PedAM
Pediatric Disease Annotations & Medicines
| gastrointestinal system cancer | ||||
| Disease ID | 1503 |
|---|---|
| Disease | gastrointestinal system cancer |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:1) |
| Disease ID | 1503 |
|---|---|
| Disease | gastrointestinal system cancer |
| Manually Symptom | (Waiting for update.) |
| Text Mined Symptom | (Waiting for update.) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
All Snps(Total Genotypes:17) | |||||||||||||
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| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs1052133 | 25323581 | 4968 | OGG1 | umls:C0685938 | BeFree | These findings supported that hOGG1 Ser326Cys polymorphism may contribute to the susceptibility of digestive cancers. | 0.000271442 | 2014 | OGG1;CAMK1 | 3 | 9757089 | C | G |
| rs1130409 | 25945024 | 328 | APEX1 | umls:C0685938 | BeFree | This meta-analysis suggests that the APE1 Asp148Glu polymorphism G allele is associated with an increased GI cancer risk, especially in gastric cancer. | 0.000271442 | 2014 | APEX1;OSGEP | 14 | 20456995 | T | A,G |
| rs11549465 | 24293391 | 3091 | HIF1A | umls:C0685938 | BeFree | To understand the role of HIF-1α P582S and A588T genotypes in digestive cancer development, we conducted a comprehensive meta-analysis involving 1,517 cases and 3,740 controls. | 0.000814326 | 2013 | HIF1A;LOC105370526 | 14 | 61740839 | C | T |
| rs11549467 | 24293391 | 3091 | HIF1A | umls:C0685938 | BeFree | To understand the role of HIF-1α P582S and A588T genotypes in digestive cancer development, we conducted a comprehensive meta-analysis involving 1,517 cases and 3,740 controls. | 0.000814326 | 2013 | HIF1A;LOC105370526 | 14 | 61740857 | G | A |
| rs11692021 | 12122597 | 54577 | UGT1A7 | umls:C0685938 | BeFree | However, the UGT1A7*3 allele combining W208R, N129K and R131K missense mutations and exhibiting substantially reduced carcinogen detoxification activity was significantly associated with proximal gastrointestinal cancer and identified as a risk allele present in 32 % of cancer patients and 19 % of controls (P = 0.0008, OR 2,02 (95 %-CI 1.33-3.07)). | 0.000542884 | 2002 | UGT1A10;UGT1A8;UGT1A7;UGT1A9 | 2 | 233682559 | T | C |
| rs17868323 | 12122597 | 54577 | UGT1A7 | umls:C0685938 | BeFree | However, the UGT1A7*3 allele combining W208R, N129K and R131K missense mutations and exhibiting substantially reduced carcinogen detoxification activity was significantly associated with proximal gastrointestinal cancer and identified as a risk allele present in 32 % of cancer patients and 19 % of controls (P = 0.0008, OR 2,02 (95 %-CI 1.33-3.07)). | 0.000542884 | 2002 | UGT1A10;UGT1A8;UGT1A7;UGT1A9 | 2 | 233682324 | T | G |
| rs2275913 | 25422215 | 3605 | IL17A | umls:C0685938 | BeFree | Association between the interleukin-17A -197G>A (rs2275913) polymorphism and risk of digestive cancer. | 0.000271442 | 2015 | IL17A | 6 | 52186235 | G | A |
| rs2910164 | 22761848 | 406938 | MIR146A | umls:C0685938 | BeFree | Lack of association of miR-146a rs2910164 polymorphism with gastrointestinal cancers: evidence from 10206 subjects. | 0.000814326 | 2012 | LOC285628;MIR146A | 5 | 160485411 | C | G |
| rs2910164 | 23534761 | 406938 | MIR146A | umls:C0685938 | BeFree | The miR-146a rs2910164 G > C polymorphism and susceptibility to digestive cancer in Chinese. | 0.000814326 | 2013 | LOC285628;MIR146A | 5 | 160485411 | C | G |
| rs2910164 | 25693929 | 406938 | MIR146A | umls:C0685938 | BeFree | MicroRNA-146a rs2910164 G/C polymorphism and gastrointestinal cancer susceptibility: a meta-analysis based on East Asian population. | 0.000814326 | 2015 | LOC285628;MIR146A | 5 | 160485411 | C | G |
| rs386519031 | 24293391 | 3091 | HIF1A | umls:C0685938 | BeFree | To understand the role of HIF-1α P582S and A588T genotypes in digestive cancer development, we conducted a comprehensive meta-analysis involving 1,517 cases and 3,740 controls. | 0.000814326 | 2013 | NA | NA | NA | NA | NA |
| rs386545044 | 18281249 | 11200 | CHEK2 | umls:C0685938 | BeFree | In contrast, a previous report suggests that individuals with the I157T missense variant of the CHEK2 gene might be at decreased risk of lung cancer and upper aero-digestive cancers. | 0.000271442 | 2008 | NA | NA | NA | NA | NA |
| rs386656364 | 12122597 | 54577 | UGT1A7 | umls:C0685938 | BeFree | However, the UGT1A7*3 allele combining W208R, N129K and R131K missense mutations and exhibiting substantially reduced carcinogen detoxification activity was significantly associated with proximal gastrointestinal cancer and identified as a risk allele present in 32 % of cancer patients and 19 % of controls (P = 0.0008, OR 2,02 (95 %-CI 1.33-3.07)). | 0.000542884 | 2002 | NA | NA | NA | NA | NA |
| rs6214 | 24608110 | 2690 | GHR | umls:C0685938 | BeFree | Here, the prevalence of the single nucleotide polymorphisms (SNPs) rs6214 in the IGF type I (IGF-I) gene and rs6898743 in the growth hormone receptor (GHR) gene in patients with GI cancer and controls was studied. | 0.000542884 | 2014 | IGF1;LOC105369942 | 12 | 102399791 | C | T |
| rs6214 | 24608110 | 3479 | IGF1 | umls:C0685938 | BeFree | Here, the prevalence of the single nucleotide polymorphisms (SNPs) rs6214 in the IGF type I (IGF-I) gene and rs6898743 in the growth hormone receptor (GHR) gene in patients with GI cancer and controls was studied. | 0.000271442 | 2014 | IGF1;LOC105369942 | 12 | 102399791 | C | T |
| rs6898743 | 24608110 | 2690 | GHR | umls:C0685938 | BeFree | Here, the prevalence of the single nucleotide polymorphisms (SNPs) rs6214 in the IGF type I (IGF-I) gene and rs6898743 in the growth hormone receptor (GHR) gene in patients with GI cancer and controls was studied. | 0.000542884 | 2014 | GHR | 5 | 42602390 | C | G |
| rs6898743 | 24608110 | 3479 | IGF1 | umls:C0685938 | BeFree | Here, the prevalence of the single nucleotide polymorphisms (SNPs) rs6214 in the IGF type I (IGF-I) gene and rs6898743 in the growth hormone receptor (GHR) gene in patients with GI cancer and controls was studied. | 0.000271442 | 2014 | GHR | 5 | 42602390 | C | G |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
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| (Waiting for update.) |
Chemical(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA approved drug and dosage information(Total Drugs:0) | |
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| (Waiting for update.) | |
FDA labeling changes(Total Drugs:0) | |
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| (Waiting for update.) | |