PedAM

Pediatric Disease Annotations & Medicines


	graft-vs-host disease

Disease ID	834
Disease	graft-vs-host disease
Definition	The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Synonym	autoimmune foreign transplant disease disease graft host versus disease graft host vs disease graft versus host disease, graft-versus-host disease, graft-vs-host disease, homologous wasting disease, runt diseases, graft-versus-host diseases, graft-vs-host graft versus host dis graft versus host disease graft versus host disease (disorder) graft versus host disease [ambiguous] graft versus host disease, nos graft vs host dis graft vs host disease graft vs host disease [disease/finding] graft vs. host disease graft-versus-host disease graft-versus-host disease (disorder) graft-versus-host disease, unspecified graft-versus-host diseases graft-versus-host nos graft-versus-host-disease graft-vs-host diseases gvh gvh disease gvhd gvhd - graft-versus-host disease homol wasting dis homologous wasting disease host versus graft disease host vs graft disease runt dis runt disease runting syndrome
Orphanet	ORPHANET:39812
ICD10	ICD10CM:D89.813
UMLS	C0018133
MeSH	D006086
SNOMED-CT	SNOMEDCT_US_2016_09_01:234646005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:123) C0023418 \| leukemia \| 12 C0314719 \| dry eye \| 9 C0011991 \| diarrhea \| 6 C0026946 \| fungal infection \| 5 C0026946 \| fungal infections \| 4 C0026764 \| multiple myeloma \| 4 C0026764 \| myeloma \| 4 C0085669 \| acute leukemia \| 4 C0376545 \| hematological malignancies \| 4 C0026986 \| myelodysplastic syndrome \| 4 C0002871 \| anemia \| 3 C0032285 \| pneumonia \| 3 C0011991 \| diarrhoea \| 3 C0042769 \| viral infection \| 3 C0006272 \| bronchiolitis obliterans \| 3 C0015230 \| rash \| 3 C0015625 \| fanconi anemia \| 3 C0155765 \| microangiopathy \| 3 C0013238 \| dry eye syndrome \| 3 C0022658 \| nephropathy \| 3 C0011644 \| scleroderma \| 3 C0023418 \| leukaemia \| 3 C1145670 \| respiratory failure \| 2 C0024523 \| malabsorption \| 2 C0006271 \| bronchiolitis \| 2 C0023467 \| acute myeloid leukemia \| 2 C0002874 \| aplastic anemia \| 2 C0002170 \| alopecia \| 2 C0152025 \| polyneuropathy \| 2 C0015230 \| exanthema \| 2 C0023890 \| cirrhosis \| 2 C0023470 \| myeloid leukemia \| 2 C0042769 \| viral infections \| 2 C0558353 \| tongue carcinoma \| 2 C0030312 \| pancytopenia \| 2 C0020443 \| hypercholesterolemia \| 2 C0017665 \| membranous nephropathy \| 2 C0032326 \| pneumothorax \| 1 C0023646 \| lichen planus \| 1 C0878544 \| cardiomyopathy \| 1 C0002171 \| alopecia areata \| 1 C0010930 \| dacryocystitis \| 1 C0035305 \| retinal detachment \| 1 C0037199 \| sinusitis \| 1 C0085655 \| polymyositis \| 1 C0040100 \| thymoma \| 1 C1955861 \| t-cell large granular lymphocyte leukemia \| 1 C0085669 \| acute leukaemia \| 1 C0004030 \| aspergillosis \| 1 C0043541 \| zygomycosis \| 1 C0007137 \| squamous cell carcinoma \| 1 C0014527 \| epidermolysis bullosa \| 1 C0085669 \| acute leukemias \| 1 C0033680 \| protein losing enteropathy \| 1 C0008312 \| primary biliary cirrhosis \| 1 C0026764 \| plasma cell myeloma \| 1 C0600260 \| obstructive lung disease \| 1 C0031117 \| peripheral neuropathy \| 1 C0017160 \| gastroenteritis \| 1 C0022575 \| keratoconjunctivitis sicca \| 1 C0013370 \| intestinal amoebiasis \| 1 C0376545 \| hematologic malignancies \| 1 C0022573 \| keratoconjunctivitis \| 1 C1258215 \| ileus \| 1 C0024314 \| lymphoproliferative disorder \| 1 C1568868 \| oral mucositis \| 1 C0023418 \| leukemias \| 1 C0013182 \| drug hypersensitivity \| 1 C0442874 \| neuropathy \| 1 C0024312 \| lymphopenia \| 1 C0008370 \| cholestasis \| 1 C0041351 \| tularemia \| 1 C0027947 \| neutropenia \| 1 C0085110 \| severe combined immunodefic \| 1 C0155237 \| acute dacryocystitis \| 1 C0024314 \| lymphoproliferative disorders \| 1 C0026986 \| myelodysplastic syndromes \| 1 C0031046 \| pericarditis \| 1 C0086543 \| cataract \| 1 C0024523 \| malabsorption syndrome \| 1 C0242770 \| bronchiolitis obliterans organizing pneumonia \| 1 C0024299 \| lymphoma \| 1 C0004623 \| bacterial infection \| 1 C0034150 \| purpura \| 1 C0376545 \| hematologic cancer \| 1 C0023448 \| lymphocytic leukemia \| 1 C0021053 \| immune disease \| 1 C1527407 \| eosinophilic pneumonia \| 1 C0023470 \| myeloid leukaemia \| 1 C0162855 \| mucinosis \| 1 C0002438 \| amoebiasis \| 1 C0024523 \| malabsorption syndromes \| 1 C0023467 \| acute myeloid leukaemia \| 1 C0019069 \| hemophilia \| 1 C0030804 \| mucous membrane pemphigoid \| 1 C0032285 \| pneumonitis \| 1 C0015397 \| eye disease \| 1 C0019829 \| hodgkin lymphoma \| 1 C0011334 \| caries \| 1 C0027121 \| myositis \| 1 C0009319 \| colitis \| 1 C0013418 \| abnormal labor \| 1 C0030805 \| pemphigoid \| 1 C0031048 \| constrictive pericarditis \| 1 C0020541 \| portal hypertension \| 1 C0020538 \| hypertension \| 1 C0026946 \| fungal disease \| 1 C0270922 \| demyelinating polyneuropathy \| 1 C0085110 \| severe combined immunodeficiency \| 1 C0007177 \| cardiac tamponade \| 1 C0042769 \| virus infection \| 1 C0030305 \| pancreatitis \| 1 C0002874 \| aplastic anaemia \| 1 C0024115 \| lung disease \| 1 C0008312 \| biliary cirrhosis \| 1 C0011334 \| dental caries \| 1 C0162429 \| malnutrition \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0346054 \| verruciform xanthoma \| 1 C0007134 \| renal cell carcinoma \| 1 C0151546 \| carcinoma of the oral cavity \| 1 C0027726 \| nephrotic syndrome \| 1 C0021843 \| bowel obstruction \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) CTLA4 \| 1493 \| CTD_human IFNG \| 3458 \| CTD_human MTHFR \| 4524 \| CTD_human IL17A \| 3605 \| CTD_human UGT2B17 \| 7367 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:100) 1234 \| CCR5 \| infer 1493 \| CTLA4 \| infer 2212 \| FCGR2A \| infer 3458 \| IFNG \| infer 3586 \| IL10 \| infer 3552 \| IL1A \| infer 3553 \| IL1B \| infer 3557 \| IL1RN \| infer 3565 \| IL4 \| infer 3569 \| IL6 \| infer 3802 \| KIR2DL1 \| infer 3803 \| KIR2DL2 \| infer 3804 \| KIR2DL3 \| infer 3805 \| KIR2DL4 \| infer 3806 \| KIR2DS1 \| infer 3808 \| KIR2DS3 \| infer 3810 \| KIR2DS5 \| infer 3811 \| KIR3DL1 \| infer 3812 \| KIR3DL2 \| infer 7040 \| TGFB1 \| infer 7124 \| TNF \| infer 11214 \| AKAP13 \| infer 328 \| APEX1 \| infer 597 \| BCL2A1 \| infer 6347 \| CCL2 \| infer 6352 \| CCL5 \| infer 2237 \| FEN1 \| infer 3105 \| HLA-A \| infer 3106 \| HLA-B \| infer 3107 \| HLA-C \| infer 3115 \| HLA-DPB1 \| infer 3117 \| HLA-DQA1 \| infer 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer 3133 \| HLA-E \| infer 57824 \| HMHB1 \| infer 3439 \| IFNA1 \| infer 3588 \| IL10RB \| infer 149233 \| IL23R \| infer 3813 \| KIR3DS1 \| infer 3938 \| LCT \| infer 3978 \| LIG1 \| infer 3980 \| LIG3 \| infer 4049 \| LTA \| infer 8174 \| MADCAM1 \| infer 8930 \| MBD4 \| infer 4350 \| MPG \| infer 4524 \| MTHFR \| infer 4595 \| MUTYH \| infer 64005 \| MYO1G \| infer 64127 \| NOD2 \| infer 4913 \| NTHL1 \| infer 4968 \| OGG1 \| infer 142 \| PARP1 \| infer 5111 \| PCNA \| infer 5175 \| PECAM1 \| infer 11284 \| PNKP \| infer 5423 \| POLB \| infer 5424 \| POLD1 \| infer 5425 \| POLD2 \| infer 5426 \| POLE \| infer 11201 \| POLI \| infer 5981 \| RFC1 \| infer 5982 \| RFC2 \| infer 5983 \| RFC3 \| infer 5984 \| RFC4 \| infer 5985 \| RFC5 \| infer 4088 \| SMAD3 \| infer 23583 \| SMUG1 \| infer 3431 \| SP110 \| infer 6996 \| TDG \| infer 7132 \| TNFRSF1A \| infer 7133 \| TNFRSF1B \| infer 7367 \| UGT2B17 \| infer 7374 \| UNG \| infer 7421 \| VDR \| infer 7515 \| XRCC1 \| infer 5243 \| ABCB1 \| infer 28 \| ABO \| infer 1636 \| ACE \| infer 183 \| AGT \| infer 185 \| AGTR1 \| infer 186 \| AGTR2 \| infer 1577 \| CYP3A5 \| infer 2099 \| ESR1 \| infer 2100 \| ESR2 \| infer 2938 \| GSTA1 \| infer 3136 \| HLA-H \| infer 3305 \| HSPA1L \| infer 3460 \| IFNGR2 \| infer 3554 \| IL1R1 \| infer 3558 \| IL2 \| infer 3566 \| IL4R \| infer 3659 \| IRF1 \| infer 4509 \| MT-ATP8 \| infer 4537 \| MT-ND3 \| infer 5027 \| P2RX7 \| infer 7042 \| TGFB2 \| infer 7099 \| TLR4 \| infer 7298 \| TYMS \| infer
Text Mined Gene	(Waiting for update.)
Locus	(Waiting for update.)

Disease ID	834
Disease	graft-vs-host disease
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:106) HP:0001909 \| Leukemia \| 11 HP:0002664 \| Neoplasia \| 9 HP:0002014 \| Diarrhea \| 6 HP:0001824 \| Weight loss \| 5 HP:0030731 \| Carcinoma \| 5 HP:0006775 \| Multiple myeloma \| 4 HP:0002488 \| Acute leukemias \| 4 HP:0002863 \| Myelodysplastic syndrome \| 4 HP:0002090 \| Pneumonia \| 3 HP:0011946 \| Constrictive bronchiolitis \| 3 HP:0000112 \| Nephropathy \| 3 HP:0001399 \| Liver failure \| 3 HP:0001903 \| Anemia \| 3 HP:0100324 \| Progressive systemic scleroderma \| 3 HP:0001596 \| Hair loss \| 3 HP:0000969 \| Dropsy \| 2 HP:0001271 \| Polyneuropathy \| 2 HP:0012578 \| Membranous glomerulonephritis \| 2 HP:0011950 \| Bronchiolitis \| 2 HP:0002024 \| Intestinal malabsorption \| 2 HP:0001915 \| Aplastic anemia \| 2 HP:0012531 \| Pain \| 2 HP:0001394 \| Hepatic cirrhosis \| 2 HP:0002013 \| Emesis \| 2 HP:0003124 \| Elevated serum cholesterol \| 2 HP:0001880 \| Eosinophilia \| 2 HP:0000988 \| Exanthem \| 2 HP:0100806 \| Sepsis \| 2 HP:0002018 \| Nausea \| 2 HP:0004808 \| Acute myelogenous leukemia \| 2 HP:0012324 \| Myeloid leukemia \| 2 HP:0002878 \| Respiratory failure \| 2 HP:0002721 \| Immunodeficiency \| 2 HP:0000670 \| Dental caries \| 1 HP:0007502 \| Hyperkeratosis follicularis \| 1 HP:0012378 \| Fatigue \| 1 HP:0000541 \| Detached retina \| 1 HP:0007468 \| Perifollicular hyperkeratosis \| 1 HP:0001888 \| Lymphocytopenia \| 1 HP:0001876 \| Low blood cell count \| 1 HP:0001114 \| Fatty deposits on eyelids \| 1 HP:0001410 \| Decreased liver function \| 1 HP:0001744 \| Splenomegaly \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0002015 \| Swallowing difficulty \| 1 HP:0100614 \| Muscle inflammation \| 1 HP:0005584 \| Renal cell carcinoma \| 1 HP:0002202 \| Pleural effusion \| 1 HP:0000620 \| Dacrocystitis \| 1 HP:0003394 \| Muscle cramps \| 1 HP:0100583 \| Corneal perforation \| 1 HP:0007133 \| Progressive peripheral neuropathy \| 1 HP:0000822 \| Hypertension \| 1 HP:0045073 \| Serositis \| 1 HP:0001746 \| Absent spleen \| 1 HP:0002039 \| Anorexia \| 1 HP:0004430 \| Severe combined immunodeficiency \| 1 HP:0002613 \| Biliary cirrhosis \| 1 HP:0006532 \| Pneumonia, recurrent episodes \| 1 HP:0005132 \| Pericardial constriction \| 1 HP:0001875 \| Neutropenia \| 1 HP:0002904 \| High blood bilirubin levels \| 1 HP:0001371 \| Flexion contractures of joints \| 1 HP:0002595 \| Gastrointestinal atony \| 1 HP:0100522 \| Thymoma \| 1 HP:0001096 \| Keratoconjunctivitis \| 1 HP:0005200 \| Retroperitoneal fibrosis \| 1 HP:0001510 \| Growth deficiency \| 1 HP:0006536 \| Obstructive lung disease \| 1 HP:0007663 \| Central visual loss \| 1 HP:0001396 \| Cholestasis \| 1 HP:0000979 \| Purpura \| 1 HP:0002017 \| Nausea and vomiting \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0001945 \| Fever \| 1 HP:0001259 \| Coma \| 1 HP:0000217 \| Dry mouth syndrome \| 1 HP:0002563 \| Constrictive pericarditis \| 1 HP:0001097 \| Keratoconjunctivitis sicca \| 1 HP:0009830 \| Peripheral neuritis \| 1 HP:0001701 \| Pericarditis \| 1 HP:0002229 \| Alopecia areata \| 1 HP:0002860 \| Squamous cell carcinoma \| 1 HP:0004395 \| Malnutrition \| 1 HP:0010783 \| Erythema \| 1 HP:0001019 \| Exfoliative dermititis \| 1 HP:0005214 \| Bowel obstruction \| 1 HP:0200034 \| Papule \| 1 HP:0000246 \| Sinus inflammation \| 1 HP:0000518 \| Cataract \| 1 HP:0005523 \| Lymphoproliferative disorder \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0001409 \| Portal hypertension \| 1 HP:0002583 \| Colitis \| 1 HP:0002958 \| Immune dysregulation \| 1 HP:0001250 \| Seizures \| 1 HP:0011945 \| Cryptogenic organizing pneumonia \| 1 HP:0002107 \| Collapsed lung \| 1 HP:0002910 \| Elevated transaminases \| 1 HP:0200016 \| Acral keratosis \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0001324 \| Muscular weakness \| 1 HP:0002027 \| Abdominal pain \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0002665 \| Lymphoma \| 1 HP:0040186 \| Maculopapular exanthema \| 1

Disease ID	834
Disease	graft-vs-host disease
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:8) C0314719 \| dry eye \| 8 C0426768 \| o sign \| 5 C0023418 \| leukemia \| 4 C0026946 \| fungal infections \| 2 C0029166 \| oral manifestations \| 2 C0270922 \| demyelinating polyneuropathy \| 1 C0043541 \| zygomycosis \| 1 C0009450 \| infection \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1061622	14688526	7133	TNFRSF1B	umls:C0018133	BeFree	Tumour necrosis factor receptor type II 196M/R genotype correlates with circulating soluble receptor levels in normal subjects and with graft-versus-host disease after sibling allogeneic bone marrow transplantation.	0.010639772	2003	TNFRSF1B	1	12192898	T	G
rs2275913	22028838	3605	IL17A	umls:C0018133	BeFree	When we examined the impact of rs2275913 in a cohort consisting of 438 pairs of patients and their unrelated donors transplanted through the Japan Marrow Donor Program, the donor IL-17 197A allele was found to be associated with a higher risk of acute graft-versus-host disease (GVHD; hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.00 to 2.13; P = 0.05).	0.120814326	2011	IL17A	6	52186235	G	A
rs4693608	24319286	10855	HPSE	umls:C0018133	BeFree	The study emphasizes the importance of rs4693608 SNP for HPSE gene expression in activated MNCs, indicating a role in allogeneic stem cell transplantation, including postconditioning, engraftment, and GVHD.	0.003181358	2014	HPSE	4	83320204	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:9)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0018133	cyclophosphamide	D003520	50-18-0	graft vs host disease	MESH:D006086	therapeutic	11014644
C0018133	cyclosporine	D016572	59865-13-3	graft vs host disease	MESH:D006086	marker/mechanism	21292993
C0018133	cyclosporine	D016572	59865-13-3	graft vs host disease	MESH:D006086	therapeutic	11100753
C0018133	everolimus	D000068338	-	graft vs host disease	MESH:D006086	therapeutic	19135948
C0018133	methotrexate	D008727	1959/5/2	graft vs host disease	MESH:D006086	therapeutic	14604289
C0018133	sirolimus	D020123	53123-88-9	graft vs host disease	MESH:D006086	therapeutic	15625544
C0018133	tacrolimus	D016559	109581-93-3	graft vs host disease	MESH:D006086	therapeutic	10918426
C0018133	thalidomide	D013792	50-35-1	graft vs host disease	MESH:D006086	therapeutic	12499476
C0018133	vorinostat	C111237	-	graft vs host disease	MESH:D006086	therapeutic	18347343

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

Web
Analytics