hemolytic anemia |
Disease ID | 329 |
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Disease | hemolytic anemia |
Manually Symptom | UMLS | Name(Total Manually Symptoms:37) C2697310 | sarcoidosis C2613439 | extramedullary hematopoiesis C2364133 | infection C1963148 | iron overload C1963124 | hemoglobinuria C1801950 | g syndrome C1280080 | posterior mediastinum C0948600 | organ failure C0947622 | gallstones C0878544 | myocardiopathies C0878544 | cardiomyopathy C0877221 | erythroblastopenia C0752303 | urological manifestations C0746604 | mitral valve endocarditis C0553720 | spherocytosis C0521530 | pulmonary consolidation C0409974 | lupus erythematosus C0398564 | adenylate kinase deficiency C0398563 | hexokinase deficiency C0264490 | acute respiratory failure C0235574 | intravascular hemolysis C0151773 | bone marrow hypoplasia C0079772 | t cell lymphoma C0040188 | tic disorder C0040053 | thrombosis C0034902 | pure red cell aplasia C0032453 | relapsing polychondritis C0032302 | mycoplasma pneumoniae pneumonia C0032285 | pneumoniae C0030472 | paraneoplastic syndrome C0026848 | myopathy C0026654 | moyamoya syndrome C0023470 | myelogenous leukemia C0022660 | acute renal failure C0017920 | glucose-6-phosphate dehydrogenase deficiency C0008312 | primary biliary cirrhosis C0002874 | erythroid aplasia |
Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:15) C0009450 | infection | 7 C0017920 | glucose-6-phosphate dehydrogenase deficiency | 7 C0019048 | hemoglobinuria | 3 C0022660 | acute renal failure | 3 C0032285 | pneumoniae | 3 C0235574 | intravascular hemolysis | 2 C0553720 | spherocytosis | 2 C0018952 | extramedullary hematopoiesis | 2 C0752303 | urological manifestations | 1 C0034902 | pure red cell aplasia | 1 C0040188 | tic disorder | 1 C0948600 | organ failure | 1 C0008350 | gallstones | 1 C0409974 | lupus erythematosus | 1 C0040053 | thrombosis | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
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(Waiting for update.) |
All Snps(Total Genotypes:9) | |||||||||||||
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snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
rs1127354 | 26030972 | 3704 | ITPA | umls:C0002878 | BeFree | Significant association of ITPA gene rs1127354 with protection against RB V-induced hemolytic anemia was found in Ukrainian patients with CHC infection. | 0.127177041 | 2015 | ITPA | 20 | 3213196 | C | A,G,T |
rs121912751 | 22126643 | 6521 | SLC4A1 | umls:C0002878 | BeFree | dRTA and hemolytic anemia: first detailed description of SLC4A1 A858D mutation in homozygous state. | 0.12680591 | 2012 | SLC4A1 | 17 | 44251241 | G | T |
rs1800562 | 15865084 | 3077 | HFE | umls:C0002878 | BeFree | Heterozygosityfor the C282Y mutation in HFE contributes to iron accumulation and fibrosis progression in chronic hepatitis C. Ribavirin could cause dose-dependent reversible haemolytic anaemia, which can be managed with dose reductions or with administration of epoetin alpha at 40,000 IU once weekly without sacrificing the optimal dosing of ribavarin. | 0.000814326 | 2005 | HFE | 6 | 26092913 | G | A |
rs1800562 | 9753042 | 3077 | HFE | umls:C0002878 | BeFree | We performed PCR-based analysis for the haemochromatosis-related HFE C282Y mutation in an extended family with inherited haemolytic anaemia in which several members exhibited iron overload. | 0.000814326 | 1998 | HFE | 6 | 26092913 | G | A |
rs1800562 | 19380292 | 3077 | HFE | umls:C0002878 | BeFree | This report discusses the pathophysiology of iron accumulation in patients with hemolytic anemia combined with HFE C282Y homozygosity. | 0.000814326 | 2009 | HFE | 6 | 26092913 | G | A |
rs33924146 | NA | 3043 | HBB | umls:C0002878 | CLINVAR | NA | 0.121628651 | NA | HBB | 11 | 5226765 | A | G,C |
rs371489738 | 22139979 | 2539 | G6PD | umls:C0002878 | BeFree | In addition, seven new mutations were found: three presented with acute hemolytic anemia following oxidative stress [G6PD Nice (c.1380G>C, p.Glu460Asp), G6PD Roubaix (c.811G>C, p.Val271Leu), and G6PD Toledo (c.496C>T, p.Arg166Cys)], three with different degrees of chronic hemolytic anemia [G6PD Lille (c.821A>T, p.Glu274Val), G6PD Villeurbanne (c.1000_1002delACC, p.Thr334del), and G6PD Amiens (c.1367A>T, p.Asp456Val)] and one found fortuitously G6PD Montpellier (c.1132G>A, p.Gly378Ser). | 0.144926502 | 2012 | G6PD | X | 154532722 | C | T |
rs386545618 | 11916749 | 2539 | G6PD | umls:C0002878 | BeFree | Some examples include the alanine-to-valine substitution at codon 222 (Ala222-->Val) [DNA: C-to-T substitution at nucleo-tide 677 (677C-->T)] in methylenetetrahydrofolate reductase (NADPH) and the cofactor FAD (in relation to cardiovascular disease, migraines, and rages), the Pro187-->Ser (DNA: 609C-->T) mutation in NAD(P):quinone oxidoreductase 1 [NAD(P)H dehy-drogenase (quinone)] and FAD (in relation to cancer), the Ala44-->Gly (DNA: 131C-->G) mutation in glucose-6-phosphate 1-dehydrogenase and NADP (in relation to favism and hemolytic anemia), and the Glu487-->Lys mutation (present in one-half of Asians) in aldehyde dehydrogenase (NAD + ) and NAD (in relation to alcohol intolerance, Alzheimer disease, and cancer). | 0.144926502 | 2002 | NA | NA | NA | NA | NA |
rs386545618 | 11916749 | 4524 | MTHFR | umls:C0002878 | BeFree | Some examples include the alanine-to-valine substitution at codon 222 (Ala222-->Val) [DNA: C-to-T substitution at nucleo-tide 677 (677C-->T)] in methylenetetrahydrofolate reductase (NADPH) and the cofactor FAD (in relation to cardiovascular disease, migraines, and rages), the Pro187-->Ser (DNA: 609C-->T) mutation in NAD(P):quinone oxidoreductase 1 [NAD(P)H dehy-drogenase (quinone)] and FAD (in relation to cancer), the Ala44-->Gly (DNA: 131C-->G) mutation in glucose-6-phosphate 1-dehydrogenase and NADP (in relation to favism and hemolytic anemia), and the Glu487-->Lys mutation (present in one-half of Asians) in aldehyde dehydrogenase (NAD + ) and NAD (in relation to alcohol intolerance, Alzheimer disease, and cancer). | 0.000542884 | 2002 | NA | NA | NA | NA | NA |
GWASdb Annotation(Total Genotypes:0) | |
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(Waiting for update.) |
GWASdb Snp Trait(Total Genotypes:0) | |
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(Waiting for update.) |
Mapped by lexical matching(Total Items:0) |
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(Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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(Waiting for update.) |
Chemical(Total Drugs:60) | |||||||||
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CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
C0002878 | acetaminophen | D000082 | 103-90-2 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 2716023 | ||
C0002878 | aminosalicylic acid | D010131 | 65-49-6 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 5058584 | ||
C0002878 | ampicillin | D000667 | 69-53-4 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 4124995 | ||
C0002878 | bleomycin | D001761 | 11056-06-7 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 9572663 | ||
C0002878 | bortezomib | D000069286 | - | anemia, hemolytic | MESH:D000743 | marker/mechanism | 16832816 | ||
C0002878 | carbamazepine | D002220 | 298-46-4 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 18055338 | ||
C0002878 | carbenicillin | D002228 | 4697-36-3 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 4124995 | ||
C0002878 | carbidopa | D002230 | 38821-49-7 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 466061 | ||
C0002878 | cefotaxime | D002439 | 63527-52-6 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 2316002 | ||
C0002878 | ceftazidime | D002442 | 78439-06-2 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 17381629 | ||
C0002878 | chlorambucil | D002699 | 305-03-3 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 2816917 | ||
C0002878 | cladribine | D017338 | 4291-63-8 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 16398735 | ||
C0002878 | chloroquine | D002738 | 1954/5/7 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 4794122 | ||
C0002878 | chlorpromazine | D002746 | 50-53-3 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 3925683 | ||
C0002878 | cimetidine | D002927 | 51481-61-9 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 19874564 | ||
C0002878 | ciprofloxacin | D002939 | 85721-33-1 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 12911170 | ||
C0002878 | clofazimine | D002991 | 2030-63-9 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 19274991 | ||
C0002878 | cyclophosphamide | D003520 | 50-18-0 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 6027686 | ||
C0002878 | cyclosporine | D016572 | 59865-13-3 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 1611201 | ||
C0002878 | dapsone | D003622 | 80-08-0 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 10028001 | ||
C0002878 | cisplatin | D002945 | 15663-27-1 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 7706473 | ||
C0002878 | diclofenac | D004008 | 15307-86-5 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 11051389 | ||
C0002878 | diethylstilbestrol | D004054 | 56-53-1 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 2712071 | ||
C0002878 | digoxin | D004077 | 20830-75-5 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 4124995 | ||
C0002878 | epirubicin | D015251 | 56420-45-2 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 9572663 | ||
C0002878 | ethambutol | D004977 | 74-55-5 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 188103 | ||
C0002878 | fenfluramine | D005277 | 458-24-2 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 4706826 | ||
C0002878 | fluorouracil | D005472 | 51-21-8 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 3093413 | ||
C0002878 | folic acid | D005492 | 59-30-3 | anemia, hemolytic | MESH:D000743 | therapeutic | 5774135 | ||
C0002878 | gemcitabine | C056507 | 103882-84-4 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 18427761 | ||
C0002878 | hydroxyurea | D006918 | 127-07-1 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 15558807 | ||
C0002878 | indinavir | D019469 | 150378-17-9 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 10533645 | ||
C0002878 | indomethacin | D007213 | 53-86-1 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 17381629 | ||
C0002878 | lansoprazole | D064747 | - | anemia, hemolytic | MESH:D000743 | marker/mechanism | 8997127 | ||
C0002878 | lovastatin | D008148 | 75330-75-5 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 7653497 | ||
C0002878 | metformin | D008687 | 657-24-9 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 10644400 | ||
C0002878 | methotrexate | D008727 | 1959/5/2 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 6871106 | ||
C0002878 | methysergide | D008784 | 361-37-5 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 5467905 | ||
C0002878 | mitomycin | D016685 | 1950/7/7 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 1782316 | ||
C0002878 | nabumetone | C035605 | 42924-53-8 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 17381629 | ||
C0002878 | omeprazole | D009853 | 73590-58-6 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 1992636 | ||
C0002878 | oxaliplatin | C030110 | - | anemia, hemolytic | MESH:D000743 | marker/mechanism | 17381629 | ||
C0002878 | peginterferon alfa-2b | C417083 | - | anemia, hemolytic | MESH:D000743 | marker/mechanism | 16340643 | ||
C0002878 | phenytoin | D010672 | 57-41-0 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 1147459 | ||
C0002878 | piperacillin | D010878 | 61477-96-1 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 10223610 | ||
C0002878 | piroxicam | D010894 | 36322-90-4 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 3227521 | ||
C0002878 | propylthiouracil | D011441 | 51-52-5 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 1110434 | ||
C0002878 | pyrimethamine | D011739 | 58-14-0 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 1124444 | ||
C0002878 | quinine | D011803 | 130-95-0 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 17381629 | ||
C0002878 | ribavirin | D012254 | 36791-04-5 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 10733558 | ||
C0002878 | rifampin | D012293 | 13292-46-1 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 11798598 | ||
C0002878 | succimer | D004113 | 304-55-2 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 7932916 | ||
C0002878 | sulindac | D013467 | 38194-50-2 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 17381629 | ||
C0002878 | tacrolimus | D016559 | 109581-93-3 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 10743694 | ||
C0002878 | tolmetin | D014046 | 26171-23-3 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 17381629 | ||
C0002878 | trimethoprim | D014295 | 738-70-5 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 20589632 | ||
C0002878 | valproic acid | D014635 | 99-66-1 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 9855327 | ||
C0002878 | vitamin a | D014801 | 11103-57-4 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 4684742 | ||
C0002878 | vitamin e | D014810 | 1406-18-4 | anemia, hemolytic | MESH:D000743 | marker/mechanism | 5094252 | ||
C0002878 | vitamin e | D014810 | 1406-18-4 | anemia, hemolytic | MESH:D000743 | therapeutic | 968551 |
FDA approved drug and dosage information(Total Drugs:0) | |
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(Waiting for update.) |
FDA labeling changes(Total Drugs:0) | |
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(Waiting for update.) |