PedAM

Pediatric Disease Annotations & Medicines


	gingival overgrowth

Disease ID	1571
Disease	gingival overgrowth
Definition	Excessive growth of the gingiva either by an increase in the size of the constituent cells (GINGIVAL HYPERTROPHY) or by an increase in their number (GINGIVAL HYPERPLASIA). (From Jablonski's Dictionary of Dentistry, 1992, p574)
Synonym	gingival bulge gingival enlargement (disorder) gingival enlargement nos gingival enlargement nos (disorder) gingival enlargement, nos gingival overgrowth [disease/finding] gingival overgrowths overgrowth, gingival overgrowths, gingival
DOID	DOID:3086
UMLS	C0376480
MeSH	D019214
SNOMED-CT	SNOMEDCT_US_2016_09_01:54711002
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:6) C0031099 \| periodontitis \| 2 C0042373 \| vascular disease \| 1 C0018553 \| cowden syndrome \| 1 C0020555 \| hypertrichosis \| 1 C0018799 \| heart disease \| 1 C0007222 \| cardiovascular disease \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:6) 5243 \| ABCB1 \| infer 3569 \| IL6 \| infer 4312 \| MMP1 \| infer 4314 \| MMP3 \| infer 6678 \| SPARC \| infer 7040 \| TGFB1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:129) 1634 \| DCN \| DISEASES 4804 \| NGFR \| DISEASES 7049 \| TGFBR3 \| DISEASES 266 \| AMELY \| DISEASES 8216 \| LZTR1 \| DISEASES 5008 \| OSM \| DISEASES 9567 \| GTPBP1 \| DISEASES 6655 \| SOS2 \| DISEASES 7076 \| TIMP1 \| DISEASES 4313 \| MMP2 \| DISEASES 7040 \| TGFB1 \| DISEASES 5054 \| SERPINE1 \| DISEASES 4353 \| MPO \| DISEASES 1277 \| COL1A1 \| DISEASES 2026 \| ENO2 \| DISEASES 51053 \| GMNN \| DISEASES 4015 \| LOX \| DISEASES 4317 \| MMP8 \| DISEASES 6237 \| RRAS \| DISEASES 3425 \| IDUA \| DISEASES 968 \| CD68 \| DISEASES 1215 \| CMA1 \| DISEASES 2006 \| ELN \| DISEASES 54453 \| RIN2 \| DISEASES 3569 \| IL6 \| DISEASES 8737 \| RIPK1 \| DISEASES 9313 \| MMP20 \| DISEASES 1559 \| CYP2C9 \| DISEASES 9360 \| PPIG \| DISEASES 3685 \| ITGAV \| DISEASES 10060 \| ABCC9 \| DISEASES 4069 \| LYZ \| DISEASES 4092 \| SMAD7 \| DISEASES 4087 \| SMAD2 \| DISEASES 7077 \| TIMP2 \| DISEASES 22858 \| ICK \| DISEASES 23523 \| CABIN1 \| DISEASES 3552 \| IL1A \| DISEASES 3553 \| IL1B \| DISEASES 1991 \| ELANE \| DISEASES 2247 \| FGF2 \| DISEASES 1950 \| EGF \| DISEASES 5243 \| ABCB1 \| DISEASES 7078 \| TIMP3 \| DISEASES 2252 \| FGF7 \| DISEASES 3756 \| KCNH1 \| DISEASES 5921 \| RASA1 \| DISEASES 79017 \| GGCT \| DISEASES 526 \| ATP6V1B2 \| DISEASES 4319 \| MMP10 \| DISEASES 814 \| CAMK4 \| DISEASES 3672 \| ITGA1 \| DISEASES 7345 \| UCHL1 \| DISEASES 5922 \| RASA2 \| DISEASES 163786 \| SASS6 \| DISEASES 7079 \| TIMP4 \| DISEASES 7039 \| TGFA \| DISEASES 64320 \| RNF25 \| DISEASES 3673 \| ITGA2 \| DISEASES 161742 \| SPRED1 \| DISEASES 144568 \| A2ML1 \| DISEASES 4314 \| MMP3 \| DISEASES 290 \| ANPEP \| DISEASES 84168 \| ANTXR1 \| DISEASES 3643 \| INSR \| DISEASES 118429 \| ANTXR2 \| DISEASES 6383 \| SDC2 \| DISEASES 54205 \| CYCS \| DISEASES 948 \| CD36 \| DISEASES 5340 \| PLG \| DISEASES 1444 \| CSHL1 \| DISEASES 3265 \| HRAS \| DISEASES 947 \| CD34 \| DISEASES 836 \| CASP3 \| DISEASES 924 \| CD7 \| DISEASES 4684 \| NCAM1 \| DISEASES 5345 \| SERPINF2 \| DISEASES 56975 \| FAM20C \| DISEASES 3039 \| HBA1 \| DISEASES 4312 \| MMP1 \| DISEASES 633 \| BGN \| DISEASES 3047 \| HBG1 \| DISEASES 5155 \| PDGFB \| DISEASES 71 \| ACTG1 \| DISEASES 4088 \| SMAD3 \| DISEASES 554 \| AVPR2 \| DISEASES 23236 \| PLCB1 \| DISEASES 1508 \| CTSB \| DISEASES 8481 \| OFD1 \| DISEASES 6275 \| S100A4 \| DISEASES 5154 \| PDGFA \| DISEASES 2331 \| FMOD \| DISEASES 871 \| SERPINH1 \| DISEASES 5599 \| MAPK8 \| DISEASES 7052 \| TGM2 \| DISEASES 7058 \| THBS2 \| DISEASES 7042 \| TGFB2 \| DISEASES 1490 \| CTGF \| DISEASES 9191 \| DEDD \| DISEASES 81030 \| ZBP1 \| DISEASES 7422 \| VEGFA \| DISEASES 4318 \| MMP9 \| DISEASES 6385 \| SDC4 \| DISEASES 9968 \| MED12 \| DISEASES 2517 \| FUCA1 \| DISEASES 367 \| AR \| DISEASES 780 \| DDR1 \| DISEASES 7102 \| TSPAN7 \| DISEASES 1906 \| EDN1 \| DISEASES 10631 \| POSTN \| DISEASES 265 \| AMELX \| DISEASES 2813 \| GP2 \| DISEASES 1186 \| CLCN7 \| DISEASES 3083 \| HGFAC \| DISEASES 10675 \| CSPG5 \| DISEASES 54499 \| TMCO1 \| DISEASES 10117 \| ENAM \| DISEASES 54826 \| GIN1 \| DISEASES 6654 \| SOS1 \| DISEASES 3550 \| IK \| DISEASES 7124 \| TNF \| DISEASES 8831 \| SYNGAP1 \| DISEASES 55799 \| CACNA2D3 \| DISEASES 80745 \| THUMPD2 \| DISEASES 4168 \| MCF2 \| DISEASES 1649 \| DDIT3 \| DISEASES 54757 \| FAM20A \| DISEASES 5608 \| MAP2K6 \| DISEASES 55539 \| KCNQ1DN \| DISEASES
Locus	(Waiting for update.)

Disease ID	1571
Disease	gingival overgrowth
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:3) HP:0000704 \| Pyorrhea \| 2 HP:0000998 \| Hypertrichosis \| 1 HP:0012531 \| Pain \| 1

Disease ID	1571
Disease	gingival overgrowth
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:3)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0376480	cyclosporine	D016572	59865-13-3	gingival overgrowth	MESH:D019214	marker/mechanism	18342291
C0376480	phenytoin	D010672	57-41-0	gingival overgrowth	MESH:D019214	marker/mechanism	14659971
C0376480	tacrolimus	D016559	109581-93-3	gingival overgrowth	MESH:D019214	marker/mechanism	18342291

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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