PedAM

Pediatric Disease Annotations & Medicines


	hemiplegia

Disease ID	1129
Disease	hemiplegia
Definition	Severe or complete loss of motor function on one side of the body. This condition is usually caused by BRAIN DISEASES that are localized to the cerebral hemisphere opposite to the side of weakness. Less frequently, BRAIN STEM lesions; cervical SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; and other conditions may manifest as hemiplegia. The term hemiparesis (see PARESIS) refers to mild to moderate weakness involving one side of the body.
Synonym	hemiplegia (disorder) hemiplegia (paralysis on one side) hemiplegia [disease/finding] hemiplegia nos hemiplegia nos (disorder) hemiplegia, nos hemiplegia, unspecified hemiplegias paralysis of one side of body paralysis one side of body
DOID	DOID:10969
UMLS	C0018991
MeSH	D006429
SNOMED-CT	SNOMEDCT_US_2016_09_01:50582007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:31) C0007785 \| cerebral infarct \| 8 C0007785 \| cerebral infarction \| 8 C0042373 \| vascular disease \| 3 C0015464 \| facial palsy \| 3 C0007789 \| cerebral palsy \| 3 C0011847 \| diabetes \| 3 C0149931 \| migraine \| 2 C0003537 \| aphasia \| 2 C0020538 \| hypertension \| 2 C0015464 \| facial nerve palsy \| 2 C0042721 \| viral hepatitis \| 1 C0003467 \| anxiety \| 1 C0026884 \| mutism \| 1 C0014544 \| epilepsy \| 1 C0042373 \| vascular diseases \| 1 C0085543 \| epilepsia partialis continua \| 1 C0014544 \| epilepsia \| 1 C0014544 \| epileptic seizure \| 1 C0014544 \| epileptic seizures \| 1 C0021400 \| influenza \| 1 C0679466 \| cognitive deficits \| 1 C0040053 \| thrombosis \| 1 C0019158 \| hepatitis \| 1 C0004114 \| astrocytoma \| 1 C0026654 \| moyamoya disease \| 1 C0015469 \| facial paralysis \| 1 C0023882 \| spastic diplegia \| 1 C0271355 \| abducens nerve palsy \| 1 C0004936 \| mental disorders \| 1 C0002871 \| anemia \| 1 C0007274 \| carotid artery thrombosis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) ATP1A2 \| 477 \| GHR ATP1A3 \| 478 \| GHR CGA \| 1081 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:176) 5009 \| OTC \| DISEASES 7544 \| ZFY \| DISEASES 10857 \| PGRMC1 \| DISEASES 2158 \| F9 \| DISEASES 5327 \| PLAT \| DISEASES 268 \| AMH \| DISEASES 2798 \| GNRHR \| DISEASES 5250 \| SLC25A3 \| DISEASES 55856 \| ACOT13 \| DISEASES 3485 \| IGFBP2 \| DISEASES 22868 \| FASTKD2 \| DISEASES 79441 \| HAUS3 \| DISEASES 5740 \| PTGIS \| DISEASES 583 \| BBS2 \| DISEASES 6662 \| SOX9 \| DISEASES 3630 \| INS \| DISEASES 7837 \| PXDN \| DISEASES 6117 \| RPA1 \| DISEASES 182 \| JAG1 \| DISEASES 1022 \| CDK7 \| DISEASES 7252 \| TSHB \| DISEASES 63982 \| ANO3 \| DISEASES 3569 \| IL6 \| DISEASES 29113 \| C6orf15 \| DISEASES 6496 \| SIX3 \| DISEASES 1800 \| DPEP1 \| DISEASES 443 \| ASPA \| DISEASES 4854 \| NOTCH3 \| DISEASES 10000 \| AKT3 \| DISEASES 5443 \| POMC \| DISEASES 2121 \| EVC \| DISEASES 6507 \| SLC1A3 \| DISEASES 54504 \| CPVL \| DISEASES 8034 \| SLC25A16 \| DISEASES 23710 \| GABARAPL1 \| DISEASES 11081 \| KERA \| DISEASES 51411 \| BIN2 \| DISEASES 79944 \| L2HGDH \| DISEASES 5373 \| PMM2 \| DISEASES 7157 \| TP53 \| DISEASES 148327 \| CREB3L4 \| DISEASES 4851 \| NOTCH1 \| DISEASES 5741 \| PTH \| DISEASES 3192 \| HNRNPU \| DISEASES 9510 \| ADAMTS1 \| DISEASES 7508 \| XPC \| DISEASES 340348 \| TSPAN33 \| DISEASES 3837 \| KPNB1 \| DISEASES 54361 \| WNT4 \| DISEASES 90525 \| SHF \| DISEASES 57465 \| TBC1D24 \| DISEASES 476 \| ATP1A1 \| DISEASES 10915 \| TCERG1 \| DISEASES 9317 \| PTER \| DISEASES 140612 \| ZFP28 \| DISEASES 1632 \| ECI1 \| DISEASES 4054 \| LTBP3 \| DISEASES 79058 \| ASPSCR1 \| DISEASES 478 \| ATP1A3 \| DISEASES 6323 \| SCN1A \| DISEASES 7543 \| ZFX \| DISEASES 11141 \| IL1RAPL1 \| DISEASES 23636 \| NUP62 \| DISEASES 2525 \| FUT3 \| DISEASES 5066 \| PAM \| DISEASES 695 \| BTK \| DISEASES 84153 \| RNASEH2C \| DISEASES 2147 \| F2 \| DISEASES 5340 \| PLG \| DISEASES 5626 \| PROP1 \| DISEASES 8557 \| TCAP \| DISEASES 133522 \| PPARGC1B \| DISEASES 6844 \| VAMP2 \| DISEASES 7915 \| ALDH5A1 \| DISEASES 3556 \| IL1RAP \| DISEASES 8575 \| PRKRA \| DISEASES 6863 \| TAC1 \| DISEASES 10611 \| PDLIM5 \| DISEASES 23017 \| FAIM2 \| DISEASES 25915 \| NDUFAF3 \| DISEASES 2535 \| FZD2 \| DISEASES 55553 \| SOX6 \| DISEASES 26230 \| TIAM2 \| DISEASES 255324 \| EPGN \| DISEASES 926 \| CD8B \| DISEASES 796 \| CALCA \| DISEASES 4692 \| NDN \| DISEASES 10052 \| GJC1 \| DISEASES 2774 \| GNAL \| DISEASES 2152 \| F3 \| DISEASES 79621 \| RNASEH2B \| DISEASES 3329 \| HSPD1 \| DISEASES 113675 \| SDSL \| DISEASES 124454 \| EARS2 \| DISEASES 197021 \| LCTL \| DISEASES 56940 \| DUSP22 \| DISEASES 54898 \| ELOVL2 \| DISEASES 7080 \| NKX2-1 \| DISEASES 27030 \| MLH3 \| DISEASES 23646 \| PLD3 \| DISEASES 55010 \| PARPBP \| DISEASES 112476 \| PRRT2 \| DISEASES 3785 \| KCNQ2 \| DISEASES 2547 \| XRCC6 \| DISEASES 4151 \| MB \| DISEASES 5792 \| PTPRF \| DISEASES 79947 \| DHDDS \| DISEASES 773 \| CACNA1A \| DISEASES 1284 \| COL4A2 \| DISEASES 477 \| ATP1A2 \| DISEASES 916 \| CD3E \| DISEASES 1756 \| DMD \| DISEASES 56259 \| CTNNBL1 \| DISEASES 7044 \| LEFTY2 \| DISEASES 6993 \| DYNLT1 \| DISEASES 2494 \| NR5A2 \| DISEASES 462 \| SERPINC1 \| DISEASES 480 \| ATP1A4 \| DISEASES 632 \| BGLAP \| DISEASES 262 \| AMD1 \| DISEASES 10500 \| SEMA6C \| DISEASES 8036 \| SHOC2 \| DISEASES 3897 \| L1CAM \| DISEASES 164045 \| HFM1 \| DISEASES 959 \| CD40LG \| DISEASES 3597 \| IL13RA1 \| DISEASES 25792 \| CIZ1 \| DISEASES 2516 \| NR5A1 \| DISEASES 1269 \| CNR2 \| DISEASES 8518 \| IKBKAP \| DISEASES 4855 \| NOTCH4 \| DISEASES 8242 \| KDM5C \| DISEASES 114769 \| CARD16 \| DISEASES 1282 \| COL4A1 \| DISEASES 10006 \| ABI1 \| DISEASES 7088 \| TLE1 \| DISEASES 6520 \| SLC3A2 \| DISEASES 2710 \| GK \| DISEASES 190 \| NR0B1 \| DISEASES 4112 \| MAGEB1 \| DISEASES 4113 \| MAGEB2 \| DISEASES 170302 \| ARX \| DISEASES 5422 \| POLA1 \| DISEASES 1761 \| DMRT1 \| DISEASES 4155 \| MBP \| DISEASES 6736 \| SRY \| DISEASES 51520 \| LARS \| DISEASES 100131390 \| SP9 \| DISEASES 4905 \| NSF \| DISEASES 64072 \| CDH23 \| DISEASES 25974 \| MMACHC \| DISEASES 643418 \| LIPN \| DISEASES 6335 \| SCN9A \| DISEASES 340351 \| AGBL3 \| DISEASES 6916 \| TBXAS1 \| DISEASES 8831 \| SYNGAP1 \| DISEASES 4152 \| MBD1 \| DISEASES 116228 \| COX20 \| DISEASES 8522 \| GAS7 \| DISEASES 6513 \| SLC2A1 \| DISEASES 9217 \| VAPB \| DISEASES 374308 \| PTCHD3 \| DISEASES 85476 \| GFM1 \| DISEASES 111 \| ADCY5 \| DISEASES 10687 \| PNMA2 \| DISEASES 3347 \| HTN3 \| DISEASES 56 \| ACRV1 \| DISEASES 100463289 \| MTRNR2L5 \| DISEASES 930 \| CD19 \| DISEASES 83695 \| RHNO1 \| DISEASES 84525 \| HOPX \| DISEASES 29115 \| SAP30BP \| DISEASES 102723508 \| KANTR \| DISEASES 79104 \| MEG8 \| DISEASES 9597 \| SMAD5-AS1 \| DISEASES 654321 \| SNORA75 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1129
Disease	hemiplegia
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:45) HP:0001297 \| Cerebral vascular events \| 70 HP:0012531 \| Pain \| 6 HP:0010628 \| Facial palsy, unilateral or bilateral \| 5 HP:0001257 \| Spasticity \| 4 HP:0100021 \| Cerebral palsy \| 3 HP:0030834 \| Shoulder pain \| 3 HP:0000822 \| Hypertension \| 2 HP:0003470 \| Inability to move \| 2 HP:0002015 \| Swallowing difficulty \| 2 HP:0002076 \| Migraine headaches \| 2 HP:0002381 \| Aphasia \| 2 HP:0001269 \| Hemiparesis \| 2 HP:0007209 \| Facial paresis \| 1 HP:0011134 \| Mild fever \| 1 HP:0001260 \| Dysarthric speech \| 1 HP:0001903 \| Anemia \| 1 HP:0001907 \| Thromboembolic disease \| 1 HP:0002140 \| Ischemic stroke \| 1 HP:0030746 \| Intraventricular hemorrhage \| 1 HP:0001250 \| Seizures \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0006562 \| Viral hepatitis \| 1 HP:0000739 \| Anxiety \| 1 HP:0012847 \| Epilepsia partialis continua \| 1 HP:0100556 \| Hemiatrophy of the body \| 1 HP:0100735 \| Hypertensive crisis \| 1 HP:0001276 \| Hypertonia \| 1 HP:0200026 \| Ocular pain \| 1 HP:0001259 \| Coma \| 1 HP:0000969 \| Dropsy \| 1 HP:0002138 \| Subarachnoid hemorrhage \| 1 HP:0002300 \| Muteness \| 1 HP:0001288 \| Gait disturbance \| 1 HP:0001348 \| Brisk reflexes \| 1 HP:0011986 \| Ectopic bone formation \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0002427 \| Loss of expressive speech \| 1 HP:0030516 \| Homonymous hemianopia \| 1 HP:0009592 \| Astrocytoma \| 1 HP:0002170 \| Intracranial hemorrhage \| 1 HP:0012444 \| Brain wasting \| 1 HP:0001239 \| Wrist flexion deformity \| 1 HP:0001264 \| Spastic diplegia \| 1 HP:0000975 \| Increased sweating \| 1 HP:0003474 \| Sensory impairment \| 1

Disease ID	1129
Disease	hemiplegia
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:8) C0030193 \| pain \| 6 C0026838 \| spasticity \| 4 C0037011 \| shoulder pain \| 3 C0040053 \| thrombosis \| 1 C0014544 \| epilepsy \| 1 C0023015 \| language disorders \| 1 C0036572 \| seizures \| 1 C0034931 \| shoulder-hand syndrome \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:10)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0018991	baclofen	D001418	1134-47-0	hemiplegia	MESH:D006429	therapeutic	12917859
C0018991	bortezomib	D000069286	-	hemiplegia	MESH:D006429	marker/mechanism	17204182
C0018991	haloperidol	D006220	52-86-8	hemiplegia	MESH:D006429	marker/mechanism	3683725
C0018991	methotrexate	D008727	1959/5/2	hemiplegia	MESH:D006429	marker/mechanism	12764767
C0018991	methylphenidate	D008774	113-45-1	hemiplegia	MESH:D006429	marker/mechanism	7115156
C0018991	morphine	D009020	57-27-2	hemiplegia	MESH:D006429	marker/mechanism	6692145
C0018991	phenytoin	D010672	57-41-0	hemiplegia	MESH:D006429	marker/mechanism	3117426
C0018991	tacrolimus	D016559	109581-93-3	hemiplegia	MESH:D006429	marker/mechanism	21321342
C0018991	tranexamic acid	D014148	1197-18-8	hemiplegia	MESH:D006429	marker/mechanism	7104262
C0018991	vincristine	D014750	-	hemiplegia	MESH:D006429	marker/mechanism	20363963

FDA approved drug and dosage information(Total Drugs:5)
DiseaseID	Drug_name	active_ingredients	strength	Dosage Form/Route	Marketing Status	TE code	RLD	RS
MESH:D006429	daytrana	methylphenidate	10MG/9HR (1.1MG/HR)	FILM, EXTENDED RELEASE;TRANSDERMAL	Prescription	None	Yes	No
MESH:D006429	daytrana	methylphenidate	10MG/9HR (1.1MG/HR)	FILM, EXTENDED RELEASE;TRANSDERMAL	Prescription	None	Yes	No
MESH:D006429	daytrana	methylphenidate	10MG/9HR (1.1MG/HR)	FILM, EXTENDED RELEASE;TRANSDERMAL	Prescription	None	Yes	No
MESH:D006429	lysteda	tranexamic acid	650MG	TABLET;ORAL	Prescription	AB	Yes	Yes
MESH:D006429	velcade	bortezomib	3.5MG/VIAL	INJECTABLE;INTRAVENOUS, SUBCUTANEOUS	Prescription	None	Yes	Yes

FDA labeling changes(Total Drugs:5)
DiseaseID	Pediatric_Labeling_Date	Trade_Name	Generic_Name_or_Proper_Name	Indications Studied	Label Changes Summary	Product Labeling	BPCA(B)	PREA(P)	BPCA(B) and PREA(P)	Pediatric Rule (R)	Sponsor	Pediatric Exclusivity Granted Date	NNPS
MESH:D006429	6/4/2006	daytrana	methylphenidate	ADHD	Summary is pending	Labeling	-	P	-	-	Shire	-	FALSE'
MESH:D006429	12/14/2009	daytrana	methylphenidate	Postmarketing safety study	Information added to Warnings and Adverse Reactions on skin reactions observed in a postmarketing dermal study in pediatric patients	Labeling	-	P	-	-	Shire	-	FALSE'
MESH:D006429	06/29/2010	daytrana	methylphenidate	ADHD	Expanded pediatric indication to include adolescent patients ages13-17 years The most commonly reported adverse reactions in a trial in patients 13-17 years included appetite decreased, nausea, insomnia, weight decreased, dizziness, abdominal pain, and anorexia. The majority of patients had erythema at the application site Information on PK parameters, Adverse Event profile and clinical studies	Labeling	-	P	-	-	Shire	-	FALSE'
MESH:D006429	08/21/2013	lysteda	tranexamic acid	Treatment of cyclic heavy menstrual bleeding	Indicated for women of reproductive age. It is not intended for use in premenarcheal girls Information on PK studyPostmarketing study	-	P	-	-	Ferring	-	FALSE'	-
MESH:D006429	09/14/2015	velcade	bortezomib	Relapsed Acute Lymphoblastic Leukemia (ALL) and Lymphoblastic Lymphoma (LL)	Effectiveness in pediatric patients with relapsed pre-B ALL has not been established. The activity and safety of Velcade in combination with intensive reinduction chemotherapy was evaluated in pediatric and young adult patients with lymphoid malignancies. There were 140 patients with ALL or LL enrolled and evaluated for safety. No new safety concerns were observed	Labeling	B	-	-	-	Millennium Pharmaceuticals, Inc.	-	FALSE

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