PedAM

Pediatric Disease Annotations & Medicines


	gastric ulcer

Disease ID	821
Disease	gastric ulcer
Definition	Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Synonym	gastric ulcer (diagnosis) gastric ulcer (disorder) gastric ulcer - (gu) gastric ulcer disease gastric ulcer nos gastric ulcer nos (disorder) gastric ulcer, nos gastric ulceration gastric ulcerations gastric ulcers gu - gastric ulcer stomach ulcer stomach ulcer [disease/finding] stomach ulcer, nos stomach ulcers stomach--ulcers ulcer gastric ulcer stomach ulcer, gastric ulcer, stomach ulcers, gastric ulcers, stomach ulcus ventriculi unspecified gastric ulcer unspecified gastric ulcer (disorder) unspecified gastric ulcer nos unspecified gastric ulcer nos (disorder)
DOID	DOID:10808
UMLS	C0038358
MeSH	D013276
SNOMED-CT	SNOMEDCT_US_2016_09_01:397825006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:28) C0017152 \| gastritis \| 4 C0013295 \| duodenal ulcer \| 3 C0011847 \| diabetes \| 3 C0003864 \| arthritis \| 3 C0162576 \| anisakiasis \| 2 C0011849 \| diabetes mellitus \| 2 C0003873 \| rheumatoid arthritis \| 2 C0006840 \| candida infection \| 2 C0024623 \| gastric cancer \| 2 C0009402 \| colorectal carcinoma \| 1 C0022116 \| ischaemia \| 1 C0011570 \| depression \| 1 C0494165 \| hepatic metastases \| 1 C0017150 \| gastrinoma \| 1 C0001173 \| gastric outlet obstruction \| 1 C0027813 \| neuritis \| 1 C0019163 \| hepatitis b \| 1 C0017160 \| gastroenteritis \| 1 C0011860 \| niddm \| 1 C0032326 \| pneumothorax \| 1 C0032266 \| pneumatosis cystoides intestinalis \| 1 C0007113 \| rectal carcinoma \| 1 C0007570 \| coeliac disease \| 1 C0031154 \| peritonitis \| 1 C0311262 \| chronic mesenteric ischaemia \| 1 C0023801 \| lipomatosis \| 1 C0013395 \| dyspepsia \| 1 C0011633 \| dermatomyositis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:18) TNF \| 7124 \| CTD_human NOS3 \| 4846 \| CTD_human LEP \| 3952 \| CTD_human MMP9 \| 4318 \| CTD_human IL1B \| 3553 \| CTD_human NOS2 \| 4843 \| CTD_human PTGS2 \| 5743 \| CTD_human VEGFA \| 7422 \| CTD_human CAT \| 847 \| CTD_human ADM \| 133 \| CTD_human EPO \| 2056 \| CTD_human EGF \| 1950 \| CTD_human PTGS1 \| 5742 \| CTD_human IAPP \| 3375 \| CTD_human NRG1 \| 3084 \| CTD_human CCK \| 885 \| CTD_human GHRL \| 51738 \| CTD_human VGF \| 7425 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:12) 3176 \| HNMT \| infer 3683 \| ITGAL \| infer 3684 \| ITGAM \| infer 3687 \| ITGAX \| infer 4312 \| MMP1 \| infer 4314 \| MMP3 \| infer 4316 \| MMP7 \| infer 4318 \| MMP9 \| infer 5327 \| PLAT \| infer 5054 \| SERPINE1 \| infer 1559 \| CYP2C9 \| infer 1557 \| CYP2C19 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:74) 6343 \| SCT \| DISEASES 4710 \| NDUFB4 \| DISEASES 9812 \| KIAA0141 \| DISEASES 9552 \| SPAG7 \| DISEASES 479 \| ATP12A \| DISEASES 973 \| CD79A \| DISEASES 1048 \| CEACAM5 \| DISEASES 10392 \| NOD1 \| DISEASES 4353 \| MPO \| DISEASES 8050 \| PDHX \| DISEASES 654231 \| OCM \| DISEASES 3306 \| HSPA2 \| DISEASES 78986 \| DUSP26 \| DISEASES 59340 \| HRH4 \| DISEASES 4951 \| OCM2 \| DISEASES 3557 \| IL1RN \| DISEASES 4316 \| MMP7 \| DISEASES 4069 \| LYZ \| DISEASES 5858 \| PZP \| DISEASES 10162 \| LPCAT3 \| DISEASES 495 \| ATP4A \| DISEASES 3553 \| IL1B \| DISEASES 84162 \| KIAA1109 \| DISEASES 7345 \| UCHL1 \| DISEASES 6750 \| SST \| DISEASES 7032 \| TFF2 \| DISEASES 7031 \| TFF1 \| DISEASES 152185 \| SPICE1 \| DISEASES 4837 \| NNMT \| DISEASES 84342 \| COG8 \| DISEASES 5653 \| KLK6 \| DISEASES 5222 \| PGA5 \| DISEASES 6868 \| ADAM17 \| DISEASES 7172 \| TPMT \| DISEASES 9448 \| MAP4K4 \| DISEASES 8834 \| TMEM11 \| DISEASES 1879 \| EBF1 \| DISEASES 65985 \| AACS \| DISEASES 7485 \| WRB \| DISEASES 2520 \| GAST \| DISEASES 63826 \| SRR \| DISEASES 259307 \| IL4I1 \| DISEASES 5348 \| FXYD1 \| DISEASES 875 \| CBS \| DISEASES 5265 \| SERPINA1 \| DISEASES 3084 \| NRG1 \| DISEASES 1510 \| CTSE \| DISEASES 5743 \| PTGS2 \| DISEASES 6279 \| S100A8 \| DISEASES 8991 \| SELENBP1 \| DISEASES 2316 \| FLNA \| DISEASES 27022 \| FOXD3 \| DISEASES 1557 \| CYP2C19 \| DISEASES 10103 \| TSPAN1 \| DISEASES 4318 \| MMP9 \| DISEASES 5225 \| PGC \| DISEASES 8200 \| GDF5 \| DISEASES 3274 \| HRH2 \| DISEASES 79135 \| APOO \| DISEASES 8544 \| PIR \| DISEASES 974 \| CD79B \| DISEASES 4780 \| NFE2L2 \| DISEASES 4357 \| MPST \| DISEASES 2950 \| GSTP1 \| DISEASES 23308 \| ICOSLG \| DISEASES 7124 \| TNF \| DISEASES 4588 \| MUC6 \| DISEASES 131 \| ADH7 \| DISEASES 64641 \| EBF2 \| DISEASES 4586 \| MUC5AC \| DISEASES 26298 \| EHF \| DISEASES 83695 \| RHNO1 \| DISEASES 51741 \| WWOX \| DISEASES 6080 \| SNORA73A \| DISEASES
Locus	(Waiting for update.)

Disease ID	821
Disease	gastric ulcer
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:24) HP:0012531 \| Pain \| 7 HP:0005202 \| Helicobacter pylori infection \| 4 HP:0005263 \| Gastritis \| 4 HP:0002027 \| Abdominal pain \| 3 HP:0002588 \| Duodenal ulcer \| 3 HP:0001369 \| Arthritis \| 3 HP:0002239 \| Gastrointestinal hemorrhage \| 2 HP:0000969 \| Dropsy \| 2 HP:0002584 \| Intestinal hemorrhage \| 2 HP:0001370 \| Rheumatoid arthritis \| 2 HP:0012126 \| Gastric cancer \| 2 HP:0002013 \| Emesis \| 1 HP:0000716 \| Depression \| 1 HP:0002015 \| Swallowing difficulty \| 1 HP:0100806 \| Sepsis \| 1 HP:0002716 \| Lymph node hyperplasia \| 1 HP:0005978 \| Noninsulin dependent diabetes mellitus \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0002586 \| Peritonitis \| 1 HP:0000421 \| Bloody nose \| 1 HP:0100790 \| Hernia \| 1 HP:0100758 \| Gangrene \| 1 HP:0002107 \| Collapsed lung \| 1 HP:0002664 \| Neoplasia \| 1

Disease ID	821
Disease	gastric ulcer
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:8) C0030193 \| pain \| 7 C0017152 \| gastritis \| 4 C0850666 \| helicobacter pylori infection \| 4 C0024623 \| gastric cancer \| 2 C0850666 \| h. pylori infection \| 2 C0232493 \| epigastric pain \| 1 C0019270 \| hernia \| 1 C0019080 \| hemorrhage \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10306114	17671743	5742	PTGS1	umls:C0038358	BeFree	In conclusion, a carrier of the -1676T allele in the COX-1 gene promoter, as well as HP infection and male gender, seem to be significant risk factors for developing gastric ulcers, and the number of -1676T alleles was also a significant risk factor for the NSAID-induced ulcer, whereas the frequency of the A-842G polymorphism was thought to be very rare in the Japanese population.	0.1289015	2007	PTGS1	9	122370243	A	G
rs2294008	25582162	8000	PSCA	umls:C0038358	BeFree	The PSCA rs2294008 C>T polymorphism may be acting through induction of gastric mucosal atrophy, finally leading to development of gastric ulcer and gastric cancer in PSCA rs2294008 T allele carriers, but not duodenal ulcer.	0.000542884	2015	PSCA	8	142680513	C	T
rs5743618	23067142	7096	TLR1	umls:C0038358	BeFree	The TLR1 I602S SNP is significantly associated with GC (p = .002) and gastric ulcer (p = .051).	0.000271442	2013	TLR1	4	38797027	C	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Chemical(Total Drugs:32)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0038358	acetylcysteine	D000111	616-91-1	stomach ulcer	MESH:D013276	therapeutic	17603938
C0038358	ampicillin	D000667	69-53-4	stomach ulcer	MESH:D013276	therapeutic	20586851
C0038358	atropine	D001285	51-55-8	stomach ulcer	MESH:D013276	therapeutic	11595415
C0038358	capsaicin	D002211	404-86-4	stomach ulcer	MESH:D013276	marker/mechanism	14504662
C0038358	capsaicin	D002211	404-86-4	stomach ulcer	MESH:D013276	therapeutic	10674923
C0038358	cimetidine	D002927	51481-61-9	stomach ulcer	MESH:D013276	therapeutic	11573854
C0038358	cisapride	D020117	81098-60-4	stomach ulcer	MESH:D013276	therapeutic	11578711
C0038358	clonidine	D003000	4205-90-7	stomach ulcer	MESH:D013276	marker/mechanism	9324159
C0038358	diclofenac	D004008	15307-86-5	stomach ulcer	MESH:D013276	marker/mechanism	17275683
C0038358	glutathione	D005978	70-18-8	stomach ulcer	MESH:D013276	marker/mechanism	23933360
C0038358	glycopyrrolate	D006024	596-51-0	stomach ulcer	MESH:D013276	marker/mechanism	3698061
C0038358	haloperidol	D006220	52-86-8	stomach ulcer	MESH:D013276	marker/mechanism	10499368
C0038358	indomethacin	D007213	53-86-1	stomach ulcer	MESH:D013276	marker/mechanism	10423059
C0038358	ketorolac	D020910	66635-83-4	stomach ulcer	MESH:D013276	marker/mechanism	19459639
C0038358	lansoprazole	D064747	-	stomach ulcer	MESH:D013276	therapeutic	11085491
C0038358	meloxicam	C065757	71125-38-7	stomach ulcer	MESH:D013276	marker/mechanism	10594344
C0038358	mirtazapine	C035133	-	stomach ulcer	MESH:D013276	therapeutic	19034656
C0038358	montelukast	C093875	158966-92-8	stomach ulcer	MESH:D013276	therapeutic	17895592
C0038358	nicotine	D009538	-	stomach ulcer	MESH:D013276	marker/mechanism	19088804
C0038358	nitric oxide	D009569	10102-43-9	stomach ulcer	MESH:D013276	marker/mechanism	15138204
C0038358	omeprazole	D009853	73590-58-6	stomach ulcer	MESH:D013276	therapeutic	10750652
C0038358	pantoprazole	C064276	102625-70-7	stomach ulcer	MESH:D013276	therapeutic	12119060
C0038358	phenylephrine	D010656	59-42-7	stomach ulcer	MESH:D013276	marker/mechanism	9324159
C0038358	piroxicam	D010894	36322-90-4	stomach ulcer	MESH:D013276	marker/mechanism	15309881
C0038358	propranolol	D011433	525-66-6	stomach ulcer	MESH:D013276	therapeutic	19783516
C0038358	epoprostenol	D011464	35121-78-9	stomach ulcer	MESH:D013276	therapeutic	10674923
C0038358	reserpine	D012110	50-55-5	stomach ulcer	MESH:D013276	marker/mechanism	14612188
C0038358	rofecoxib	C116926	-	stomach ulcer	MESH:D013276	marker/mechanism	10594344
C0038358	sucralfate	D013392	54182-58-0	stomach ulcer	MESH:D013276	therapeutic	10423059
C0038358	sulpiride	D013469	15676-16-1	stomach ulcer	MESH:D013276	therapeutic	21315700
C0038358	thalidomide	D013792	50-35-1	stomach ulcer	MESH:D013276	therapeutic	15138204
C0038358	vitamin e	D014810	1406-18-4	stomach ulcer	MESH:D013276	therapeutic	10749339

FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
(Waiting for update.)