PedAM

Pediatric Disease Annotations & Medicines


	hemosiderosis

Disease ID	777
Disease	hemosiderosis
Definition	Conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the MONONUCLEAR PHAGOCYTE SYSTEM, without demonstrable tissue damage. The name refers to the presence of stainable iron in the tissue in the form of hemosiderin.
Synonym	haemosiderosis haemosiderosis nos haemosiderosis, nos hemosideroses hemosiderosis (disorder) hemosiderosis [disease/finding] hemosiderosis nos hemosiderosis nos (disorder) hemosiderosis, nos
DOID	DOID:12119
UMLS	C0019114
MeSH	D006486
SNOMED-CT	SNOMEDCT_US_2016_09_01:39011001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:26) C0007570 \| celiac disease \| 3 C0085220 \| cerebral amyloid angiopathy \| 2 C0035078 \| renal failure \| 2 C0002871 \| anemia \| 2 C0852949 \| arteriopathy \| 1 C0006287 \| bronchopulmonary dysplasia \| 1 C0024115 \| lung disease \| 1 C0023895 \| liver disease \| 1 C0022661 \| chronic renal failure \| 1 C0035229 \| respiratory insufficiency \| 1 C0553662 \| juvenile idiopathic arthritis \| 1 C0042373 \| angiopathy \| 1 C0035439 \| rheumatic heart disease \| 1 C0042373 \| vascular disease \| 1 C0878544 \| cardiomyopathy \| 1 C0155877 \| allergic asthma \| 1 C0282193 \| iron overload \| 1 C0039730 \| thalassemia \| 1 C0003864 \| arthritis \| 1 C0271623 \| secondary hypogonadism \| 1 C0026269 \| mitral stenosis \| 1 C0008370 \| cholestasis \| 1 C0004096 \| asthma \| 1 C0018799 \| cardiac disease \| 1 C0005283 \| beta thalassemia \| 1 C0019045 \| hemoglobinopathies \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:65) 3162 \| HMOX1 \| DISEASES 973 \| CD79A \| DISEASES 57817 \| HAMP \| DISEASES 5917 \| RARS \| DISEASES 5657 \| PRTN3 \| DISEASES 8161 \| COIL \| DISEASES 968 \| CD68 \| DISEASES 3630 \| INS \| DISEASES 2056 \| EPO \| DISEASES 1144 \| CHRND \| DISEASES 1134 \| CHRNA1 \| DISEASES 30061 \| SLC40A1 \| DISEASES 4659 \| PPP1R12A \| DISEASES 10483 \| SEC23B \| DISEASES 1 \| A1BG \| DISEASES 50937 \| CDON \| DISEASES 10000 \| AKT3 \| DISEASES 8626 \| TP63 \| DISEASES 6652 \| SORD \| DISEASES 85407 \| NKD1 \| DISEASES 6769 \| STAC \| DISEASES 2495 \| FTH1 \| DISEASES 100996939 \| PYURF \| DISEASES 2796 \| GNRH1 \| DISEASES 1145 \| CHRNE \| DISEASES 6862 \| T \| DISEASES 3479 \| IGF1 \| DISEASES 1140 \| CHRNB1 \| DISEASES 375611 \| SLC26A5 \| DISEASES 9836 \| LCMT2 \| DISEASES 2688 \| GH1 \| DISEASES 79901 \| CYBRD1 \| DISEASES 10938 \| EHD1 \| DISEASES 6014 \| RIT2 \| DISEASES 23762 \| OSBP2 \| DISEASES 3043 \| HBB \| DISEASES 1908 \| EDN3 \| DISEASES 5313 \| PKLR \| DISEASES 7100 \| TLR5 \| DISEASES 3240 \| HP \| DISEASES 146059 \| CDAN1 \| DISEASES 617 \| BCS1L \| DISEASES 57016 \| AKR1B10 \| DISEASES 10447 \| FAM3C \| DISEASES 7037 \| TFRC \| DISEASES 6708 \| SPTA1 \| DISEASES 959 \| CD40LG \| DISEASES 6005 \| RHAG \| DISEASES 8813 \| DPM1 \| DISEASES 84890 \| ADO \| DISEASES 2512 \| FTL \| DISEASES 54790 \| TET2 \| DISEASES 6439 \| SFTPB \| DISEASES 4891 \| SLC11A2 \| DISEASES 7122 \| CLDN5 \| DISEASES 7018 \| TF \| DISEASES 57703 \| CWC22 \| DISEASES 3077 \| HFE \| DISEASES 4700 \| NDUFA6 \| DISEASES 846 \| CASR \| DISEASES 51366 \| UBR5 \| DISEASES 2053 \| EPHX2 \| DISEASES 9843 \| HEPH \| DISEASES 3892 \| KRT86 \| DISEASES 7138 \| TNNT1 \| DISEASES
Locus	(Waiting for update.)

Disease ID	777
Disease	hemosiderosis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:15) HP:0002608 \| Celiac disease \| 3 HP:0001903 \| Anemia \| 2 HP:0011970 \| Cerebral amyloid angiopathy \| 2 HP:0000083 \| Renal insufficiency \| 2 HP:0001880 \| Eosinophilia \| 1 HP:0007902 \| Vitreous hemorrhage \| 1 HP:0002099 \| Asthma \| 1 HP:0005505 \| Refractory anemia \| 1 HP:0001718 \| Mitral stenosis \| 1 HP:0001396 \| Cholestasis \| 1 HP:0001369 \| Arthritis \| 1 HP:0005681 \| Juvenile idiopathic arthritis \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0002093 \| progressive respiratory failure \| 1 HP:0001638 \| Cardiomyopathy \| 1

Disease ID	777
Disease	hemosiderosis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:3) C1384672 \| hypoparathyroidism C0272183 \| neutrophil dysfunction C0043407 \| yersinia infection
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1799945	11473464	3077	HFE	umls:C0019114	BeFree	The possibility of cirrhosis-associated hemosiderosis secondary to an iron metabolism abnormality associated with the H63D mutation of the HFE gene is proposed.	0.002909916	2001	HFE	6	26090951	C	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:3)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0019114	dapsone	D003622	80-08-0	hemosiderosis	MESH:D006486	marker/mechanism	17053738
C0019114	methotrexate	D008727	1959/5/2	hemosiderosis	MESH:D006486	marker/mechanism	845977
C0019114	vitamin e	D014810	1406-18-4	hemosiderosis	MESH:D006486	marker/mechanism	4214104

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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