| 1 C0023890 \| liver cirrhosis \| 1 C0003615 \| appendicitis \| 1 C0267841 \| acalculous cholecystitis \| 1 C0021845 \| intestinal perforation \| 1 C0008325 \| cholecystitis \| 1 C0022658 \| renal disease \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) PLAU \| 5328 \| CTD_human C3 \| 718 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:7) 3117 \| HLA-DQA1 \| infer 4846 \| NOS3 \| infer 7827 \| NPHS2 \| infer 720 \| C4A \| infer 7356 \| SCGB1A1 \| infer 3123 \| HLA-DRB1 \| infer 26191 \| PTPN22 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:105) 6376 \| CX3CL1 \| DISEASES 5603 \| MAPK13 \| DISEASES 623 \| BDKRB1 \| DISEASES 4210 \| MEFV \| DISEASES 8797 \| TNFRSF10A \| DISEASES 973 \| CD79A \| DISEASES 56913 \| C1GALT1 \| DISEASES 4353 \| MPO \| DISEASES 40 \| ASIC2 \| DISEASES 6347 \| CCL2 \| DISEASES 3558 \| IL2 \| DISEASES 41 \| ASIC1 \| DISEASES 3458 \| IFNG \| DISEASES 3565 \| IL4 \| DISEASES 5657 \| PRTN3 \| DISEASES 3623 \| INHA \| DISEASES 718 \| C3 \| DISEASES 5199 \| CFP \| DISEASES 3306 \| HSPA2 \| DISEASES 968 \| CD68 \| DISEASES 79148 \| MMP28 \| DISEASES 8431 \| NR0B2 \| DISEASES 6737 \| TRIM21 \| DISEASES 1401 \| CRP \| DISEASES 2799 \| GNS \| DISEASES 3569 \| IL6 \| DISEASES 3557 \| IL1RN \| DISEASES 7097 \| TLR2 \| DISEASES 10068 \| IL18BP \| DISEASES 7450 \| VWF \| DISEASES 3383 \| ICAM1 \| DISEASES 26277 \| TINF2 \| DISEASES 6687 \| SPG7 \| DISEASES 7356 \| SCGB1A1 \| DISEASES 55079 \| FEZF2 \| DISEASES 4325 \| MMP16 \| DISEASES 1636 \| ACE \| DISEASES 643 \| CXCR5 \| DISEASES 6352 \| CCL5 \| DISEASES 3889 \| KRT83 \| DISEASES 7412 \| VCAM1 \| DISEASES 213 \| ALB \| DISEASES 5648 \| MASP1 \| DISEASES 9311 \| ASIC3 \| DISEASES 56547 \| MMP26 \| DISEASES 719 \| C3AR1 \| DISEASES 6037 \| RNASE3 \| DISEASES 661 \| POLR3D \| DISEASES 929 \| CD14 \| DISEASES 29071 \| C1GALT1C1 \| DISEASES 375611 \| SLC26A5 \| DISEASES 3627 \| CXCL10 \| DISEASES 5066 \| PAM \| DISEASES 157570 \| ESCO2 \| DISEASES 2147 \| F2 \| DISEASES 84868 \| HAVCR2 \| DISEASES 4327 \| MMP19 \| DISEASES 1776 \| DNASE1L3 \| DISEASES 6401 \| SELE \| DISEASES 3320 \| HSP90AA1 \| DISEASES 114548 \| NLRP3 \| DISEASES 123283 \| TARSL2 \| DISEASES 3572 \| IL6ST \| DISEASES 29949 \| IL19 \| DISEASES 545 \| ATR \| DISEASES 3605 \| IL17A \| DISEASES 26762 \| HAVCR1 \| DISEASES 728 \| C5AR1 \| DISEASES 2204 \| FCAR \| DISEASES 355 \| FAS \| DISEASES 5265 \| SERPINA1 \| DISEASES 2224 \| FDPS \| DISEASES 23556 \| PIGN \| DISEASES 5169 \| ENPP3 \| DISEASES 26191 \| PTPN22 \| DISEASES 4192 \| MDK \| DISEASES 3123 \| HLA-DRB1 \| DISEASES 183 \| AGT \| DISEASES 80222 \| TARS2 \| DISEASES 959 \| CD40LG \| DISEASES 4318 \| MMP9 \| DISEASES 129685 \| TAF8 \| DISEASES 4153 \| MBL2 \| DISEASES 7099 \| TLR4 \| DISEASES 169981 \| SPIN3 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 1471 \| CST3 \| DISEASES 7056 \| THBD \| DISEASES 83715 \| ESPN \| DISEASES 5420 \| PODXL \| DISEASES 5277 \| PIGA \| DISEASES 64423 \| INF2 \| DISEASES 5076 \| PAX2 \| DISEASES 720 \| C4A \| DISEASES 7124 \| TNF \| DISEASES 3106 \| HLA-B \| DISEASES 7148 \| TNXB \| DISEASES 3920 \| LAMP2 \| DISEASES 1589 \| CYP21A2 \| DISEASES 389549 \| FEZF1 \| DISEASES 3586 \| IL10 \| DISEASES 721 \| C4B \| DISEASES 56 \| ACRV1 \| DISEASES 567 \| B2M \| DISEASES 7732 \| RNF112 \| DISEASES
Locus	(Waiting for update.)

Disease ID	642
Disease	henoch-schoenlein purpura
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:49) HP:0002633 \| Vasculitis \| 6 HP:0000123 \| Nephritis \| 4 HP:0002027 \| Abdominal pain \| 3 HP:0002584 \| Intestinal hemorrhage \| 3 HP:0001298 \| Encephalopathy \| 3 HP:0001369 \| Arthritis \| 3 HP:0000093 \| Proteinuria \| 2 HP:0001945 \| Fever \| 2 HP:0002576 \| Intussusception \| 2 HP:0001370 \| Rheumatoid arthritis \| 2 HP:0000099 \| Glomerular nephritis \| 2 HP:0000979 \| Purpura \| 2 HP:0003613 \| Antiphospholipid antibodies \| 2 HP:0012531 \| Pain \| 2 HP:0100279 \| Ulcerative colitis \| 2 HP:0001733 \| Pancreatic inflammation \| 2 HP:0001735 \| Acute pancreatitis \| 2 HP:0100584 \| Endocarditis \| 2 HP:0002664 \| Neoplasia \| 1 HP:0000618 \| Blindness \| 1 HP:0005202 \| Helicobacter pylori infection \| 1 HP:0005318 \| Cerebral vasculitis \| 1 HP:0100704 \| Cortical visual impairment \| 1 HP:0002583 \| Colitis \| 1 HP:0100519 \| Anuria \| 1 HP:0000246 \| Sinus inflammation \| 1 HP:0002586 \| Peritonitis \| 1 HP:0001970 \| Interstitial nephritis \| 1 HP:0000790 \| Hematuria \| 1 HP:0006689 \| Bacterial endocarditis \| 1 HP:0002243 \| Protein-losing enteropathy \| 1 HP:0002242 \| Enteropathy \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0003326 \| Muscle pain \| 1 HP:0000100 \| Nephrosis \| 1 HP:0002608 \| Celiac disease \| 1 HP:0001342 \| Intracerebral hemorrhage \| 1 HP:0030078 \| Lung adenocarcinoma \| 1 HP:0000969 \| Dropsy \| 1 HP:0002239 \| Gastrointestinal hemorrhage \| 1 HP:0012735 \| Coughing \| 1 HP:0011505 \| Cystoid macular edema \| 1 HP:0000822 \| Hypertension \| 1 HP:0011128 \| Acute esophageal necrosis \| 1 HP:0012596 \| Moderate proteinuria \| 1 HP:0030357 \| Small cell lung carcinoma \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0000031 \| Epididymitis \| 1 HP:0002720 \| Decreased immunoglobulin A \| 1

Disease ID	642
Disease	henoch-schoenlein purpura
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:5) C0019080 \| hemorrhage \| 3 C0009450 \| infection \| 2 C0030305 \| pancreatitis \| 2 C0021933 \| intussusception \| 2 C0020538 \| hypertension \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:4)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs28940579	22783597	4210	MEFV	umls:C0034152	BeFree	MEFV gene mutations (M694V, V726A, M680I, and A744S) in Iranian children with Henoch-Schönlein purpura.	0.009544073	2012	MEFV	16	3243310	A	T,G
rs28940580	22783597	4210	MEFV	umls:C0034152	BeFree	MEFV gene mutations (M694V, V726A, M680I, and A744S) in Iranian children with Henoch-Schönlein purpura.	0.009544073	2012	MEFV	16	3243447	C	T,G
rs3743930	20602240	4210	MEFV	umls:C0034152	BeFree	MEFV E148Q polymorphism is associated with Henoch-Schönlein purpura in Chinese children.	0.009544073	2010	MEFV	16	3254626	C	G
rs61732874	22783597	4210	MEFV	umls:C0034152	BeFree	MEFV gene mutations (M694V, V726A, M680I, and A744S) in Iranian children with Henoch-Schönlein purpura.	0.009544073	2012	MEFV	16	3243257	C	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:7)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0034152	acetaminophen	D000082	103-90-2	purpura, schoenlein-henoch	MESH:D011695	marker/mechanism	16939070
C0034152	ciprofloxacin	D002939	85721-33-1	purpura, schoenlein-henoch	MESH:D011695	marker/mechanism	19892516
C0034152	codeine	D003061	76-57-3	purpura, schoenlein-henoch	MESH:D011695	marker/mechanism	16939070
C0034152	diclofenac	D004008	15307-86-5	purpura, schoenlein-henoch	MESH:D011695	marker/mechanism	8882757
C0034152	enalapril	D004656	75847-73-3	purpura, schoenlein-henoch	MESH:D011695	marker/mechanism	1353212
C0034152	propylthiouracil	D011441	51-52-5	purpura, schoenlein-henoch	MESH:D011695	marker/mechanism	18044264
C0034152	tinidazole	D014011	19387-91-8	purpura, schoenlein-henoch	MESH:D011695	marker/mechanism	6636666

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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