PedAM

Pediatric Disease Annotations & Medicines


	hemoglobinuria

Disease ID	1060
Disease	hemoglobinuria
Definition	The presence of free HEMOGLOBIN in the URINE, indicating hemolysis of ERYTHROCYTES within the vascular system. After saturating the hemoglobin-binding proteins (HAPTOGLOBINS), free hemoglobin begins to appear in the urine.
Synonym	[d]haemoglobinuria [d]haemoglobinuria (situation) [d]hemoglobinuria [d]hemoglobinuria (context-dependent category) [d]hemoglobinuria (situation) haemoglobinuria haemoglobinuria, nos hemoglobin in urine hemoglobin positive urine hemoglobin uria hemoglobinuria (finding) hemoglobinuria [disease/finding] hemoglobinuria, nos
DOID	DOID:582
ICD10	ICD10CM:R82.3
UMLS	C0019048
MeSH	D006456
SNOMED-CT	SNOMEDCT_US_2016_09_01:68600005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:24) C0002871 \| anemia \| 7 C0040053 \| thrombosis \| 5 C0002878 \| hemolytic anemia \| 3 C0002874 \| aplastic anemia \| 3 C0856761 \| budd-chiari syndrome \| 2 C0030312 \| bone marrow failure \| 2 C0015624 \| fanconi syndrome \| 1 C0024530 \| malaria \| 1 C0026764 \| multiple myeloma \| 1 C0836924 \| thrombocytosis \| 1 C0040188 \| tic disorders \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0024535 \| falciparum malaria \| 1 C0026986 \| myelodysplastic syndrome \| 1 C0409974 \| lupus erythematosus \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0023418 \| leukemia \| 1 C0023448 \| lymphocytic leukemia \| 1 C0022661 \| chronic kidney disease \| 1 C0026764 \| myeloma \| 1 C0039128 \| syphilis \| 1 C0022658 \| kidney disease \| 1 C0282193 \| iron overload \| 1 C0026986 \| myelodysplastic syndromes \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) PIGA \| 5277 \| GHR
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:154) 6344 \| SCTR \| DISEASES 9488 \| PIGB \| DISEASES 6128 \| RPL6 \| DISEASES 7414 \| VCL \| DISEASES 6948 \| TCN2 \| DISEASES 5283 \| PIGH \| DISEASES 63035 \| BCORL1 \| DISEASES 166 \| AES \| DISEASES 973 \| CD79A \| DISEASES 727 \| C5 \| DISEASES 1440 \| CSF3 \| DISEASES 7448 \| VTN \| DISEASES 952 \| CD38 \| DISEASES 173 \| AFM \| DISEASES 4254 \| KITLG \| DISEASES 420 \| ART4 \| DISEASES 3458 \| IFNG \| DISEASES 80329 \| ULBP1 \| DISEASES 11126 \| CD160 \| DISEASES 1088 \| CEACAM8 \| DISEASES 718 \| C3 \| DISEASES 5199 \| CFP \| DISEASES 9526 \| MPDU1 \| DISEASES 2056 \| EPO \| DISEASES 2694 \| GIF \| DISEASES 5279 \| PIGC \| DISEASES 3569 \| IL6 \| DISEASES 4836 \| NMT1 \| DISEASES 7450 \| VWF \| DISEASES 8482 \| SEMA7A \| DISEASES 5939 \| RBMS2 \| DISEASES 945 \| CD33 \| DISEASES 10483 \| SEC23B \| DISEASES 3249 \| HPN \| DISEASES 6403 \| SELP \| DISEASES 2651 \| GCNT2 \| DISEASES 683 \| BST1 \| DISEASES 10923 \| SUB1 \| DISEASES 5286 \| PIK3C2A \| DISEASES 3263 \| HPX \| DISEASES 2212 \| FCGR2A \| DISEASES 710 \| SERPING1 \| DISEASES 51604 \| PIGT \| DISEASES 5281 \| PIGF \| DISEASES 27163 \| NAAA \| DISEASES 135228 \| CD109 \| DISEASES 114757 \| CYGB \| DISEASES 6006 \| RHCE \| DISEASES 2215 \| FCGR3B \| DISEASES 213 \| ALB \| DISEASES 308 \| ANXA5 \| DISEASES 3562 \| IL3 \| DISEASES 1437 \| CSF2 \| DISEASES 11318 \| GPR182 \| DISEASES 5724 \| PTAFR \| DISEASES 51523 \| CXXC5 \| DISEASES 43 \| ACHE \| DISEASES 929 \| CD14 \| DISEASES 2147 \| F2 \| DISEASES 29984 \| RHOD \| DISEASES 5340 \| PLG \| DISEASES 947 \| CD34 \| DISEASES 653499 \| LGALS7B \| DISEASES 4179 \| CD46 \| DISEASES 5187 \| PER1 \| DISEASES 10859 \| LILRB1 \| DISEASES 1604 \| CD55 \| DISEASES 51301 \| GCNT4 \| DISEASES 4684 \| NCAM1 \| DISEASES 10331 \| B3GNT3 \| DISEASES 6181 \| RPLP2 \| DISEASES 7485 \| WRB \| DISEASES 716 \| C1S \| DISEASES 338328 \| GPIHBP1 \| DISEASES 2811 \| GP1BA \| DISEASES 7490 \| WT1 \| DISEASES 6007 \| RHD \| DISEASES 1675 \| CFD \| DISEASES 2689 \| GH2 \| DISEASES 3043 \| HBB \| DISEASES 2152 \| F3 \| DISEASES 80128 \| TRIM46 \| DISEASES 5329 \| PLAUR \| DISEASES 3805 \| KIR2DL4 \| DISEASES 966 \| CD59 \| DISEASES 7225 \| TRPC6 \| DISEASES 3804 \| KIR2DL3 \| DISEASES 728 \| C5AR1 \| DISEASES 3792 \| KEL \| DISEASES 3240 \| HP \| DISEASES 6288 \| SAA1 \| DISEASES 3683 \| ITGAL \| DISEASES 2213 \| FCGR2B \| DISEASES 2526 \| FUT4 \| DISEASES 9332 \| CD163 \| DISEASES 4151 \| MB \| DISEASES 3123 \| HLA-DRB1 \| DISEASES 7037 \| TFRC \| DISEASES 6693 \| SPN \| DISEASES 4478 \| MSN \| DISEASES 2993 \| GYPA \| DISEASES 6533 \| SLC6A6 \| DISEASES 10724 \| MGEA5 \| DISEASES 10580 \| SORBS1 \| DISEASES 23038 \| WDTC1 \| DISEASES 1378 \| CR1 \| DISEASES 80328 \| ULBP2 \| DISEASES 5788 \| PTPRC \| DISEASES 462 \| SERPINC1 \| DISEASES 2214 \| FCGR3A \| DISEASES 962 \| CD48 \| DISEASES 93183 \| PIGM \| DISEASES 2209 \| FCGR1A \| DISEASES 914 \| CD2 \| DISEASES 965 \| CD58 \| DISEASES 1081 \| CGA \| DISEASES 959 \| CD40LG \| DISEASES 5688 \| PSMA7 \| DISEASES 732 \| C8B \| DISEASES 11093 \| ADAMTS13 \| DISEASES 5328 \| PLAU \| DISEASES 310 \| ANXA7 \| DISEASES 1441 \| CSF3R \| DISEASES 4153 \| MBL2 \| DISEASES 5592 \| PRKG1 \| DISEASES 1043 \| CD52 \| DISEASES 11326 \| VSIG4 \| DISEASES 5320 \| PLA2G2A \| DISEASES 2650 \| GCNT1 \| DISEASES 3105 \| HLA-A \| DISEASES 7056 \| THBD \| DISEASES 3963 \| LGALS7 \| DISEASES 54790 \| TET2 \| DISEASES 9365 \| KL \| DISEASES 10455 \| ECI2 \| DISEASES 5277 \| PIGA \| DISEASES 3717 \| JAK2 \| DISEASES 399 \| RHOH \| DISEASES 3822 \| KLRC2 \| DISEASES 10288 \| LILRB2 \| DISEASES 80196 \| RNF34 \| DISEASES 344022 \| NOTO \| DISEASES 8091 \| HMGA2 \| DISEASES 7124 \| TNF \| DISEASES 51686 \| OAZ3 \| DISEASES 1379 \| CR1L \| DISEASES 51428 \| DDX41 \| DISEASES 2533 \| FYB \| DISEASES 4067 \| LYN \| DISEASES 3250 \| HPR \| DISEASES 8972 \| MGAM \| DISEASES 102723508 \| KANTR \| DISEASES 378805 \| LINC-PINT \| DISEASES 26774 \| SNORD80 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1060
Disease	hemoglobinuria
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:19) HP:0001903 \| Anemia \| 7 HP:0001945 \| Fever \| 3 HP:0001915 \| Aplastic anemia \| 3 HP:0001878 \| Haemolytic anaemia \| 3 HP:0002639 \| Budd-Chiari syndrome \| 2 HP:0004936 \| Blood clot in vein \| 2 HP:0005528 \| Bone marrow hypoplasia \| 2 HP:0006775 \| Multiple myeloma \| 1 HP:0002863 \| Myelodysplastic syndrome \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0030247 \| Blood clot in splanchnic vein \| 1 HP:0001909 \| Leukemia \| 1 HP:0001894 \| Thrombocytosis \| 1 HP:0004870 \| hemolytic anemia, chronic \| 1 HP:0100033 \| Tic disorder \| 1 HP:0100806 \| Sepsis \| 1 HP:0012622 \| Chronic kidney disease \| 1 HP:0012393 \| Allergy \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1

Disease ID	1060
Disease	hemoglobinuria
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0002878 \| hemolytic anemia \| 3 C0235573 \| hemoglobinemia \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:5)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0019048	diclofenac	D004008	15307-86-5	hemoglobinuria	MESH:D006456	marker/mechanism	9207477
C0019048	diltiazem	D004110	42399-41-7	hemoglobinuria	MESH:D006456	marker/mechanism	9207477
C0019048	etomidate	D005045	33125-97-2	hemoglobinuria	MESH:D006456	marker/mechanism	7898032
C0019048	phenylpropanolamine	D010665	14838-15-4	hemoglobinuria	MESH:D006456	marker/mechanism	7109141
C0019048	ribavirin	D012254	36791-04-5	hemoglobinuria	MESH:D006456	marker/mechanism	12642748

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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