PedAM

Pediatric Disease Annotations & Medicines


	guillain-barre syndrome

Disease ID	62
Disease	guillain-barre syndrome
Definition	An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur. (From Adams et al., Principles of Neurology, 6th ed, pp1312-1314)
Synonym	gbs gbs - guillain-barre syndrome guillain barre disease guillain barre syndrome guillain barrÃ© syndrome guillain-barre disease guillain-barre syndrome (disorder) guillain-barre syndrome (gbs) guillain-barre syndrome [disease/finding] guillain-barre syndrome, familial guillain-barrÃ© syndrome guillain-barrÃ© syndrome (disorder) guillaine barre syndrome guillaine-barre syndrome gullian barre syndrome landry guillain barre syndrome landry paralysis landry's paralysis landry-guillain-barre syndrome landry-guillain-barrÃ© syndrome syndrome guillain-barre syndrome, guillain-barre syndrome, guillaine-barre syndrome, landry-guillain-barre
Orphanet	ORPHANET:2103
OMIM	OMIM:139393
DOID	DOID:12842
ICD10	ICD10CM:G61.0
UMLS	C0018378
MeSH	D020275
SNOMED-CT	SNOMEDCT_US_2016_09_01:40956001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:83) C0085293 \| hepatitis e \| 7 C0019158 \| hepatitis \| 7 C0442874 \| neuropathy \| 5 C0042769 \| virus infection \| 5 C1145670 \| respiratory failure \| 4 C0393799 \| fisher syndrome \| 3 C0021400 \| influenza \| 3 C0015464 \| facial nerve palsy \| 2 C0027121 \| myositis \| 2 C0006818 \| campylobacter infection \| 2 C0026934 \| mycoplasma \| 2 C0270921 \| axonal neuropathy \| 2 C0032285 \| pneumoniae \| 2 C0032302 \| mycoplasma pneumonia \| 2 C0878544 \| cardiomyopathy \| 1 C0022658 \| nephropathy \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0001175 \| acquired immune deficiency syndrome (aids) \| 1 C0031511 \| pheochromocytoma \| 1 C0017601 \| glaucoma \| 1 C0004623 \| bacterial infection \| 1 C0015469 \| facial paralysis \| 1 C0032587 \| polyradiculoneuropathy \| 1 C1847523 \| abducens palsy \| 1 C0001175 \| acquired immune deficiency syndrome \| 1 C0021345 \| mononucleosis \| 1 C0035258 \| restless legs syndrome \| 1 C0031117 \| peripheral neuropathy \| 1 C0162293 \| papillitis \| 1 C0270922 \| demyelinating polyneuropathy \| 1 C0020255 \| hydrocephalus \| 1 C0035258 \| restless legs \| 1 C0005697 \| neurogenic bladder \| 1 C0015469 \| facial nerve paralysis \| 1 C0036202 \| sarcoidosis \| 1 C0017665 \| membranous nephropathy \| 1 C0003864 \| arthritis \| 1 C0019829 \| hodgkin's lymphoma \| 1 C0003873 \| rheumatoid arthritis \| 1 C0085273 \| parvovirus b19 infection \| 1 C0030442 \| bulbar palsy \| 1 C0041466 \| typhoid \| 1 C0259749 \| autonomic neuropathy \| 1 C0276357 \| swine influenza \| 1 C0041471 \| typhus \| 1 C0039144 \| syringomyelia \| 1 C0011882 \| diabetic neuropathy \| 1 C0004623 \| bacterial infections \| 1 C0021345 \| infectious mononucleosis \| 1 C0027059 \| myocarditis \| 1 C0026769 \| multiple sclerosis \| 1 C0015464 \| facial palsy \| 1 C0009377 \| colonic pseudo-obstruction \| 1 C0034150 \| purpura \| 1 C0041327 \| pulmonary tuberculosis \| 1 C0034735 \| raynaud's phenomenon \| 1 C0017605 \| angle-closure glaucoma \| 1 C0014057 \| japanese encephalitis \| 1 C0152025 \| polyneuropathy \| 1 C0041466 \| typhoid fever \| 1 C0037928 \| myelopathy \| 1 C0034152 \| henoch-schonlein purpura \| 1 C0037317 \| sleep disturbances \| 1 C0023449 \| acute lymphoblastic leukemia \| 1 C0023903 \| hepatic cancer \| 1 C0154946 \| acute angle-closure glaucoma \| 1 C0018818 \| ventricular septal defect \| 1 C0020538 \| hypertension \| 1 C0006309 \| brucellosis \| 1 C0019348 \| herpes simplex \| 1 C0011880 \| diabetic ketoacidosis \| 1 C0001175 \| acquired immune deficiency \| 1 C0027726 \| nephrotic syndrome \| 1 C0409974 \| lupus erythematosus \| 1 C0037317 \| sleep disturbance \| 1 C0023448 \| lymphoblastic leukemia \| 1 C0016735 \| frontal sinusitis \| 1 C0024305 \| non-hodgkin's lymphoma \| 1 C0393799 \| miller fisher syndrome \| 1 C0014038 \| encephalitis \| 1 C0393819 \| chronic inflammatory demyelinating polyradiculoneuropathy \| 1 C0021053 \| immune disease \| 1 C0036472 \| scrub typhus \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) TNF \| 7124 \| GHR PMP22 \| 5376 \| ORPHANET
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:17) 348 \| APOE \| infer 929 \| CD14 \| infer 909 \| CD1A \| infer 912 \| CD1D \| infer 913 \| CD1E \| infer 2212 \| FCGR2A \| infer 2214 \| FCGR3A \| infer 2215 \| FCGR3B \| infer 3117 \| HLA-DQA1 \| infer 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer 3586 \| IL10 \| infer 4153 \| MBL2 \| infer 4318 \| MMP9 \| infer 2908 \| NR3C1 \| infer 7099 \| TLR4 \| infer 7124 \| TNF \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:188) 3385 \| ICAM3 \| DISEASES 7132 \| TNFRSF1A \| DISEASES 6793 \| STK10 \| DISEASES 2765 \| GML \| DISEASES 7991 \| TUSC3 \| DISEASES 2217 \| FCGRT \| DISEASES 7040 \| TGFB1 \| DISEASES 973 \| CD79A \| DISEASES 55851 \| PSENEN \| DISEASES 79176 \| FBXL15 \| DISEASES 6347 \| CCL2 \| DISEASES 3558 \| IL2 \| DISEASES 3458 \| IFNG \| DISEASES 2026 \| ENO2 \| DISEASES 3820 \| KLRB1 \| DISEASES 3565 \| IL4 \| DISEASES 6402 \| SELL \| DISEASES 7276 \| TTR \| DISEASES 3375 \| IAPP \| DISEASES 1959 \| EGR2 \| DISEASES 718 \| C3 \| DISEASES 826 \| CAPNS1 \| DISEASES 6320 \| CLEC11A \| DISEASES 5894 \| RAF1 \| DISEASES 348 \| APOE \| DISEASES 9253 \| NUMBL \| DISEASES 5375 \| PMP2 \| DISEASES 3569 \| IL6 \| DISEASES 10850 \| CCL27 \| DISEASES 7097 \| TLR2 \| DISEASES 2581 \| GALC \| DISEASES 10681 \| GNB5 \| DISEASES 9172 \| MYOM2 \| DISEASES 8731 \| RNMT \| DISEASES 6521 \| SLC4A1 \| DISEASES 7305 \| TYROBP \| DISEASES 3553 \| IL1B \| DISEASES 645 \| BLVRB \| DISEASES 4811 \| NID1 \| DISEASES 941 \| CD80 \| DISEASES 200576 \| PIKFYVE \| DISEASES 8506 \| CNTNAP1 \| DISEASES 23415 \| KCNH4 \| DISEASES 5443 \| POMC \| DISEASES 3383 \| ICAM1 \| DISEASES 80273 \| GRPEL1 \| DISEASES 1039 \| CDR2 \| DISEASES 150094 \| SIK1 \| DISEASES 2212 \| FCGR2A \| DISEASES 5972 \| REN \| DISEASES 90226 \| UCN2 \| DISEASES 23500 \| DAAM2 \| DISEASES 4841 \| NONO \| DISEASES 2895 \| GRID2 \| DISEASES 7345 \| UCHL1 \| DISEASES 56896 \| DPYSL5 \| DISEASES 6285 \| S100B \| DISEASES 729230 \| CCR2 \| DISEASES 1234 \| CCR5 \| DISEASES 92304 \| SCGB3A1 \| DISEASES 6352 \| CCL5 \| DISEASES 3060 \| HCRT \| DISEASES 7412 \| VCAM1 \| DISEASES 213 \| ALB \| DISEASES 1230 \| CCR1 \| DISEASES 10085 \| EDIL3 \| DISEASES 6228 \| RPS23 \| DISEASES 27242 \| TNFRSF21 \| DISEASES 717 \| C2 \| DISEASES 94235 \| GNG8 \| DISEASES 3603 \| IL16 \| DISEASES 3688 \| ITGB1 \| DISEASES 1493 \| CTLA4 \| DISEASES 29071 \| C1GALT1C1 \| DISEASES 3627 \| CXCL10 \| DISEASES 5376 \| PMP22 \| DISEASES 8534 \| CHST1 \| DISEASES 23536 \| ADAT1 \| DISEASES 55790 \| CSGALNACT1 \| DISEASES 641371 \| ACOT1 \| DISEASES 4744 \| NEFH \| DISEASES 6773 \| STAT2 \| DISEASES 5551 \| PRF1 \| DISEASES 6764 \| ST5 \| DISEASES 80381 \| CD276 \| DISEASES 730 \| C7 \| DISEASES 27036 \| SIGLEC7 \| DISEASES 26005 \| C2CD3 \| DISEASES 9282 \| MED14 \| DISEASES 1272 \| CNTN1 \| DISEASES 50616 \| IL22 \| DISEASES 942 \| CD86 \| DISEASES 5813 \| PURA \| DISEASES 342035 \| GLDN \| DISEASES 3423 \| IDS \| DISEASES 3329 \| HSPD1 \| DISEASES 966 \| CD59 \| DISEASES 4076 \| CAPRIN1 \| DISEASES 123228 \| SENP8 \| DISEASES 6614 \| SIGLEC1 \| DISEASES 25870 \| SUMF2 \| DISEASES 124454 \| EARS2 \| DISEASES 3455 \| IFNAR2 \| DISEASES 3605 \| IL17A \| DISEASES 875 \| CBS \| DISEASES 23114 \| NFASC \| DISEASES 3767 \| KCNJ11 \| DISEASES 6227 \| RPS21 \| DISEASES 23481 \| PES1 \| DISEASES 100506658 \| OCLN \| DISEASES 2204 \| FCAR \| DISEASES 3240 \| HP \| DISEASES 10146 \| G3BP1 \| DISEASES 337 \| APOA4 \| DISEASES 7456 \| WIPF1 \| DISEASES 4478 \| MSN \| DISEASES 26047 \| CNTNAP2 \| DISEASES 4283 \| CXCL9 \| DISEASES 1270 \| CNTF \| DISEASES 913 \| CD1E \| DISEASES 910 \| CD1B \| DISEASES 911 \| CD1C \| DISEASES 6280 \| S100A9 \| DISEASES 7073 \| TIAL1 \| DISEASES 4803 \| NGF \| DISEASES 1847 \| DUSP5 \| DISEASES 959 \| CD40LG \| DISEASES 5563 \| PRKAA2 \| DISEASES 774 \| CACNA1B \| DISEASES 9211 \| LGI1 \| DISEASES 6342 \| SCP2 \| DISEASES 5730 \| PTGDS \| DISEASES 4318 \| MMP9 \| DISEASES 5476 \| CTSA \| DISEASES 54209 \| TREM2 \| DISEASES 2833 \| CXCR3 \| DISEASES 7099 \| TLR4 \| DISEASES 4593 \| MUSK \| DISEASES 2582 \| GALE \| DISEASES 1896 \| EDA \| DISEASES 6891 \| TAP2 \| DISEASES 3376 \| IARS \| DISEASES 50943 \| FOXP3 \| DISEASES 7133 \| TNFRSF1B \| DISEASES 1471 \| CST3 \| DISEASES 2550 \| GABBR1 \| DISEASES 8573 \| CASK \| DISEASES 4897 \| NRCAM \| DISEASES 5251 \| PHEX \| DISEASES 22866 \| CNKSR2 \| DISEASES 3456 \| IFNB1 \| DISEASES 551 \| AVP \| DISEASES 5555 \| PRH2 \| DISEASES 51199 \| NIN \| DISEASES 4155 \| MBP \| DISEASES 361 \| AQP4 \| DISEASES 55576 \| STAB2 \| DISEASES 4099 \| MAG \| DISEASES 9047 \| SH2D2A \| DISEASES 124599 \| CD300LB \| DISEASES 2719 \| GPC3 \| DISEASES 93487 \| MAPK1IP1L \| DISEASES 3119 \| HLA-DQB1 \| DISEASES 8091 \| HMGA2 \| DISEASES 27124 \| INPP5J \| DISEASES 7122 \| CLDN5 \| DISEASES 3120 \| HLA-DQB2 \| DISEASES 720 \| C4A \| DISEASES 7124 \| TNF \| DISEASES 3106 \| HLA-B \| DISEASES 387 \| RHOA \| DISEASES 4049 \| LTA \| DISEASES 3115 \| HLA-DPB1 \| DISEASES 3586 \| IL10 \| DISEASES 5554 \| PRH1 \| DISEASES 627 \| BDNF \| DISEASES 26137 \| ZBTB20 \| DISEASES 51428 \| DDX41 \| DISEASES 342538 \| NACA2 \| DISEASES 10687 \| PNMA2 \| DISEASES 4359 \| MPZ \| DISEASES 3684 \| ITGAM \| DISEASES 11331 \| PHB2 \| DISEASES 8284 \| KDM5D \| DISEASES 23601 \| CLEC5A \| DISEASES 7732 \| RNF112 \| DISEASES 6223 \| RPS19 \| DISEASES 103164619 \| PCAT2 \| DISEASES
Locus	(Waiting for update.)

Disease ID	62
Disease	guillain-barre syndrome
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:1) HP:0007131 \| Acute demyelinating polyneuropathy
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:68) HP:0012115 \| Liver inflammation \| 6 HP:0003470 \| Inability to move \| 5 HP:0010628 \| Facial palsy, unilateral or bilateral \| 4 HP:0001349 \| Facial paresis, bilateral \| 4 HP:0012531 \| Pain \| 3 HP:0002902 \| Hyponatremia \| 3 HP:0012378 \| Fatigue \| 3 HP:0002878 \| Respiratory failure \| 3 HP:0200119 \| Acute liver inflammation \| 3 HP:0001298 \| Encephalopathy \| 2 HP:0100614 \| Muscle inflammation \| 2 HP:0003477 \| Peripheral axonal neuropathy \| 2 HP:0001347 \| Hyperreflexia \| 2 HP:0003390 \| Sensory axonal neuropathy \| 2 HP:0012452 \| Restless legs \| 1 HP:0001369 \| Arthritis \| 1 HP:0006882 \| Severe hydrocephalus \| 1 HP:0001336 \| Myoclonic jerks \| 1 HP:0002383 \| Encephalitis \| 1 HP:0002273 \| Tetraparesis \| 1 HP:0002360 \| Sleep disturbance \| 1 HP:0000112 \| Nephropathy \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1 HP:0430025 \| Bilateral facial paralysis \| 1 HP:0000011 \| Neurogenic bladder \| 1 HP:0001324 \| Muscular weakness \| 1 HP:0012578 \| Membranous glomerulonephritis \| 1 HP:0009830 \| Peripheral neuritis \| 1 HP:0000501 \| Glaucoma \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0001953 \| Diabetic ketosis \| 1 HP:0002013 \| Emesis \| 1 HP:0002203 \| Respiratory paralysis \| 1 HP:0003401 \| Paresthesia \| 1 HP:0000979 \| Purpura \| 1 HP:0040078 \| Axonal degeneration \| 1 HP:0000238 \| Nonsyndromal hydrocephalus \| 1 HP:0001271 \| Polyneuropathy \| 1 HP:0000100 \| Nephrosis \| 1 HP:0011349 \| Sixth nerve palsy \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0011986 \| Ectopic bone formation \| 1 HP:0001945 \| Fever \| 1 HP:0006721 \| Acute lymphocytic leukemia \| 1 HP:0000127 \| Salt wasting \| 1 HP:0000822 \| Hypertension \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0002196 \| Myelopathy \| 1 HP:0011665 \| Takotsubo cardiomyopathy \| 1 HP:0001283 \| Bulbar palsies \| 1 HP:0003396 \| Syringomyelia \| 1 HP:0002459 \| Dysautonomia \| 1 HP:0003447 \| Axonal loss \| 1 HP:0001171 \| Hand ectrodactyly \| 1 HP:0012799 \| Unilateral facial weakness \| 1 HP:0002015 \| Swallowing difficulty \| 1 HP:0001993 \| Ketoacidosis \| 1 HP:0001629 \| Ventricular septal defects \| 1 HP:0012819 \| Myocarditis \| 1 HP:0007209 \| Facial paresis \| 1 HP:0030880 \| Raynaud phenomenon \| 1 HP:0002318 \| Cervical myelopathy \| 1 HP:0002664 \| Neoplasia \| 1 HP:0003326 \| Muscle pain \| 1 HP:0012393 \| Allergy \| 1 HP:0002666 \| Pheochromocytoma \| 1

Disease ID	62
Disease	guillain-barre syndrome
Manually Symptom	UMLS \| Name(Total Manually Symptoms:20) C2364133 \| infection C2364051 \| fatigue C2108077 \| atrioventricular block C2096315 \| headache C1963137 \| hydrocephalus C1962971 \| myocarditis C1145670 \| respiratory failure C1135207 \| ataxia C0271650 \| impaired glucose tolerance C0239889 \| severe headache C0221165 \| diplegia C0155320 \| cortical blindness C0155288 \| papilledema C0028866 \| oculomotor nerve palsy C0027813 \| neuritis C0027726 \| nephrotic syndrome C0024535 \| plasmodium falciparum malaria C0018378 \| acute inflammatory demyelinating polyradiculoneuropathy C0011860 \| diabetes C0010403 \| cryoglobulinemia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:7) C0009450 \| infection \| 8 C0221165 \| diplegia \| 4 C0015672 \| fatigue \| 3 C1145670 \| respiratory failure \| 3 C0020255 \| hydrocephalus \| 1 C0027059 \| myocarditis \| 1 C0027726 \| nephrotic syndrome \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs397514767	25818314	966	CD59	umls:C0018378	BeFree	The Cys89Tyr mutation in CD59 was clinically manifested in infancy, and associated with chronic hemolysis and relapsing peripheral demyelinating disease resembling recurrent Guillain-Barré syndrome (GBS) or chronic inflammatory demyelinating polyneuropathy (CIDP).	0.000271442	2015	CD59	11	33710247	C	T
rs4986790	19913922	7099	TLR4	umls:C0018378	BeFree	Association of TLR4 Asp299Gly and Thr399Ile polymorphisms with Guillain-Barré syndrome in Northern Indian population.	0.000271442	2010	TLR4	9	117713024	A	G
rs4986791	19913922	7099	TLR4	umls:C0018378	BeFree	Association of TLR4 Asp299Gly and Thr399Ile polymorphisms with Guillain-Barré syndrome in Northern Indian population.	0.000271442	2010	TLR4	9	117713324	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:7)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0018378	cladribine	D017338	4291-63-8	guillain-barre syndrome	MESH:D020275	marker/mechanism	11342351
C0018378	colchicine	D003078	64-86-8	guillain-barre syndrome	MESH:D020275	marker/mechanism	17097509
C0018378	cyclophosphamide	D003520	50-18-0	guillain-barre syndrome	MESH:D020275	marker/mechanism	11960272
C0018378	cyclosporine	D016572	59865-13-3	guillain-barre syndrome	MESH:D020275	marker/mechanism	17097509
C0018378	cisplatin	D002945	15663-27-1	guillain-barre syndrome	MESH:D020275	marker/mechanism	17129846
C0018378	gemcitabine	C056507	103882-84-4	guillain-barre syndrome	MESH:D020275	marker/mechanism	17129846
C0018378	pravastatin	D017035	81093-37-0	guillain-barre syndrome	MESH:D020275	marker/mechanism	15389662

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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