PedAM

Pediatric Disease Annotations & Medicines


	gastric adenocarcinoma

Disease ID	1491
Disease	gastric adenocarcinoma
Definition	An adenocarcinoma arising from the stomach glandular epithelium. Gastric adenocarcinoma is primarily a disease of older individuals. It most commonly develops after a long period of atrophic gastritis and is strongly associated with Helicobacter pylori infection. The lack of early symptoms often delays the diagnosis of gastric cancer. The majority of patients present with advanced tumors which have poor rates of curability. Microscopically, two important histologic types of gastric adenocarcinoma are recognized: the intestinal and diffuse type. The overall prognosis of gastric adenocarcinomas is poor, even in patients who receive a "curative" resection (adapted from Sternberg's Surgical Pathology, 3rd ed., 1999).
Synonym	adenocarcinoma - stomach adenocarcinoma gastric adenocarcinoma of stomach adenocarcinoma of stomach (disorder) adenocarcinoma of the stomach adenocarcinoma stomach adenocarcinomas gastric cancer of stomach, adenocarcinoma gastric cancer, adenocarcinoma stomach adenocarcinoma stomach cancer, adenocarcinoma stomach, adenocarcinoma of the
DOID	DOID:3717
UMLS	C0278701
SNOMED-CT	SNOMEDCT_US_2016_09_01:408647009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:52) C0017152 \| gastritis \| 5 C0024299 \| lymphoma \| 4 C0494165 \| hepatic metastasis \| 3 C0948303 \| peritoneal carcinoma \| 3 C0494165 \| liver metastases \| 3 C0238198 \| gastrointestinal stromal tumor \| 3 C0879615 \| stromal tumor \| 2 C0494165 \| hepatic metastases \| 2 C0024299 \| lymphomas \| 2 C0238198 \| gastrointestinal stromal tumors \| 2 C0028754 \| obesity \| 2 C0000889 \| acanthosis nigricans \| 2 C0079744 \| diffuse large b-cell lymphoma \| 2 C0024623 \| gastric cancer \| 1 C0024225 \| lymphangitis \| 1 C0220654 \| carcinomatous meningitis \| 1 C0017168 \| gastroesophageal reflux \| 1 C0206696 \| signet ring cell carcinoma \| 1 C0019829 \| hodgkin's lymphoma \| 1 C0012739 \| disseminated intravascular coagulation \| 1 C0017154 \| chronic atrophic gastritis \| 1 C0022595 \| darier's disease \| 1 C0678222 \| breast carcinoma \| 1 C0001173 \| gastric outlet obstruction \| 1 C0017168 \| oesophageal reflux \| 1 C0017154 \| atrophic gastritis \| 1 C0021843 \| bowel obstruction \| 1 C0017168 \| esophageal reflux \| 1 C0281361 \| pancreatic adenocarcinoma \| 1 C0242647 \| malt lymphoma \| 1 C0023743 \| linitis plastica \| 1 C0002878 \| hemolytic anemia \| 1 C0205696 \| anaplastic carcinoma \| 1 C0030920 \| peptic ulcer \| 1 C0011847 \| diabetes \| 1 C0001125 \| lactic acidosis \| 1 C0025289 \| meningitis \| 1 C0206695 \| neuroendocrine carcinoma \| 1 C0686619 \| lymph node metastases \| 1 C0079731 \| b-cell lymphoma \| 1 C0002170 \| alopecia \| 1 C0037274 \| dermatosis \| 1 C0040053 \| thrombosis \| 1 C0030920 \| peptic ulcers \| 1 C0242647 \| mucosa-associated lymphoid tissue \| 1 C1704231 \| leptomeningeal metastasis \| 1 C0008497 \| choriocarcinoma \| 1 C0153676 \| pulmonary metastases \| 1 C0002892 \| pernicious anemia \| 1 C0494165 \| liver metastasis \| 1 C0014145 \| yolk sac tumor \| 1 C1335302 \| pancreatic ductal adenocarcinoma \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) 80781 \| COL18A1 \| infer 3119 \| HLA-DQB1 \| infer 3123 \| HLA-DRB1 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:426) 1087 \| CEACAM7 \| DISEASES 4830 \| NME1 \| DISEASES 2067 \| ERCC1 \| DISEASES 6591 \| SNAI2 \| DISEASES 1015 \| CDH17 \| DISEASES 634 \| CEACAM1 \| DISEASES 54474 \| KRT20 \| DISEASES 51208 \| CLDN18 \| DISEASES 4680 \| CEACAM6 \| DISEASES 28954 \| REM1 \| DISEASES 7384 \| UQCRC1 \| DISEASES 2099 \| ESR1 \| DISEASES 1943 \| EFNA2 \| DISEASES 4320 \| MMP11 \| DISEASES 1113 \| CHGA \| DISEASES 5721 \| PSME2 \| DISEASES 57167 \| SALL4 \| DISEASES 140733 \| MACROD2 \| DISEASES 113278 \| SLC52A3 \| DISEASES 7076 \| TIMP1 \| DISEASES 479 \| ATP12A \| DISEASES 4313 \| MMP2 \| DISEASES 973 \| CD79A \| DISEASES 1048 \| CEACAM5 \| DISEASES 2057 \| EPOR \| DISEASES 6142 \| RPL18A \| DISEASES 11045 \| UPK1A \| DISEASES 10392 \| NOD1 \| DISEASES 11333 \| PDAP1 \| DISEASES 7126 \| TNFAIP1 \| DISEASES 3558 \| IL2 \| DISEASES 3732 \| CD82 \| DISEASES 595 \| CCND1 \| DISEASES 84519 \| ACRBP \| DISEASES 80736 \| SLC44A4 \| DISEASES 1839 \| HBEGF \| DISEASES 1044 \| CDX1 \| DISEASES 4292 \| MLH1 \| DISEASES 4436 \| MSH2 \| DISEASES 4953 \| ODC1 \| DISEASES 2023 \| ENO1 \| DISEASES 1509 \| CTSD \| DISEASES 51146 \| A4GNT \| DISEASES 79365 \| BHLHE41 \| DISEASES 79586 \| CHPF \| DISEASES 5335 \| PLCG1 \| DISEASES 6615 \| SNAI1 \| DISEASES 1026 \| CDKN1A \| DISEASES 9271 \| PIWIL1 \| DISEASES 6495 \| SIX1 \| DISEASES 2952 \| GSTT1 \| DISEASES 968 \| CD68 \| DISEASES 79132 \| DHX58 \| DISEASES 1890 \| TYMP \| DISEASES 341 \| APOC1 \| DISEASES 84660 \| CCDC62 \| DISEASES 84152 \| PPP1R1B \| DISEASES 3845 \| KRAS \| DISEASES 27299 \| ADAMDEC1 \| DISEASES 891 \| CCNB1 \| DISEASES 83998 \| REG4 \| DISEASES 2694 \| GIF \| DISEASES 301 \| ANXA1 \| DISEASES 2016 \| EMX1 \| DISEASES 3569 \| IL6 \| DISEASES 27141 \| CIDEB \| DISEASES 11227 \| GALNT5 \| DISEASES 3557 \| IL1RN \| DISEASES 5460 \| POU5F1 \| DISEASES 4316 \| MMP7 \| DISEASES 51196 \| PLCE1 \| DISEASES 2984 \| GUCY2C \| DISEASES 5037 \| PEBP1 \| DISEASES 5687 \| PSMA6 \| DISEASES 51283 \| BFAR \| DISEASES 57551 \| TAOK1 \| DISEASES 999 \| CDH1 \| DISEASES 904 \| CCNT1 \| DISEASES 2324 \| FLT4 \| DISEASES 51201 \| ZDHHC2 \| DISEASES 7528 \| YY1 \| DISEASES 495 \| ATP4A \| DISEASES 7077 \| TIMP2 \| DISEASES 7515 \| XRCC1 \| DISEASES 2549 \| GAB1 \| DISEASES 5595 \| MAPK3 \| DISEASES 6855 \| SYP \| DISEASES 3553 \| IL1B \| DISEASES 5775 \| PTPN4 \| DISEASES 8850 \| KAT2B \| DISEASES 3791 \| KDR \| DISEASES 5290 \| PIK3CA \| DISEASES 9693 \| RAPGEF2 \| DISEASES 3589 \| IL11 \| DISEASES 6774 \| STAT3 \| DISEASES 22915 \| MMRN1 \| DISEASES 3383 \| ICAM1 \| DISEASES 1950 \| EGF \| DISEASES 64374 \| SIL1 \| DISEASES 7365 \| UGT2B10 \| DISEASES 6717 \| SRI \| DISEASES 29999 \| FSCN3 \| DISEASES 8379 \| MAD1L1 \| DISEASES 7078 \| TIMP3 \| DISEASES 347902 \| AMIGO2 \| DISEASES 8549 \| LGR5 \| DISEASES 55040 \| EPN3 \| DISEASES 1000 \| CDH2 \| DISEASES 2627 \| GATA6 \| DISEASES 7157 \| TP53 \| DISEASES 2064 \| ERBB2 \| DISEASES 207 \| AKT1 \| DISEASES 114783 \| LMTK3 \| DISEASES 49860 \| CRNN \| DISEASES 6242 \| RTKN \| DISEASES 151230 \| KLHL23 \| DISEASES 1956 \| EGFR \| DISEASES 9046 \| DOK2 \| DISEASES 8795 \| TNFRSF10B \| DISEASES 85479 \| DNAJC5B \| DISEASES 340419 \| RSPO2 \| DISEASES 220064 \| ORAOV1 \| DISEASES 7424 \| VEGFC \| DISEASES 55294 \| FBXW7 \| DISEASES 84539 \| MCHR2 \| DISEASES 2043 \| EPHA4 \| DISEASES 2321 \| FLT1 \| DISEASES 10413 \| YAP1 \| DISEASES 8404 \| SPARCL1 \| DISEASES 81552 \| VOPP1 \| DISEASES 6750 \| SST \| DISEASES 123803 \| NTAN1 \| DISEASES 3815 \| KIT \| DISEASES 144406 \| WDR66 \| DISEASES 8365 \| HIST1H4H \| DISEASES 5304 \| PIP \| DISEASES 7032 \| TFF2 \| DISEASES 7031 \| TFF1 \| DISEASES 79671 \| NLRX1 \| DISEASES 3856 \| KRT8 \| DISEASES 58191 \| CXCL16 \| DISEASES 6159 \| RPL29 \| DISEASES 10630 \| PDPN \| DISEASES 23528 \| ZNF281 \| DISEASES 51127 \| TRIM17 \| DISEASES 129401 \| NUP35 \| DISEASES 27306 \| HPGDS \| DISEASES 3577 \| CXCR1 \| DISEASES 5584 \| PRKCI \| DISEASES 213 \| ALB \| DISEASES 4486 \| MST1R \| DISEASES 308 \| ANXA5 \| DISEASES 3248 \| HPGD \| DISEASES 2150 \| F2RL1 \| DISEASES 116379 \| IL22RA2 \| DISEASES 55568 \| GALNT10 \| DISEASES 216 \| ALDH1A1 \| DISEASES 65268 \| WNK2 \| DISEASES 360 \| AQP3 \| DISEASES 143689 \| PIWIL4 \| DISEASES 4837 \| NNMT \| DISEASES 5245 \| PHB \| DISEASES 1548 \| CYP2A6 \| DISEASES 558 \| AXL \| DISEASES 8000 \| PSCA \| DISEASES 83547 \| RILP \| DISEASES 23524 \| SRRM2 \| DISEASES 4255 \| MGMT \| DISEASES 9839 \| ZEB2 \| DISEASES 5734 \| PTGER4 \| DISEASES 255738 \| PCSK9 \| DISEASES 10960 \| LMAN2 \| DISEASES 7324 \| UBE2E1 \| DISEASES 51237 \| MZB1 \| DISEASES 1495 \| CTNNA1 \| DISEASES 2353 \| FOS \| DISEASES 23627 \| PRND \| DISEASES 26579 \| MYEOV \| DISEASES 3872 \| KRT17 \| DISEASES 3626 \| INHBC \| DISEASES 8609 \| KLF7 \| DISEASES 3265 \| HRAS \| DISEASES 947 \| CD34 \| DISEASES 9610 \| RIN1 \| DISEASES 836 \| CASP3 \| DISEASES 6578 \| SLCO2A1 \| DISEASES 2944 \| GSTM1 \| DISEASES 91464 \| ISX \| DISEASES 6396 \| SEC13 \| DISEASES 3172 \| HNF4A \| DISEASES 56475 \| RPRM \| DISEASES 7298 \| TYMS \| DISEASES 4728 \| NDUFS8 \| DISEASES 8560 \| DEGS1 \| DISEASES 4233 \| MET \| DISEASES 55626 \| AMBRA1 \| DISEASES 3579 \| CXCR2 \| DISEASES 8289 \| ARID1A \| DISEASES 84289 \| ING5 \| DISEASES 3039 \| HBA1 \| DISEASES 4312 \| MMP1 \| DISEASES 7586 \| ZKSCAN1 \| DISEASES 6657 \| SOX2 \| DISEASES 57491 \| AHRR \| DISEASES 56992 \| KIF15 \| DISEASES 3309 \| HSPA5 \| DISEASES 162963 \| ZNF610 \| DISEASES 6432 \| SRSF7 \| DISEASES 168620 \| BHLHA15 \| DISEASES 2863 \| GPR39 \| DISEASES 84864 \| MINA \| DISEASES 1606 \| DGKA \| DISEASES 346389 \| MACC1 \| DISEASES 3855 \| KRT7 \| DISEASES 200504 \| GKN2 \| DISEASES 56849 \| TCEAL7 \| DISEASES 6753 \| SSTR3 \| DISEASES 842 \| CASP9 \| DISEASES 9798 \| IST1 \| DISEASES 10539 \| GLRX3 \| DISEASES 2520 \| GAST \| DISEASES 682 \| BSG \| DISEASES 196528 \| ARID2 \| DISEASES 887 \| CCKBR \| DISEASES 9075 \| CLDN2 \| DISEASES 375318 \| AQP12A \| DISEASES 9765 \| ZFYVE16 \| DISEASES 2036 \| EPB41L1 \| DISEASES 677 \| ZFP36L1 \| DISEASES 9166 \| EBAG9 \| DISEASES 3091 \| HIF1A \| DISEASES 23583 \| SMUG1 \| DISEASES 29102 \| DROSHA \| DISEASES 7100 \| TLR5 \| DISEASES 166824 \| RASSF6 \| DISEASES 5781 \| PTPN11 \| DISEASES 10164 \| CHST4 \| DISEASES 4089 \| SMAD4 \| DISEASES 2359 \| FPR3 \| DISEASES 1508 \| CTSB \| DISEASES 2272 \| FHIT \| DISEASES 1364 \| CLDN4 \| DISEASES 388228 \| SBK1 \| DISEASES 8360 \| HIST1H4D \| DISEASES 7517 \| XRCC3 \| DISEASES 864 \| RUNX3 \| DISEASES 1499 \| CTNNB1 \| DISEASES 5757 \| PTMA \| DISEASES 4734 \| NEDD4 \| DISEASES 538 \| ATP7A \| DISEASES 56937 \| PMEPA1 \| DISEASES 6227 \| RPS21 \| DISEASES 6275 \| S100A4 \| DISEASES 8294 \| HIST1H4I \| DISEASES 5325 \| PLAGL1 \| DISEASES 8363 \| HIST1H4J \| DISEASES 55107 \| ANO1 \| DISEASES 5265 \| SERPINA1 \| DISEASES 8368 \| HIST1H4L \| DISEASES 84458 \| LCOR \| DISEASES 30968 \| STOML2 \| DISEASES 6477 \| SIAH1 \| DISEASES 11186 \| RASSF1 \| DISEASES 60 \| ACTB \| DISEASES 8362 \| HIST1H4K \| DISEASES 25913 \| POT1 \| DISEASES 121504 \| HIST4H4 \| DISEASES 1612 \| DAPK1 \| DISEASES 1510 \| CTSE \| DISEASES 6714 \| SRC \| DISEASES 841 \| CASP8 \| DISEASES 7048 \| TGFBR2 \| DISEASES 10761 \| PLAC1 \| DISEASES 10814 \| CPLX2 \| DISEASES 8359 \| HIST1H4A \| DISEASES 1366 \| CLDN7 \| DISEASES 8367 \| HIST1H4E \| DISEASES 4311 \| MME \| DISEASES 4326 \| MMP17 \| DISEASES 2475 \| MTOR \| DISEASES 2736 \| GLI2 \| DISEASES 5742 \| PTGS1 \| DISEASES 6136 \| RPL12 \| DISEASES 919 \| CD247 \| DISEASES 9181 \| ARHGEF2 \| DISEASES 10724 \| MGEA5 \| DISEASES 4513 \| MT-CO2 \| DISEASES 3880 \| KRT19 \| DISEASES 57829 \| ZP4 \| DISEASES 2590 \| GALNT2 \| DISEASES 142 \| PARP1 \| DISEASES 25936 \| NSL1 \| DISEASES 64710 \| NUCKS1 \| DISEASES 81788 \| NUAK2 \| DISEASES 5743 \| PTGS2 \| DISEASES 10370 \| CITED2 \| DISEASES 356 \| FASLG \| DISEASES 481 \| ATP1B1 \| DISEASES 6375 \| XCL1 \| DISEASES 4582 \| MUC1 \| DISEASES 1942 \| EFNA1 \| DISEASES 6098 \| ROS1 \| DISEASES 6273 \| S100A2 \| DISEASES 6279 \| S100A8 \| DISEASES 8661 \| EIF3A \| DISEASES 554313 \| HIST2H4B \| DISEASES 8370 \| HIST2H4A \| DISEASES 840 \| CASP7 \| DISEASES 22986 \| SORCS3 \| DISEASES 57463 \| AMIGO1 \| DISEASES 8771 \| TNFRSF6B \| DISEASES 51750 \| RTEL1 \| DISEASES 3149 \| HMGB3 \| DISEASES 4919 \| ROR1 \| DISEASES 1791 \| DNTT \| DISEASES 3725 \| JUN \| DISEASES 5728 \| PTEN \| DISEASES 7422 \| VEGFA \| DISEASES 128209 \| KLF17 \| DISEASES 4318 \| MMP9 \| DISEASES 7075 \| TIE1 \| DISEASES 5225 \| PGC \| DISEASES 55869 \| HDAC8 \| DISEASES 51552 \| RAB14 \| DISEASES 7099 \| TLR4 \| DISEASES 5774 \| PTPN3 \| DISEASES 8518 \| IKBKAP \| DISEASES 9314 \| KLF4 \| DISEASES 3118 \| HLA-DQA2 \| DISEASES 7046 \| TGFBR1 \| DISEASES 5089 \| PBX2 \| DISEASES 3397 \| ID1 \| DISEASES 50943 \| FOXP3 \| DISEASES 23590 \| PDSS1 \| DISEASES 5514 \| PPP1R10 \| DISEASES 4524 \| MTHFR \| DISEASES 11074 \| TRIM31 \| DISEASES 10082 \| GPC6 \| DISEASES 3274 \| HRH2 \| DISEASES 8366 \| HIST1H4B \| DISEASES 55735 \| DNAJC11 \| DISEASES 688 \| KLF5 \| DISEASES 219 \| ALDH1B1 \| DISEASES 8361 \| HIST1H4F \| DISEASES 8364 \| HIST1H4C \| DISEASES 56287 \| GKN1 \| DISEASES 4609 \| MYC \| DISEASES 2857 \| GPR34 \| DISEASES 51182 \| HSPA14 \| DISEASES 3400 \| ID4 \| DISEASES 168400 \| DDX53 \| DISEASES 9770 \| RASSF2 \| DISEASES 81567 \| TXNDC5 \| DISEASES 4507 \| MTAP \| DISEASES 1045 \| CDX2 \| DISEASES 6443 \| SGCB \| DISEASES 29126 \| CD274 \| DISEASES 7158 \| TP53BP1 \| DISEASES 137868 \| SGCZ \| DISEASES 254251 \| LCORL \| DISEASES 6624 \| FSCN1 \| DISEASES 26524 \| LATS2 \| DISEASES 5268 \| SERPINB5 \| DISEASES 10232 \| MSLN \| DISEASES 3875 \| KRT18 \| DISEASES 10477 \| UBE2E3 \| DISEASES 12 \| SERPINA3 \| DISEASES 4831 \| NME2 \| DISEASES 27032 \| ATP2C1 \| DISEASES 2719 \| GPC3 \| DISEASES 79633 \| FAT4 \| DISEASES 8513 \| LIPF \| DISEASES 57019 \| CIAPIN1 \| DISEASES 1365 \| CLDN3 \| DISEASES 174 \| AFP \| DISEASES 6387 \| CXCL12 \| DISEASES 7325 \| UBE2E2 \| DISEASES 51147 \| ING4 \| DISEASES 7913 \| DEK \| DISEASES 5609 \| MAP2K7 \| DISEASES 5634 \| PRPS2 \| DISEASES 1500 \| CTNND1 \| DISEASES 23353 \| SUN1 \| DISEASES 2011 \| MARK2 \| DISEASES 6336 \| SCN10A \| DISEASES 3481 \| IGF2 \| DISEASES 9058 \| SLC13A2 \| DISEASES 51292 \| GMPR2 \| DISEASES 25801 \| GCA \| DISEASES 1029 \| CDKN2A \| DISEASES 26354 \| GNL3 \| DISEASES 56616 \| DIABLO \| DISEASES 960 \| CD44 \| DISEASES 7124 \| TNF \| DISEASES 3491 \| CYR61 \| DISEASES 387 \| RHOA \| DISEASES 340547 \| VSIG1 \| DISEASES 55611 \| OTUB1 \| DISEASES 6173 \| RPL36A \| DISEASES 284111 \| SLC13A5 \| DISEASES 4588 \| MUC6 \| DISEASES 100131827 \| ZNF717 \| DISEASES 2263 \| FGFR2 \| DISEASES 154664 \| ABCA13 \| DISEASES 7153 \| TOP2A \| DISEASES 3586 \| IL10 \| DISEASES 4583 \| MUC2 \| DISEASES 8842 \| PROM1 \| DISEASES 26261 \| FBXO24 \| DISEASES 4585 \| MUC4 \| DISEASES 25816 \| TNFAIP8 \| DISEASES 285782 \| CAGE1 \| DISEASES 170960 \| ZNF721 \| DISEASES 7033 \| TFF3 \| DISEASES 4586 \| MUC5AC \| DISEASES 59082 \| CARD18 \| DISEASES 152687 \| ZNF595 \| DISEASES 10071 \| MUC12 \| DISEASES 84133 \| ZNRF3 \| DISEASES 8437 \| RASAL1 \| DISEASES 90416 \| C15orf57 \| DISEASES 51741 \| WWOX \| DISEASES 154860 \| FEZF1-AS1 \| DISEASES 100124700 \| HOTAIR \| DISEASES 100506465 \| LINC01234 \| DISEASES 104472713 \| PCAT29 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1491
Disease	gastric adenocarcinoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:31) HP:0002664 \| Neoplasia \| 17 HP:0100723 \| Gastrointestinal stroma tumor \| 6 HP:0005263 \| Gastritis \| 5 HP:0002665 \| Lymphoma \| 4 HP:0030731 \| Carcinoma \| 3 HP:0000956 \| Keratosis nigricans \| 2 HP:0005202 \| Helicobacter pylori infection \| 2 HP:0001513 \| Obesity \| 2 HP:0005231 \| Chronic gastritis \| 2 HP:0012743 \| Central obesity \| 2 HP:0001541 \| Ascites \| 1 HP:0001596 \| Hair loss \| 1 HP:0002113 \| Pulmonary infiltrates \| 1 HP:0001878 \| Haemolytic anaemia \| 1 HP:0001937 \| Microangiopathic hemolytic anemia \| 1 HP:0001287 \| Meningitis \| 1 HP:0012126 \| Gastric cancer \| 1 HP:0004398 \| Peptic ulcer \| 1 HP:0005214 \| Bowel obstruction \| 1 HP:0003128 \| Lactic acidosis \| 1 HP:0002582 \| Chronic atrophic gastritis \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0010310 \| Chylothorax \| 1 HP:0001907 \| Thromboembolic disease \| 1 HP:0006725 \| Pancreatic adenocarcinoma \| 1 HP:0100768 \| Choriocarcinoma \| 1 HP:0001941 \| acidemia \| 1 HP:0012191 \| B-cell lymphoma \| 1 HP:0002020 \| Heartburn \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0005521 \| Disseminated intravascular coagulation \| 1

Disease ID	1491
Disease	gastric adenocarcinoma
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:11) C0494165 \| liver metastases \| 3 C0205875 \| papillomatosis \| 2 C0000889 \| acanthosis nigricans \| 2 C0850666 \| helicobacter pylori infection \| 2 C0494165 \| hepatic metastases \| 2 C0850666 \| h. pylori infection \| 2 C0024623 \| gastric cancer \| 1 C0012739 \| disseminated intravascular coagulation \| 1 C0021311 \| infections \| 1 C2242635 \| tumor thrombosis \| 1 C0153676 \| pulmonary metastases \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:27)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs10216533	26006239	404663	LINC01194	umls:C0278701	BeFree	Two SNPs of rs2294008 (C>T) and rs2976392 (G>A) were identified to be associated with GAC risk. rs2294008, rs2976392 and rs10216533 made up two statistically significant haplotypes (Hap-CGG and Hap-TAG).	0.000542884	2015	PSCA	8	142682272	G	A
rs16944	22891178	3576	CXCL8	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.004538567	2012	IL1B	2	112837290	A	G
rs16944	22891178	3553	IL1B	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.001085767	2012	IL1B	2	112837290	A	G
rs16944	22891178	3586	IL10	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.000542884	2012	IL1B	2	112837290	A	G
rs16944	22891178	7124	TNF	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.001900093	2012	IL1B	2	112837290	A	G
rs1800629	22891178	3576	CXCL8	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.004538567	2012	TNF	6	31575254	G	A
rs1800629	22891178	3553	IL1B	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.001085767	2012	TNF	6	31575254	G	A
rs1800629	22891178	3586	IL10	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.000542884	2012	TNF	6	31575254	G	A
rs1800629	22891178	7124	TNF	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.001900093	2012	TNF	6	31575254	G	A
rs1800896	22891178	3576	CXCL8	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.004538567	2012	IL10	1	206773552	T	C
rs1800896	22891178	3586	IL10	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.000542884	2012	IL10	1	206773552	T	C
rs1800896	22891178	3553	IL1B	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.001085767	2012	IL10	1	206773552	T	C
rs1800896	22891178	7124	TNF	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.001900093	2012	IL10	1	206773552	T	C
rs1801282	18372284	5468	PPARG	umls:C0278701	BeFree	The study suggests that Pro12Ala PPARgamma polymorphism is associated with gastric adenocarcinoma and PUD, and is a potential marker for genetic susceptibility to these two diseases in the presence of H. pylori infection.	0.000271442	2008	PPARG	3	12351626	C	G
rs1805192	18372284	5468	PPARG	umls:C0278701	BeFree	The study suggests that Pro12Ala PPARgamma polymorphism is associated with gastric adenocarcinoma and PUD, and is a potential marker for genetic susceptibility to these two diseases in the presence of H. pylori infection.	0.000271442	2008	PPARG	3	12379739	C	G
rs2057768	22891178	3553	IL1B	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.001085767	2012	NA	16	27310774	C	T
rs2057768	22891178	7124	TNF	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.001900093	2012	NA	16	27310774	C	T
rs2057768	22891178	3576	CXCL8	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.004538567	2012	NA	16	27310774	C	T
rs2057768	22891178	3586	IL10	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.000542884	2012	NA	16	27310774	C	T
rs2294008	26006239	404663	LINC01194	umls:C0278701	BeFree	Two SNPs of rs2294008 (C>T) and rs2976392 (G>A) were identified to be associated with GAC risk. rs2294008, rs2976392 and rs10216533 made up two statistically significant haplotypes (Hap-CGG and Hap-TAG).	0.000542884	2015	PSCA	8	142680513	C	T
rs2976392	26006239	404663	LINC01194	umls:C0278701	BeFree	Two SNPs of rs2294008 (C>T) and rs2976392 (G>A) were identified to be associated with GAC risk. rs2294008, rs2976392 and rs10216533 made up two statistically significant haplotypes (Hap-CGG and Hap-TAG).	0.000542884	2015	PSCA	8	142681514	G	A
rs391957	21382870	3309	HSPA5	umls:C0278701	BeFree	These data provide the first evidence that the GRP78 rs391957 polymorphism can predict clinical outcome in localized GA and locally advanced CRC patients.	0.000542884	2011	HSPA5;GAPVD1	9	125241745	T	C
rs397507444	17972183	4524	MTHFR	umls:C0278701	BeFree	Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and susceptibility to gastric adenocarcinoma in an Italian population.	0.000271442	2007	MTHFR	1	11794407	T	G
rs4073	22891178	3586	IL10	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.000542884	2012	CXCL8	4	73740307	A	T
rs4073	22891178	3553	IL1B	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.001085767	2012	CXCL8	4	73740307	A	T
rs4073	22891178	3576	CXCL8	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.004538567	2012	CXCL8	4	73740307	A	T
rs4073	22891178	7124	TNF	umls:C0278701	BeFree	To investigate the potential association between five cytokine promoter polymorphisms (interleukin [IL] 1b -511C→T [rs16944], IL-4 receptor [IL-4R] -3223C→T [rs2057768], IL-8 -251T→A [rs4073], IL-10 -1082A→G [rs1800896] and tumour necrosis factor-alpha -308G→A [rs1800629]) and susceptibility to gastric adenocarcinoma in a Romanian population.	0.001900093	2012	CXCL8	4	73740307	A	T

GWASdb Annotation(Total Genotypes:0)
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GWASdb Snp Trait(Total Genotypes:0)
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Mapped by lexical matching(Total Items:0)
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Mapped by homologous gene(Total Items:0)
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Chemical(Total Drugs:0)
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FDA approved drug and dosage information(Total Drugs:0)
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FDA labeling changes(Total Drugs:0)
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