PedAM
Pediatric Disease Annotations & Medicines
| granulosa cell tumor of the ovary | ||||
| Disease ID | 1212 |
|---|---|
| Disease | granulosa cell tumor of the ovary |
| Definition | A granulosa-stromal cell tumor that arises from the ovary. It is characterized by the presence of granulosa cells that comprise at least ten percent of the cellular population. The granulosa cells are often found in a background that contains theca and fibrous cells. There are two major subtypes recognized, adult and juvenile granulosa cell tumor. Clinically, patients may present with an abdominal mass. Symptoms depend on the patient's age. The most important indicator of prognosis is tumor stage. Age over forty years at the time of the initial diagnosis, large tumor size, bilaterality, cellular atypia, and increased mitotic activity are factors indicating a potentially aggressive clinical course and relative poor prognosis. |
| Synonym | adult granulosa cell tumor of the ovary cell granulosa ovary tumor gct of the ovary granulosa cell neoplasm of ovary granulosa cell neoplasm of the ovary granulosa cell tumor of ovary granulosa cell tumor of ovary (disorder) granulosa cell tumour of ovary granulosa theca cell tumor granulosa theca cell tumor of the ovary ovarian cancer, sex chord-mesenchymal ovarian granulosa cell neoplasm ovarian granulosa cell tumor ovary, granulosa cell tumor ovary, sex chord-mesenchymal tumor |
| UMLS | C1370419 |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:4) |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:1) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 1212 |
|---|---|
| Disease | granulosa cell tumor of the ovary |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:3) |
| Disease ID | 1212 |
|---|---|
| Disease | granulosa cell tumor of the ovary |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:1) C0494165 | hepatic metastasis |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:2) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs137853226 | NA | 2771 | GNAI2 | umls:C1370419 | CLINVAR | NA | 0.12 | NA | GNAI2 | 3 | 50256262 | C | G,T |
| rs137853227 | NA | 2771 | GNAI2 | umls:C1370419 | CLINVAR | NA | 0.12 | NA | GNAI2 | 3 | 50256263 | G | A |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CUI | ChemicalName | ChemicalID | CasRN | DiseaseName | DiseaseID | DirectEvidence | PubMedIDs | ||
| C1370419 | cisplatin | D002945 | 15663-27-1 | granulosa cell tumor of the ovary | MESH:C537296 | therapeutic | 3379758 | ||
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |